Search Results:　 1-20 of 109

1

No increase of drug-resistant HIV type 1 prevalence among drug-naive individuals in northern vietnam

Tran Vuong Thi , Ishizaki Azumi , Nguyen Cuong Hung , Hoan Huyen Thi , Pham Hung Viet , Bi Xiuqiong , Pham Thuc Van , Ichimura Hiroshi

… Nonnucleoside reverse-transcriptase inhibitor resistance mutations were found in two (2.0%) of the 102 successfully analyzed cases (one case with the Y181C and one with the K101E). … No nucleoside reverse-transcriptase inhibitor resistance or protease inhibitor resistance mutations were detected. …

AIDS Research and Human Retroviruses 28(10), 1349-1351, 2012-10-01

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2

Plasma Exchange in the Treatment of Thrombotic Thrombocytopenic Purpura [in Japanese]

Ueda Yasunori

… Deficiency of ADAMTS13 (a cleaving protease of von Willebrand factor) was demonstrated to be a main pathogenesis of TTP in the 1990s. … Exacerbation during PEx and relapse and resistance occur at a rate of 20 to 50%. …

Japanese journal of apheresis 31(1), 14-19, 2012-02-29

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3

Thrombotic Thrombocytopenic Purpura [in Japanese]

Isonishi Ayami , Hayakawa Masaki , Matsumoto Masanori , Yagi Hideo , Fujimura Yoshihiro

… Since the discovery of ADAMTS13, a von Willebrand factor-cleaving protease, it has been well established that TTP lacks the ADAMTS13 activity due to its gene mutations (termed Upshaw-Schulman syndrome, USS) or acquired auto-antibodies. … Recent studies have further indicated that approximately 20% of patients with acquired TTP have resistance to PE therapy, for whom a diagnosis of 'relapsing or intractable' TTP was made. …

Japanese journal of apheresis 31(1), 7-13, 2012-02-29

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4

Genetic heterogeneity of hepatitis C virus in association with antiviral therapy determined by ultra-deep sequencing

Nasu Akihiro , Marusawa Hiroyuki , Ueda Yoshihide , Nishijima Norihiro , Takahashi Ken , Osaki Yukio , Yamashita Yukitaka , Inokuma Tetsuro , Tamada Takashi , Fujiwara Takeshi , Sato Fumiaki , Shimizu Kazuharu , Chiba Tsutomu

… We also demonstrated that clones resistant to direct-acting antivirals for HCV, such as viral protease and polymerase inhibitors, preexist with various abundances in all 27 treatment-naïve patients, suggesting the risk of the development of drug resistance against these agents. …

PLoS One 6(9), e24907, 2011-09-00

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5

Genotype differences in susceptibility and resistance development of hepatitis C virus to protease inhibitors telaprevir (VX-950) and danoprevir (ITMN-191) [in Japanese]

Imhof Ingrid , Simmonds Peter

Hepatology 6(2), 2-11, 2011-08-00
6

Protective effect of FUT-175 on pulmonary function of xenografts in a guinea pig-to-rat lung perfusion model

Ryu Chusei/Tagawa Tsutomu/Nagayasu Takeshi

… in addition to its stable potent serine protease inhibitory activity, it exerts far stronger anti-complement activity than other protease inhibitors. … The following parameters were serially measured in these three groups: complement activity causing 50% hemolysis (CH50 units) in the perfusion blood either before or during perfusion, pulmonary arterial pressure, dynamic pulmonary compliance, and airway resistance. …

Acta medica Nagasakiensia 56(2), 43-48, 2011-08-00

IR
7

Antibacterial activities, interactions with phospholipid membranes and resistance to enzyme treatment of peptides containing α- and β-amino acids

AOYAGI Haruhiko , KUNIHARA Makoto , IJICHI Sumie 他

九州栄養福祉大学研究紀要 -(8), 13-23, 2011-00-00
8

The foundation of shiitake cultivation on logs [in Japanese]

