Search Results:　 1-8 of 8

1

Novel Iodocyclization Method Based on the Controlling of Oxidative Aromatization [in Japanese]

OKITSU Takashi

… The utility of our methodology was demonstrated in the synthesis of valdecoxib and its 2,5-dihydro analogs. …

YAKUGAKU ZASSHI 131(9), 1323-1327, 2011

J-STAGE Ichushi Web CrossRef
2

Preparation, Characterization and in Vitro Dissolution Studies of Solid Systems of Valdecoxib with Chitosan

VIJAYA KUMAR Sengodan Gurusamy , MISHRA Dina Nath

… In the present study, the solubilizing and amorphizing properties of Valdecoxib (a poorly water soluble anti inflammatory drug) with low molecular weight chitosan (a polymer), have been investigated. … Enhanced dissolution combined with its direct compression feasibility and anti ulcerogenic action results in low molecular weight chitosan for developing fast release oral solid dosage forms of valdecoxib. …

Chemical & pharmaceutical bulletin 54(8), 1102-1106, 2006-08-01

CiNii Fulltext PDF - Open Access J-STAGE CrossRef References (38)
3

Spray Dried Excipient Base : A Novel Technique for the Formulation of Orally Disintegrating Tablets

MISHRA Dina Nath , BINDAL Madhu , SINGH Shailendra Kumar , VIJAYA KUMAR Sengodan Gurusamy

… The purpose of this study is to assess the suitability of spray dried excipient base in the formulation of ODTs of Valdecoxib (low aqueous solubility) and Metoclopramide (high aqueous solubility). …

Chemical & pharmaceutical bulletin 54(1), 99-102, 2006-01-01

CiNii Fulltext PDF - Open Access J-STAGE CrossRef References (17)
4

Possible mechanisms of cyclooxygenase (COX)-2 hazard : Is COX-2 in the cardiovascular system a friend or a foe? [in Japanese]

SHINMURA Ken

… An increased risk of cardiovascular events has also been reported with valdecoxib in patients with coronary artery bypass grafting and in a recent colon cancer trial of high-dose celecoxib.The reason for the propensity of COX-2 inhibitors to facilitate cardiovascular events remains unclear. …

Ensho Saisei 25(6), 517-524, 2005-11-25

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5

Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery

NUSSMEIER NA

N Engl J Med 352(11), 1081-1091, 2005

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6

Quantitation of Valdecoxib in human plasma by high-performance liquid chromatography with ultraviolet absorbance detection using liquid-liquid extraction

RAMAKRISHNA N. V. S. , VISHWOTTAM K. N. , WISHU S. , KOTESHWARA M.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 802(2), 271-275, 2004-04-05

References (9)
7

Determination of valdecoxib and its metabolites in human urine by automated solid-phase extraction-liquid chromatography-tandem mass spectrometry

ZHANG Ji Y. , FAST Douglas M. , BREAU Alan P.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 785(1), 123-134, 2003-02-25

References (21)
8

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ORMROD D.

Valdecoxib, Drugs 62, 2059-2071, 2002

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