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Altered arachidonic acid-mediated responses in the perfused kidney of the streptozotocin-induced diabetic rat
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KAMATA Katsuo
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HOSOKAWA Masao
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MATSUMOTO Takayuki
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KOBAYASHI Tsuneo
… In the diabetic group, the AA-induced sustained relaxation was completely inhibited by indomethacin [cyclooxygenase (COX) inhibitor], SKF525A [cytochrome P450 (CYP450) inhibitor], or clotrimazole (epoxygenase inhibitor), but not by furegrelate [thromboxane A_2 (TXA_2)-synthase inhibitor], SQ29548 (TXA_2-receptor antagonist), or baicalein [lipoxygenase (LOX) inhibitor]. … In the diabetic kidney, more-or-less additive inhibitions of the AA-induced relaxation were seen when indomethacin was given with either SKF525A or clotrimazole. …
Journal of smooth muscle research 42(5), 171-187, 2006-10-00
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