検索結果 959件中 1-20 を表示

  • Utility of human hepatocyte spheroids without feeder cells for evaluation of hepatotoxicity

    Ogihara Takuo , Arakawa Hiroshi , Jomura Tomoko , Idota Yoko , Koyama Satoshi , Yano Kentaro , Kojima Hajime

    … Sph(f-) and spheroids cultured on feeder cells (Sph(f+)) were exposed to the hepatotoxic drugs flutamide, diclofenac, isoniazid and chlorpromazine at various concentrations for 14 days, and albumin secretion and cumulative leakages of toxicity marker enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and γ-glutamyl transpeptidase (γ-GTP), were measured. … In the case of Sph(f-), significant correlations among all the toxicity markers except for γ-GTP were observed. …

    The Journal of Toxicological Sciences 42(4), 499-507, 2017-08

    機関リポジトリ DOI

  • 水生生物への複合毒性のスクリーニング評価における急性慢性毒性比の検討

    大西 洋平 , 竹田 宜人

    環境毒性学会誌 20(1), 21-33, 2017-07

  • Krebs Cycle Intermediates Protective against Oxidative Stress by Modulating the Level of Reactive Oxygen Species in Neuronal HT22 Cells

    Sawa Kenta , Uematsu Takumi , Korenaga Yusuke , Hirasawa Ryuya , Kikuchi Masatoshi , Murata Kyohei , Zhang Jian , Gai Xiaoqing , Sakamoto Kazuichi , Koyama Tomoyuki , Satoh Takumi

    … Here we found that pyruvate, oxaloacetate, and α-ketoglutarate, but not lactate, citrate, iso-citrate, succinate, fumarate, or malate, protected HT22 cells against hydrogen peroxide-mediated toxicity. … Because these protective KCIs did not have any toxic effects (at least up to 10 mM), they have potential use for therapeutic intervention against chronic neurodegenerative diseases. …

    Antioxidants 6(1), 21, 2017-03

    機関リポジトリ DOI

  • Pyraziflumid (Pesticides)

    Food Safety Commission of Japan

    … Increased incidences of thyroid follicular cell adenomas and carcinomas in males, and also of hepatocellular adenomas in females were identified in a two-year combined chronic toxicity/carcinogenicity study in rats. … The lowest no-observed-effect level (NOAEL) obtained from all the studies was 2.15 mg/kg bw/day in a two-year combined chronic toxicity/carcinogenicity study in rats. …

    Food Safety 5(3), 118-119, 2017

    J-STAGE

  • A Case of Unilateral Posterior Reversible Encephalopathy Syndrome Occurring after Carotid Artery Stenting

    Kikuchi Osamu , Ishizaki Kenichi

    … Temporary disruption of the blood–brain barrier due to blood pressure fluctuations in chronic unilateral hypoperfusion caused by stenosis of the right internal carotid artery or toxicity of the contrast medium was suspected.</p><p><b>Conclusion:</b> …

    脳神経血管内治療 11(8), 403-408, 2017

    J-STAGE

  • Utility of human hepatocyte spheroids without feeder cells for evaluation of hepatotoxicity

    Ogihara Takuo , Arakawa Hiroshi , Jomura Tomoko , Idota Yoko , Koyama Satoshi , Yano Kentaro , Kojima Hajime

    … Sph(f-) and spheroids cultured on feeder cells (Sph(f+)) were exposed to the hepatotoxic drugs flutamide, diclofenac, isoniazid and chlorpromazine at various concentrations for 14 days, and albumin secretion and cumulative leakages of toxicity marker enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and γ-glutamyl transpeptidase (γ-GTP), were measured. … In the case of Sph(f-), significant correlations among all the toxicity markers except for γ-GTP were observed. …

    The Journal of Toxicological Sciences 42(4), 499-507, 2017

    J-STAGE

  • 肝細胞肥大の毒性学的特徴の解明に向けた農薬のラット反復投与毒性試験結果データベースの構築

    増田 茜 , 増田 雅美 , 川野 拓歩 , 橘内 陽子 , 中山 晴香 , 中島 宏之 , 小島 弘幸 , 北村 繁幸 , 浦丸 直人 , 保坂 卓臣 , 佐々木 崇光 , 吉成 浩一

    … Using risk assessment reports of pesticides that are publicly available from the Food Safety Commission of Japan, we extracted all observations/findings that were based on 90-day subacute toxicity tests and 2-year chronic toxicity and carcinogenicity tests in rats. …

    薬学雑誌 137(5), 611-622, 2017

    J-STAGE 医中誌Web

  • Isofetamid (Pesticides)

