検索結果:　2369件中 1-20 を表示

1

Isolation and Characterization of Bovine Intestinal Subepithelial Myofibroblasts

Iwanaga Koichi , Murata Takahisa , Hori Masatoshi [他] , Ozaki Hiroshi

… 10 nM bradykinin) dose-dependently induced an increase in intracellular Ca2+ concentration in bovine ISMFs (passage 3 and 7). …

Journal of Pharmacological Sciences advpub(0), 0912160327, 2010

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2

OE-219 Role of Bradykinin and Chymase in Cardiorenal Function under Chronic ACE Inhibition in Heart Failure(OE37,Kidney/Renal Circulation/CKD 1 (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Wada Atsuyuki , Matsumoto Takehiro , Ohnishi Masato , Fujii Masanori , Yamamoto Takashi , Tsutamoto Takayoshi , Horie Minoru

Circulation journal : official journal of the Japanese Circulation Society 73(Supplement_I), 228, 20090301

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3

メシル酸ナファモスタット不耐性患者における白血球除去療法中のブラジキニンによる症状をメシル酸ガベキサートで改善できた1例

梶原健吾 , 中村享道 , 勝屋弘明 , 柿添豊 , 前川愛 , こう健博 , 井上秀樹 , 北村健一郎 , 冨田公夫

白血球除去療法 (LCAP) は，体外循環下に患者末梢血から白血球を除去する治療法であり，潰瘍性大腸炎（UC）の重要な治療法の一つである．LCAP施行の際には，メシル酸ナファモスタット（NM）が抗凝固剤として選択される．これはUC患者における消化管出血のリスク軽減のためや，セルソーバEX® を構成する陰性荷電膜と血液の接触によるブラジキニン（BK）の産生を抑制し，BKに誘発される血圧低下 …

日本透析医学会雑誌 42(6), 459-463, 2009

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4

Analysis of the Mechanism for the Development of Allergic Skin Inflammation and the Application for Its Treatment:Mechanisms and Management of Itch in Atopic Dermatitis

Ikoma Akihiko

… Inflammatory mediators such as bradykinin that, normally, do not induce itch can function as pruritogens under neural sensitization, which also affects the treatment to a considerable extent. …

Journal of Pharmacological Sciences 110(3), 265-269, 2009

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5

New Aspects for the Treatment of Cardiac Diseases Based on the Diversity of Functional Controls on Cardiac Muscles: Mitochondrial Ion Channels and Cardioprotection

Nishida Hirofumi , Sato Toshiaki , Ogura Takehiko [他] , Nakaya Haruaki

… Several endogenous substances such as adenosine and bradykinin can reduce infarct size by activation of mitoKATP channels in a PKC-dependent manner. …

Journal of Pharmacological Sciences advpub(0), 0903060214, 2009

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6

Impairment of Calcium-Activated Potassium Channels in Endothelium-Derived Hyperpolarizing Factor Responses in Spontaneously Hypertensive Rats

Hasegawa Kazushi , Oikawa Koichi , Yoshida Ikko , Ishizaka Hiroshi , Osanai Tomohiro , Motomura Shigeru , Okumura Ken

… Bradykinin increased coronary fl ow（ CF） dosedependentlyand this was not aff ected by NG-nitro-L-arginine methyl ester or indomethacin, indicating that bradykinin’seff ect on CF was not mediated by nitric oxide or prostacyclin but by EDHF. … Bradykinin-induced CF increase was smallerin SHR than in WKY. … Tetrabutylammonium（ a non-specific KCa channel blocker） abolished bradykinin-induced CFincrease in both rats. …

弘前醫學 60(1/2/3/4), 86-95, 20090000

医中誌機関リポジトリ
7

Functional characterization of Arabidopsis calreticulin1a: a key alleviator of endoplasmic reticulum stress

Christensen Anna , Svensson Karin , Persson Staffan [他]

Plant and Cell Physiology 49(6), 912〜924, 2008/6
8

Effectiveness of Statin-Eluting Stent on Early Inflammatory Response and Neointimal Thickness in a Porcine Coronary Model

Miyauchi Katsumi , Kasai Takatoshi , Yokayama Takayuki , Aihara Kouichiro , Kurata Takeshi , Kajimoto Kan , Okazaki Shinya , Ishiyama Haruo , Daida Hiroyuki

… At day 28, endothelial function with intracoronary infusion of bradykinin was preserved in both the CES and BMS groups. …

Circulation journal : official journal of the Japanese Circulation Society 72(5), 832-838, 20080420

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9

A Novel Model of Pain Sensation Using Superfused Gastrosplenic Omentum Preparation of Anesthetized Rats

YANG Shi-Jie , KATORI Makoto , MAJIMA Masataka

… Administration of bradykinin (BK) in the chamber elicited the reflex hypertensive response (RHR). …

Journal of pharmacological sciences 106(2), 249-256, 20080220

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10

Effects of interleukin-1α on the production and release of basic fibroblast growth factor in cultured nifedipine-reactive gingival fibroblasts

Sato Naoto , Fujii Akira

… Ca2+-mobilizing agents, thapsigargin and bradykinin, were also tested to determine whether they affected the production and release of bFGF. … Levels of released bFGF were significantly higher in cells pretreated with IL-1α, followed by bradykinin and thapsigargin in the presence of extracellular Ca2+. …

Journal of Oral Science 50(1), 83-90, 2008

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11

Interaction between α-Linolenic Acid-Enriched Oil and ACE Inhibitor Concerning the Decrease in Blood Pressure in SHR

Matsuo Tatsuhiro , Yagi Kanako

α-Linolenic acid (ALA) has been reported to exhibit an antihypertensive effect. Angiotensin-converting enzyme inhibitor (ACEI) is also an antihypertensive agent. We evaluated the interaction between A …

