検索結果:　 804件中 1-20 を表示

1

DHEA Administration Activates Local Bioactive Androgen Metabolism in Cancellous Site of Tibia of Ovariectomized Rats

Park Jong-Hoon , Aizawa Katsuji , Iemitsu Motoyuki , Sato Koji , Akimoto Takayuki , Agata Umon , Maeda Seiji , Ezawa Ikuko , Omi Naomi , 前田清司 , 麻見直美

… It is not known whether local androgen metabolism is involved in the mechanisms underlying the dehydroepiandrosterone (DHEA) administration-induced improvement of bone mineral density (BMD) in an estrogen-deficiency state. … The aim of the present study was to clarify whether DHEA administration would improve local androgen metabolism and BMD in cancellous site of tibia of ovariectomized (OVX) rats. …

Calcified tissue international 89(2), 105-110, 2011-08

機関リポジトリ CrossRef
2

Apoptotic effect of tolfenamic acid in androgen receptor-independent prostate cancer cell and xenograft tumor through specificity protein 1

CHOI Eun-Sun , SHIM Jung-Hyun , JUNG Ji-Youn , KIM Hyeong-Jin , CHOI Kyeong-Hee , SHIN Ji-Ae , NAM Jeong-Seok , CHO Nam-Pyo , CHO Sung-Dae

Cancer science 102(4), 742-748, 2011-04-10

医中誌参考文献24件
3

Comparison of the mRNA expression rates of the androgen receptor, estrogen receptor β, and bone morphogenic protein 2b in dorsal, anal, pectoral, and caudal fins between normal males and females in Japanese and Thai medaka (Teleostei) and in sex-undeterminable individuals in Thai medaka

Ngamniyom Arin

年報金沢大学環日本海域環境研究センター 21(2009), 108, 2011-03-31

機関リポジトリ
4

Testosterone induces activation of porcine primordial follicles in vitro

MAGAMAGE Manjula P. S. , ZENGYO Mai , MONIRUZZAMAN Mohammad , MIYANO Takashi

Reproductive medicine and biology 10(1), 21-30, 2011-03-01

医中誌参考文献47件
5

Epigenetic setting for long-term expression of estrogen receptor α and androgen receptor in cells.

Imamura Takuya

… Epigenetic regulation of the nuclear estrogen and androgen receptors, ER and AR, constitutes the molecular basis for the long-lasting effects of sex steroids on gene expression in cells. … The effects prevail at hundreds of gene loci in the proximity of estrogen- and androgen-responsive elements and many more such loci through intra- and even inter-chromosomal level regulation. … The factors affecting the DNA methylation of the ERα and AR genes in cells include estrogen and androgen. …

Hormones and behavior 59(3), 345-352, 2011-03

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6

Sex and circadian modulatory effects on rat liver as assessed by transcriptome analyses

HIRAO Jun , NISHIMURA Masatoshi , ARAKAWA Shingo , NIINO Noriyo , MORI Kazuhiko , FURUKAWA Tadashi , SANBUISSHO Atsushi , MANABE Sunao , NISHIHARA Masugi , MORI Yuji

… The identified sexually dimorphic genes were over-represented in the metabolism of retinols, xenobiotics, linoleic acids, or androgen and estrogen, or bile acid biosynthesis. … The circadian-regulated genes included clock or clock-controlled genes such as aryl hydrocarbon receptor nuclear translocator-like (Arntl), period homolog 2 (Per2), and D site albumin promoter binding protein (Dbp). …

Journal of toxicological sciences 36(1), 9-22, 2011-02-01

J-STAGE 医中誌 CrossRef 参考文献58件
7

Immunolocalization of androgen receptor, aromatase cytochrome P450, estrogen receptor alpha and estrogen receptor beta proteins during the breeding season in scent glands of muskrats (Ondatra zibethicus)

Lu Lu , Zhang Haolin , Lv Na [他]

Zoological science 28(10), 727-732, 2011-10
8

骨組織・骨代謝と核内性ホルモン受容体の機能 (特集骨粗鬆症--骨粗鬆症研究の進歩) -- (骨粗鬆症の成因と骨代謝研究の進歩)

今井祐記 , 加藤茂明

日本臨床 69(7), 1198-1202, 2011-07

医中誌
9

内分泌療法の新展開アンドロゲン合成阻害剤と新規アンドロゲン受容体拮抗剤 (前立腺癌(第2版)--基礎・臨床研究のアップデート) -- (臨床前立腺癌の治療)

西山勉

日本臨床 69(-) (1001), 511-515, 2011-06

医中誌
10

アンドロゲン受容体共役因子の異常 (前立腺癌(第2版)--基礎・臨床研究のアップデート) -- (前立腺癌のアンドロゲン非依存性進展)

塩田真己 , 横溝晃 , 藤本直浩 [他]

日本臨床 69(-) (1001), 108-111, 2011-06

医中誌
11

アンドロゲン受容体異常 (前立腺癌(第2版)--基礎・臨床研究のアップデート) -- (前立腺癌のアンドロゲン非依存性進展)

溝上敦 , 並木幹夫

日本臨床 69(-) (1001), 104-107, 2011-06

医中誌
12

アンドロゲン受容体の標的ネットワークの同定--ゲノム医学的手法による系統的なアンドロゲン受容体下流因子の同定 (第1土曜特集エネルギー代謝転写因子ネットワークと生活習慣病) -- (転写因子ネットワークシステムの新しい俯瞰)

高山賢一 , 井上聡

医学のあゆみ 237(6), 646-652, 2011-05-07
13

Androgen Receptor Antagonists and Anti-prostate Cancer Activities of Some Synthesized Steroidal Candidates

