Search Results:　 1-15 of 15

OHSHIMA Takashi

… In the first part of this review, I discuss the great improvement of catalyst efficiency in an ALB-catalyzed asymmetric Michael reaction of malonate and application to the pre-manufacturing scale (greater than kilogram scale) and enantioselective total synthesis of (-)-strychnine with the development of novel domino cyclization. … In the second section, I discuss enantioselective total synthesis of (+)-decursin using catalytic asymmetric epoxidation. …

Chemical & pharmaceutical bulletin 52(9), 1031-1052, 2004-09-01

CiNii Fulltext PDF - Open Access  J-STAGE CrossRef References (224)

NAKATA Tadashi , KOMATSU Toshiya , NAGASAWA Kazuo

… The C24-C32 segment 4 of swinholide A (1) was stereoselectively synthesized starting from (S)-methyl 3-hydroxybutyrate, and the convergent synthesis of the C11-C32 segment 5 was accomplished via stereoselective aldol condensation of 3 and 4 …

Chemical & pharmaceutical bulletin 42(11), 2403-2405, 1994-11-15

CiNii Fulltext PDF - Open Access 

MORI Yuji

… A 1,3-polyhydroxylated chain is often found on the backbone of biologically important natural products. … We have developed a new general synthetic method of 1,3-polyols based on the coupling of a chiral dithiane, a four-carbon unit, and an epoxide, followed by 1,3-diastereoselective reduction. … We applied the method to the synthesis of polymethoxy-1-alkenes isolated from blue-green algae to establish their absolute stereochemistry. …

Journal of the Pharmaceutical Society of Japan 113(6), 438-453, 1993-06-25

CiNii Fulltext PDF - Open Access 

Kohchi Y. , Suzuki M. , Mori Y. , Moore R. E.

… Polymethoxy-1-alkenes 3-5 were first found in a field-collected sample of Tolypothrix conglutinata. … Scytonema mirabile produced 1 and 2, whereas 3 and 4 were isolated from S. … Synthesis of 1-8 were carried out in a convergent method, where a common synthetic intermediate 13 was used. … The epoxide 13 was prepared by the 1,3-polyol synthesis using a C_4-chiral building block 14 developed by us. …

天然有機化合物討論会講演要旨集 (33), 70-77, 1991-09-07

CiNii Fulltext PDF - Open Access 

MORI Yuji , KAGEYAMA Hitomi , SUZUKI Makoto

… The coupling reaction of the chiral building block (2) with the chiral epoxide (3) and highly syn-1,3-stereoselective reduction of the resulting β-hydroxy ketone (5) allowed us to achieve the stereoselective synthesis of tarchonanthuslactone (1). …

Chemical & pharmaceutical bulletin 38(9), 2574-2576, 1990-09-25

CiNii Fulltext PDF - Open Access 

Mori Yuji , Suzuki Makoto

… In connection with the stereochemical studies of sporaviridin, a polyol macrolide antibiotic, we have developed a convergent general protocol for syn-1,3-polyol synthesis. … Using this new method, total synthesis of 4,6,8,10,12,14,16,18,20-nonamethoxy-1-pentacosene (3), isolated from blue-green alga Tolypothrix conglutinate var. …

天然有機化合物討論会講演要旨集 (31), 52-59, 1989-09-17

CiNii Fulltext PDF - Open Access 

Nakata T. , Hata N. , Suenaga T. , Oishi T.

… The characteristic structural feature of the antibiotics is that they involve 1,3-polyol and all-trans-polyene moieties. … However, in most cases even a relative configuration of these 1,3-polyols remains unknown. … Convergent synthesis of 1,3-polyols: We have already reported a stereoselective and stepwise method for the synthesis of 1,3-syn and anti-polyols. …

天然有機化合物討論会講演要旨集 (30), 540-547, 1988-09-26

CiNii Fulltext PDF - Open Access