CiNii Articles - bredinin

1

The biochemical inhibition mode of bredinin-5'-monophosphate on DNA polymerase β [in Japanese]

MIZUSHINA Yoshiyuki , MATSUKAGE Akio , SAKAGUCHI Kengo

日本分子生物学会年会プログラム・講演要旨集 21, 588, 1998-12-01

References (2)
2

Dose comparison of Bredinin^<【○!R】> on rheumatoid arthritis : A multicenter, long-term administration post-marketing surveillance study [in Japanese]

KONDO Hirobumi , KOIKE Takao , SAITO Terunobu , KASUKAWA Reiji , KASHIWAGI Heihachiro , AKIZUKI Masashi , WARABI Haruaki , MIZUSHIMA Yutaka , HASHIMOTO Akira , TORIGAI Katsutaka , NAGAYA Ikuo , OCHI Takahiro , KOMATSUBARA Yoshio , EZAWA Hidemitsu , YAMAMOTO Sumiki , NOBUNAGA Tadashi , KASHIWAZKI Sadao

炎症 : 日本炎症学会雑誌 : Japanese journal of inflammation 18(1), 61-80, 1998-01-30

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3

A5'-monophosphate form of bredinin selectively inhibits the activities of mammalian DNA polymerases in vitro

HORIE T.

Int. J. Mol. Med. 1, 83-90, 1998

Cited by (2)
4

Dose comparison of Bredinin^<【○!R】> on rheumatoid arthritis : A multicenter post-marketing surveillance study [in Japanese]

KASHIWAZAKI Sadao , KONDO Hirobumi , KOIKE Takao , SAITO Terunobu , KASUKAWA Reiji , KASHIWAGI Heihachiro , AKIZUKI Masashi , WARABI Haruaki , MIZUSHIMA Yutaka , HASHIMOTO Akira , TORIGAI Katsutaka , NAGAYA Ikuo , OCHI Takahiro , KOMATSUBARA Yoshio , EZAWA Hidemitsu , YAMAMOTO Sumiki , NOBUNAGA Tadashi

Jpn. J. Inf. 16(4), 269-289, 1996-07-10

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5

Effect of Bredinin on Early Embryonic Development in Mice

KAWAI Yuichi , YOSHIDA Akihiko , NAKAGAWA Shinsaku , HAMA Takao , MAYUMI Tadanori

… Bredinin, an immunosuppressive agent, had a teratogenic effect and a decreasing effect in litter size in mice and in rats. … Bredinin strongly inhibited the first differentiation step from the morula to the blastocyst stage, whereas the steps from the two-cell embryo to the morula stage were not inhibited. … or 10^<-5>M of bredinin, only one or none of the morula embryos developed to a blastocyst after a 48 h culture; …

Biological & pharmaceutical bulletin 16(2), 133-136, 1993-02-15

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6

Effect of Bredinin on the Primary Culture of Fetal Mouse Cells and Adult Mouse Lung Cells

NAKAGAWA Shinsaku , HAMA Takao , MAYUMI Tadanori

… The effects of bredinin on the primary culture of fetal mouse cells (fetal cells) and adult mouse lung cells (lung cells) were compared. … Bredinin inhibited the growth of both cells, and this inhibition was found to be caused, at least in part, by the inhibition of the S phase and/or the transition from the G1 to S phase of the cell cycle. … Bredinin inhibited both DNA and RNA synthesis without affecting protein synthesis. …

Chemical & pharmaceutical bulletin 40(11), 3009-3012, 1992-11-25

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7

A Sequential Immunosuppressive Treatment with Mizoribin (Bredinin) plus Cyclosporin A on the Subrenal Capsule Assay.

USHIJIMA KIMIO , NISHIDA TAKASHI , ODA TAKAAKI , SUGIYAMA TORU , YAKUSHIJI MICHIAKI

… To minimize immunological interferences on the subrenal capsule (SRC) assay, a new immunosuppressor, mizoribin (MZB: Bredinin) alone or combined with cyclosporin A (ScA) was evaluated by an experimental SRC assay system using a rat ovarian cancer tissue. …

The Kurume Medical Journal 38(3), 195-198, 1991

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8

Chemosensitivity test using subrenal capsule assays Part 1. Experimental evaluation [in Japanese]

多田敦彦

… The effects of various immunosuppressants-cyclosporin A (CSA), cyclophosphamide, whole body irradiation, and Bredinin were studied using human small cell lung cancer cell line (SBC-3) serially transplanted in nude mice. …

岡山医学会雑誌 102(11-12), 1287-1297, 1990-12-00

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9

Dual inhibitory effect of bredinin

KASUMI T

Cell Biochem Func 7, 201-204, 1988

Cited by (10)
10

EVALUATION OF BONE MARROW TOXICITY BY HEMATOPOIETIC STEM CELLS (CFU-C AND CFU-S) OF AZATHIOPRINE, BREDININ AND LEVAMISOLE

MATSUMOTO Kazuhiko , FUJII Hiroko , YAMAMOTO Hiroshi

Journal of toxicological sciences 12(4), 578, 1987-11-25

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11

SYNTHESIS OF BREDININ 5'-ALKYLPHOSPHATES INVOLVING PHOTOCHEMICAL MANIPULATION OF THE IMIDAZOLE MOIETY, AND THEIR ANTITUMOR ACTIVITIES(Communications to the Editor)

