Search Results:　 1-20 of 1055

1

Activation of STAT5 confers imatinib resistance on leukemic cells through the transcription of TERT and MDR1

YAMADA 　Osamu , OZAKI 　Kohji , FURUKAWA 　Thoru , MACHIDA 　Mitsuyo , Yan-Hua Wang , MOTOJI 　Toshiko , MITSUISHI 　Tsuyoshi , AKIYAMA 　Masaharu , YAMADA 　Hisashi , KAWAUCHI 　Kiyotaka , Rumiko Matsuoka

Cellular Signalling 23(7), 1119-1127, 2011-07

IR CrossRef
2

Rapid determination of multidrug resistance-associated protein in cancer cells by capillary electrophoresis immunoassay

Mbuna Julius , Kaneta Takashi , Imasaka Totaro

… The ABC superfamily consists of P-glycoprotein, multidrug resistance-associated proteins (MRP) and breast cancer-related proteins, of which MRP is of particular interest because of its ability to efflux a broader range of substrates. …

Journal of Chromatography A 1218(25), 3923-3927, 2011-06-24

IR CrossRef
3

Upregulation of P-Glycoprotein Activity in Porcine Oocytes and Granulosa Cells During In Vitro Maturation

YOKOTA Kazuko , HIRANO Takuro , URATA Narumi , YAMAUCHI Nobuhiko , HATTORI Masa-aki

… Multidrug resistance P-glycoprotein (Pgp), coded by the multidrug resistance type I (MDR1/ABCB1) gene, is an energy-dependent efflux pump and functions in systemic detoxification processes. … Collectively, the present results indicate that the transporting activity of P-glycoprotein upregulates in porcine oocytes and granulosa cells during exposure to gonadotropins or prior to ovulation. …

Journal of Reproduction and Development 57(3), 322-326, 2011-06-01

J-STAGE CrossRef References (30)
4

The Diagnosis and Management of Extranodal NK/T-Cell Lymphoma, Nasal-Type and Aggressive NK-Cell Leukemia

KWONG Yok-Lam

… Regimens containing drugs not affected by the P-glycoprotein, particularly in combination with L-asparaginase, have resulted in much improvement in treatment outcome for high-risk, refractory or relapsed patients. …

Journal of Clinical and Experimental Hematopathology 51(1), 21-28, 2011-05-01

J-STAGE CrossRef References (37)
5

Relationship between structure and P-glycoprotein inhibitory activity of dimeric opioid peptides containing the Dmt-Tic pharmacophore

AMBO Akihiro , OHKATSU Hiromichi , MINAMIZAWA Motoko , WATANABE Hideko , SUGAWARA Shigeki , NITTA Kazuo , TSUDA Yuko , OKADA Yoshio , SASAKI Yusuke

Peptide science : proceedings of the ... Japanese Peptide Symposium 2010, 133, 2011-03-01

References (2)
6

Effect of 5-fluorouracil treatment on SN-38 absorption from intestine in rats

Shibayama Yoshihiko , Iwashita Yoshitaka , Yoshikawa Yoshimi [他]

… 5-FU treatment (400 mg/kg) also significantly downregurated expression levels of P-glycoprotein (P-gp) and breast cancer resistance protein (Bcrp) to 41.2 ± 14.7%, 15.7 ± 4.3% of control, respectively. … 5-FU treatment decreased expression levels of P-glycoprotein and Bcrp in intestine. …

Biological & pharmaceutical bulletin 34(9), 1418-1425, 2011-09

IR CrossRef
7

Blood-Brain Barrier Transport of Opioid Analgesics

SUZUKI Toyofumi

Opioid analgesics exhibit cationic properties under physiological conditions, and the mechanism underlying permeation of the blood-brain barrier thus cannot be fully explained by simple di …

YAKUGAKU ZASSHI 131(10), 1445-1451, 2011

J-STAGE CrossRef
8

Inhibitory Effects of Furanocoumarin Derivatives in Kampo Extract Medicines on P-Glycoprotein at the Blood–Brain Barrier

