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倉林 譲

… of thebody of the skin for this case.It is necessary to use and the analgesic regardless of strength..experiment..Invading when the animal experiment treatment is given because there is a narcotic to which the action of relieving pain is weak,too,even if general anesthesia is given.The kind of the analgesic canrecommend non-steroid analgesic from an insignifficant thing of the certainty and the side effect in theeffect,and is technology in the animal experiment where the …

岡山実験動物研究会報 28, 44-49, 2012-04-00

IR Ichushi Web

LEAN Lyn Li , HEGARTY Dominic , HARMON Dominic

Journal of anesthesia 26(1), 128-129, 2012-02-20

References (5)

Moriyama Ayako , Nishizawa Daisuke , Kasai Shinya , Hasegawa Junko , Fukuda Ken-ichi , Nagashima Makoto , Katoh Ryoji , Ikeda Kazutaka

… Individual differences in the sensitivity to fentanyl, a widely used opioid analgesic, can hamper effective pain treatment. … gene on individual differences in pain and analgesic sensitivity. … The analgesic effect was significantly less in females who carried the G-allele of the G1165C SNP than the females who did not carry the G-allele. …

Journal of Pharmacological Sciences, 2012

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Suzuki Nao , Yoshida Ayako , Nakagawa Yuko , Hatano Miho , Yokomichi Noriyuki , Hosonuma Shinji , Yoshioka Norihito , Ohara Tatsuru , Tozawa Akiko , Kiguchi Kazushige

がん疼痛に対するオピオイド鎮痛薬の開始薬として用いられるオキシコドン徐放性製剤は, その副作用である眠気や便秘が特に婦人科がん患者にとって生活の質を低下させる要因となりうる. 一方, フェンタニル貼付薬は鎮痛効力が強く, 副作用が少ないプロファイルを有しているものの, 用法・用量が「オピオイド鎮痛薬から切り替えて使用する」ことになっている. オキシコドン徐放性製剤の副作用発現例からフェンタニル貼付 …

Palliative Care Research 7(2), 363-367, 2012

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Ishii Yuji , Iida Naoko , Miyauchi Yuu , Mackenzie Peter I. , Yamada Hideyuki

… This opiate is mainly metabolized by glucuronidation to a non-analgesic metabolite, morphine-3-glucuronide (M-3-G) and an active metabolite morphine-6-glucuronide (M-6-G). … To understand the modulation of morphine glucuronidation activity by environmental factors, the effect of endogenous and food-derived compounds on morphine uridine 5′-diphosphate (UDP)-glucuronosyltransferase (UGT) in rat and human microsomes was evaluated examining the 50% inhibitory concentration (IC50). …

Biological and Pharmaceutical Bulletin 35(10), 1811-1817, 2012

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Liang Yingxia , Jiang Weijian , Zhang Zhiyu , Yu Jianfeng , Tao Liang , Zhao Shujin

… In our laboratory, we observed that najanalgesin, a novel peptide isolated from the venom of Naja naja atra, exerts significant analgesic effects on acute pain in mice and neuropathic pain in rats. … The objective of the present study was to determine whether spinal glia are associated with the antinociceptive effect of najanalgesin in an L5 spinal nerve ligation (SNL) rodent model of neuropathic pain. …

Biological and Pharmaceutical Bulletin 35(6), 850-854, 2012

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Mohamed Eissa Amal Abdel Haleem , Soliman Gamal Abd El-Hakeem , Khataibeh Moayad Hussein

… Simple, three classes of new anthranilic acid derivatives were aimed at, synthesized and tested for their toxicity, anti-inflammatory, analgesic, antipyretic activity. … Furthermore, their effect on liver and kidney functions was detected through measurement of the serum level of alanine transaminase (ALT), aspartate aminotransferase (AST), urea, creatinine and other parameters. …

Chemical and Pharmaceutical Bulletin 60(10), 1290-1300, 2012

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KAWAI Sumiko , TAKAGI Yasuhiro , KANEKO Shiro , KUROSAWA Tsutomu

… Ketamine is usually used for murine anesthesia in animal experiments with other anesthetics for its sedation and analgesic effects. … After this act came into effect, a narcotic handling license became necessary for using and possessing ketamine. …

Experimental Animals 60(5), 481-487, 2011-10-01

J-STAGE Ichushi Web CrossRef References (26)

NIKI Yuriko , KANAI Akifumi , OKAMOTO Hirotsugu

三叉神経痛は三叉神経第2，3枝に好発し，飲食や会話を困難にする．口腔粘膜領域の三叉神経痛を有する患者12人に8%リドカインスプレー（キシロカインポンプスプレー®：LPS）を処方し，粘膜の痛み部位への塗布を指示した．1回使用量は最大24 mg，使用間隔を4時間以上空けて，痛み出現時に使用可能とし，痛みを視覚アナログスケール（VAS）で評価した．LPSは痛みをVASで塗布直前58 ± 17 …

Journal of Japan Society of Pain Clinicians 18(4), 388-391, 2011-09-25

J-STAGE Ichushi Web References (8)