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Children's Immunology, what can we learn from animal studies (2) : Modulation of systemic Th1/Th2 immune response in infant mice after prenatal exposure to low-level toluene and toll-like receptor (TLR) 2 ligand
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Yamamoto Shoji
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Shwe Tin-Tin-Win
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Yoshida Yasuhiro
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Kunugita Naoki
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Arashidani Keiichi
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Fujimaki Hidekazu
… We examined Th1/Th2 balance in the offspring's at 3 weeks old using ELISA and real-time RT-PCR methods. … On the other hand, splenic expression of transcription factor T-bet (Th1-specific), GATA-3 (Th2-specific) and Foxp3 (gene marker for regulatory CD4+CD25+ T-cells) mRNAs was suppressed in these mice, but not in the combination of 5 or 50ppm toluene with PGN. …
The Journal of Toxicological Sciences 34(Special Issue II), SP341-SP348, 20090700
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