    Food Safety Commission of Japan

    … None of neurotoxicity, carcinogenicity, reproductive toxicity, teratogenicity, immunotoxicity and genotoxicity were observed. … The lowest no-observed-adverse-effect level (NOAEL) obtained in all the toxicity studies was 5.34 mg/kg bw/day in a one-year chronic toxicity study in dogs. …

    Food Safety 5(1), 31-33, 2017

    J-STAGE

  • Cyclaniliprole (Pesticides)

    Food Safety Commission of Japan

    … None of neurotoxicity, carcinogenicity, reproductive toxicity, teratogenicity, immunotoxicity and genotoxicity were observed. … The lowest no-observed-adverse-effect level (NOAEL) obtained in all the toxicity studies was 1.29 mg/kg bw/day in a one-year chronic toxicity study in dogs. …

    Food Safety 5(1), 29-30, 2017

    J-STAGE

  • Oral acute and chronic toxicity studies of β, β-dimethylacrylalkannin in mice and rats

    Zhang Piao-Piao , Yan Xiao-Dan , Fan Xiao-Yu , Ling Ya-Hao , Li Chao , Lin Lin , Qin Dan , Liu Tian-Tian , Li Ye , Li Hui , Zhang Qianqian , Mu Wen-Bo , Wang Ai-Ping , Jin Hong-Tao , Wei Jin-Feng

    … However, its potential toxicity has not been rigorously studied. … To confirm its safety, the oral toxicity of β, β-dimethylacrylalkannin was evaluated <i>in vivo</i>. … An acute oral toxicity study in mice demonstrated that β, β-dimethylacrylalkannin was practically nontoxic based on its high median lethal dose (LD<sub>50 </sub>> …

    Fundamental Toxicological Sciences 4(2), 45-56, 2017

    J-STAGE

  • Kidney Cadmium Toxicity, Diabetes and High Blood Pressure: The Perfect Storm

    Satarug Soisungwan , Vesey David A. , Gobe Glenda C.

    … <p>Cadmium (Cd) is an environmental toxicant of widespread exposure and pervasive toxicity. … Dietary Cd intake of 10-30 µg/day has been linked with reduced tubular reabsorption, chronic kidney disease, hypertension, coronary arterial and peripheral arterial diseases, macular degeneration, obesity-independent diabetes, and cancer. … This review adds to these connections by presenting the synergism of kidney Cd toxicity on blood pressure control and glucose homeostasis. …

    The Tohoku Journal of Experimental Medicine 241(1), 65-87, 2017

    J-STAGE

  • Reduced-dose methotrexate in combination with tacrolimus was associated with rapid engraftment and recovery from oral mucositis without affecting the incidence of GVHD

    Matsukawa Toshihiro , Hashimoto Daigo , Sugita Junichi , Nakazawa Seitarou , Matsushita Takae , Kashiwazaki Haruhiko , Goto Hideki , Onozawa Masahiro , Kahata Kaoru , Fujimoto Katsuya , Endo Tomoyuki , Kondo Takeshi , Hashino Satoshi , Yamazaki Yutaka , Teshima Takanori

    … In the present study, we compared the efficacy and toxicity of 15-10-10 MTX (day +1: 15 mg/m2; … The cumulative incidence rates of grades II-IV acute GVHD, grades III-IV acute GVHD and chronic GVHD in the 15-10-10 MTX and 10-7-7 MTX groups did not differ to a statistically significant extent. …

    International journal of hematology 104(1), 117-124, 2016-07

    機関リポジトリ DOI

  • Control Efficacy of Pongam (Pongamia pinnata L.) Leaf Extract against the Turnip Aphid Lipaphis pseudobrassicae (Davis) (Hemiptera: Aphididae)

    Tran Dang Hoa , Le Khac Phuc , Tran Hoang Dong Thi , Ueno Takatoshi

    … In laboratory tests, pongam leaf extract showed acute toxicity to the turnip aphid; … Pongam leaf extract has thus nonlethal chronic toxicity. …

    九州大学大学院農学研究院紀要 61(1), 141-145, 2016-02-29

    機関リポジトリ

  • 慢性期CMLに対するTKI療法

    高橋 直人

    <p>BCR-ABLチロシンキナーゼ阻害剤(TKI)は慢性骨髄性白血病(CML)の予後を劇的に改善させ,今やCML患者の予後を規定する最大の要因は合併症の有無となった。これまでTKIの有害事象は可逆的でマネージメント可能と考えられてきた。ところが臨床試験の長期観察から第二世代TKIに関連した心血管障害の頻度が予想以上に高いことが明らかになってきた。本事象の発症機序は正確にはわかっていな …