Iwanaga Kazunori , Yoneda Shinji , Hamahata Yukimi , Miyazaki Makoto , Shibano Makio , Taniguchi Masahiko , Baba Kimiye , Kakemi Masawo

… Furanocoumarin derivatives, known as components of grapefruit juice, showing inhibitory effects against P-glycoprotein (P-gp) in the intestine are also contained in the plants of rutaceae and umbelliferae families, which are used as components of Kampo extract medicines. …

Biological & Pharmaceutical Bulletin 34(8), 1246-1251, 2011

J-STAGE CrossRef
9

Alteration of P-gp Expression after Intestinal Ischemia-reperfusion Following 16-h Fasting in Rats

OGURA Jiro , FUJIKAWA Asuka , MARUYAMA Hajime , KOBAYASHI Masaki , ITAGAKI Shirou , ISEKI Ken

… Alteration of P-glycoprotein (P-gp) expression influences the pharmacokinetics of P-gp substrates after intestinal ischemia-reperfusion (I/R). … However, the effect of fasting on the alteration of P-gp expression after intestinal I/R has not been clarified. … We previously reported that P-gp expression was altered after intestinal I/R following feeding. …

YAKUGAKU ZASSHI 131(3), 453-462, 2011

J-STAGE Ichushi Web CrossRef
10

Nitric Oxide Synthase-mediated Alteration of Intestinal P-glycoprotein under Hyperglycemic Stress

NAWA Ayaka , FUJITA-HAMABE Wakako , NAKAMOTO Kazuo , TOKUYAMA Shogo

… P-glycoprotein (P-gp), one of the important drug-efflux pumps, is known to be affected by pathological conditions such as inflammation or infection. … Recently, it is reported that high glucose or hyperglycemia can alter P-gp expression levels at the blood-brain barrier or in kidney, although the details are still unknown. …

YAKUGAKU ZASSHI 131(4), 487-492, 2011

J-STAGE CrossRef
11

Comparative Study of Culture Conditions for Maintaining CYP3A4 and ATP-Binding Cassette Transporters Activity in Primary Cultured Human Hepatocytes

Takeba Yuko , Matsumoto Naoki , Takenoshita-Nakaya Sachiko , Harimoto Yoshie , Kumai Toshio , Kinoshita Yuichi , Nakano Hiroshi , Ohtsubo Takehito , Kobayashi Shinichi

… The aim of this study was to determine suitable culture conditions for maintaining the activity of cytochrome p450 (CYP) 3A4 and drug transporters in primary cultured human hepatocytes. … The protein levels of P-glycoprotein, multi-drug-resistance-2, and breast cancer-resistance protein were maintained for 7 days in all media. …

Journal of Pharmacological Sciences 115(4), 516-524, 2011

J-STAGE CrossRef
12

Regulatory Action of Nitric Oxide Synthase on Ileal P-glycoprotein Expression under Streptozotocin-Induced Diabetic Condition

Nawa Ayaka , Fujita-Hamabe Wakako , Tokuyama Shogo

… P-glycoprotein (P-gp), a drug efflux transporter, affects the pharmacokinetics of a wide range of substrate drugs. … Our previous study clearly revealed that intestinal P-gp expression levels were decreased via an inducible nitric oxide synthase (iNOS)-mediated mechanism in the early phases of diabetes. …

Biological & Pharmaceutical Bulletin 34(3), 436-438, 2011

J-STAGE CrossRef
13

Changes in the Localization of Ileal P-Glycoprotein Induced by Intestinal Ischemia/Reperfusion

Takizawa Yusuke , Kishimoto Hisanao , Kitazato Takuya , Tomita Mikio , Hayashi Masahiro

… P-Glycoprotein is one of the most important transporters in the ATP binding cassette transporter. … Moreover, it is well known that the efficacy of immunosuppressants, which are used after organ transplantation, is controlled by P-glycoprotein (P-gp). … We investigated how ischemia/reperfusion (I/R), which occurs after transplantation, influences the expression level and function of P-gp. …

Biological & Pharmaceutical Bulletin 34(3), 408-414, 2011

J-STAGE CrossRef
14

Preparations of Anthraquinone and Naphthoquinone Derivatives and Their Cytotoxic Effects

