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Search Results:　 1-20 of 86

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1

Comparison of in vitro metabolic conversion of capecitabine to 5-FU in rats, mice, monkeys and humans - toxicological implications

SHINDOH Hidetoshi , NAKANO Kohnosuke , YOSHIDA Takemi , ISHIGAI Masaki

… is an oral anticancer prodrug which is converted to 5-fluorouracil (5-FU) via 3 enzymatic steps, these being 5'-deoxy-5-fluorocytidine (5'-DFCR), 5'-deoxy-5-fluorouridine (5'-DFUR), and finally 5-FU by carboxylesterase (CES), cytidine deaminase (CDA), and …

The Journal of Toxicological Sciences 36(4), 411-422, 2011-08-01

J-STAGE Ichushi Web CrossRef References (25)
2

Phosphorylation of 5'-Deoxy-5-fluorouridine with Inorganic Phosphorylating Agents

Maeda Hideko , Kusuhara Takuma , Tsuhako Mitsutomo , Nakayama Hirokazu

… The phosphorylation of 5′-deoxy-5-fluorouridine (doxifluridine, 5′-DFUR) has been achieved using inorganic cyclo-triphosphate (P3m, Na3P3O9) and monoimido-cyclo-triphosphate (MCTP, Na3P3O8NH) in aqueous solution. … In the reaction of 5′-DFUR with P3m, 2′-monophospho-5′-DFUR and 3′-monophospho-5′-DFUR were synthesized with a total yield of more than 95%. …

Chemical and Pharmaceutical Bulletin 59(12), 1447-1451, 2011

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3

Chronic Myeloid Leukemia following Chemotherapy with 5'-deoxy-5-fluorouridine for Gastric Cancer

Tsuzuki Motohiro , Handa Kousuke , Yamamoto Kiyoko , Hasegawa Akio , Yamamoto Yukiya , Watanabe Masato , Mizuta Syuichi , Maruyama Fumio , Okamoto Masataka , Emi Nobuhiko , Ezaki Kohji

… We report here a very rare case of chronic myeloid leukemia (CML) following long-term chemotherapy with 5'-deoxy-5-fluorouridine (5'-DFUR) for gastric cancer. … Six years previously, he underwent radical subtotal gastrectomy for gastric cancer, and was subsequently treated with oral anti-metabolite 5'-DFUR as adjuvant chemotherapy for 6 years. …

Internal Medicine 47(19), 1739-1741, 2008

J-STAGE Ichushi Web CrossRef Cited by (1)
4

Clinical Usefulness of Oral Combination Chemotherapy of 5'-Deoxy-5-Fluorouridine (5'-DFUR) and Cyclophosphamide for Metastatic Breast Cancer

YAMASHITA Toshinari , YAMASHITA Hiroko , ITOH Yukashi , KARAMATSU Shoji , ITOH Kazuko , HARA Yasuo , ANDO Yoshiaki , SUGIURA Hiroshi , KUZUSHIMA Tatsuya , TOYAMA Tatsuya , IWATA Hiroji , KOBAYASHI Shunzo , IWASE Hirotaka

Breast cancer : the journal of the Japanese Breast Cancer Society 13(4), 334-339, 2006-10-31

Ichushi Web References (8)
5

RELATIONSHIP BETWEEN AUC of 5'-DFUR AND TOXICITY OF CAPECITABINE, FLUOROPYRIMIDINE CARBAMATE ANALOGS, AND 5'-DFUR IN MONKEYS, MICE, AND RATS

SHINDOH Hidetoshi , KAWASHIMA Akira , SHISHIDO Nobuyuki , NAKANO Kounosuke , KOBAYASHI Kazuko , HORII Ikuo

… Capecitabine is an oral fluoropyrimidine carbamate which is converted to 5-fluorouracil (5-FU) via 3 enzymatic step to 5'-deoxy-5-fluorocytidine (5'-DFCR), 5'-deoxy-5-fluorouridine (5'-DFUR), and finally 5-FU. …

Journal of toxicological sciences 31(3), 265-285, 2006-08-23

CiNii Fulltext PDF - Open Access J-STAGE Ichushi Web CrossRef References (30) Cited by (1)
6

The efficacy of long-term oral chemotherapy with 5'-deoxy-5-fluorouridine and cyclophosphamide for recurrent breast cancer

IBA Toshiaki , KIDOKORO Akio , FUKUNAGA Masaki , SUGIYAMA Kazuyoshi , AIHARA Nobuyoshi , SUDA Masaru

International journal of clinical oncology : official journal of the Japan Society of Clinical Oncology 9(5), 383-387, 2004-10-01

Ichushi Web References (10)
7

The ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase in tumour tissues of patiehts with metastatic gastric cancer is predictive of the clinical response to 5'-deoxy-5-fluorouridine

NISHINA T.

