Doi Masao
,
Takahashi Yukari
,
Komatsu Rie
,
Yamazaki Fumiyoshi
,
Yamada Hiroyuki
,
Haraguchi Shogo
,
Emoto Noriaki
,
Okuno Yasushi
,
Tsujimoto Gozoh
,
Kanematsu Akihiro
,
Ogawa Osamu
,
Todo Takeshi
,
Tsutsui Kazuyoshi
,
van der Horst Gijsbertus T J
,
Okamura Hitoshi
,
岡村 均
,
土居 雅夫
… We show that mice lacking the core clock components Cryptochrome-1 (Cry1) and Cryptochrome-2 (Cry2) (Cry-null mice) show salt-sensitive hypertension due to abnormally high synthesis of the mineralocorticoid aldosterone by the adrenal gland. … Hsd3b6 is expressed exclusively in aldosterone-producing cells and is under transcriptional control of the circadian clock. …
Nature medicine 16(1), 67-74, 2010-01
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