Yoshioka Kazuaki
,
Yoshida Kotaro
,
Cui Hong
,
Wakayama Tomohiko
,
Takuwa Noriko
,
Okamoto Yasuo
,
Du Wa
,
Qi Xun
,
Asanuma Ken
,
Sugihara Kazushi
,
Aki Sho
,
Miyazawa Hidekazu
,
Biswas Kuntal
,
Nagakura Chisa
,
Ueno Masaya
,
Iseki Shoichi
,
Schwartz Robert J.
,
Okamoto Hiroshi
,
Sasaki Takehiko
,
Matsui Osamu
,
Asano Masahide
,
Adams Ralf H.
,
Takakura Nobuyuki
,
Takuwa Yoh
… Global or endothelial-cell-specific deficiency of PI3K-C2α resulted in embryonic lethality caused by defects in sprouting angiogenesis and vascular maturation. … Endothelial PI3K-C2α deficiency in vivo suppressed postischemic and tumor angiogenesis and diminished vascular barrier function with a greatly augmented susceptibility to anaphylaxis and a higher incidence of dissecting aortic aneurysm formation in response to angiotensin II infusion. …
Nature Medicine 18(10), 1560-1569, 2012-10-00
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