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  • アルギニンによる血管拡張機能増強効果に対する抗酸化ビタミンの影響に関する研究

    田川 辰也 , 青木 るみ子 , 境田 靖子 , 石本 祐子 , 近江 雅代

    … 血液検査では総コレステロール、中性脂肪、HDL- コレステロール、高感度C 反応性蛋白(CRP)、高分子アディポネクチン、尿検査では尿中NOx 濃度とNOx/Cr 値を測定した。 …

    西南女学院大学紀要 = Bulletin of Seinan Jo Gakuin University 21, 125-134, 2017-03-01

    機関リポジトリ

  • Relationships between lifestyle patterns and cardio-renal-metabolic parameters in patients with type 2 diabetes mellitus: A cross-sectional study

    Ogihara Takeshi , Mita Tomoya , Osonoi Yusuke , Osonoi Takeshi , Saito Miyoko , Tamasawa Atsuko , Nakayama Shiho , Someya Yuki , Ishida Hidenori , Gosho Masahiko , Kanazawa Akio , Watada Hirotaka

    … Subjects characterized by high consumption of food, alcohol and cigarettes (type 2 pattern) had high levels of γ-glutamyl transpeptidase, triglycerides, HDL-cholesterol, blood pressure, and brachial-ankle pulse wave velocity. … Type 2 pattern was associated with higher HDL-cholesterol levels, triglycerides, aspartate aminotransferase, ɤ- glutamyl transpeptidase levels, and diastolic BP.ConclusionsThe study identified three lifestyle patterns that were associated with distinct cardio-metabolic-renal parameters in T2DM patients. …

    PLOS ONE 12(3), e0173540, 2017-03

    機関リポジトリ DOI

  • Serum albumin levels and their correlates among individuals with motor disorders at five institutions in Japan

    Ohwada Hiroko , Nakayama Takeo , Kanaya Yuki , Tanaka Yuki

    … Low serum albumin level was related with female sex, older age, low calf circumference, low relative daily energy intake, low hemoglobin (Hb), low blood platelet count, low high-density lipoprotein cholesterol (HDL-C), low HbA1c, and high C-reactive protein (CRP) levels. … The strongest correlates, based on standardized betas, were Hb (0.321), CRP (-0.279), and HDL-C (0.279) levels. …

    Nutrition Research and Practice 11(1), 57-63, 2017-02

    機関リポジトリ DOI

  • Homogeneous Assays for LDL-C and HDL-C are Reliable in Both the Postprandial and Fasting State

    Miida Takashi , Nishimura Kunihiro , Hirayama Satoshi , Miyamoto Yoshihiro , Nakamura Masakazu , Masuda Daisaku , Yamashita Shizuya , Ushiyama Masaji , Komori Toshiaki , Fujita Naohisa , Yokoyama Shinji , Teramoto Tamio

    … Although the homogeneous assays with poor analytical performance were withdrawn from the market, it remained unclear whether the currently available reagents for LDL-C and high-density lipoprotein-cholesterol (HDL-C) are as accurate for postprandial samples as for fasting samples.</p><p><b><i>Methods</i></b><b>: </b>Fresh blood samples were collected from 59 non-diseased and 109 diseased subjects. …

    Journal of Atherosclerosis and Thrombosis 24(6), 583-599, 2017

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  • Recent Advances in Fluorescent Angioscopy for Molecular Imaging of Human Atherosclerotic Coronary Plaque

    Uchida Yasumi

    … Using specific biomarkers, native pro-atherogenic substances such as oxidized low-density lipoprotein (ox-LDL), LDL, triglycerides (TG), apolipoprotein B-100 (ApoB-100), and lysophosphatidylcholine (LPC), and the anti-atherogenic substance such as high-density lipoprotein (HDL) were visualized by CFA, and LDL and cholesterol by NIRFA, in coronary plaques obtained from autopsy subjects. …

    Journal of Atherosclerosis and Thrombosis 24(6), 539-551, 2017

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  • アテローム性動脈硬化症と脂肪性肝炎をともに改善し得る新規治療戦略

    池田 義人

    … LXRは,腸細胞や肝細胞など多くの細胞に発現しており,脂質代謝関連遺伝子群の発現制御を介してHDL粒子の形成などに関与する.そのためLXRを活性化することで,動脈硬化病巣に認められるプラークからコレステロールを排出させる治療が可能になると期待されている.しかし,合成アゴニストを用いたLXR活性化は,脂肪酸合成関連遺伝子群の転写因子sterol regulatory element-binding protein 1c(SREBP-1c)の発現を上昇させることが …

    ファルマシア 53(6), 590-590, 2017

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  • Is High Serum LDL/HDL Cholesterol Ratio an Emerging Risk Factor for Sudden Cardiac Death? Findings from the KIHD Study

    Kunutsor Setor K. , Zaccardi Francesco , Karppi Jouni , Kurl Sudhir , Laukkanen Jari A.

