Search Results:　 1-20 of 26

1

Effect of Acute Hepatic Failure on Epirubicin Pharmacokinetics after Intrahepatic Arterial Injection in Rats(Biopharmacy)

NAGATA Masashi , MATSUO Yasuko , HIDAKA Muneaki , KAWANO Yohei , OKUMURA Manabu , TOKUNAGA Jin , TAKAMURA Norito , ARIMORI Kazuhiko

… The anthracyclines are eliminated primarily by the liver, and the use of these drugs in patients with hepatic failure can be difficult. … In this study, we investigated the effect of acute hepatic failure on the pharmacokinetics of epirubicin after i.a. … Experimental acute hepatic failure was induced by carbon tetrachloride-treatment. …

Biological & pharmaceutical bulletin 31(3), 493-496, 2008-03-01

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2

Pharmacokinetic Behavior of Micafungin in Rats with Carbon Tetrachloride-Induced Acute Hepatic Failure(Biopharmacy)

KONISHI Hiroki , SUDO Masatomo , SUMI Masaki , MORII Hiroaki , MINOUCHI Tokuzo , AIMOTO Tachio , YAMAJI Akira

We examined the pharmacokinetic behavior of micafungin, a novel antifungal agent, in rats receiving carbon tetrachloride (CCl_4) at a single dose of 2.5ml/kg. There was no significant change in the to …

Biological & pharmaceutical bulletin 28(3), 556-559, 2005-03-01

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3

Effect of Experimental Acute Renal and Hepatic Failure on Absorption of Tacrolimus in Rat Small Intestine

TAMURA Shigeki , OHIKE Atsuo , TOKUNAGA Yuji , IBUKI Rinta , AMIDON Gordon. L. , SEZAKI Hitoshi , YAMASHITA Shinji

Drug metabolism and pharmacokinetics 19(3), 190-197, 2004-06-30

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4

Effect of Experimental Renal Failure on the Pharmacokinetics of Losartan in Rats

YOSHITANI Takashi , YAGI Hitoshi , INOTSUME Nobuo , YASUHARA Masato

… The purpose of this investigation was to determine whether the pharmacokinetics of the angiotensin II receptor antagonist losartan is altered in renal failure. … Male Wistar rats were pretreated with uranyl nitrate or subjected to bilateral ureteral ligation to produce acute renal failure (ARF). … In order to investigate the mechanisms of reduced clearance of losartan associated with ARF, a hepatic microsome fraction was prepared from normal and ARF rats. …

Biological & pharmaceutical bulletin 25(8), 1077-1083, 2002-08-01

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5

Evaluation of Effectiveness of Glucocorticoid Treatment using a Rat Acute Hepatic Failure Model [in Japanese]

SATO Akihiro , TAKIKAWA Yasuhiro , SATO Shinichiro , SUZUKI Kazuyuki

急性肝不全モデルに対する糖質コルチコイド治療の有効性, 機序, 臨床応用の可能性について検討した. Wistar系雄性ラットにD-galactosamine 200mg/kg, lipopolysaccharide 10μg/kgを経門脈的に投与し肝不全モデルを作成し, 治療薬としてmethylprednisolone (20mg/kg) を投与した. 未治療群ではtumor necrosis f …

Kanzo 40(4), 217-226, 1999-04-25

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6

Pharmacokinetics of Cyclosporin A after Intravenous Administration to Rats in Various Disease States

SHIBATA Nobuhito , SHIMAKAWA Harumi , MINOUCHI Tokuzo , YAMAJI Akira

… The CL_t was reduced in anemic (ANE) rats prepared by venesection, in carbon tetrachloride-induced acute hepatic failure (AHF) rats, and in glycerol-induced acute renal failure (ARF) rats. …

Biological & pharmaceutical bulletin 16(11), 1130-1135, 1993-11-15

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7

Determimation of digitalis-like substances in sera of patients with acute hepatic failure and its clinical significance : with special reference to middle molecular substances

TOMODA Takashi , SUGIHARA Jun-ichi , MORIWAKI Hisataka , MUTO Yasutoshi

急性肝不全(AHF)患者血清中では,細胞膜Na+, K+-ATPase活性を阻害し,ジゴキシン抗体と交差反応を示す内因性ジギタリス様物質(DLS)が,急性肝炎や急性肝炎重症型に比し有意に増加し,肝障害の重症度と併行した.またAHF患者の血清DLS濃度は,死亡例では生存例に比し,さらに脳浮腫合併例は非合併例に …

Kanzo 34(1), 8-17, 1993

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8

Endogenous benzodiazepine receptor ligands in human and animal hepatic encephalopathy