Bahashwan Saleh Abd El-Rahman , Al-Omar Mohamed Abd El-Rahman , Ezzeldin Essam , Abdalla Mohamed Mostafa , Fayed Ahmed Abd El-Hameed , Amr Abdel-Galil El-Sayed

… In continuation of our previous work, a novel series of steroid derivatives were synthesized and their androgen receptor (AR) antagonist activities and in vivo antiandrogenic properties were evaluated. …

CHEMICAL & PHARMACEUTICAL BULLETIN 59(11), 1363-1368, 2011

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14

Dihydrotestosterone Inhibits Interleukin-1α or Tumor Necrosis Factor α-Induced Proinflammatory Cytokine Production via Androgen Receptor-Dependent Inhibition of Nuclear Factor-κB Activation in Rheumatoid Fibroblast-Like Synovial Cell Line

Xu Jian , Itoh Yuka , Hayashi Hidetoshi , Takii Takemasa , Miyazawa Keiji , Onozaki Kikuo

… We found that a potent androgen, 5α-dihydrotestosterone (DHT) inhibits IL-1α-induced production and mRNA expression of IL-8, IL-6 and IL-1β from RA patient-derived fibroblast-like synovial cell line MH7A. … Promoter analysis of the IL-8 gene revealed that nuclear factor (NF)-κB activation is critical for its transcriptional activation by IL-1α, and DHT inhibited the IL-1α-induced NF-κB activation in a manner dependent on the androgen receptor (AR). …

Biological & Pharmaceutical Bulletin 34(11), 1724-1730, 2011

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15

Maternal Exposure to Low Doses of DES altered mRNA Expression of Hepatic Microsomal Enzymes in Male Rat Offspring

NISHIKAWA Osamu , ARISHIMA Kazuyoshi , KOBAYASHI Tetsuo , SHIRAI Mitsuyuki , MURAKAMI Masaru , SAKAUE Motoharu , YAMAMOTO Masako

… Our previous studies demonstrated that prenatal diethylstilbestrol (DES) treatment disrupts steroidogenesis but induces high-level expression of androgen receptor (AR) mRNA to inhibit the disruption of spermatogenesis. …

Journal of Veterinary Medical Science advpub(0), 1109270637, 2011

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16

Physalins A and B Inhibit Androgen-Independent Prostate Cancer Cell Growth through Activation of Cell Apoptosis and Downregulation of Androgen Receptor Expression

Han Huiying , Qiu Li , Wang Xianghong , Qiu Feng , Wong Yongchuan , Yao Xinsheng

… Androgen deprivation therapy is a common treatment strategy for advanced prostate cancer. … Though effective initially, the tumor often progresses to androgen independent stage in most patients eventually after a period of remission. … One of the key factors of development of resistance is reflected in expression of androgen receptor (AR). …

Biological & Pharmaceutical Bulletin 34(10), 1584-1588, 2011

J-STAGE CrossRef
17

化学物質の毒性発現における種差・性差の解析：シトクロムP450 1A サブファミリー分子種（CYP1As）の発現変動における相違を指標として

関本征史

… We found that: 1) newly established reporter cell lines, HepG2-A10 and KanR2-XL8, can be used for determining of activation of the aryl hydrocarbon receptor (AhR), a key transcription factor in the expression of CYP1As; … 3) androgen suppressed the constitutive expression or heterocyclic aromatic amine (Trp-P-1)-dependent induction of these enzymes in pigs and mice; …

YAKUGAKU ZASSHI 131(3), 415-422, 2011

J-STAGE 医中誌 CrossRef
18

SM-368229, a Novel Selective and Potent Non-steroidal Mineralocorticoid Receptor Antagonist With Strong Urinary Na+ Excretion Activity

Nariai Tetsuro , Fujita Katsuya , Mori Masaya , Katayama Seiji , Hori Seiji , Matsui Kazuki

… Mineralocorticoid receptor (MR) antagonists, such as spironolactone (SPI) and eplerenone (EPL), are useful for the treatment of hypertension and heart failure. … The selectivity of SM-368229 for MR was 18-fold higher than that for other steroid receptors, such as androgen, progesterone, and glucocorticoid receptors. …

Journal of Pharmacological Sciences 115(3), 346-353, 2011

J-STAGE CrossRef
19

(17α,20E)-17,20-[(1-Methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic Acid Methyl Ester (YK11) Is a Partial Agonist of the Androgen Receptor

Kanno Yuichiro , Hikosaka Ritsuko , Zhang Shu-Yun , Inoue Yoshimi , Nakahama Takayuki , Kato Keisuke , Yamaguchi Akemi , Tominaga Nobuaki , Kohra Shinya , Arizono Koji , Inouye Yoshio

… A novel steroid compound, (17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11), was found to be a partial agonist of the androgen receptor (AR) in an androgen responsive element (ARE)-luciferase reporter assay. … The effect of YK11 on gene expression relative to that of androgen agonist varies depending on the gene context. …

Biological & Pharmaceutical Bulletin 34(3), 318-323, 2011

J-STAGE CrossRef
20

P-039 マウスの味覚嫌悪学習の消去記憶関連脳部位でのアンドロゲン受容体遺伝子の発現(ポスターセッション,2010年度日本味と匂学会第44回大会)

川邊ともこ , 鈴木惠雅 , 藤原宏子 , 齋藤理佳 , 佐藤亮平 , 宮本武典

日本味と匂学会誌 17(3), 277-280, 2010-12

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