Search Results:　 1-20 of 78

1

Effect of Environmental Conditions on the α-Glucosidase Inhibitory Activity of Mulberry Leaves

NAKANISHI Hiromitsu , ONOSE Shinji , KITAHARA Eriko , CHUMCHUEN Sukunya , TAKASAKI Midori , KONISHI Hajime , KANEKATSU Rensuke

… Mulberry leaf components, for example 1-deoxynojirimycin (1-DNJ), inhibit the activity of α-glucosidase and prevent increased blood glucose levels, and they are highly toxic to caterpillars other than silkworms. …

Bioscience, Biotechnology, and Biochemistry 75(12), 2293-2296, 2011-12-23

J-STAGE Ichushi Web CrossRef References (12)
2

Interactions between Glycoside Hydrolase Family 94 Cellobiose Phosphorylase and Glucosidase Inhibitors

FUSHINOBU Shinya , HIDAKA Masafumi , HAYASHI Andressa M. , WAKAGI Takayoshi , SHOUN Hirofumi , KITAOKA Motomitsu

Journal of applied glycoscience 58(3), 91-97, 2011-07-20

References (29) Cited by (1)
3

Silkworm Pupae (Bombyx mori) Are New Sources of High Quality Protein and Lipid

TOMOTAKE Hiroyuki , KATAGIRI Mitsuaki , YAMATO Masayuki

… The 50% ethanol extract of silkworm pupae contained 1-deoxynojirimycin (DNJ), which is a potent α-glucosidase inhibitor. …

Journal of Nutritional Science and Vitaminology 56(6), 446-448, 2010-12-01

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4

Ammonium-Directed Oxidation of Cyclic Allylic and Homoallylic Amines [in Japanese]

KUROSAWA Wataru , ROBERTS Paul M. , DAVIES Stephen G.

… We have developed a metal-free and highly diastereoselective ammonium-directed dihydroxylation of 3-aminocyclohex-1-enes upon treatment with Cl3CCO2H followed by mCPBA. … The reaction mechanism involves protection of the amine by protonation, hydrogen-bonded delivery of the oxidant by the allylic ammonium ion formed in situ, followed by highly regioselective ring-opening of the intermediate syn-epoxide by trichloroacetic acid, to give a 1,2-anti-2,3-syn amino diol after deprotection. …

Journal of Synthetic Organic Chemistry, Japan 68(12), 1295-1306, 2010-12-01

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5

Development of Mulberry Leaf Product with α-Glucosidase Inhibitor for the Prevention of Type2 Diabetes Mellitus [in Japanese]

KIMURA Toshiyuki

近年の疫学的研究により、食後高血糖が心筋梗塞などの動脈硬化性疾患に対する独立した危険因子であることが明らかにされ、食事後の血糖のコントロールが糖尿病予防のターゲットと考えられている。我々が摂取している食品成分の中には食後血糖値の上昇を穏やかにするものがあり、食習慣に取り入れることで糖尿病の予防効果が期待される。桑葉は古くから糖尿病の予防効果が謳われてきた素材であり、科学的アプローチにより、その有効 …

Nippon Shokuhin Kagaku Kogaku Kaishi 57(2), 57-62, 2010-02-15

Japanese Agricultural Sciences Index J-STAGE CrossRef References (24) Cited by (2)
6

Optimization of 1-Deoxynojirimycin Extraction from Mulberry Leaves by Using Response Surface Methodology

VICHASILP Chaluntorn , NAKAGAWA Kiyotaka , SOOKWONG Phumon , SUZUKI Yasuyo , KIMURA Fumiko , HIGUCHI Ohki , MIYAZAWA Teruo

… Mulberry 1-deoxynojirimycin (DNJ, a potent α-glycosidase inhibitor) has therapeutic potency against diabetes mellitus. … However, the amount of DNJ in mulberry leaves is low (about 0.1%), and a more effective extraction method is needed. …