Cui Xing-Ri , Saito Ryota , Kubo Takatsugu , Kon Daijiro , Hirano Yuich , Saito Setsuo

… The cytotoxic effects of these derivatives on HCT 116 cells, which poorly express P-glycoprotein (P-gp), and Hep G2 cells, which stably express P-gp, were evaluated by performing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. …

CHEMICAL & PHARMACEUTICAL BULLETIN 59(3), 302-314, 2011

J-STAGE CrossRef
15

Evidence for Time-Dependent Interactions between Ritonavir and Lopinavir/Ritonavir Plasma Levels Following P-Glycoprotein Inhibition in Sprague-Dawley Rats

Plooy Michael du , Viljoen Michelle , Rheeders Malie

… The interaction between verapamil, a P-glycoprotein (P-gp) inhibitor, with ritonavir and lopinavir/ritonavir (LPV/r) after acute and chronic treatment was investigated in rats. … Verapamil significantly increased ritonavir plasma levels, administered as monotherapy, following acute (p<0.005) and chronic treatment (day 21) (p<0.005). …

Biological & Pharmaceutical Bulletin 34(1), 66-70, 2011

J-STAGE Ichushi Web CrossRef
16

Increased ABCB1 Expression in TP-110-Resistant RPMI-8226 Cells

IIJIMA Masatomi , MOMOSE Isao , IKEDA Daishiro

… P-glycoprotein (MDR1), encoded by ABCB1, was elevated in the RPMI-8226/TP-110 cells, and the MDR1 inhibitor verapamil overcame their resistance to TP-110. … This indicates that resistance in RPMI-8226/TP-110 cells is involved in the expression of P-glycoprotein, a drug-efflux pump. …

Bioscience, Biotechnology, and Biochemistry 74(9), 1913-1919, 2010-09-23

J-STAGE Ichushi Web CrossRef References (27)
17

Production of monoclonal antibodies to P-glycoprotein : its application in detection of soluble and surface P-glycoprotein of leukemia patients

CHIAMPANICHAYAKUL Sawitree , ANUCHAPREEDA Songyot , CHRUEWKAMLOW Nuttapol , MAHASONGKRAM Kodchakorn , THANARATANAKORN Pattra , KASINRERK Watchara

International journal of hematology 92(2), 326-333, 2010-09-15

Ichushi Web References (25)
18

Inhibition of P-glycoprotein-Mediated Efflux of Digoxin and Its Metabolites by Macrolide Antibiotics

HUGHES Jeff , CROWE Andrew

… This study was conducted to determine the rate of P-glycoprotein (P-gp)–mediated efflux of digoxin analogues and metabolites and to assess the effects of macrolide antibiotics on this efflux. … Bidirectional transport studies were conducted using our Caco-2 sub clone with high P-gp expression (CLEFF9). … All digoxin metabolites were P-gp substrates, although digoxin had the greatest efflux ratio. …

Journal of Pharmacological Sciences 113(4), 315-324, 2010-08-20

J-STAGE Ichushi Web CrossRef References (40)
19

Synthesis and evaluation of [^<11>C]XR9576 to assess the function of drug efflux transporters using PET

KAWAMURA Kazunori , KONNO Fujiko , YUI Joji , YAMASAKI Tomoteru , HATORI Akiko , YANAMOTO Kazuhiko , WAKIZAKA Hidekatsu , TAKEI Makoto , NENGAKI Nobuki , FUKUMURA Toshimitsu , ZHANG Ming-Rong

Annals of nuclear medicine 24(5), 403-412, 2010-06-01

References (37)
20

Effect of genipin on cholestasis induced by estradiol-17β-glucuronide and lithocholate-3-O-glucuornide in rats

GOTO Hideaki , TAKIKAWA Hajime

Hepatology research : the official journal of the Japan Society of Hepatology 40(5), 524-529, 2010-05-01

Ichushi Web References (40)

Search Results:　 1-20 of 1055

Related Authors

Related Journals

Search Results: 1-20 of 1055

Related Authors

Related Journals

Search Results:　 1-20 of 1055