Search Results:　 1-19 of 19

  • 1

    Fullerenes as a New Lead Compound for Anti-cancer Agent  [in Japanese]

    増野 匡彦

    Bio industry 29(3), 27-32, 2012-03-00

  • 2

    Synthesis and Biological Evaluation of the 12,12-Dimethyl Derivative of Aplog-1, an Anti-Proliferative Analog of Tumor-Promoting Aplysiatoxin

    NAKAGAWA Yu , KIKUMORI Masayuki , YANAGITA Ryo C. , MURAKAMI Akira , TOKUDA Harukuni , NAGAI Hiroshi , IRIE Kazuhiro

    … While the structural features relevant to the biological activities of Aplog-1 remain to be identified, recent studies by us have suggested that local hydrophobicity around the spiroketal moiety of Aplog-1 is a crucial determinant of its anti-proliferative activity. … As expected, 3 was more effective than Aplog-1 in inhibiting cancer cell growth and binding to protein kinase Cδ, a putative receptor responsible for the biological response of Aplog-1. …

    Bioscience, Biotechnology, and Biochemistry 75(6), 1167-1173, 2011-06-23

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  • 3

    Novel Natural Products Open the Door of Chemical Biology and Medicinal Chemistry  [in Japanese]

    KAKEYA Hideaki , NISHIMURA Shinichi

    … Exploitation of novel small molecules from natural sources such as microbial metabolites, medicinal plants, and marine invertebrates has contributed to the discovery of lead molecules for drugs as well as research tools on chemical biology. …

    Journal of Synthetic Organic Chemistry, Japan 68(5), 490-500, 2010-05-01

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  • 4

    Prenylation of aromatic compounds, a key diversification of plant secondary metabolites

    Yazaki Kazufumi , Sasaki Kanako , Tsurumaru Yusuke

    … Many prenylated flavonoids have been identified as active components in medicinal plants with biological activities, such as anti-cancer, anti-androgen, anti-leishmania, and anti-nitric oxide production. … Due to their beneficial effects on human health, prenylated flavonoids are of particular interest as lead compounds for producing drugs and functional foods. …

    Phytochemistry 70(15-16), 1739-1745, 2009-10-00

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  • 5

    Development of vector-projected 187-ch ECG and clinical application  [in Japanese]

    NAKAI Kenji

    … DREAM-ECG can analyze 12-leads ECG, ventricular late potential (LP) by signal-averaged X,Y,Z-leads ECG, and synthesized 187-ch body surface ECGs using the Mason-Likar lead system. … Furthermore, a functional map of RTc (corrected recovery time) dispersion as a repolarization might evaluate a risk stratification of drug-induced QT prolongation and myocardial injury by anti-cancer drugs. …

    Dental journal of Iwate Medical University 33(3), 99-108, 2008-12-19

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  • 6

    How to Cope with DNA Damage Induced by Ionizing Radiation and Anti-Cancer Drugs?(WHAT IS LIFE? THE NEXT 100 YEARS OF YUKAWA'S DREAM)

    ENOMOTO Atsushi , MIYAGAWA Kiyoshi

    … The inability to respond properly to or to repair DSBs may lead to hypersensitivity to DNA damaging agents and genomic instability including chromosomal aberrations. … Chromosomal instability, a state of continuous accumulation of chromosomal change, is a common feature of many human cancers and of chromosome instability syndromes with increased cancer susceptibility. …

    Progress of theoretical physics. Supplement (173), 109-123, 2008-08-08

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  • 7

    Molecular Design of Hypoxia-Targeting Chemotherapy agent  [in Japanese]

    NAGASAWA Hideko

    近年、腫瘍の微小環境が、癌の治療成果のみならず、癌細胞の増殖・分化、転移などを制御する重要な要因と考えられている。中でも低酸素微小環境(ハイポキシア)は癌の基本的な環境であり、これまで放射線や化学療法に対して抵抗性を示し、完治を妨げる要因として問題視されてきた。低酸素誘導因子(HIF-1α)の発見に端を発し、ハイポキシアの分子機構に関する研究が急速に進展し、細胞の低酸素ストレス応答に関わる様々な分 …