SETOGUCHI Yoichi , OZAKI Iwata , YAMAMOTO Kyosuke , MIZUTA Toshihiko , KAJIHARA Susumu , HARA Toshiya , WADA Ikuko , FUKUSHIMA Noriko , SAKAI Takahiro

急性肝不全および肝硬変による肝性脳症患者,チオアセトアミド肝不全ラットおよびコントロールの血漿ベンゾジアゼピン濃度をレセプターアッセイ法と酵素抗体法にて測定し,両測定法での相関はY=-0.22+0.73X, r=0.95と高かった.酵素抗体法での血漿ベンゾジアゼピン濃度の平均値は,肝性脳症のヒトおよびラットとコントロール間に有意差はなかったが,急性肝不全患者11名中5名および肝不全ラット7匹中4匹 …

Kanzo 34(4), 321-327, 1993

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9

Pharmacokinetics of [6]-Gingerol after Intravenous Administration in Rats with Acute Renal or Hepatic Failure

NAORA Kohji , DING Guohua , HAYASHIBARA Masakazu , KATAGIRI Yoshihiro , KANO Yoshihiro , IWAMOTO Kikuo

… The pharmacokinetics of [6]-gingerol were investigated in rats with acute renal failure induced by bilateral nephrectomy, or those with acute hepatic faliure induced by a single oral administration of carbon tetrachloride (CCl_4), to clarify the contribution of the kidney and liver to the elimination process of [6]-gingerol. … In contrast, hepatic intoxication with CCl_4 elevated the plasma concentration of [6]-gingerol at the terminal phase. …

Chemical & pharmaceutical bulletin 40(5), 1295-1298, 1992-05-25

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10

Studies on the Metabolic Fate of Gomisin A (TJN-101). II. Absorption and Excretion in CCl_4 Treated Rats [in Japanese]

MATSUZAKI Yutaka , MATSUZAKI Tamae , ONO Hiromasa , KOGUCHI Sachiko , TAKEDA Shuichi , TAKEDA Shigefumi , FUNO Shuji , ABURADA Masaki , HOSOYA Eikichi , OYAMA Tsutomu

… It was speculated that these results were originated from suppression of the enzyme activity in the oxidative drug metabolism following the decrease of cytochrome P-450 induced by treatment with CCl_4 and depression of re-absorption ratio in entero-hepatic circulation by hepatic failure. …

Journal of the Pharmaceutical Society of Japan 111(9), 531-537, 1991-09-25

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11

A possible role of circulating Na+, K+-pump inhibitors in the pathogenesis of multi-organ failure in acute hepatic failure

MATSUBARA Yukiko , SUGIHARA Jun-ichi , SAITO Koshiro , MORIWAKI Hisataka , MUTO Yasutoshi

急性肝不全(AHF)に合併する多臓器不全(MOF)発生機序の一つとして細胞膜Na+, K+-pump障害に着目し,AHF時に血中で増加する物質がラット脳,腎およびヒト末梢血白血球のNa+, K+-pump活性に及ぼす …

Kanzo 32(1), 34-42, 1991

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12

Impaired liver regeneration and EGF receptor in experimentaly induced "acute on chronic" type liver failure

SHIRASAWA Hiroyuki

… ラットCCl4肝線維症モデル作成後,D-Galactosamine(D-Gal)を投与し,ラットAcute on chronic (AOC)モデルを作成した.このモデルで血液生化学的,組織学的検討ならびにlabelling index(LI),肝ミクロゾーム分画EGF receptor,肝組織中EGF濃度を測定し,ラットD-Gal急性肝障害モデル(コントロール)と比較検討した.AOCではコントロールに比し速やかにGPTが上昇した.組織学的にはAOCでD-Gal投与48時間後に偽胆管形成が増加し,72時間後には残 …

Kanzo 31(10), 1152-1158, 1990

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13

Biochemical analysis of accelerated liver regeneration with epidermal growth factor in rat with acute liver injury

MURAKAMI Fujio

CCl4によるラット急性肝障害モデルを用いて,Epidermal Growth Factor (EGF)の肝再生促進効果を経時的に検討した.障害作製後第1日目のEGF receptor数は,正常ラットの約25%にまで減少していた.同時に肝組織中内因性EGF濃度も著明に減少していた.しかし門脈内に外因性にhuman EGF (hEGF)を10μg/kg投 …

Kanzo 31(8), 921-927, 1990

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14

急性肝不全時の窒素代謝に関する基礎的研究―クアニジノ酢酸および腎グリシンアミヂノトランスフェラーゼ活性の変動― [in Japanese]

株丹浩二

… It was reported that serum guanidinoacetic acid (GAA) levels are elevated in acute hapatic failure. … To explore the mechanism of this GAA level change, the activities of kidney glycine amidinotransferase (GAT) and liver GAA-methyltransferase (GAA-MT) were measured in experimental rat models of acute hepatic failure. …