    … Low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c), which are components of total cholesterol, have each been suggested to be linked to the risk of sudden cardiac death (SCD). … However, the relationship between LDL-c/HDL-c ratio and the risk of SCD has not been previously investigated. …

    Journal of Atherosclerosis and Thrombosis 24(6), 600-608, 2017

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  • Additive Beneficial Effect of Epigallocatechin Gallate and Quercetin on the Arteriosclerosis Index in Mice

    Yamaki Kohji , Takahashi Yoko

    … Blood samples were collected by cardiac puncture and total, HDL, and LDL cholesterol levels were measured. …

    Food Science and Technology Research 23(2), 355-361, 2017

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  • The Impact of Supplementation with Folic Acid on Homocysteine Concentration and Selected Lipoprotein Parameters in Patients with Primary Hypertension

    BASZCZUK Aleksandra , THIELEMANN Anna , MUSIALIK Katarzyna , KOPCZYNSKI Jaroslaw , BIELAWSKA Lena , DZUMAK Anna , KOPCZYNSKI Zygmunt , WYSOCKA Ewa

    … The aim of the study was the assessment of the impact of supplementation with folic acid on the concentration of homocysteine, total cholesterol (TC), HDL- and LDL-cholesterol, triglycerides (TG), apoprotein AI (apoAI) and apoprotein B (apoB) in patients suffering from primary hypertension. … All examined patients underwent laboratory tests as follows: concentration of homocysteine, folic acid, TC, LDL-cholesterol, HDL-cholesterol, TG, apoAI and apoB. …

    Journal of Nutritional Science and Vitaminology  63(2), 96-103, 2017

    DOI

  • イオン交換高速液体クロマトグラフィー法を用いたホルスタイン種成乳牛におけるコレステロールリポ蛋白質分画の分析

    高橋 知也 , 森 昭博 , 廣渡 祐史 , 小田 民美 , 田高良 聡恵 , 真仁田 大輔 , 水谷 尚 , 三木 陽平 , 板橋 由起子 , 左向 敏紀

    … イオン交換高速クロマトグラフィー(AEX-HPLC)法は近年、ヒト領域で開発され、血清リポ蛋白質を高密度リポ蛋白質(HDL)、低密度リポ蛋白質(LDL)、中間密度リポ蛋白質、および超低密度リポ蛋白質に分けて測定することが可能となった。 …

    ペット栄養学会誌 20(1), 30-38, 2017

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  • Effects of exercise training on nitric oxide, blood pressure and antioxidant enzymes

    Tsukiyama Yorika , Ito Tatsuo , Nagaoka Kenjiro , Eguchi Eri , Ogino Keiki

    … A cross-sectional study using 184 employees was conducted to observe the association of exercise habits with serum arginase (ELISA and activity), <span style="font-variant: small-caps;">l</span>-arginine, <span style="font-variant: small-caps;">l</span>-citrulline, <span style="font-variant: small-caps;">l</span>-ornithine, NOx, exhaled nitric oxide, blood pressure, FEV1%, hs-CRP, HDL-cholesterol, IgE, and life style factors. …

    Journal of Clinical Biochemistry and Nutrition 60(3), 180-186, 2017

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  • Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans

    Tomosugi Naohisa , Yamamoto Shoko , Takeuchi Masayoshi , Yonekura Hideto , Ishigaki Yasuhito , Numata Noriaki , Katsuda Shogo , Sakai Yasuo

    … The effect of CTP on atherosclerosis was verified by measuring several indices, including serum lipid levels, toxic advanced glycation end-products (TAGE), and the cardio-ankle vascular index (CAVI), at baseline and 6 months.</p><p><b><i>Results</i></b><b>: </b>The low-density lipoprotein cholesterol (LDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio (LDL-C/HDL-C ratio) was significantly reduced in patients with an initial ratio of ≥2.5 (<i>p</i>=0.025). …

    Journal of Atherosclerosis and Thrombosis 24(5), 530-538, 2017

    DOI

  • Relationship between Metabolic Syndrome Components and Periodontal Disease in a Japanese General Population: the Suita Study

    Kikui Miki , Kokubo Yoshihiro , Ono Takahiro , Kida Momoyo , Kosaka Takayuki , Yamamoto Masaaki , Watanabe Makoto , Maeda Yoshinobu , Miyamoto Yoshihiro