Shuto Satoshi , Itoh Hiromichi , Endo Eriko , Fukukawa Kiyofumi , Tsujino Masatoshi , Ueda Tohru

… Bredinin 5'-oleyl and 5'-cetyl phosphates (2a and 2b), prepared from 1-β-D-ribofuranosyl-5-aminoimidazole-4-carboxamide via a photochemical ring-opening reaction of the imidazole moiety, showed remarkable antitumor effects against various transplantable mouse tumors, and were clearly superior to bredinin (1). …

Chemical & pharmaceutical bulletin 35(8), 3523-3526, 1987-08-25

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12

Synthesis of Bredinin from 1-β-D-Ribofuranosyl-5-aminoimidazole-4-carboxamide by a Photo-Reaction

FUKUKAWA KIYOFUMI , SHUTO SATOSHI , HIRANO TAKAO , UEDA TOHRU

… Photolysis of 1-β-D-ribofuranosyl-5-aminoimidazole-4-carboxamide (AICA-riboside) gave 2-amino-N-(β-D-ribofuranosyl)malondiamide, which was cyclized by treatment with ethyl orthoformate to furnish 1-β-D-ribofuranosyl-5-hydroxyimidazole-4-carboxamide (bredinin), a potent immunosuppressive nucleoside antibiotic. …

Chemical & pharmaceutical bulletin 34(9), 3653-3657, 1986-09-25

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13

LONG-TERM TOXICOLOGICAL STUDIES WITH MIZORIBINE (BREDININ^<(R)>) IN BEAGLE DOGS (THE SECOND REPORT) : PHTHOLOGICAL STUDIES ON VISCERAL ORGANS [in Japanese]

OKUDAIRA Masahiko , OHBU Makoto

… 免疫抑制剤 HE-69 (mizoribine, Bredinin^<(R)>) 2.5 mg/kg/day を36ヵ月間にわたり長期投与されたビーグル犬の諸臓器を病理学的に検討した。 …

Journal of toxicological sciences 10(1), 51-65, 1985-02-25

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14

LONG-TERM TOXICOLOGICAL STUDIES WITH MIZORIBINE (BREDININ^<(R)>) IN BEAGLE DOGS (THE FIRST REPORT) : BLOOD CHEMISTRIES, PHARMACOKINETICS OF MIZORIBINE AND FERTILITY STUDIES OF THE MALE DOGS [in Japanese]

UCHIDA Hisanori , MASAKI Yoshihiko , TAIRA Miyako , MARUYAMA Shigeyoshi , YASUDA Shuichi

mizoribine の長期慢性毒性試験の目的で, 生後6ヵ月のビーグル犬, オス・メス2頭ずつ計4頭に対し, 2.5 mg/kg/day の mizoribine を週6日投与し1日休薬する方法で, 36ヵ月間連続投与した。対照群として無処置ビーグル犬, オス・メス2頭ずつ計4頭を同じ条件で飼育し, 比較を行った。(1) 一般状態, 体重増加率に差はなかった。(2) 血液学検査について, 白血球 …

Journal of toxicological sciences 10(1), 35-49, 1985-02-25

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15

Elimination characteristics of bredinin from patients serum in hemodialysis

TAKADA K.

Int. J. Clin. Pharmacol. Ther. Toxicol. 23, 197-199, 1985

Cited by (3)
16

SYNTHESIS OF BREDININ FROM 5-AMINOIMIDAZOLE-4-CARBOXAMIDE-RIBOFURANOSIDE (AICA-RIBOSIDE)

Fukukawa Kiyofumi , Shuto Satoshi , Hirano Takao , Ueda Tohru

… A novel synthesis of bredinin by the conversion of AICA-riboside through a photo-degradation product is described. …

Chemical & pharmaceutical bulletin 32(4), 1644-1646, 1984-04-25

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17

Studies on antinephritic effect of mizoribine (p-INN, Bredinin), a new immunosuppressive agent, and azathioprine (2). Effect on crescentic-type anti-GBM nephritis in rats.

OKAMOTO Kyoko , ITO Mikio , SUZUKI Yoshio

Crescentic-type nephritis was induced in rats by immunizing with rabbit γ-globulin following i.v.injection of rabbit anti-rat glomerular basement membrane (anti-GBM) serum. The antinephritic effect of …

The Japanese Journal of Pharmacology 34(1), 33-41, 1984

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18

Bredininによる親子間腎移植15例の臨床成績 : 第47回東部連合総会 [in Japanese]

木村太紀 , 星長清隆 , 川村猛 , 長谷川昭

The Japanese Journal of Urology 74(10), 1868, 1983-10-20

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19

Genetic and biochemical studies on the activation and cytotoxic mechanism of bredinin, a potent inhibitor of purine biosynthesis in mammalian cells

KOYAMA H

Biochem Pharmacol 32, 3547-3553, 1983

Cited by (13)
20

Mizoribine (Bredinin)の生殖試験 (第3報) ラットにおける周産期および授乳期投与試験

小林洋四郎

応用薬理 26, 397-407, 1983

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