検索結果:　424件中 1-20 を表示

1

関節リウマチに続発するAAアミロイドーシスの現況と課題

田村裕昭 , 長谷川公範

関節リウマチ（RA）などの慢性炎症性疾患に続発するAAアミロイドーシスは，難溶性の線維性蛋白（アミロイド線維）が細胞外に沈着して様々な臓器の機能障害を引き起こす予後不良の病態である．近年，そのポリペプチド鎖の三次元構造を規定するfoldingの異常とアミロイド蛋白の難溶化・組織沈着の関連が明らかにされ，アミロイドーシスは“Conformation Disease”として認識 …

日本臨床免疫学会会誌 = Japanese journal of clinical immunology 32(1), 35-42, 20090228

CrossRef 医中誌 J-STAGE 参考文献46件
2

Genipin Suppresses A23187-Induced Cytotoxicity in Neuro2a Cells

Yamazaki Matsumi , Chiba Kenzo , Yoshikawa Chiaki

… We have previously reported that genipin induces neurite outgrowth in PC12h and Neuro2a cells and protects against cytotoxicity induced by several conditions such as β-amyloid peptide, serum deprivation, and oxidative stress in rat primary hippocampal neurons and Neuro2a cells. …

Biological & Pharmaceutical Bulletin 32(6), 1043-1046, 2009

CrossRef 医中誌 J-STAGE
3

Verification of Measurement of the Feline Serum Amyloid A (SAA) Concentration by Human SAA Turbidimetric Immunoassay and Its Clinical Application(Clinical Pathology)

TAMAMOTO Takashi , OHNO Koichi , OHMI Aki , GOTO-KOSHINO Yuko , TSUJIMOTO Hajime

… Serum amyloid A (SAA) is one of the major acute phase proteins in cats that has potential to be used as an inflammatory marker. … Recombinant feline SAA protein (rfSAA) was expressed in Escherichia coli and purified for SDS-PAGE and immunoblot analysis with anti-human SAA antibodies. …

The journal of veterinary medical science 70(11), 1247-1252, 20081125

CiNii PDF 医中誌参考文献32件
4

Systemic AL Amyloidosis Mimicking Rheumatoid Arthritis

Katoh Nagaaki , Tazawa Ko-ichi , Ishii Wataru , Matsuda Masayuki , Ikeda Shu-ichi

… He was diagnosed as having systemic AL amyloidosis based on deposition of κ-light chain-immunoreactive amyloid in biopsied tissue and Bence Jones protein in serum and urine. …

Internal Medicine 47(12), 1133-1138, 2008

CrossRef 医中誌 J-STAGE
5

The Etiology of ‘Smoker’s Paradox’ in Acute Myocardial Infarction With Special Emphasis on the Association With Inflammation

Katayama Toshiro , Iwasaki Yoshihiro , Sakoda Naoya , Yoshioka Masato

… The value of high sensitivity C-reactive protein (hs-CRP) on admission and 24 hours after onset, and serum amyloid A protein (SAA) were significantly higher, and acute phase BNP was significantly lower (hs-CRP on admission 1.36 ± 1.03 mg/dL versus 0.75 ± 0.82 mg/dL, P = 0.02, hs-CRP at 24 hours 3.86 ± 4.32 mg/dL versus 2.90 ± 3.46 mg/dL, P = 0.008, SAA; …

International Heart Journal 49(1), 13-24, 2008

CrossRef 医中誌 J-STAGE
6

Recent Advances in Immunopathophysiology of Interleukin-6 : An Innovative Therapeutic Drug, Tocilizumab (Recombinant Humanized Anti-human Interleukin-6 Receptor Antibody), Unveils The Mysterious Etiology of Immune-Mediated Inflammatory Diseases

OHSUGI Yoshiyuki

… From the clinical viewpoint, it is especially important that IL-6 acts on hepatocytes to induce acute-phase reactants, including C-reactive protein, serum amyloid A protein, and fibrinogen, and to decrease serum albumin levels. …

Biological & pharmaceutical bulletin 30(11), 2001-2006, 20071101

CiNii PDF CrossRef 医中誌 J-STAGE 参考文献70件被引用文献2件
7

細菌性肺炎罹患馬の病態を把握するための血清中血清アミロイドAおよび肺サーファクタント・プロテインDの評価(内科学)

