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Synthesis of Diphenylmethyl Analogues and Their Affinity for the Melanocortin-4 Receptor and the Serotonin Transporter
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NOZAWA Dai
,
OKUBO Taketoshi
,
ISHII Takaaki
,
CHAKI Shigeyuki
,
OKUYAMA Shigeru
,
NAKAZATO Atsuro
… While examining antagonists of the melanocortin-4 receptor (MC4 receptor), we found that compound 12b, containing a diphenylmethyl moiety, had a relatively high affinity for the MC4 receptor. … When diphenylmethyl analogues were further examined, compounds 12c and 18 were also found to exhibit a high affinity for the MC4 receptor (IC_<50>=46.7nM and 33.2 nM, respectively). …
Chemical & pharmaceutical bulletin 55(7), 1044-1050, 2007-07-01
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