Search Results:　 1-20 of 285

  • 1

    CD4 T Cell-Mediated Masking Effects of the Immunogenicity of Tumor-Associated Antigens are Qualitatively and Quantitatively Different Depending on the Individual Antigens

    Okano Shinji , Matsumoto Yoshihiro , Yoshiya Shohei , Yamashita Yo-Ichi , Harimoto Norifumi , Ikegami Toru , Shirabe Ken , Harada Mamoru , Yoshikai Yasunobu , Maehara Yoshihiko , 岡野 慎士 , 松本 佳大 , 吉屋 匠平 , 山下 洋市 , 播本 憲史 , 池上 徹 , 調 憲 , 原田 守 , 吉開 泰信 , 前原 喜彦 , オカノ シンジ , マツモト ヨシヒロ , ヨシヤ ショウヘイ , ヤマシタ ヨウイチ , ハリモト ノリフミ , イケガミ トオル , シラベ ケン , ハラダ マモル , ヨシカイ ヤスノブ , マエハラ ヨシヒコ

    … CD4 T-cell depletion simply enhanced the tyrosinase-related protein (TRP) -2_<180-188> … peptide-specific cytotoxic T-cell (CTL) responses, and CD4 T-cell depletion provided immunogenicity for mgp100_<25-33> …

    福岡医学雑誌 104(1), 1-14, 2013-01-25

    IR

  • 2

    Initiation of Genome Instability and Preneoplastic Processes through Loss of Fhit Expression

    Saldivar Joshua C. , Miuma Satoshi , Bene Jessica , Hosseini Seyed Ali , Shibata Hidetaka , Sun Jin , Wheeler Linda J. , Mathews Christopher K. , Huebner Kay

    … A frequent, perhaps earliest, genetic alteration in preneoplasias is deletion within the fragile FRA3B/FHIT locus, leading to loss of Fhit protein expression. … Here, we show in normal, transformed, and cancer-derived cell lines that Fhit-depletion causes replication stress-induced DNA double-strand breaks. … Depletion of Fhit did not activate the DNA damage response nor cause cell cycle arrest, allowing continued cell proliferation and ongoing chromosomal instability. …

    PLoS Genetics 8(11), e1003077, 2012-11-29

    IR

  • 3

    Membrane Protein Rim21 Plays a Central Role in Sensing Ambient pH in Saccharomyces cerevisiae

    Obara Keisuke , Yamamoto Hayashi , Kihara Akio

    … This finding strongly suggests that Rim21 is the pH-sensor protein and that Dfg16 and Rim9 play auxiliary functions through maintaining the Rim21 level and assisting its plasma membrane localization. … Even without external alkalization, the Rim101 pathway was activated in a Rim21-dependent manner by either protonophore treatment or depletion of phosphatidylserine in the inner leaflet of the plasma membrane, both of which caused plasma membrane depolarization like the external alkalization. …

    Journal of Biological Chemistry 287(46), 38473-38481, 2012-11-09

    IR CrossRef

  • 4

    Enhanced activation of T lymphocytes by urease-deficient recombinant bacillus Calmette-Guerin producing heat shock protein 70-major membrane protein-II fusion protein  [in Japanese]

    MAKINO Masahiko , MUKAI Tetsu

    …   To activate naïve T cells convincingly using Mycobacterium bovis BCG (BCG), rBCG (BCG-D70M) that was deficient in urease, expressed with gene encoding the fusion of BCG-derived heat shock protein (HSP) 70 and Mycobacterium leprae-derived major membrane protein (MMP)-II, one of the immunodominant Ags of M. …

    JAPANESE JOURNAL OF LEPROSY 81(3), 199-203, 2012-09-01

    J-STAGE CrossRef References (9)

  • 5

    A rat model for LGI1-related epilepsies.