帆保誠二 , 丹羽秀和 , 安斉了

細菌性肺炎に罹患した馬の病態を把握するために血清中の血清アミロイドA(SAA)および肺サーファクタント.プロテインD(SP-D)を測定した.供試馬として,正常値を明らかにするために185頭の臨床的に健康なサラブレッドを,またStreptococcus equi subsp. zooepidemicus(S. zooepidemicus)を用いた感染実験のために9頭のサラブレッドをそれぞれ使用した. …

The journal of veterinary medical science 69(8), 827-830, 20070825

CiNii PDF 医中誌参考文献19件被引用文献2件
8

血漿のプロテオミクス解析

苗代康可 , 鈴木知佐子 , 木村成寿 , 山本元久 , 高橋裕樹 , 相馬仁 , 堀司 , 篠村恭久 , 小海康夫 , 今井浩三

プロテオミクスの技術が，近年，非常に発展してきている．プロテオミクス解析は複雑な，多種類のタンパク質混合物のプロファイルを一挙に解析することができる．さらに発現量のみではなく，タンパク質の修飾状態までも検出可能である．とくに，血漿のような，多くのタンパク質を含む，複雑なサンプルの解析に有効であると考えられ，関節リウマチにおける診断，疾患活動性および治療効果判定に有用と思われ …

日本臨床免疫学会会誌 = Japanese journal of clinical immunology 30(3), 145-150, 20070628

CrossRef 医中誌 J-STAGE 参考文献10件
9

Serum Amyloid A is a Better Predictor of Clinical Outcomes than C-Reactive Protein in Non-ST-Segment Elevation Acute Coronary Syndromes

Kosuge Masami , Ebina Toshiaki , Ishikawa Toshiyuki , Hibi Kiyoshi , Tsukahara Kengo , Okuda Jyun , Iwahashi Noriaki , Ozaki Hiroyuki , Yano Hideto , Kusama Ikuyoshi , Nakati Tastuya , Umemura Satoshi , Kimura Kazuo

… Background Elevated C-reactive protein (CRP) is associated with adverse outcomes in non-ST-segment elevation acute coronary syndromes (NSTE-ACS); … however, the prognostic significance of serum amyloid A (SAA), also an important inflammatory marker, remains unclear. …

Circulation journal : official journal of the Japanese Circulation Society 71(2), 186-190, 20070120

CiNii PDF CrossRef 医中誌 J-STAGE 参考文献28件被引用文献2件
10

Amyloid shoulder padsの1例

三笠貴彦 , 濱田一壽 , 松村昇 , 高橋正明 , 山中芳

… To report a case of amyloid shoulder pads in the course of multiple myeloma. … The serum data revealed WBC 6580 /μl, negative CRP, TP6.6 g/dl, BUN32.9 mg/dl, Cr3.3 mg/dl, Ca10.3 mEq/L. … Postoperatively, Bence-Jones protein was positive and he was diagnosed as a multiple myeloma by a bone-marrow biopsy. … The specimens taken from the left shoulder showed amyloid by Congo red staining and the left shoulder was diagnosed as amyloid arthropathy. …

肩関節 31(2), 457-460, 2007

医中誌 J-STAGE
11

The Relationship Between Acute Phase Serum Amyloid A (SAA) Protein Concentrations and Left Ventricular Systolic Function in Acute Myocardial Infarction Patients Treated With Primary Coronary Angioplasty

Katayama Toshiro , Nakashima Hiroshi , Honda Yukiharu , Suzuki Shin , Yamamoto Tadashi , Iwasaki Yoshihiro , Yano Katsusuke

… Background: Our study was planned to investigate the relationship between plasma levels of serum amyloid A protein (SAA) concentrations and the subsequent left ventricular systolic function in patients with acute myocardial infarction (AMI) treated with primary coronary angioplasty. … (II) The SAA concentration was significantly correlated with both highly sensitive C-reactive protein (hs-CRP) and the peak-CK value (hs-CRP: r = 0.69, P < …

International Heart Journal 48(1), 45-55, 2007

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12

Discovery and identification of serum amyloid A protein elevated in lung cancer serum

DAI SW

Sci China 50, 305-311, 2007

被引用文献1件
13

Serum amyloid A protein : a potential biomarker correlated with clinical stage of lung cancer

LIU DH

Biomed Environ Sci 20, 33-40, 2007

被引用文献1件
14

Clarithromycin, amikacin, imipenem/cilastatin による化学療法が有効と考えられた Mycobacterium abscessus 肺感染症の1例

鹿間裕介 , 神尾義人 , 栗生和幸 , 澁谷泰弘 , 木村聡 , 中島宏昭

日本呼吸器学会雑誌 = The journal of the Japanese Respiratory Society 44(11), 800-806, 20061110