    … The associations of the MetS and its components with periodontal disease were investigated using multiple logistic regression analysis adjusting for age, drinking, and smoking.</p><p><b><i>Results</i></b><b>: </b>Among the components of the MetS, low HDL cholesterol level was significantly associated with periodontal disease in men and women [odds ratios (OR)=2.39 and 1.53; …

    Journal of Atherosclerosis and Thrombosis 24(5), 495-507, 2017

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  • Role of Ketotifen on metabolic profiles, inflammation and oxidative stress in diabetic rats

    Chen Zimiao , Sun Hongwei , Wang Jian , Ni Liansong , Gu Xuejiang , Ge Shengjie , Chen Qiong , Mu Liangshan , Cheng Xingbo

    … Fasting insulin (FINS), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), interleukin-6 (IL-6) and tumor necrosis factor-α … and MDA, and lower levels of HDL and SOD (All <i>p</i> … in KT group decreased significantly, and levels of HDL and SOD elevated significantly (All <i>p</i> …

    Endocrine Journal 64(4), 411-416, 2017

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  • HDL<sub>3</sub> Cholesterol Levels in an Elderly Population

    Inazu Akihiro

    Journal of Atherosclerosis and Thrombosis, 2017

    DOI

  • Association of High-Density Lipoprotein Subclasses with Carotid Intima-Media Thickness: Shimane CoHRE Study

    Notsu Yoshitomo , Yano Shozo , Takeda Miwako , Yamasaki Masayuki , Isomura Minoru , Nabika Toru , Nagai Atsushi

    … <p><i><b>Aims</b></i><b>: </b>Recent studies suggested that subclasses of high-density lipoprotein (HDL) may be a better biomarker to predict the risk of atherosclerotic disorders. …

    Journal of Atherosclerosis and Thrombosis, 2017

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  • The Combination Therapy of Fenofibrate and Ezetimibe Improved Lipid Profile and Vascular Function Compared with Statins in Patients with Type 2 Diabetes

    Shinnakasu Atsushi , Yamamoto Kiyoaki , Kurano Mihoko , Arimura Hiroshi , Arimura Aiko , Kikuti Akira , Hashiguchi Hiroshi , Deguti Takahisa , Nishio Yoshihiko

    … The lipoprotein profile of both groups was compared using high-performance liquid chromatography, and the vascular function was assessed using flow-mediated dilation (FMD) at the forearm.</p><p><b><i>Results</i></b>: The levels of very low-density lipoprotein (VLDL) cholesterol, malondialdehyde low-density lipoprotein (MDA-LDL), total TG, chylomicron-TG, VLDL-TG, and HDL-TG decreased in the F/E group, whereas those of HDL cholesterol increased. …

    Journal of Atherosclerosis and Thrombosis, 2017

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  • 高齢2型糖尿病者におけるサルコペニア有病率と血糖コントロールの関連性

    舘 友基 , 木村 圭佑 , 松本 和隆 , 山本 実香

    … 血糖コントロール指標としてHbA1c,空腹時血糖,HDL-C,LDL-C,中性脂肪,糖尿病罹患期間,運動習慣の有無,インスリン抵抗性改善薬使用の有無を調査した。 … 血糖コントロール指標は,サルコペニア群はHbA1c8.4±1.0%,空腹時血糖163.8±47.4mg/dl,HDL-C55.0±14.8mg/dl,LDL-C94.5±34.2mg/dl,中性脂肪108.3±26.0mg/dl,糖尿病罹患期間16.3±5.3年,運動習慣(有)25%,インスリン抵抗性改善薬使用(有)75%。 …

    理学療法学Supplement 2016(0), 1473, 2017

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  • 理学療法介入のない外来通院をしている男性2型糖尿病患者の身体機能

    白井 信行 , 椿 淳裕 , 森下 慎一郎 , 礒部 純代 , 五十嵐 佳南 , 村山 悟

    … また,カルテより年齢,性別,罹患歴,BMI,HbA1c,eGFR,中性脂肪,HDL-C,LDL-Cを収集した。 …

    理学療法学Supplement 2016(0), 1471, 2017

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  • Detection of Lipomannan in Cattle Infected with Bovine Tuberculosis

    VU Dung M. , SAKAMURI Rama M. , WATERS W. Ray , SWANSON Basil I. , MUKUNDAN Harshini

    … We apply an ultra-sensitive detection strategy developed by our team, termed lipoprotein capture, that exploits the pull-down of high-density lipoprotein (HDL) nanodiscs from cattle blood that allows for the recovery and detection of associated LM. …

    Analytical Sciences 33(4), 457-460, 2017

    DOI

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