    The annual proceedings of Gifu College of Pharmacy 56, 23-31, 2007-06-30

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  • 8

    An Up-to-Date Anti-Cancer Treatment Strategy Focusing on HIF-1α Suppression : Its Application for Refractory Ovarian Cancer

    Fujita Mariko , Yasuda Masanori , Kitatani Kanae , Miyazawa Masaki , Hirabayashi Kenichi , Takekoshi Susumu , Iida Tetsuji , Hirasawa Takeshi , Murakami Masaru , Mikami Mikio , Ishiwata Isamu , Shimizu Michio , Osamura Yoshiyuki R.

    … It is supposed that HIF-1α is also an extremely important factor in cancer treatment. … Based on the results of our recent analyses using ovarian tumors, which indicated the close association of HIF-1α expression with the acquisition of malignancy and the characterization of histology, we further investigated the possibility of a new strategy of cancer therapy that targeted HIF-1α inhibition in the ovarian carcinoma. …

    Acta histochemica et cytochemica 40(1-6), 139-142, 2007-00-00

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  • 9

    Design of Hypoxia-Targeting Drugs as New Cancer Chemotherapeutics

    NAGASAWA Hideko , UTO Yoshihiro , KIRK Kenneth Lee , MORI Hitoshi

    … The tumor microenvironment is now recognized as a major factor that influences not only the response to conventional anti-cancer therapies but also helps define the potential for malignant progression and metastasis. … This in turn has led to the current extensive interest in the signal molecules related to tumor hypoxia as potential molecular targets for cancer therapeutics. …

    Biological & pharmaceutical bulletin 29(12), 2335-2342, 2006-12-01

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  • 10

    Molecular Mechanisms of Anti-cancer Therapies(<SPECIAL ISSUE>Pathology and Treatment of Malignant Brain Tumors)  [in Japanese]

    Saya Hideyuki

    ゲノムの不安定性は悪性腫瘍の主たる特徴であり,細胞周期チェックポイントの異常はそれを誘導するきわめて重要な要因である.現在広く使用されている抗腫瘍薬として,DNA傷害性薬剤,微小管作動性薬剤があるが,これらの薬剤は腫瘍細胞のチェックポイントの異常を利用して選択的に癌に細胞死を引き起こすことが明らかにされてきた.タイムラブス顕微鏡とRNA干渉法を用いた解析により,これらの薬剤によって癌細胞に誘導され …

    Japanese journal of neurosurgery 15(10), 688-693, 2006-10-20

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  • 11

    7. GENOME ANALYSIS AND CANCER THERAPY  [in Japanese]

    Tahara Hideaki

    Journal of Japan Surgical Society 106(11), 706-709, 2005-11-01

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  • 12

    Luotonin A: A Lead toward Anti-Cancer Agent Development

    Ma Zhongze , Hano Yoshio , Nomura Taro

    Heterocycles 65(9), 2203-2219, 2005-09-01

  • 13

    40 A Synthesis of Natural Product Like Library : Combinatorial Synthesis of Macrosphelide Analogues  [in Japanese]

    Kusaka Shin-ichi , Dohi Suguru , Doi Takayuki , Takahashi Takashi

    … Consequently, macrosphelides have received much attention as a lead compound for the development of new anti-cancer drugs and hence, a synthetic method for producing those molecules and their analogues is urgently required. …

    天然有機化合物討論会講演要旨集 (45), 233-238, 2003-09-01

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  • 14

    Exploration for Anti-cancer Leads through Synthetic Approach Utilizing Biologically Active Natural Products as Seed Principles  [in Japanese]

