Taniguchi Yuko
,
Nosaka Kisato
,
Yasunaga Jun-ichirou
,
Maeda Michiyuki
,
Mueller Nancy
,
Okayama Akihiko
,
Matsuoka Masao
… To clarify the role of epigenetic changes, we analyzed DNA methylation and histone modification in the whole HTLV-I provirus genome. … [Results]The gag, pol and env genes of HTLV-I provirus were more methylated than pX region, whereas methylation of 5'-LTR was variable and 3'-LTR was not methylated at all. … HTLV-I provirus was more methylated in primary ATL cells than in carrier state, indicating the association with disease progression. …
Retrovirology 2, 64, 2005-10-22
IR
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