Search Results:　 1-20 of 223

1

Adipocytokine and Insulin Resistance during Pregnancy : Potential Role of Adipocytokines in Pathophysiology of Glucose Intolerance and Pregnancy-induced Hypertension and Investigation for Novel Therapeutic Target [in Japanese]

MASUYAMA Hisashi

… The pathogenesis of PE is thought to involve three steps: defective placentation, placental ischemia and endothelial cell dysfunction. … In HepG2 cells, CAR ligands suppressed the gluconeogenic and lipogenic gene expressions in the presence of E2 and/or P. …

Acta Obstetrica et Gynaecologica Japonica 64(11), 2279-2289, 2012-11-01

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2

Possible involvement of glutathione balance disruption in dihydropyrazine-induced cytotoxicity on human hepatoma HepG2 cells

ISHIDA Takumi , TAKECHI Shinji , YAMAGUCHI Tadatoshi

The Journal of toxicological sciences 37(5), 1065-1069, 2012-10-01

References (17)
3

Cytotoxic Profiling of Some Compounds of Natural Origin against HepG2 Liver Cancer Cell Line in-vitro

MAHMOUD Ali M. , EL-SHEMY Hany A.

沙漠研究 : 日本沙漠学会誌 22(1), 191-194, 2012-06-25

References (22)
4

Determination of Cellular Aminopropyltransferase Activity Using Precolumn Fluorescent Etheno-Derivatization with High-Performance Liquid Chromatography

YAMAZAKI Kenichi , IKEGUCHI Yoshihiko , NIWA Takuya , HAYASHI Kaoru , IWAKI Takahiro , ISHII Ikumi , NIITSU Masaru , PEGG Anthony E. , SHIRAHATA Akira

… Polyamines such as spermidine (Spd) and spermine (Spm), produced by aminopropyltransferase (Apt), play roles in cell growth and differentiation. … The developed method determined Spdsyn and Spmsyn activities in HepG2 cells treated with oleic acid as a cellular lipid accumulation model. …

Analytical Sciences 28(6), 621-624, 2012-06-10

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5

Cytotoxic Profiling of Some Compounds of Natural Origin against HepG2 Liver Cancer Cell Line in-vitro (THE 1st INTERNATIONAL CONFERENCE ON ARID LAND (ICAL 1) "DESERT TECHNOLOGY ？ (DT ？)")

MAHMOUD Ali M. , EL-SHEMY Hany A.

沙漠研究 = Journal of arid land studies : 日本沙漠学会誌 22(1), 191-194, 2012-06-00
6

Aryl hydrocarbon receptor nuclear translocator in human liver is regulated by miR-24

Oda Yuki , Nakajima Miki , Mohria Takuya , Takamiya Masataka , Aoki Yasuhiro , Fukami Tatsuki , Yokoi Tsuyoshi

… These stimuli increase the miR-24 level in various human cell lines. … Overexpression of miR-24 into HuH-7 and HepG2 cells significantly decreased the ARNT protein level, but not the ARNT mRNA level, indicating translational repression. …

Toxicology and Applied Pharmacology 260(3), 222-231, 2012-05-01

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7

Protective role of intestinal bacterial metabolism against baicalin-induced toxicity in HepG2 cell cultures

KHANAL Tilak , KIM Hyung Gyun , CHOI Jae Ho , PARK Bong Hwan , DO Minh Truong , KANG Mi Jeong , YEO Hee Kyung , KIM Dong Hyun , KANG Wonku , JEONG Tae Cheon , JEONG Hye Gwang

The Journal of toxicological sciences 37(2), 363-371, 2012-04-01

Ichushi Web References (22)
8

Iron facilitator LS081 reduces hypoxia-inducible factor-1α protein and functions as anticancer agent in hepatocellular carcinoma.