    Murakami Nobutoshi

    … Aiming at exploration for new anti-cancer leads utilizing biologically active natural products as seed principles, several synthetic lead compounds have been disclosed through structure-activity relationship analyses by means of a synthetic approach. … According to the synthetic protocol of callystatin A, the first synthesis of leptomycin B, congeneric anti-tumor polyketide, was achieved to determine its absolute structure. …

    Natural medicines 56(3), 73-77, 2002-06-20

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  • 15

    Development and Application of Enantioselective Lewis Acid-Lewis Base Bifunctional Catalyst  [in Japanese]

    KANAI Motomu

    … Catalytic enantioselective synthesis of several drug lead compounds, such as anti-cancer epothilones, potent N-methyl-D-aspartate(NMDA) receptor antagonists, phenytoin analogs, salsolinol carboxylic acid, and anti-cancer camptothecin was achieved, using these reactios as key steps. …

    Journal of the Pharmaceutical Society of Japan 121(12), 949-960, 2001-12-01

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  • 16

    Physiological Effects of γ-Linolenic Acid and Its Production by Fungal Cultivation  [in Japanese]

    NAKAHARA Toro , YOKOCHI Toshihiro , KAMISAKA Yasushi , SUZUKI Osamu

    … Its effects cover anti-atherosclerosis including hypocholesterolic and anti-thrombogenic effect, anti-cancer, higher alcohol oxidation, anti-inflammatory effect and others. … The optimum culture conditions for lipid accumulation were lower both in pH and temperature than those for growth, which lead to our proposal of 2 tanks continuous system to separate growth from lipid accumulation phase. …

    Journal of Japan Oil Chemists' Society 42(4), 242-253, 1993-04-20

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  • 17

    APPLICATION OF IMMUNOCYTOCHEMISTRY TO THE CYTOLOGIC STUDY OF PERITONEAL FLUIDS IN PATIENTS WITH OVARIAN CANCER

    SHINOZUKA Takao , EBISAWA Kazuko , MIYAMOTO Tsuyoshi , MURAKAMI Masaru , FUJII Akikazu , OSAMURA Yoshiyuki

    卵巣癌に対する腹腔内細胞診は, 臨床進行期の決定や再発の診断には不可欠の手段であるが, 臨床の実際においては, しばしばその診断に迷う症例に遭遇する。これに対する新たな診断法として, 複数の抗体を用いた酵素抗体染色の応用につき検討した。使用した抗体は抗CA-125, 抗CA19-9, 抗CEA, 抗EMA抗体である。良性疾患より採取した腹水細胞診での中皮細胞の陽性率は, CA-125: 39.4% …

    Acta Obstetrica et Gynaecologica Japonica 43(10), 1355-1362, 1991-10-01

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  • 18

    A Case of Leiomyosarcoma of the Thyroid

    Semba Osamu , Okuda Minoru , Kawabori Shin-ichi , Takahashi Mitsuaki

    … Use of electron microscopy to establish the correct diagnosis in cases of cancer has been emphasized by many investigators. … The patient presented here had been initially diagnosed (light microscope) as undifferentiated carcinoma, but a leiomyosarcoma was the final diagnosis, as the characteristic ultrastructure could be demonstrated under the electron microscope.A 25-year-old Japanese male had a rapidly enlarging cervical tumor which was resistant to irradiation and anti-cancer drugs. …

    Practica Oto-Rhino-Laryngologica 71(4), 371-378, 1978

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  • 19

    Studies on Effects of Various Anti-Cancer Drugs on the Cultivated Normal Cells of Fetus of Albino Rat  [in Japanese]

    Tateishi Toshiaki

    … However, since there is to date no anti-cancer drug available, the effect of which is restricted to the cancer cells alone, there are a number of cases where the normal tissues and cells are also affected and even some cases lead to serious side effect. …

    The Journal of the Kyushu Dental Society 29(5), 486-522, 1976-01-31

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