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1

Synthesis of Haptens for Use in Immunoassays of Tetrahydrocortisol, Tetrahydrocortisone and Their Glucuronides

HOSODA HIROSHI , SAITO KEIKO , ITO YUKO , YOKOHAMA HIROMITSU , ISHII KAZUO , NAMBARA TOSHIO

… The preparation of the 3-hemisuccinates (23,27), 21-hemisuccinates (8,14), 3-hemiglutarates (24,28), and 21-hemiglutarates (9,15) of these corticosteroids was carried out starting from cortisol 21-acetate (1). …

Chemical & pharmaceutical bulletin 30(6), 2110-2118, 1982-06-25

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2

Synthesis of Corticosteroid Haptens Possessing the Bridge at the C-4 Position

HOSODA HIROSHI , MIYAIRI SHINICHI , NAMBARA TOSHIO

… In order to obtain specific antisera for use in radioimmunoassay and enzyme immunoassay, new haptens of cortisol, 11-deoxycortisol and cortisone were prepared. … In addition, the preparation of related haptens is described. …

Chemical & pharmaceutical bulletin 28(4), 1294-1299, 1980-04-25

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