田中宏樹 , Zhen Li , Katsuya Ikuta , Lynda Addo , Hiroaki Akutsu , Masao Nakamura , Katsunori Sasaki , Takaaki Ohtake , Mikihiro Fujiya , Yoshihiro Torimoto , Jonathan Glass , Yutaka Kohgo

… In the human hepatocellular carcinoma cell lines Hep3B and HepG2, a combination of LS081 and ferric ammonium citrate (LS081/FeAC) inhibited HIF-1α protein expression but did not inhibit HIF-1α mRNA expression. … Furthermore, the iron-facilitating activity of LS081 resulted in Hep3B and HepG2 growth inhibition in vitro and in vivo. …

Cancer Science 103(4), 767-774, 2012-04-00

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9

A-26 Development of a new in vitro embryotoxicity test system using the hybrid culture of mouse embryonic stem cell and human hepatocyte [in Japanese]

Imai K , Takeda S , Nakamura K , Tanoue A

… The hepatocyte lines are human and mouse floating cell lines and HepG2. …

The journal of the Japanese Society for Dental Materials and Devices 31(2), 139, 2012-03-25

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10

SirT1 Confers Hypoxia-induced Radioresistance via the Modulation of c-Myc Stabilization on Hepatoma Cells

XIE Yuexia , ZHANG Jianghong , XU Yanwu , SHAO Chunlin

… Intratumoral hypoxia is an important contributory factor to tumor cell resistance to radiotherapy. … It was found that the administration with resveratrol, a putative SirT1 activator, enhanced the resistance of HepG2 cells against radiation-induced DNA damage of MN formation under hypoxia condition; …

Journal of Radiation Research 53(1), 44-50, 2012-01-16

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11

All-trans retinoic acid inhibits the recruitment of ARNT to DNA, resulting in the decrease of CYP1A1 mRNA expression in HepG2 cells

Ohno Marumi , Ikenaka Yoshinori , Ishizuka Mayumi

… We hence investigated the effects of all-trans retinoic acid (atRA) on cytochrome P450 (CYP)1A1 gene transcription as a model of AHR-regulated transcription mechanisms in HepG2 cells, a human hepatoma cell line. …

Biochemical and Biophysical Research Communications 417(1), 484-489, 2012-01-06

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12

Design, Synthesis and Anticancer Activity of N3,N11-Bis(2-hydroxyethyl)-14-Aryl-14H-Dibenzo[a,j]xanthenes-3,11-Dicarboxamide

Song Yongbin , Yang Yihui , You Jun , Liu Bo , Wu Lijun , Hou Yunlong , Wang Wenji , Zhu Jiuxin

… The antitumor activities of these molecules were evaluated on five cancer cell lines. … The results of in vitro assay against human hepatocellular carcinoma cell lines (SK-HEP-1 and HepG2 and SMMC-7721 cells), acute promyelocytic leukemia NB4 cells and uterine cervix cancer HeLa cells, show several compounds to be endowed with cytotoxicity in micromolar to submicromolar range. …

Chemical and Pharmaceutical Bulletin, 2012

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13

Radiosensitization by Inhibiting Complex I activity in Human Hepatoma HepG2 cells to X-ray Radiation

ZHANG Xin , ZHOU Xin , CHEN Ruping , ZHANG Hong

… The purpose of this study is to investigate the influence of mitochondrial respiratory chain complex I inhibition on the radiosensitivity of HepG2 cells. … The complex I inhibitor rotenone was used to inhibit complex I activity on HepG2 cells before X-ray irradiation. …

Journal of Radiation Research 53(2), 257-263, 2012

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14

Identification of Small Molecule Activators of the Janus Kinase/Signal Transducer and Activator of Transcription Pathway Using a Cell-Based Screen

Tai Zheng Fu , Zhang Guo Lin , Wang Fei

… To screen a natural products-based library, we established a cell-based screening assay using human hepatoma HepG2 cells stably transfected with a plasmid where the luciferase reporter activity is driven by interferon α-stimulated response element (ISRE), the motif specifically recognized by type I IFN-induced activation of JAK/STAT pathway. …