    Baulac Stéphanie , Ishida Saeko , Mashimo Tomoji , Boillot Morgane , Fumoto Naohiro , Kuwamura Mitsuru , Ohno Yukihiro , Takizawa Akiko , Aoto Toshihiro , Ueda Masatsugu , Ikeda Akio , LeGuern Eric , Takahashi Ryosuke , Serikawa Tadao

    … LGI1 encodes a neuronal secreted protein, whose brain function is still poorly understood. … We found that the L385R mutation prevents the secretion of Lgi1 protein by COS7 transfected cells. … However, the L385R-Lgi1 protein was found at low levels in the brains and cultured neurons of Lgi1-mutant rats, suggesting that mutant protein may be destabilized in vivo. …

    Human molecular genetics 21(16), 3546-3557, 2012-05-15

    IR CrossRef

  • 6

    Role of Dlg5/lp-dlg, a Membrane-Associated Guanylate Kinase Family Protein, in Epithelial-Mesenchymal Transition in LLc-PK1 Renal Epithelial Cells.

    Sezaki Takuhito , Inada Kohki , Sogabe Takayuki , Kakuda Kumiyo , Tomiyama Lucia , Matsuno Yohsuke , Ichikawa Takafumi , Matsuo Michinori , Ueda Kazumitsu , Kioka Noriyuki

    … Depletion of Dlg5 expression by knockdown promoted the expression of the mesenchymal marker proteins, fibronectin and α-smooth muscle actin, and suppressed the expression of E-cadherin. … In addition, activation of JNK and p38, which are stimulated by TGF-β, was enhanced by Dlg5 depletion. … Furthermore, inhibition of the TGF-β receptor suppressed the effects of Dlg5 depletion. …

    PloS one 7(4), 2012-04-23

    IR CrossRef

  • 7

    Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling.

    Nakajima Saeko , Igyártó Botond Z , Honda Tetsuya , Egawa Gyohei , Otsuka Atsushi , Hara-Chikuma Mariko , Watanabe Norihiko , Ziegler Steven F , Tomura Michio , Inaba Kayo , Miyachi Yoshiki , Kaplan Daniel H , Kabashima Kenji

    … Background: The clarification of cutaneous dendritic cell subset and the role of thymic stromal lymphopoietin (TSLP) signaling in epicutaneous sensitization with protein antigens, as in the development of atopic dermatitis, is a crucial issue. … Objectives: Because TSLP is highly expressed in the vicinity of Langerhans cells (LCs), we sought to clarify our hypothesis that LCs play an essential role in epicutaneous sensitization with protein antigens through TSLP signaling. …

    The Journal of allergy and clinical immunology 129(4), 1048-1055.e6, 2012-04-00

    IR CrossRef

  • 8

    Soy Peptides Enhance Heterologous Membrane Protein Productivity during the Exponential Growth Phase of Saccharomyces cerevisiae

    ITO Keisuke , HIKIDA Aya , KITAGAWA Sayuri , MISAKA Takumi , ABE Keiko , KAWARASAKI Yasuaki

    … In this study, the production of eight G protein-coupled receptors by <I>Saccharomyces cerevisiae</I> … The enhancement of protein expression by soy peptides can be explained by alleviation of metabolite stress due to amino acid source depletion caused by heterologous protein expression. …

    Bioscience, Biotechnology, and Biochemistry 76(3), 628-631, 2012-03-23

    J-STAGE CrossRef References (26)

  • 9

    DIACHRONIC CHANGES IN PROTEIN ACQUISITION AMONG THE BONGANDO IN THE DEMOCRATIC REPUBLIC OF THE CONGO

    Daiji KIMURA Hirokazu YASUOKA &Takeshi FURUICHI , YASUOKA Hirokazu , FURUICHI Takeshi

    … A comparison of data obtained in the 1970s, 1980s, and 2000s revealed diachronic changes in protein acquisition among the Bongando people living in the Wamba region of the Democratic Republic of the Congo. … The main protein source changed from bushmeat to fish due to depletion of the game animal population. …