Journal of Oleo Science 57(1), 11-14, 2008

医中誌 J-STAGE
12

Effect of Chronic Topical Exposure to Low-Dose Noxious Chemicals and Stress on Skin Sensitivity in Mice

NAKANO Yumiko

… At the formalin-treated sites, genes related to neurogenic inflammation, i.e., bradykinin (BK) B2 receptor, IL-6, and membrane metallo endopeptidase (NEP) mRNA were upregulated. …

Journal of occupational health 49(6), 431-442, 20071100

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13

LDLアフェレシス(LDL-A)中にブラジキニン起因性ショックを起こしたと考えられたアンギオテンシンII type 1受容体拮抗薬服用中の1症例(<特集>急性臓器障害に対するアフェレシス)

永山嘉恭 , 岩崎滋樹 , 河嶋英里 , 井上嘉彦 , 由利康裕 , 吉村吾志夫

… Plasma bradykinin (p-BK) levels were measured on the four points of pre-LDL-A, before and after the column after 1, 000ml of plasma treatment and post-LDL-A in the presence of FUT or DA. …

日本アフェレシス学会雑誌 26(3), 346-349, 20071031

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14

Endoplasmic Reticulum Is a Key Organella in Bradykinin-Triggered ATP Release From Cultured Smooth Muscle Cells

ZHAO Yumei , MIGITA Keisuke , SATO Chiemi , USUNE Sadaharu , IWAMOTO Takahiro , KATSURAGI Takeshi

… Here we show that bradykinin via B2-receptor stimulation induces the extracellular release of ATP via the inositol 1,4,5-trisphosphate [Ins(1,4,5)P3]-signaling pathway in cultured taenia coli smooth muscle cells. … It was found that bradykinin also increased the production of Ins(1,4,5)P3 and 2-APB-inhibitable [Ca2+]i. … Bradykinin caused a quick and transient accumulation of intracellular ATP from cells treated with 1% perchloric acid solution (PCA), but not with the cell lysis buffer. …

Journal of pharmacological sciences 105(1), 57-65, 20070920

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15

アンジオテンシンタイプ2受容体を介した血管弛緩機構

屋山勝俊 , 岡本博

… Ang II binding to up-regulated AT_2 receptors induces vasodilation in these aortas through bradykinin B_2-receptor-mediated phosphorylation of endothelial nitric oxide synthase (eNOS) at Ser^<633> … These studies provide evidence that the vascular AT_2 receptor is up-regulated in the course of hypertension through the activation of AT_1 receptor, thereby activating a vasodilatory pathway in vessels through the AT_2 receptor via the bradykinin/nitric oxide/cGMP. …

藥學雜誌 127(9), 1357-1367, 20070901

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16

Effects of Bradykinin on Aortic Endothelial Function in ApoE-Knockout Mice With Chronic Chlamydia Pneumoniae Infection

Liuba Petru , Karnani Paivi , Pesonen Erkki , Paakkari Ilari , Persson Kenneth , Forslid Anders

… Using additional aorta samples the present study investigated the responses to bradykinin. … At 2, 6, and 10 weeks after the first inoculation, precontracted aorta rings from both groups were exposed to bradykinin in the absence and presence of L-NAME and diclofenac. … In noninfected animals, the vasomotor responses to bradykinin were similar at all timepoints (p>0.5). …

Circulation journal : official journal of the Japanese Circulation Society 71(9), 1480-1484, 20070820

CiNii PDF CrossRef 医中誌 J-STAGE 参考文献34件
17

α_1-Acid Glycoprotein Suppresses Rat Acute Inflammatory Paw Edema through the Inhibition of Neutrophils Activation and Prostaglandin E_2 Generation(Pharmacology)

MATSUMOTO Kazuaki , NISHI Koji , KIKUCHI Mari , KADOWAKI Daisuke , TOKUTOMI Yoshiko , TOKUTOMI Naofumi , NISHI Katsuhide , SUENAGA Ayaka , OTAGIRI Masaki

… These results suggest that both initia inflammatory mediators (serotonin and histamine) and later inflammatory mediators (prostaglandin and bradykinin) are involved in the anti-inflammatory effects of AGP. …

Biological & pharmaceutical bulletin 30(7), 1226-1230, 20070701

CiNii PDF CrossRef 医中誌 J-STAGE 参考文献42件被引用文献1件
18

ラット培養脊髄後根神経節ニューロンにおけるノルアドレナリンのブラジキニン応答への影響--ホールセルパッチクランプ法による電気生理学的解析

前田亮

口腔病学会雑誌 74(2), 99〜107, 2007/6

医中誌
19

ブタ舌動脈血管平滑筋に対する炎症性ケミカルメディエータの影響

西健 , 佐藤健一

… These specimens were attached to the thermostat incubator of an intracellular calcium ion concentration measurement unit, stimulated with 40 mM KCl, noradrenalin (NA), or U46619, followed by administration of acetylcholine (ACh) or bradykinin (BK), and the isometric contractile tension generated and fluorescence intensity ratio were simultaneously measured ; …

岩手医科大学歯学雑誌 32(1), 25-34, 20070425

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20

Antioxidant and Vascular Protective Activities of Cratoxylum formosum, Syzygium gratum and Limnophila aromatica(Pharmacology)

KUKONGVIRIYAPAN Upa , LUANGARAM Saowanee , LEEKHAOSOONG Krissadarut , KUKONGVIRIYAPAN Veerapol , PREEPRAME Srisomporn

… Vascular responsiveness to bradykinin, acetylcholine, and phenylephrine in PHZ-control rats was markedly impaired, and the plant extracts or NAC largely restored the vascular responses. …

Biological & pharmaceutical bulletin 30(4), 661-666, 20070401

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