    臨床血液 57(10), 1956-1961, 2016

    J-STAGE

  • 尿路結石を認めなかった2,8-DHA結晶尿の1症例

    永田 勝宏 , 田中 佳 , 松本 正美 , 田中 千津 , 新田 恭子 , 宮澤 克人 , 飯沼 由嗣

    <p>2,8-ジヒドロキシアデニン結晶(2,8-dihydroxyadenine; 2,8-DHA)は,黄~黄褐色で大小不同の球状結晶であり,アデニンホスホリボシルトランスフェラーゼ(adenine phosphoribosyl transferase; APRT)欠損症で生じる異常結晶である。症例は60歳代男性で,2012年に糖尿病と診断され糖尿病性腎症による慢性腎不全のため通院中で …

    医学検査 65(6), 695-699, 2016

    J-STAGE

  • Overview of pharmacology-induced mechanisms of carcinogenesis by drug classes based on the analysis of the data set from the three parties

    LAAN Jan Willem VAN DER , KASPER Peter , LIMA Beatriz SILVA , JONES David , PASANEN Markku

    … Predicting the outcome of life-time carcinogenicity studies in rats based on chronic (6-month) toxicity studies in this species is possible in some instances. … <br>The goal of this analysis is to review the pharmacological properties of compounds together with the histopathology findings from the chronic toxicity study in rodents in order to introduce an integrated approach to estimate the risk of human carcinogenicity of pharmaceuticals. …

    日本毒性学会学術年会 43.1(0), W2-4, 2016

    J-STAGE

  • 肺Percellome Project-シックハウスレベル吸入から経口暴露時までの肺応答からみる肺毒性-

    北嶋 聡 , 相﨑 健一 , 菅野 純

    Toxicity of volatile organic compounds (VOCs) in indoor air, such as formaldehyde (FA), Xylene (Xy) and Paradichlorobenzene (pDB), at the levels of Sick House/Building Syndrome (SHS) is difficult to assess by the ordinary inhalation animal studies; … histopathological endpoints are negative for toxicity at such concentration level. … Here, we report that the Percellome analysis is capable of predicting functional insults that might lead to chronic toxicity.<br> …

    日本毒性学会学術年会 43.1(0), S2-4, 2016

    J-STAGE

  • メタクリル酸=2,3-エポキシプロピルのラット及びマウスへの吸入曝露による発がん性

    齋藤 新 , 笠井 辰也 , 梅田 ゆみ , 妹尾 英樹 , 大西 誠 , 竹内 哲也 , 西沢 共司 , 福島 昭治

    【目的】メタクリル酸=2,3-エポキシプロピルのがん原性を検索する目的でF344/DuCrlCrljラットとB6D2F1/Crljマウスを用いた吸入による2年間(104週間)の試験を実施した。<br>【方法】ラットとマウスの雌雄各群50匹に、メタクリル酸=2,3-エポキシプロピルを1日6時間、1週5日間で104週間、動物に全身暴露した。投与濃度は、ラットは0、3.2、8、20 ppm、 …

    日本毒性学会学術年会 43.1(0), P-244, 2016

    J-STAGE

  • Acute and sub chronic oral toxicity study of Antangin Fit in rats and its immunostimulatory activity

    SHOLIKHAH Eti Nurwening , WIJAYANTI Mahardika Agus , MUSTOFA Mustofa

    … This study was conducted to evaluate the acute and sub chronic oral toxicity of Antangin Fit in rats and the immunostimulatory activity in mice. … The acute toxicity study was conducted on 50 Wistar rats, divided into 4 treatment groups and 1 control. … The subchronic toxicity study was conducted on 80 Wistar rats. …

    日本毒性学会学術年会 43.1(0), O-1, 2016

    J-STAGE

  • Mechanisms of CCl₄-induced liver fibrosis with combined transcriptomic and proteomic analysis

    Dong Shu , Chen Qi-Long , Song Ya-Nan , Sun Yang , Wei Bin , Li Xiao-Yan , Hu Yi-Yang , Liu Ping , Su Shi-Bing

    … <p>The classic toxicity of carbon tetrachloride (CCl<sub>4</sub>) is to induce liver lesion and liver fibrosis. … Liver fibrosis is a consequence of chronic liver lesion, which can progress into liver cirrhosis even hepatocarcinoma. …

    The Journal of Toxicological Sciences 41(4), 561-572, 2016

    J-STAGE

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