    African study monographs. Supplementary issue 43, 161-178, 2012-03-01

    CiNii Link1 IR

  • 10

    An X-chromosome RNA-binding motif protein (RBMX) is required for proper kinetochore formation

    LEE Mei Hann , LIN Linyen , TAKATA Hideaki , MORIMOTO Akihiro , UCHIYAMA Susumu , MATSUNAGA Sachihiro , FUKUI Kiichi

    … RBMX is an RNA-binding motif protein identified as a component of purified human metaphase chromosomes. … We revealed that depletion of RBMX results in the accumulation of mitotic cells. … EM investigation further showed that RBMX depletion leads to an increase in the fuzzy ball structure that is reminiscent of the prekinetochore. …

    Chromosome Science 14(1), 17-21, 2012-03-01

    J-STAGE References (24)

  • 11

    Molecular Cloning of the Silkworm p53R2–like Gene

    Fujii Mie , Takahashi Masateru , Mon Hiroaki , Tatsuke Tsuneyuki , Lee Jae Man , Kusakabe Takahiro , 藤井 美江 , 高橋 将晃 , 門 宏明 , 田附 常幸 , 李 在萬 , 日下部 宜宏

    … In this study, we have isolated and determined cDNA sequence for Bombyx mori p53R2–like (p53R2–L) protein. … The Bmp53R2–like protein had high homology to the Hsp53R2, but had histidine residue at a position corresponding to Y241 of Hsp53R2, which is a key residue in discriminating human p53R2 and R2. … This G1/S arrest may be caused by the retardation of DNA synthesis due to the depletion of dNTPs in nucleus under the conditions of the knockdown of Bmp53R2–L. …

    Journal of the Faculty of Agriculture, Kyushu University 57(1), 79-82, 2012-02-00

    IR

  • 12

    Comprehensive characterization of two different Nicotiana tabacum cell lines leads to doubled GFP and HA protein production by media optimization(PLANT BIOTECHNOLOLGY)

    Ullisch David A. , Muller Christina A. , Maibaum Sabrina , Kirchhoff Janina , Schiermeyer Andreas , Schillberg Stefan , Roberts Jean L. , Treffenfeldt Wiltrud , Buchs Jochen

    … The objective of this study is to comprehensively characterize the growth of a transgenic BY-2 cell line and to investigate the expression profile of the model protein GFP. … A reproducibly observed shift of the oxygen transfer rate (OTR) could be identified to indicate animonium depletion in the medium. … Concurrent with this ammonium depletion, the total protein concentration began to decrease. …

    Journal of bioscience and bioengineering 113(2), 242-248, 2012-02-00

    CiNii Fulltext PDF - Paid  References (59)

  • 13

    Ebp2 and Brx1 function cooperatively in 60S ribosomal subunit assembly in Saccharomyces cerevisiae

    Shimoji Kaori , Jakovljevic Jelena , Tsuchihashi Kanako , Umeki Yuka , Wan Kun , Kawasaki Suzuka , Talkish Jason , Woolford Jr John L. , Mizuta Keiko , シモジ カオリ , ツチハシ カナコ , ウメキ ユカ , ミズタ ケイコ , 下地 加織 , 梅木 悠花 , 万 坤 , 河崎 鈴加 , 水田 啓子

    … The yeast protein Ebp2 is required for early steps in production of 60S ribosomal subunits. … Depletion of either Ebp2 or Brx1 revealed that Brx1 requires Ebp2 for its stable association with pre-ribosomes, but Ebp2 does not depend on the presence of Brx1 to enter pre-ribosomes. …

    Nucleic Acids Research 40(10), 4574-4588, 2012-00-00

    IR CrossRef

  • 14

    Effects of Depletion of Dihydropyrimidine Dehydrogenase on Focus Formation and RPA Phosphorylation

    SOMEYA Masanori , SAKATA Koh-ichi , MATSUMOTO Yoshihisa , TAUCHI Hiroshi , KAI Masahiro , HAREYAMA Masato , FUKUSHIMA Masakazu