Bioscience, Biotechnology, and Biochemistry 73(12), 2684-2689, 2009-12-23

J-STAGE CrossRef References (22)
7

Validation of an Ion Trap Tandem Mass Spectrometric Analysis of Mulberry 1-Deoxynojirimycin in Human Plasma : Application to Pharmacokinetic Studies

NAKAGAWA Kiyotaka , KUBOTA Hiroyuki , TSUZUKI Tsuyoshi , KARIYA Jun , KIMURA Toshiyuki , OIKAWA Shinichi , MIYAZAWA Teruo

… Mulberry 1-deoxynojirimycin (DNJ) is a potent α-glucosidase inhibitor. …

Bioscience, Biotechnology, and Biochemistry 72(8), 2210-2213, 2008-08-23

J-STAGE Ichushi Web CrossRef References (15) Cited by (2)
8

Development and functional evaluation of 1-deoxynojirimycin enriched mulberry leaf product [in Japanese]

宮澤陽夫 , 木村俊之 , 仲川清隆

Food style 21 12(8), 24-26, 2008-08-00

Ichushi Web
9

The relationship between 1-deoxynojirimycin content and α-glucosidase inhibitory activity in leaves of 276 mulberry cultivars (Morus spp.) of Kyoto, Japan

YATSUNAMI Kazuhisa , ICHIDA Masatoshi , ONODERA Satoshi

Journal of natural medicines 62(1), 63-66, 2008-02-20

Ichushi Web References (12)
10

α-glucosidase inhibitory activity of mulberry leaves and fruits : its relationship with the quantity of 1-deoxynojirimycin in mulberry leaves [in Japanese]

KOYAMA Akio , MURAKAMI Ritsuko , KURIOKA Akira

日本シルク学会誌 : 日本シルク学会研究発表要旨集録 16, 130-131, 2007-12-01
11

Palladium(2)-catalyzed cyclization of urethanes and its application to a total synthesis of 1-deoxynojirimycin

Yokoyama Hajime , Kobayashi Hisatake , Miyazawa Masahiro 他

Heterocycles 74(-), 283-292, 2007-12-00
12

Stereoselective synthesis of D-1-deoxynojirimycin and its stereoisomers

Kim In Su , Lee Ho Young , Jung Young Hoon

Heterocycles 71(8), 1787-1800, 2007-08-01
13

Basic and Clinical Study-Effects and Toxicity Studies of the Mulberry Leaf Powder (Morus alba Leaves) in Volunteers with Hyperglycemia and Normoglycemia [in Japanese]

WATANABE Kenichi , NAKANO Ruriko , INOUE Mikio , WEN Juan , KUNIZAKI Megumi , MITO Sayaka , MA Meilei , VEERAVEEDU Punniyakoti T , GURUSAMY Narasimman , SELVARAJ Suresh P , PRAKASH Paras , WAHED Mir I , ALI Fadia K , ELBARBARY Reyad A , HESHMATIAN Behnam , NAKAYAMA Kayoko , HIRAYAMA Masao , KOBAYASHI Takashi , OYAMA Hiroshi , NAKAMURA Masahiko , ODA Yuji

… 【目的】桑葉にはα-グルコシダーゼ阻害活性をもつ1-デオキシノジリマイシンが含まれている.桑葉パウダーのデオキシノジリマイシン含有量と糖質分解能を検討した.更に,耐糖能異常者と正常血糖値成人における桑葉粉末の有効性と安全性について検討した.【方法と対象】(1)桑葉パウダーの基礎実験として,ラット小腸アセトンパウダーを用いて二糖類水解酵素阻害活性を茶葉と比較検討し,蒸発光散 …

Niigata medical journal 121(4), 191-200, 2007-04-00

CiNii Fulltext PDF - Open Access Ichushi Web
14

Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans

KIMURA T.