Eur. J. Cancer 40, 1566-1571, 2004

CrossRef Cited by (1)
8

Positive Response to Oral Chemoendocrine Combination Therapy Using 5'-Deoxy-5-Fluorouridine for Locally Advanced Breast Cancer with Carcinomatous Pleurisy : Report of a Case

SUZUKI ON , SEKISHITA YOSHIAKI , SHIONO TUNEO , KONDO SATOSHI , KATO HIROYUKI

Surgery today : the Japanese journal of surgery 33(12), 913-916, 2003-12-01

References (10)
9

Pharmacological and clinical properties of Xeloda (Capecitabine), a new oral active derivative of fluoropyrimidine [in Japanese]

NISHIDA Masanori

… は，腫瘍選択的に5-FUを生成するようにデザインされたフルオロシチジン誘導体である．本薬は消化管より未変化体のまま速やかに吸収され，肝臓でカルボキシルエステラーゼ（CE）による加水分解を受け5'-deoxy-5-fluorocytidine（5'-DFCR）となる．次に主として肝臓や腫瘍組織に存在するシチジンデアミナーゼ（CD）により5'- …

Folia Pharmacologica Japonica 122(6), 549-553, 2003-12-01

J-STAGE Ichushi Web CrossRef References (7)
10

A Case of Chest Wall Recurrence of Breast Cancer Treated with Paclitaxel Weekly, 5'-Deoxy-5-Fluorouridine, Arterial Embolization and Chest Wall Resection

TOKUNAGA Yukihiko , HOSOGI Hisahiro , NAKAGAMI Mikio , TOKUKA Atsuo , OHSUMI Kiyoshi

Breast cancer : the journal of the Japanese Breast Cancer Society 10(4), 366-370, 2003-10-01

References (11)
11

The potential for oral combination chemotherapy of 5'-deoxy-5-fluorouridine, a 5FU prodrug, and cyclophosphamide for metastatic breast cancer

YOSHIMOTO M

Br J Cancer 89, 1627-1632, 2003

CrossRef Cited by (1)
12

164 上皮性卵巣癌細胞株におけるpaclitaxel接触によるthymidine phosphorylase発現と5'-deoxy-5-fluorouridine感受性の検討 [in Japanese]

秦幸吉 , 金崎春彦 , 藤脇律人 , 中山健太郎 , 宮崎康二

Acta Obstetrica et Gynaecologica Japonica 54(2), 297, 2002-02-01

CiNii Fulltext PDF - Subscription Ichushi Web
13

Lymphatic Delivery of Anticancer Drug by Lipid MicrospheresContaining Prodrug of 5'-Deoxy-5-fluorouridine

Endoh Hirotaka , Kumakura Katsuyori , Ohmori Hiromasa , Okumura Mutsuo , Ukigaya Tadashi , Seki Toshinobu , Juni Kazuhiko

Pharmaceutical bulletin of Josai University 22, 68, 2002-01-31
14

The effect of adjuvant 5 '-deoxy-5-fluorouridine in early stage breast cancer patients: Results from a multicenter randomized controlled trial

INTERNATIONAL JOURNAL OF ONCOLOGY 20(3), 517-525, 2002-00-00

IR
15

Plasma, Intestine and Tumor Levels of 5-Fluorouracil in Mice Bearing L1210 Ascites Tumor Following Oral Administration of 5-Fluorouracil, UFT(Mixed Compound of Tegafur and Uracil), Carmofur and 5'-Deoxy-5-fluorouridine

OOI Kazuya , OHKUBO Toshiki , HIGASHIGAWA Masamune , KAWASAKI Hajime , KAKITO Hideshi , KAGAWA Yoshiyuki , KOJIMA Michio , SAKURAI Minoru

