Search Results:　 1-20 of 929

1

Alteration of Enzyme Expressions in Mevalonate Pathway : Possible Role for Cardiovascular Remodeling in Spontaneously Hypertensive Rats

HAN Jie , JIANG Dong-Mei , DU Chang-Qing , HU Shen-Jiang

… The aim of this study was to define whether the enzyme expression in mevalonate pathway changes during cardiovascular remodelling in spontaneously hypertensive rats (SHR). … Methods and Results: Hearts and thoracic aortas were removed for the study of cardiovascular remodeling in SHR and Wistar-Kyoto rats (WKY). …

Circulation Journal 75(6), 1409-1417, 2011-05-25

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2

Vascular Smooth Muscle Cell Proliferation Is Influenced by let-7d MicroRNA and Its Interaction With KRAS

YU Man-Li , WANG Jia-Feng , WANG Guo-Kun , YOU Xiao-Hua , ZHAO Xian-Xian , JING Qing , QIN Yong-Wen

… Methods and Results: Primary VSMCs were isolated from the medial layer of the thoracic aorta obtained from spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). … miRNA microarrays were used to analyze the difference in miRNA expression between VSMCs of SHR and WKY rats and were validated using TaqMan real-time PCR. …

Circulation Journal 75(3), 703-709, 2011-02-25

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3

Antihypertensive Effect of Angiotensin I-Converting Enzyme Inhibitory Peptides Derived from Wheat Bran in Spontaneously Hypertensive Rats [in Japanese]

NOGATA Yoichi , NAGAMINE Takashi , SEKIYA Keizo

… 小麦ふすま由来WBPのSHRに対する血圧降下作用を検討した．WBPのふすまからの収量は約2.0％であり，500gのふすまから9.8g (IC50＝80μg/mL）が得られた．SHRに対する単回経口投与試験では，WBPは10, 50，および200mg WBP/kgの投与量において投与後2時間から用量依存的にSBPの低下を示し，50および200mg WBP/kgでは8時間まで降圧が持続した．SHRに対する長期投与試験では，0.02％ WBP投与群は試験開 …

Nippon Shokuhin Kagaku Kogaku Kaishi 58(2), 67-70, 2011-02-15

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4

Effects of extruded polished rice, brown rice, and germinated brown rice supplemented with NaCl on the blood pressure and adipocytokines of spontaneously hypertensive rats (SHR/Izm) [in Japanese]

白井展也 , 鈴木啓太郎 , 大坪研一

Journal of the Japanese Society for Food Science and Technology 58(7), 324-329, 2011-07
5

Preventive effects of the extract of kinka-cha, a folk tea, on a rat model of metabolic syndrome

Oku Hisae , Ogawa Yuko , Iwaoka Emiko [他]

Journal of natural medicines 65(3・4), 610-616, 2011
6

Antihypertensive Effects of Continuous Oral Administration of Nattokinase and Its Fragments in Spontaneously Hypertensive Rats

Fujita Mitsugu , Ohnishi Katsunori , Takaoka Shinsaku , Ogasawara Kazuya , Fukuyama Ryo , Nakamuta Hiromichi

… To determine whether the antihypertensive effect of nattokinase is associated with the protease activity of this enzyme, we compared nattokinase with the fragments derived from nattokinase, which possessed no protease activity, in terms of the effect on hypertension in spontaneously hypertensive rats (SHR). …

Biological & Pharmaceutical Bulletin 34(11), 1696-1701, 2011

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7

Production of GABA-Enriched Powder by a Brown Variety of Flammulina velutipes (Enokitake) and Its Antihypertensive Effects in Spontaneously Hypertensive Rats

Harada Akira , Nagai Takeshi , Yamamoto Miho

… 中でもエノキタケのGABA生成能が高く，ブラウン系エノキタケの子実体を原料とした場合20°C 6〜8時間の反応により原料の6〜7％に相当するGABA生成が可能であった．GABAを増やしたブラウン系統エノキタケを高血圧自然発症ラット（SHR）に強制経口投与した結果，0.9mg/kgのGABAを含むエノキタケの投与により，収縮期に30mmHg程度の降圧作用を示した．正常血圧ラット（WIST）の実験では，血圧に顕著な変化が見られなかった． …

Nippon Shokuhin Kagaku Kogaku Kaishi 58(9), 446-450, 2011

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8

Cardiovascular Protection with Danshensu in Spontaneously Hypertensive Rats

Tang Yiqun , Wang Minhui , Chen Chunlin , Le Xiaoyong , Sun Shujuan , Yin Yuemiao

… The objective of the present study was to evaluate the cardiovascular protective effects of Danshensu, a water-soluble active component of Danshen, in spontaneously hypertensive rats (SHR). … SHR (male, 9 weeks old, n=30) were divided into three groups: 1) saline control (n=10); … Age-matched Wistar-Kyoto rats (n=10) were used as normotensive controls. …

