Search Results:　 1-20 of 141

1

Chrysophanol-8-O-glucoside, an Anthraquinone Derivative in Rhubarb, Has Antiplatelet and Anticoagulant Activities

SEO Eun Ji , NGOC Tran Minh , LEE Sun-Mee , KIM Yeong Shik , JUNG Yi-Sook

… Rhubarb is a widely used traditional medicine and has been reported to elicit a number of biological effects including anti-inflammatory and antiplatelet effects. … In the present study, we investigated the effects of anthraquinone derivatives isolated from rhubarb on platelet activity. …

Journal of Pharmacological Sciences 118(2), 245-254, 2012-02-20

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2

The Influence of Rhein 8-O-β-D-Glucopyranoside on the Purgative Action of Sennoside A from Rhubarb in Mice

Takayama Kento , Tsutsumi Hiroyuki , Ishizu Takashi , Okamura Nobuyuki

… Rhubarb is one of the most well-known herbal medicines that constitute daiokanzoto (DKT), which is clinically effective for constipation. … Sennoside A in rhubarb showed significantly accelerated metabolic activity in intestinal bacteria in comparison with sennoside A alone. … In this study, we investigated the influence of rhubarb constituents on the metabolism and purgative activity of sennoside A. …

Biological and Pharmaceutical Bulletin 35(12), 2204-2208, 2012

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3

Report on Four Cases of Chronic Renal Failure Effectively Treated with Astragali Radix [in Japanese]

NAGASAKA Kazuhiko , FUKUDA Hidehiko , WATANABE Tetsuo , NAGATA Yutaka

漢方薬はこれまでも腎疾患に応用されてきた。漢方薬の大黄や温脾湯には，透析導入までの期間を延ばす働きがあることが知られている。しかし，その効果は1/Cr の傾きを改善するにとどまり，Cr 自体を改善するわけではない。今回，西洋薬が無効であった慢性腎不全患者に漢方薬の黄耆が奏功した4症例を報告する。4例ともCr 値は明らかに改善し，透析導入までの期間が延長された。このうち2例は4年以上にわたり安定的に …

Kampo Medicine 63(2), 98-102, 2012

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4

Antibacterial properties of anthraquinones extracted from rhubarb against Aeromonas hydrophila

LU Chunxia , WANG Hongxin , LV Wenping , XU Pao , ZHU Jian , XIE Jun , LIU Bo , LOU Zaixiang

Fisheries science : FS 77(3), 375-384, 2011-05-01

References (37)
5

The Influence of Glycyrrhiza and Antibiotics on the Purgative Action of Sennoside A from Daiokanzoto in Mice

Matsui Emi , Takayama Kento , Sato Eiji , Okamura Nobuyuki

… Daiokanzoto (DKT), a Kampo medicine that includes the combination of two crude drugs (rhubarb and glycyrrhiza), is clinically effective for constipation. … The aim of this study is to clarify the influence of glycyrrhiza, three glycyrrhiza constituents (glycyrrhizin, liquiritin, and liquiritin apioside), and eight antibiotics on the purgative action of DKT, rhubarb, or sennoside A, a constituent of rhubarb, in mice. …

Biological and Pharmaceutical Bulletin 34(9), 1438-1442, 2011

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6

High-Performance Liquid Chromatographic Determination and Metabolic Study of Sennoside A in Daiokanzoto by Mouse Intestinal Bacteria

Takayama Kento , Matsui Emi , Kobayashi Takeshi , Inoue Hirofumi , Tsuruta Yasuto , Okamura Nobuyuki

… Daiokanzoto (DKT, combination of rhubarb and glycyrrhiza), a Kampo medicine, is clinically effective for constipation. …

Chemical and Pharmaceutical Bulletin 59(9), 1106-1109, 2011

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7

Cytology of Rheum, a vulnerable medicinal plant from Kashmir Himalaya

Saggoo Manjit Inder Singh , Farooq Umer

… <I>Rheum</I>, common name rhubarb is a source of number of chemical compounds like emodin, rutin and rhein. …

