Search Results:　 1-20 of 60

Inami Kaoru , Sawai Hirofumi , Katao Yuko , Domae Naochika , Matsumoto Naoyuki

… We found that sustained release of NO by NOC-18 induces osteoclast differentiation of not only RAW264 cells but also bone marrow macrophages, and that the inhibition of ERK and activation of p38 MAPK may be involved in NOC-18-induced osteoclast differentiation. …

The Journal of the Osaka Odontological Society 72(3/4), 129-130, 2009-12-25

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TANABE Makoto , WATANABE Machiko , YANAGI Mashiho , NISHIZAWA Satoru , CHIGONO Yoshiho , MATSUDA Juzo , YAMAOKA Keiko , INOUE Keizo

… To develop a film formulation allowing controlled release for long-term analgesia, we selected ethyl cellulose (EC) as a novel additive, prepared a film formulation using indomethacin (IM film), and evaluated it in vitro and clinically. … In the in vitro experiments, the effects of the EC concentration on the release rate of IM and on the adhesion force to the mucous membrane were investigated. …

Journal of the Pharmaceutical Society of Japan 128(11), 1673-1679, 2008-11-01

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YIN Dongfeng , LU Ying , ZHANG He , ZHANG Guoqing , ZOU Hao , SUN Duxin , ZHONG Yanqiang

… To provide a optimal formulation to overcome this limitation, we developed a GLP-1 entrapped microspheres to achieve sustained release GLP-1 for 4-week. … The drug encapsulation efficiency and GLP-1 controlled release profile was tested by HPLC; …

Chemical & pharmaceutical bulletin 56(2), 156-161, 2008-02-01

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TAHARA Kohei , YAMAMOTO Hiromitsu , TAKEUCHI Hirofumi , KAWASHIMA Yoshiaki

… The development of nonviral vectors for the efficient and safe delivery to cells has long been awaited to facilitate gene therapy. … The resultant nanospheres show better cellular uptake and different gene therapeutic effects compared with conventional vectors due to their improved adherence to cells and sustained release of polynucleic acid in the cells. …

Journal of the Pharmaceutical Society of Japan 127(10), 1541-1548, 2007-10-01

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GAO Ping , DING Pingtian , XU Hui , YUAN Zhenting , CHEN Dawei , WEI Jing , CHEN Dong

… The purpose of this work was to develop biodegradable microspheres for long term delivery of a potent acetyl cholinesterase inhibitor, huperzine A (Hup-A), which is of interest in the palliative treatment of Alzheimer's disease. … The morphology, particle size and size distribution, drug loading capacity, drug entrapment efficiency (EE) and in vitro drug release were studied in detail. …

Chemical & pharmaceutical bulletin 54(1), 89-93, 2006-01-01

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ONISHI Hiraku , TAKAHASHI Mari , MACHIDA Yoshiharu

… An implant tablet of ketoprofen (KP) was developed in order to achieve its sustained supply for approximately one week, and its release was evaluated in vitro and in vivo. … lactic acid:glycolic acid=1:1 (mol/mol)) as a matrix, exhibited similar week-long sustained release in vitro. …

Biological & pharmaceutical bulletin 28(10), 2011-2015, 2005-10-01

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SHIMONO Norihito , UEDA Masumi , NAKAMURA Yasuhiko

… The influences of the structural difference of the sustained release layer and curing conditions on the drug release rate were investigated. … Drug release profiles were influenced by the combination of the WAX layer and the Mg-St layer. …

Chemical & pharmaceutical bulletin 50(9), 1169-1175, 2002-09-01

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