医中誌参考文献20件
15

Serum levels of free light chain before and after chemotherapy in primary systemic AL amyloidosis

Matsuda M , Yamada T , Gono T , Shimojima Y , Ishii W , Fushimi T , Sakashita K , Koike K , Ikeda S

… This is an electronic version of an article published in AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS. … 13: 71(2006) [AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS] is available online at: http://www.informaworld.com/openurl?genre=article&issn=1350-6129&volume=13&issue=3&spage=71 …

Amyloid-Journal of Protein Folding Disorders 13(Suppl. 1), 45-45, 2006-11

CrossRef 機関リポジトリ
16

新しいメディエーター, Pentraxin 3 の炎症反応における役割

奥谷大介

1994年，Long Pentraxinとして最初に発見されたPentraxin 3 (PTX3）は免疫や炎症において重要な役割を担っている．Pentraxin類はLong PentraxinとShort Pentraxin (CRP : C反応性蛋白，SAP:血清アミロイドP）に分類されるが，その共通点はC-端末Pentraxinドメインを有することであり，その違いはLo …

日本臨床免疫学会会誌 = Japanese journal of clinical immunology 29(3), 107-113, 20060630

CrossRef 医中誌 J-STAGE 参考文献38件
17

小腸憩室穿孔で発病した続発性消化管アミロイドーシスの1例(症例報告)

坂田直昭 , 和田靖 , 森川孝則 , 有明恭平 , 富永剛

患者は慢性関節リウマチで治療中の72歳の女性で,食思不振のため入院中.上腹部痛が出現し,腹部CTにて,Free air像と著明な腹水がみられ,さらにショック状態を呈した.消化管穿孔による汎発性腹膜炎と診断,開腹手術を施行した.上部空腸に穿孔を認め,空腸部分切除術を施行した.術後,全身状態は徐々に悪化し,第6病日に多臓器不全のため死亡した.血清アミロイドA蛋白(SAA)の著明な上昇と,組織学的に切除 …

日本消化器外科学会雑誌 39(6), 702-707, 20060601

CiNii PDF 医中誌参考文献31件被引用文献3件
18

Serum Amyloid A Protein as a Predictor of Cardiac Rupture in Acute Myocardial Infarction Patients Following Primary Coronary Angioplasty(CLINICAL INVESTIGATION)

Katayama Toshiro , Nakashima Hiroshi , Takagi Chisa , Honda Yukiharu , Suzuki Shin , Iwasaki Yoshihiro , Yamamoto Tadashi , Yoshioka Masato , Yano Katsusuke

… Plasma levels of both high-sensitivity C-reactive protein (hsCRP) and serum amyloid-A protein (SAA) were significantly higher in the CR patients than in the others (hsCRP: 6.7±6.7mg/dl vs 3.3±3.8mg/dl, p=0.007; …

Circulation journal : official journal of the Japanese Circulation Society 70(5), 530-535, 20060420

CiNii PDF CrossRef 医中誌 J-STAGE 参考文献29件
19

PJ-579 Serum Amyloid A is a Better Predictor of Clinical Outcome than C-reactive Protein in Non-ST-segment Elevation Acute Coronary Syndrome(Acute coronary syndrome, basic/clinical-8 (IHD) PJ97,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Kosuge Masami , Kimura Kazuo , Ebina Toshiaki , Hibi Kiyoshi , Tukahara Kengo , Kanna Masahiko , Okuda Jun , Tahara Yoshio , Nozawa Naoki , Ozaki Hiroyuki , Yano Hideto , Kusama Ikuyoshi , Iwahashi Noriaki , Hashiba Katsutaka , Nakaji Tatuya , Umemura Satoshi

Circulation journal : official journal of the Japanese Circulation Society 70(Supplement_I), 633, 20060301

CiNii PDF 医中誌
20

PJ-292 Serum Amyloid A protein as a Predictor of Cardiac Rupture in Acute Myocardial Infarction Patients Following Primary Coronary Angioplasty(Acute coronary syndrome, basic/clinical-6 (IHD) PJ49,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Katayama Toshiro , Iwasaki Yoshihiro , Yamamoto Tadashi , Yoshioka Masato , Nakashima Hiroshi , Honda Yukiharu , Suzuki Shin , Yano Katsusuke

Circulation journal : official journal of the Japanese Circulation Society 70(Supplement_I), 562, 20060301

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