TOKIMOTO Keisuke

シイタケの原木栽培技術を理論化するためにシイタケの生理的性質などを調査してきたが,ここではそれらの研究結果を振り返ってみたい.コナラ原木とシイタケ子実体との成分比較から,子実体の発生を制限するほだ木成分はN,P,およびKの3元素と考えられ,理論的な子実体の最大発生量はほだ木一代で10,000cm^3当たり約260g(乾燥重量)と推察された.シイタケの原木栽培は(1)ほだ木育成,(2)子実体原基の形 …

Mushroom science and biotechology 18(4), 131-138, 2010-12-31

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9

Engineering of protease-resistant phytase from Penicillium sp. : High thermal stability, low optimal temperature and pH(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)

Zhao Qianqian , Liu Honglei , Zhang Ying , Zhang Yuzhen

… It is important to investigate the thermal stability, optimal pH and temperature and protease resistance of phytases in application. … We introduced random mutations in a protease-resistance phytase gene of Penicillium sp. …

Journal of bioscience and bioengineering 110(6), 638-645, 2010-12-00

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10

Escherichia coli outer membrane protease OmpT confers resistance to urinary cationic peptides

HUI Chang-Ye , GUO Yan , HE Qiu-Shan , PENG Liang , WU Shu-Chi , CAO Hong , HUANG Sheng-He

Microbiology and immunology 54(8), 452-459, 2010-08-20

Ichushi Web References (29)
11

High Performance Liquid Chromatography Using UV Detection for the Simultaneous Quantification of the New Non-nucleoside Reverse Transcriptase Inhibitor Etravirine (TMC-125), and 4 Protease Inhibitors in Human Plasma

Hirano Atsushi , Takahashi Masaaki , Kinoshita Eri , Shibata Masaaki , Nomura Toshiharu , Yokomaku Yoshiyuki , Hamaguchi Motohiro , Sugiura Wataru

… Thus, ETV has been used in combination with ritonavir-boosted protease inhibitor (PI) and integrase inhibitor for therapy-experienced HIV-1-infected patients. … In order to ensure optimal drug efficacy and prevention of resistance, it is essential to monitor plasma concentrations of ETV and PIs. …

Biological and Pharmaceutical Bulletin 33(8), 1426-1429, 2010

J-STAGE CrossRef
12

Prognosis and prediction of virological responses to anti-hepatitis C virus (HCV) therapy by protein polymorphisms in HCV NS3 region [in Japanese]

SAITO Takafumi , NISHISE Yuko , ISHII Rika , WATANABE Hisayoshi , SUZUKI Katsunori , KAWATA Sumio

… 遺伝子上には，抗HCV療法に感受性を有するアミノ酸変異領域として，コア領域（70番/91番）やNS5A領域のinterferon sensitivity determining region（ISDR），interferon/ribavirin resistance-determining region（IRRDR），などが知られている．HCV NS3領域はHCV serine proteaseをコードし，そのウイルス蛋白質は宿主蛋白質との相互作用により，HCV感染の経過や治療に影響を及ぼす．HCV NS3蛋白質は，感染細胞内でCardif分子を不活化して …

Nippon Shokakibyo Gakkai Zasshi 106(4), 502-507, 2009-04-05

J-STAGE Ichushi Web References (28)
13

Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naive patients [in Japanese]

Kuntzen Thomas , Timm Joerg , Berical Andrew 他

Hepatology 4(1), 2-11, 2009-04-00
14

Constitutive Expression of a Trypsin Protease Inhibitor Confers Multiple Stress Tolerance in Transgenic Tobacco

SRINIVASAN Tantravahi , KUMAR Koppolu Raja Rajesh , KIRTI Pulugurtha Bharadwaja

Plant and Cell Physiology 50(3), 541-553, 2009-03-01

References (62)
15

High Molecular Weight Form of Adiponectin in Antiretroviral Drug-induced Dyslipidemia in HIV-Infected Japanese Individuals Based on in vivo and in vitro Analyses