Biological and Pharmaceutical Bulletin 35(1), 65-71, 2012

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15

Caffeine Increases the Antitumor Effect of Cisplatin in Human Hepatocellular Carcinoma Cells

Kawano Yohei , Nagata Masashi , Kohno Takafumi , Ichimiya Akihiro , Iwakiri Tomomi , Okumura Manabu , Arimori Kazuhiko

… We examined the combined effects of caffeine and cisplatin in human HCC cell lines, and screened for a more effective administration method of caffeine in vitro. … Human HCC cell lines (HepG2, HLF, HuH-7, and Li-7) were exposed to caffeine (0—0.5 mM) and cisplatin (0—1.2 μg/mL) for 72 h, either alone or in combination. …

Biological and Pharmaceutical Bulletin 35(3), 400-407, 2012

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16

2,3,22,23-Tetrahydroxyl-2,6,10,15,19,23-hexamethyl-6,10,14,18-tetracosatetraene, an Acyclic Triterpenoid Isolated from the Seeds of Alpinia katsumadai, Inhibits Acyl-CoA : Cholesterol Acyltransferase Activity

Choi Soon-Yong , Lee Moon Hee , Choi Jung Ho , Kim Young Kook

… It also decreased cholesteryl ester formation with IC50 values of 26 µM in human hepatocyte HepG2 cell. …

Biological and Pharmaceutical Bulletin 35(11), 2092-2096, 2012

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17

Establishment of a Stable Human Cell Line, HPL-A3, for Use in Reporter Gene Assays of Cytochrome P450 3A Inducers

Sekimoto Masashi , Sano Shinsuke , Hosaka Takuomi , Nemoto Kiyomitsu , Degawa Masakuni

… We have established a stable human cell line, termed HPL-A3, by co-transfection of a human pregnane X receptor (hPXR) expression vector and a reporter plasmid (p3A4-hPXRE-Luc) containing a luciferase gene and a promoter/enhancer region of the human cytochrome P450 3A4 (CYP3A4) gene into a human hepatoma-derived cell line, HepG2. …

Biological and Pharmaceutical Bulletin 35(5), 677-685, 2012

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18

Direct Cytotoxicity of Lentinula edodes Mycelia Extract on Human Hepatocellular Carcinoma Cell Line

Yukawa Hiroshi , Ishikawa Satoru , Kawanishi Takashi , Tamesada Makoto , Tomi Hironori

… LEP) on HepG2 human hepatocellular carcinoma (HCC) cells were investigated. … LEP directly killed the HepG2 cells efficaciously, but had only minor effects on normal rat hepatocytes and normal mouse dermal cells under the same conditions. … The caspase-3 and -8 death receptor pathway was found largely responsible for the apoptotic death of HepG2 cells treated with LEP. …

Biological and Pharmaceutical Bulletin 35(7), 1014-1021, 2012

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19

Design, Synthesis and Cytotoxicity of Novel 2-Arylvinyl-4-aminoquinoline Derivatives

Jiang Nan , Zhai Xin , Chen Zhichao , Liang Chuang , Sun Chao , Han Jing , Gong Ping

… With an aim to develop promising anti-tumor agents, a novel series of 2-arylvinyl-4-aminoquinoline derivatives were designed, synthesized and evaluated for their cytotoxicity against H-460, HT-29, HepG2 and SGC-7901 cell lines in vitro. …

Chemical and Pharmaceutical Bulletin 60(5), 659-664, 2012

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20

Unusual Pyrrolyl 4-Quinolinone Alkaloids from the Marine-Derived Fungus Penicillium sp. ghq208

Gao Huquan , Zhang Lianqing , Zhu Tianjiao , Gu Qianqun , Li Dehai

… Compounds (2, 3) exhibited moderate cytotoxicities against the HepG2 cell line with IC50 values of 11.3 and 13.2 µM, respectively. …

Chemical and Pharmaceutical Bulletin 60(11), 1458-1460, 2012

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