Biological & Pharmaceutical Bulletin 34(10), 1596-1601, 2011

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9

Gαq-Protein Carboxyl Terminus Imitation Polypeptide GCIP-27 Attenuates Proliferation of Vascular Smooth Muscle Cells and Vascular Remodeling in Spontaneously Hypertensive Rats

Zhang Hai-Gang , Cheng Yi-Qun , Liu Ya , Zhou Jian-Zhi , Jia Yi , Wang Xiu-Qin , Li Xiao-Hui

… The present study was designed to explore the effects of a synthetic Gαq carboxyl terminus imitation peptide, namely GCIP-27, on vascular smooth muscle cells (VSMC) in vitro and vascular remodeling in spontaneous hypertensive rats (SHR). … Systolic blood pressure (SBP), the ratio of media thickness to lumen diameter (MT/LD) of aorta, collagen content, and phospholipase C activity in aorta were measured in SHR. …

Biological & Pharmaceutical Bulletin 34(10), 1527-1532, 2011

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10

Irbesartan Prevents Metabolic Syndrome in Rats via Activation of Peroxisome Proliferator-Activated Receptor γ

Takai Shinji , Jin Denan , Miyazaki Mizuo

… In this study, thirteen-week-old spontaneously hypertensive (SHR)/NDmcr-cp rats, representing a genetic model of metabolic syndrome, were treated daily with placebo, irbesartan (30 mg/kg), valsartan (10 mg/kg), or pioglitazone (10 mg/kg) for 4 weeks. …

Journal of Pharmacological Sciences 116(3), 309-315, 2011

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11

Synthesis and Pharmacological Evaluation of 1-Isopropyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Novel Antihypertensive Agents

Watanuki Susumu , Matsuura Keisuke , Tomura Yuichi , Okada Minoru , Okazaki Toshio , Ohta Mitsuaki , Tsukamoto Shin-ichi

… Oral administration of 6-fluoro-1-isopropyl-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline (3b) to spontaneously hypertensive rats (SHR) elicited antihypertensive effects without inducing reflex tachycardia, which is often caused by traditional L-type Ca2+ channel blockers. …

CHEMICAL & PHARMACEUTICAL BULLETIN 59(8), 1029-1037, 2011

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12

Comparison of Receptors and Enzymes Regulating Cholesterol Levels in Liver between SHR/NDmcr-cp Rats and Normotensive Wistar Kyoto Rats at Ten Weeks of Age

Michihara Akihiro , Anraku Makoto , Abe Aoi , Kinoshita Haruko , Kamizaki Yohei , Tomida Hisao , Akasaki Kenji

… The spontaneously hypertensive rat (SHR)/NDmcr-cp (SHR-cp), which is a metabolic syndrome model rat, was reported to show hypercholesteremia, as compared with lean littermates. … The serum total cholesterol level in SHR-cp at 18 weeks of age is higher than that of normotensive Wistar Kyoto rat (WKY), but that in SHR-cp at 10 weeks of age is the same. …

Biological & Pharmaceutical Bulletin 34(7), 1116-1119, 2011

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13

A Special Focus on the Role of α1D-Adrenoreceptors in the Assessment of Renal Tubular Sodium Re-absorptive Responses in Spontaneously Hypertensive Rats Subjected to High Sodium Diet

KAZI Raisa N. , SATTAR Munavvar A. , ABDULLAH Nor A. , KHAN Md A. Hye , RATHORE Hassaan A. , ABDULLA Mohammed H. , SALMAN Ibrahim M. , JOHNS Edward J.

… α1D-Adrenoceptors are involved in the genesis/maintenance of hypertension in spontaneously hypertensive rats (SHR). … This study aims to investigate the role of α1D-adrenoceptors in the antinatriuretic and antidiuretic responses in SHR subjected to high sodium (SHRHNa) and normal sodium (SHRNNa) intake for six weeks. … Results show that feeding SHR for six weeks with high salt did not cause any change in blood pressure. …

YAKUGAKU ZASSHI 131(3), 431-436, 2011

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14

PGC-1α mRNA Level and Oxidative Capacity of the Plantaris Muscle in Rats with Metabolic Syndrome, Hypertension, and Type 2 Diabetes

Nagatomo Fumiko , Fujino Hidemi , Kondo Hiroyo , Gu Ning , Takeda Isao , Ishioka Noriaki , Tsuda Kinsuke , Ishihara Akihiko

… We examined the fiber profiles and the mRNA levels of peroxisome proliferator-activated receptors (PPARα and PPARδ/β) and of the PPARγ coactivator-1α (PGC-1α) in the plantaris muscles of 15-week-old control (WR), metabolic syndrome (CP), hypertensive (SHR), and type 2 diabetic (GK) rats. …

ACTA HISTOCHEMICA ET CYTOCHEMICA advpub(0), 1104190105, 2011

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15

Reparixin, an Inhibitor of CXCR1 and CXCR2 Receptor Activation, Attenuates Blood Pressure and Hypertension-Related Mediators Expression in Spontaneously Hypertensive Rats