Minami Rumi , Yamamoto Masahiro , Takahama Soichiro , Ando Hitoshi , Miyamura Tomoya , Suematsu Eiichi

… Objective High molecular weight (HMW)-adiponectin has been found to be a better negative regulator of insulin resistance than total adiponectin. … (II) patients who started ART containing a protease inhibitor without atazanavir (ATV); …

Internal Medicine 48(20), 1799-1875, 2009

J-STAGE Ichushi Web CrossRef
16

P-Glycoprotein Mediates Efflux Transport of Darunavir in Human Intestinal Caco-2 and ABCB1 Gene-Transfected Renal LLC-PK1 Cell Lines

Fujimoto Hiromi , Higuchi Maiko , Watanabe Hiroshi , Koh Yasuhiro , Ghosh Arun K. , Mitsuya Hiroaki , Tanoue Naomi , Hamada Akinobu , Saito Hideyuki

… Darunavir (DRV) is a nonpeptidic protease inhibitor (PI) approved for the treatment of human immunodeficiency virus (HIV) infection. … This study was performed to explore the involvement of P-glycoprotein in transcellular DRV transport in monolayers of human intestinal Caco-2 and in ABCB1 multidrug resistance 1, (MDR1) gene-transfected renal LLC-PK1 (L-MDR1) cell lines. …

Biological and Pharmaceutical Bulletin 32(9), 1588-1593, 2009

J-STAGE Ichushi Web CrossRef Cited by (1)
17

Montelukast Is a Potent and Durable Inhibitor of Multidrug Resistance Protein 2-Mediated Efflux of Taxol and Saquinavir

Roy Upal , Chakravarty Geetika , Honer Zu Bentrup Kerstin , Mondal Debasis

… The ATP binding cassette (ABC)-transporters are energy dependent efflux pumps which regulate the pharmacokinetics of both anti-cancer chemotherapeutic agents, e.g. taxol, and of human immunodeficiency virus-1 (HIV-1) protease inhibitors (HPIs), e.g. saquinavir. … Increased expression of several ABC-transporters, especially P-glycoprotein (P-gp) and multidrug resistance protein 2 (MRP2), are observed in multidrug resistant (MDR) tumor cells and on HIV-1 infected lymphocytes. …

Biological and Pharmaceutical Bulletin 32(12), 2002-2009, 2009

J-STAGE Ichushi Web CrossRef
18

An Escherichia coli expression system for glutamyl endopeptidases optimized by complete suppression of autodegradation

Ono Toshio , Nemoto Takayuki K , Shimoyama Yu , Kimura Shigenobu , Ohara-Nemoto Yuko

… V8 protease (GluV8), a member of the glutamyl endopeptidase I family isolated from the V8 strain of Staphylococcus aureus, is widely used for proteome analysis because of its unique substrate specificity and resistance to detergents. …

Analytical Biochemistry 381(1), 74-80, 2008-10-01

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19

Vaspin and Insulin Resistance [in Japanese]

WADA Jun

The Official journal of Japanese Society of Laboratory Medicine 56(8), 705-711, 2008-08-25

Ichushi Web References (21)
20

Tenderizing of Meat by Using Maitake (Grifola frondosa) Extract with Low Temperature Steam Cooking

Yamazaki Takako , Ito Naoko , Oshima Ichiro , Iwamori Hajime , Hotta Yasuo , Murayama Atsuko

マイタケに含まれるプロテアーゼの作用と低温スチーミング調理の併用による牛肉軟化について検討した。マイタケ抽出液は50-70℃で最もカゼイン分解活性が高く,70℃で8h反応させたあとでも30-40%の活性が残っており,熱安定性が高かった。マイタケ抽出液とともに牛モモ肉を低温スチーミングすると,茹でた場合や,水またはしょうが抽出液を使った場合に比べて,溶出するタンパク量が多かった。しかしうま味に関係す …

Journal of cookery science of Japan 41(3), 176-183, 2008-06-20

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