Chromosome Botany 6(2), 41-44, 2011

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8

Herbological Studies on Combination of Rhubarb and Mirabilite [in Japanese]

DOUI Misato , ANDO Hirokazu , GOI Chihiro , KAKIUCHI Nobuko , MIKAGE Masayuki

The Japanese journal for history of pharmacy 45(2), 106-111, 2010-12-30

Ichushi Web References (30)
9

Considering the Sustainable Utility of Crude Drug Resources : As the Examples on Rhubarb and Ephedra Herb [in Japanese]

KOMATSU Katsuko

Kampo medicine 61(5), 764-773, 2010-07-20

Ichushi Web
10

To Get the Resources of Crude Drugs [in Japanese]

YONEDA Kaisuke

日本東洋醫學雜誌 = Japanese journal of oriental medicine 61(5), 754-755, 2010-07-20
11

Study on Decocting Time for Rhubarb from Ancient Times [in Japanese]

DOUI Misato , EBARA Toshiaki , GOI Chihiro , ANDO Hirokazu , KAKIUCHI Nobuko , MIKAGE Masayuki

中国では古来，生薬の目的としている薬効の向上のために煎じ時間の調節を行ってきた。医方書には各処方の煎じ時間を煎液の減少量によって定めている。本研究では，中国最古の医方書である『傷寒論』及び『金匱要略』に収載される「大黄」配合処方の煎じ時間を液量変化から調査した。その結果，大黄の煎じ時間は他生薬と同煎の場合，10，20，30，50分の4群に，後下の場合，1，5，10，20分の4群に分類できた。また， …

Kampo Medicine 61(3), 252-288, 2010-05-20

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12

Simple and rapid analysis of sennoside A and sennoside B contained in crude drugs and crude drug products by solid-phase extraction and high-performance liquid chromatography

YAMASAKI Katsuhiro , KAWAGUCHI Masami , TAGAMI Takaomi , SAWABE Yoshiyuki , TAKATORI Satoshi

Journal of natural medicines 64(2), 126-132, 2010-05-20

Ichushi Web References (13)
13

A Herbological Study on the Medicinal Effects and Employments of Rhubarb Processed with Liquor (2) : Comparison of Principal Compound Contents in the Liquor-dipped Rhubarb and Liquor-soaked Rhubarb

DOUI Misato , KAKIUCHI Nobuko , EBARA Toshiaki , MIKAGE Masayuki

… Rhubarb (<I>Da-huang</I> … In this report, we describe how processing with ethanol altered the levels of the principal compounds in rhubarb: sennoside A, sennoside B, aloe-emodin, rhein, emodin, chrysophanol, physcion, lindleyin, isolindleyin, and total tannins. … Liquor-dipping, dipping rhubarb in 16% ethanol for 30 seconds, did not affect the content of sennosides. … Thus, the purgative effect of rhubarb is likely to be preserved. …

Kampo Medicine 61(2), 133-137, 2010-03-20

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14

yaluronidase inhibitory effect and SOD-like effect of rhubarb leafstalk [in Japanese]

定森耕平 , 藤木成忠 , 播磨章一 , 駒井功一郎

… [Synopsis]　This research examined hyaluronidase（HYAL） inhibitory effect and superoxide dismutase（SOD）-like effect observed to the rhubarb leafstalk. … There were HYAL inhibitory effect and SOD-like effect in 50％EtOH extract of the rhubarb leafstalk. …

近畿大学資源再生研究所報告 (8), 47-53, 2010-03-00

IR
15

Chemical changes in rhubarb heated after processed with liquor

DOUI M , Kakiuchi Nobuko , 御影雅幸

漢方生薬「大黄」は中国において古来，酒洗（LDi），酒浸（LSo）及び酒炒（LH）と呼ばれる酒を用いる修治が行われてきた。我々はこれまでに，古文献の記載内容から，酒炒品は瀉下作用を示す LDi 品または駆瘀血作用を示す LSo 品と同様の薬効を期待して用いられていたと考察した。また，現在は駆瘀血作用を期待し，「酒大黄」と称する酒噴霧した LH 品（LSpH）が用いられて …