Kim Hye Young , Choi Jin Hee , Kang Young Jin , Park So Young , Choi Hyoung Chul , Kim Hee Sun

… Spontaneously hypertensive rats (SHR) at the age of 18 weeks were administered a subcutaneous injection of reparixin (5 mg/kg) daily for 3 weeks (SHR-R, n=5). … Control groups consisted of normal saline-treated SHR (SHR-N, n=5) and normotensive Wistar–Kyoto rats (WKY-N, n=5). …

Biological & Pharmaceutical Bulletin 34(1), 120-127, 2011

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16

Antihypertensive Effect of Angiotensin I-converting Enzyme Inhibitory Peptides from tamari Cake in Spontaneously Hypertensive Rats [in Japanese]

UMEKAWA Hayato , FUJIWARA Toshihiro , YOSHIDA Saori , OKIMURA Koji , UCHIYAMA Yusuke , NISHIO Masahiro , KATSUZAKI Hirotaka , IMAI Kunio , MATSUNAGA Masayoshi

… たまり醤油粕アルカリ抽出物からダイアイオンAMP 01およびトヨパールHW-50Fによるクロマトグラフィー，さらにCosmosil 5C18-ARによるHPLCによりACE阻害活性を有する4種のペプチド，Leu-Val-Gly, Val-Thr-Ser-Tyr, Phe-Ser-Ala-ThrおよびPhe-Glu-Thr-Argを精製した．これらのペプチドを5mg/kgでSHRに対して経口単回投与を行ったところ，Leu-Val-GlyとPhe-Glu-Thr-Argに有意な血圧降下作用が認められた． …

Nippon Shokuhin Kagaku Kogaku Kaishi 57(8), 361-365, 2010-08-15

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17

Blood Pressure-Independent Factors Determine the Susceptibility to Delayed Neuronal Death in the Stroke-Prone Spontaneously Hypertensive Rats.

Sakurai-Yamashita Yasuko , Nabika Toru , Niwa Masami

… Male rats of the four strains, SHRSP/Izm, SHRSP/Ngsk, SHR/Izm and a congenic strain for the blood pressure quantitative trait locus on chromosome 1 [SHRSP.WKY-(D1Wox29-D1Arb21)/Izm]were used in the experiments. … At 13 weeks of age, the bilateral carotid arteries of rats were occluded for 10 min under anesthesia with their body temperature kept at 37 degrees C. …

Cellular and molecular neurobiology 30(2), 283-287, 2010-03

IR
18

Role of Angiontensin Receptors on Remodeling Perivascular Nerves

HOBARA Narumi , GODA Mitsuhiro , HASHIKAWA Naoya , JIN Xin , ZAMAMI Yoshito , TAKATORI Shingo , KAWASAKI Hiromu

… The aim of this study was to investigate age-related changes in the density of calcitonin gene-related peptide (CGRP)-containing nerve fibers in spontaneously hypertensive rats (SHR) and the effects of long-term inhibition of the renin-angiotensin system on these changes. …

YAKUGAKU ZASSHI 130(11), 1421-1425, 2010

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19

Atorvastatin Prevents Left Ventricular Remodeling in Spontaneously Hypertensive Rats

Zhao Xiao-yan , Li Ling , Zhang Jin-ying , Liu Gang-qiong , Chen Ya-li , Yang Pei-ling , Liu Rui-yun

… Statins improve left ventricular (LV) remodeling in spontaneously hypertensive rats (SHRs). … This study was designed to investigate the effects of atorvastatin administered in the early stage on LV remodeling in SHRs, and to explore the underlying mechanisms.Sixteen male 8-week-old SHRs were randomized to receive distilled water (SHR-DW) or atorvastatin (SHR-ATV) for 12 weeks. … Age-matched male Wistar-Kyoto (WKY) rats gavaged with distilled water served as controls. …

International Heart Journal 51(6), 426-431, 2010

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20

Year-Long Antihypertensive Therapy With Candesartan Completely Prevents Development of Cardiovascular Organ Injuries in Spontaneously Hypertensive Rats

Ishimitsu Toshihiko , Honda Takeaki , Ohno Eri , Furukata Satoshi , Sudo Yasuyo , Nakano Nobuyuki , Takahashi Toshiaki , Ono Hidehiko , Matsuoka Hiroaki

… In this study, spontaneously hypertensive rats (SHR) were treated for 1 year with an angiotensin-II receptor antagonist (ARB) and the development of hypertensive organ injury was evaluated. … Male 15-week-old SHR (n = 9) were given 25 mg/L candesartan (CS) in their drinking water for 1 year. … Twelve SHR and 9 normotensive Wistar-Kyoto rats (WKY) were given normal tap water. …

International Heart Journal 51(5), 359-364, 2010

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