J. Agric. Food Chem. 55, 5869-5874, 2007

CrossRef Cited by (12)
15

Current Topics in Food and Biodynamic Chemistry Research

MIYAZAWA Teruo , KAWAKAMI Yuki , KIMURA Toshiyuki , SUZUKI Yoshihiro , YAMASHITA Shinji , ABE Renpei , IBUSUKI Daigo , SOOKWONG Phumon , TSUZUKI Tsuyoshi , KIMURA Fumiko , NAKAGAWA Kiyotaka

… glucosidase inhibition by mulberry 1-deoxynojirimycin; …

Tohoku journal of agricultural research 57(1/2), 33-54, 2006-11-00

CiNii Fulltext PDF - Open Access IR
16

Extraction of Mulberry Leaf Components Using an Ethanol Solution with Electrolyzed Water [in Japanese]

KOBAYASHI Kenji , HARA Yasuo , KATSUBE Takuya

… 水道水を原水として隔膜電解槽で電気分解して得られた電解水で希釈した含水エタノールで桑葉成分の抽出について検討を行い以下の結果を得た．<BR>（1）DNJの抽出量は酸性電解水pH 4で水道水に対して3％程増加したが，α-グルコシダーゼ阻害活性は酸性電解水pH 4，pH 5共に10％高い活性を示した．<BR>（2）DPPHラジカル消去能は酸性電解水，アルカリ性電解水共に原水に対して増加し，その増加量は電解強度に比 …

Nippon Shokuhin Kagaku Kogaku Kaishi 53(10), 548-550, 2006-10-15

J-STAGE CrossRef References (13) Cited by (1)
17

Hydrophilic Interaction Chromatography for Determination of 1-Deoxynojirimycin in Mulberry Leaves [in Japanese]

NAKAGAWA Kiyotaka , KIMURA Toshiyuki

ぶんせき (381), 437-440, 2006-09-05

References (11) Cited by (1)
18

1-Deoxynojirimycin Derivatives from the Marine Sponge Lendenfeldia chondrodes

SAKAI Ryuichi , KAMIYA Hisao

Journal of antibiotics = An International Journal Devoted to Research on Bioactive Microbial Products 59(8), 507-511, 2006-08-25

References (24)
19

Evaluation of α-glucosidase Inhibitory Activity in Colored Foods : a Trial Using Slope Factors of Regression Curves [in Japanese]

YAMAKI Kohji , MORI Yutaka

血糖値の気になる人に対する食品の成分として，αグルコシダーゼの抑制活性が有効と考えられる．この活性を持つ食品の探索において，有色試料の測定に汎用できる，簡便な測定法を開発した．吸光度直線の傾きをその活性の指標として96穴マイクロプレート用いた簡便な測定法を考案し，お茶等の飲料のαグルコシダーゼの抑制活性の測定に応用した．その結果，用いた試料の内で，桑茶は最も強力な抑制活性を示し，次にグワバ茶，市販 …

Nippon Shokuhin Kagaku Kogaku Kaishi 53(4), 229-231, 2006-04-15

J-STAGE CrossRef References (6) Cited by (1)
20

Isolation of a Human Intestinal Bacterium That Transforms Mangiferin to Norathyriol and Inducibility of the Enzyme That Cleaves a C-Glucosyl Bond(Pharmacognosy)

SANUGUL Kanjana , AKAO Teruaki , LI Yan , KAKIUCHI Nobuko , NAKAMURA Norio , HATTORI Masao

… We isolated the specific bacterium involved in the metabolism of mangiferin (2-β-D-glucopyranosyl-1, 3, 6, 7-tetrahydroxyxanthone), C-glucosyl xanthone, from a mixture of human fecal bacteria. … The C-glucosyl-cleavage in cell-free extracts was not altered by potent glucosidase inhibitors such as 1-deoxynojirimycin and gluconolactone. …

Biological & pharmaceutical bulletin 28(9), 1672-1678, 2005-09-01

CiNii Fulltext PDF - Open Access J-STAGE Ichushi Web CrossRef Cited by (2)

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