Search Results:　 1-9 of 9

NAKAICHI Munekazu , TAKESHITA Yoko , OKUDA Masaru , NAKAMOTO Yuya , ITAMOTO Kazuhito , UNE Satoshi , SASAKI Nobuo , KADOSAWA Tsuyoshi , TAKAHASHI Tomoko , TAURA Yasuho

… MDR1の産物であるP糖蛋白質(P-gp)は,構造に類似性のない多数の抗癌剤を細胞外へ排出するポンプとして機能し,抗癌剤の細胞内濃度を有効濃度以下に下げることが知られている.今回,犬で発生頻度の高い肥満細胞腫について,3種類の培養細胞におけるMDR1/P-gpの発現とP-gpの薬物輸送ポンプとしての機能を,MDR1特異プライマーを用いたRT-PCR,P-gp特異抗体を用いたウェスタン・ブロッティン …

The journal of veterinary medical science 69(2), 111-115, 2007-02-25

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OKA Ayako , ODA Masako , SAITOH Hiroshi , NAKAYAMA Akira , TAKADA Masahiko , J.Bruce AUNGST

… We recently reported that P-glycoprotein (MDR1) is capable of interfering with the absorption of methylprednisolone in the rat small intestine. … This study was undertaken to examine the interaction between methyl-prednisolone and MDR1 using Caco-2 cells. … When verapamil (0.1mM), a potent modulator of MDR1,was added to both apical and basolateral sides of Caco-2 cells, the absorptive permeation of methylprednisolone was increased and its secretory permeation was decreased. …

Biological & pharmaceutical bulletin 25(3), 393-396, 2002-03-01

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