Journal of traditional medicines 27(4), 143-147, 2010-00-00

IR Ichushi Web Cited by (1)
16

Chemical differences between steamed rhubarbs with or without pre-processing with liquor

Doui Misato , Kakiuchi Nobuko , 御影雅幸

中国では，漢方生薬「大黄」に，特定の薬効の向上や副作用の低減を目的に種々の加工を施してきた。その内の一つに熟大黄（JD）が挙げられる。古代， JD の調製法は「蒸す（蒸）」と「酒をかけた後蒸す（酒蒸）」の 2 種あったが，現在は酒蒸のみとなり，それに伴って JD の薬効が変化した可能性がある。本研究では，蒸（St）品と酒蒸品の薬効を解明するために，中国の本 …

Journal of traditional medicines 27(3), 109-114, 2010-00-00

IR Ichushi Web
17

To Get the Resources of Crude Drugs:1. Quality Assurance of Crude Drugs for Kampo and Conventional Crude Drug Products in Japan2. Considering the Sustainable Utility of Crude Drug Resources—As the Examples on Rhubarb and Ephedra Herb—

TOMITSUKA Hiroyuki , KOMATSU Katsuko

Kampo Medicine 61(5), 754-773, 2010

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18

Studies on rhubarb processed with liquor : The reason why rhubarb is processed with huangjiu : the liquor contains a small amount of alcohol

DOUI Misato , KAKIUCHI Nobuko , MIKAGE Masayuki

漢方生薬「大黄」は中国において古来，酒を用いた修治（酒製）が施されてきた。酒製に使用する酒は主にアルコール度が低い黄酒とアルコール度が高い白酒の 2 種があり，大黄の酒製には黄酒が用いられてきたが，その理由は明確でない。本研究では，蒸留水， 16 % エタノール溶液， 50 % エタノール溶液または黄酒の一種である紹興酒を用いて酒浸大黄を調製し，主成分含量（sennosid …

Journal of traditional medicines 26(4), 160-168, 2009-11-30

IR Ichushi Web References (23) Cited by (2)
19

A Herbological Study on the Medicinal Effects and Employments of Rhubarb Processed with Liquor [in Japanese]

DOUI Misato , MIKAGE Masayuki

漢方生薬「大黄」は中国で古来，酒による修治（酒製）が行われてきた。大黄の酒製には酒浸，酒洗及び酒炒の3種があり，現在も「酒大黄」と称する酒炒品が用いられているが，酒製法の違いによる薬効の相違点や酒炒品が使用され始めた経緯は明確でない。本研究では，理論的治療を目的とした金元代以降の古文献の記載内容を調査した結果，「酒浸大黄」の薬効は活血など駆瘀血，「酒洗大黄」の薬効は瀉下または健胃であ …

Kampo Medicine 60(4), 429-434, 2009-07-20

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20

Analysis of Crude Drugs Using Reversed-phase TLC/Scanning Densitometry : Identification of Bitter Cardamon, Epimedium Herb, Lithospermum Root, Rhubarb, Saussurea Root and Sophora Root [in Japanese]

Ikeda Seiei , Mikami Eiichi , Ohno Tsutomu

… We performed identification tests of the main components (nootkatone, icariin, acetylshikonin, sennoside A, costunolide, and oxymatrine) of the following crude drugs in the Japanese pharmacopoeia, 15th edition (JP15): Bitter Cardamon, Epimedium Herb, Lithospermum Root, Rhubarb, Saussurea Root, and Sophora Root. …

The Japanese journal of pharmacognosy 63(1), 6-9, 2009-02-20

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