岡山医学会雑誌 101(3-4), 363-369, 1989-04

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15

Clinical significance of serum γ-glutamyl transpeptidase in patients with acute hepatic failure

KANO Takashi , TAKAHASHI Takeshi , SUGIHARA Junichi , SEISHIMA Mitsuru , TOMITA Eiichi , KIMURA Ken , MUTO Yasutoshi

急性肝不全(AHF)における血清γ-glutamyl transpeptidase (GGT)の臨床的意義を検討した.劇症肝炎(FH)及び亜急性肝炎の入院時における血清GGTは急性肝炎に比し有意な低値を示した(ともにp<0.001).血清GGTの予後別にみた経時的変動からは,FH生存例では病状の改善に並行して著増が認められたのに対し,死亡例では低値を持続させた.なお,生存例の半数は入院早期に …

Kanzo 30(10), 1499-1507, 1989

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16

Decreased Diuretic Response to Furosemide in Rats with Acute Hepatic Failure

HUANG Ye , KAMIYA Akira , HAYASHI Yoshie , INUI Kenichi , HORI Ryohei

… To define this phenomenon, the amounts of water, electrolytes, and furosemide excreted in urine were measured in control and CCl_4-induced acute hepatic failure (AHF) rats. …

Journal of pharmacobio-dynamics 11(8), 583-589, 1988-08

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17

Appearance of middle molecular substances in serum associated with increased permeability of blood-brain barrier in experimental models of acute hepatic failure

SUGIHARA Jun-ichi , SAITO Koshiro , TOMITA Eiichi , MUTO Yasutoshi

… 用を有することを報告してきた.本報ではAHFモデルを作成し,MMSの動態と血液脳関門(BBB)の透過性を検討した.AHFモデル血清中には,臨床例と同様にHPLC上,脳症の進行とともにMMS(分子量約4,000以下)が著増した.MMSはhepatic devascularization後に増加し,血漿メチオニンや芳香族アミノ酸と正の相関を示すことから,広範な肝細胞壊死と並行して増加すると考えられた.さらにAHFモデルでは脳内水分含量の増加とともに,inulin(分子量約5,200) …

Kanzo 29(10), 1346-1356, 1988

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18

Determination of middle molecular substances in sera and cerebro-spinal fluids of patients with acute hepatic failure : with special reference to the development of brain edema

SUGIHARA Jun-ichi , SAITO Koshiro , TOMITA Eiichi , MUTO Yasutoshi

急性肝不全患者血清中には,in vitroにおいてラット脳ミクロゾーム分画のNa+, K+ATPase活性を阻害する因子が存在し,その分子サイズはゲルクロマトグラフィー上,約2,000〜4,600(中分子量物質)と推定された.さらに高速液体クロマトグラフィーにて,急性肝不全患者の血清および脳脊髄液中には中分 …

Kanzo 29(9), 1181-1193, 1988

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19

STUDY ON TOXICITY OF SF-1008C (I) : ACUTE TOXICITY STUDY IN MICE AND RATS [in Japanese]

NINOMIYA Shin-ichiro , HASHIMOTO Kazuya , TANAKA Nobuyuki

SF-1008C及びその配合成分であるペプチド並びに米油の急性毒性試験をマウス及びラットを用いて経口投与にて実施した。得られた結果を以下に示す。1. 致死量: SF-1008Cの最小致死量はマウス雌雄及びラット雌雄とも 40g/kg以上であった。ペプチドの最小致死量はマウス雌雄及びラット雌雄とも 6 g/kg以上であった。米油の最小致死量はマウス雌雄及びラット雌雄とも 20 ml/kg以上であった …

Journal of toxicological sciences 11(Supplement II), 107-119, 1986-05-01

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20

INFLUENCE OF ACUTE RENAL FAILURE ON PHARMACOKINETICS OF PHENOLSULFONPHTHALEIN IN RATS : A COMPARATIVE STUDY IN VIVO AND IN THE SIMULTANEOUS PERFUSION SYSTEM OF LIVER AND KIDNEY

YASUHARA MASATO , KATAYAMA HIROKAZU , FUJIWARA JUNKO , OKUMURA KATSUHIKO , HORI RYOHEI

… The effect of acute renal failure (ARF) on the disposition of phenolsulfonphthalein (PSP) after intravenous administration was investigated in rats. … In order to clarify the regulatory mechanisms of PSP excretion between liver and kidney in ARF, we developed a simultaneous perfusion system of rat liver and kidney, which could control the flow rate and the constituent of the perfusate. …

Journal of pharmacobio-dynamics 8(5), 377-384, 1985-05

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