… Several 5-fluorouracil (5-FU) derivatives, 1-hexylcarbamoyl-5-fluorouracil (HCFU), 5'-deoxy-5-fluorouridine (5'-DFUR) and UFT (mixed compound of tegafur and uracil), have been developed and clinically widely used. …

Biological & pharmaceutical bulletin 24(11), 1329-1331, 2001-11-01

CiNii Fulltext PDF - Open Access J-STAGE Ichushi Web CrossRef References (20)
16

Elevated Expression of Pyrimidine Nucleoside Phosphorylase (PyNPase) in Renal Cell Carcinoma Tissue

Maeda Kanenori , Noguchi Mitsuru , Nomata Koichiro , Koga Shigehiko , Kanetake Hiroshi

… Background: Pyrimidine nucleoside phosphorylase (PyNPase) is an enzyme that converts 5'-deoxy-5-fluorouridine to 5- fluorouracil. …

Acta medica Nagasakiensia 46(1/2), 27-31, 2001-06-00

IR Ichushi Web
17

5'-Deoxy-5-Fluorouridine, Medroxyprogestrone Acetate and Mitoxantrone Hydrochloride for Advanced or Recurrent Breast Cancer

SATA Kazuhiko , HIRAIDE Hoshio , TAMAKUMA Shoetsu , TABEI Toshio , MARUYAMA Masashige , TOUMA Mituyuki , OKAMURA Haruaki , MATSUMOTO Fumio , AKAO Shuichi , ISHIKAWA Hiroshi , YAGI Yoshihiro , MOCHIZUKI Hidetaka

Breast cancer : the journal of the Japanese Breast Cancer Society 8(1), 58-62, 2001-01-25

Ichushi Web References (18)
18

A CASE OF ADVANCED GASTRIC CANCER WITH MULTIPLE LIVER METASTASES SUCCESSFULLY TREATED WITH POST OPERATIVE INTRAHEPATIC CHEMOTHERAPY AND ORAL ADMINISTRATION OF 5'-DEOXY-5-FLUOROURIDINE [in Japanese]

NAKASHIMA Hiroshi , HAYASHI Yoshihiko , FURUGAKI Kouichi , NISHINAKA Hidekazu , KASHIWAGI Takahito

日本臨床外科学会雑誌 = The journal of the Japan Surgical Association 61(10), 2647-2651, 2000-10-25

Ichushi Web References (17)
19

Lymphatic delivery of anticancer drug by lipid microspheres containing prodrug of 5'-deoxy-5-fluorouridine [in Japanese]

ENDOH Hirotaka , KUMAKURA Katsuyori , OHMORI Hiromasa , OKUMURA Mutsuo , UKIGAYA Tadashi , SEKI Toshinobu , JUNI Kazuhiko

… Lipid microspheres (LM) containing lipophilic prodrug of 5'-deoxy-5-fluorouridine(5'-DFUR), 2', 3'-didecanoyl-5'-deoxy-5-fluorouridine(C 10-5'-DFUR), were prepared. …

Drug Delivery System 15(5), 457-465, 2000-09-10

J-STAGE Ichushi Web CrossRef References (15)
20

P-50 卵巣癌細胞の浸潤能および5'-deoxy-5-fluorouridine感受性に対する性ステロイドと増殖因子の効果 [in Japanese]

熊谷広治 , 植田政嗣 , 寺井義人 , 植木健 , 金村昌徳 , 植木實

Acta Obstetrica et Gynaecologica Japonica 52(2), "389(S-313)", 2000-02-01

CiNii Fulltext PDF - Subscription Ichushi Web

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Related Authors

Related Journals

Breast cancer : the journal of the Japanese Breast Cancer Society
Acta Obstetrica et Gynaecologica Japonica
Acta medica Nagasakiensia
Biological & pharmaceutical bulletin
Br J Cancer
Chemical and Pharmaceutical Bulletin
Drug Delivery System
Eur. J. Cancer
Folia Pharmacologica Japonica
INTERNATIONAL JOURNAL OF ONCOLOGY
Internal Medicine
International journal of clinical oncology : official journal of the Japan Society of Clinical Oncology
Journal of toxicological sciences
Pharmaceutical bulletin of Josai University
Surgery today : the Japanese journal of surgery
The Journal of Toxicological Sciences
日本臨床外科学会雑誌 = The journal of the Japan Surgical Association

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