    … DPYD is the target protein for radiosensitization by Gimeracil. … DPYD depletion by siRNA significantly restrained the formation of radiation-induced foci of Rad51 and RPA, whereas it increased the number of foci of NBS1. … These results suggest that DPYD depletion is attributable to decreased single-stranded DNA generated by the Mre11/Rad50/NBS1 complex-dependent resection of DNA double-strand break ends. …

    Journal of Radiation Research 53(2), 250-256, 2012

    J-STAGE Ichushi Web CrossRef

  • 15

    The Regulatory Mechanisms of Calcitonin Gene-related Peptide (CGRP) in Skin Inflammation  [in Japanese]

    Mikami Norihisa , Fukada So-ichiro , Yamamoto Hiroshi , Tsujikawa Kazutake

    … CGRP binds to CGRP receptors composed of receptor activity-modifying protein 1 (RAMP1) and calcitonin receptor-like receptor (CLR) to modulate various functions such as pain transmission and vasodilation. … Studies showing that CGRP physiologically regulates skin inflammation using a CGRP antagonist, capsaicin-induced depletion model, RAMP1-deficient mice and mouse contact hypersensitivity (CHS) model have been reported. …

    YAKUGAKU ZASSHI 132(11), 1211-1215, 2012

    J-STAGE CrossRef

  • 16

    Mode of ATM-dependent suppression of chromosome translocation

    Yamauchi Motohiro , Suzuki Keiji , Oka Yasuyoshi , Suzuki Masatoshi , Kondo Hisayoshi , Yamashita Shunichi

    … It is well documented that deficiency in ataxia telangiectasia mutated (ATM) protein leads to elevated frequency of chromosome translocation, however, it remains poorly understood how ATM suppresses translocation frequency. … We found ATM also suppresses dicentric occurrence independently of its checkpoint role, as ATM inhibitor showed additional effect on dicentric frequency in the context of p53 depletion and Chk1/2 inactivation. …

    Biochemical and Biophysical Research Communications 416(1-2), 111-118, 2011-12-09

    IR

  • 17

    The Effect of Low-Pressure Carbonation on the Heat Inactivation of Escherichia coli

    KLANGPETCH Wannaporn , NOMA Seiji , IGURA Noriyuki , SHIMODA Mitsuya

    … Following the depletion of intracellular ATP, the failure of the cells to discard protons caused an abnormal decrease in the intracellular pH. However, in the presence of glucose, the inactivation ratio decreased. … In addition, a further increase in inactivation of more than 2log orders occurred in the presence of the protein synthesis inhibitor chloramphenicol. …

    Bioscience, Biotechnology, and Biochemistry 75(10), 1945-1950, 2011-10-23

    J-STAGE Ichushi Web CrossRef References (20)

  • 18

    DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation.

    Miyata Yoshihiko , Nishida Eisuke

    … Here we have identified WDR68, an evolutionarily conserved protein with WD40-repeat domains, as a cellular binding partner of DYRK1A. … Experiments with RNA interference showed that WDR68 was indispensable for the optimal proliferation and survival of mammalian cultured cell, and WDR68 depletion induced cell apoptosis. …

    Biochimica et biophysica acta 1813(10), 1728-1739, 2011-10-00

    IR CrossRef

  • 19

    Alleviation of body weight loss by dietary methionine is independent of insulin-like growth factor-I in protein-starved young chickens

    NAGAO Kenji , OKI Mai , TSUKADA Akira , KITA Kazumi

    Animal science journal 82(4), 560-564, 2011-08-01

    References (28)

  • 20

    先端推奨論文 Ascorbic acid depletion enhances expression of the sodium-dependent vitamin C transporters, SVCT1 and SVCT2, and uptake of ascorbic acid in livers of SMP30/GNL knockout mice (平成23年度助成研究論文)

    天野 晶子 , Aigaki Toshiro , Maruyama Naoki [他]

    Pre symptomatic medicine and anti aging 20(1), 131-138, 2011-06-00

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