Search Results:　 1-20 of 93

1

Altered Expression of Both β-Carotene 15,15'Monooxygenase and Lecithin : Retinol Acyltransferase in Obese Zucker Rats

TAKITANI Kimitaka , MIYAZAKI Hiroshi , FUKUNISHI Shinya , TAKAYA Ryuzo , YODEN Atsushi , HIGUCHI Kazuhide , TAMAI Hiroshi

… Retinol and its active derivative retinoic acid have an important role in development, reproduction, immunity, and cell proliferation/differentiation. …

Journal of Nutritional Science and Vitaminology 57(1), 108-113, 2011-02-01

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2

Effects of Novel All-Trans Retinoic Acid Retinamide Derivatives on the Proliferation and Apoptosis of Human Lung Adenocarcinoma Cell Line A549 Cells

GUI Shu-Yu , CHEN Fei-Hu , ZHOU Qing , WANG Yuan

… The aim of the present study was to synthesize a series of retinamide derivatives using all-trans retinoic acid (ATRA) as raw material and observe their effects on the differentiation and apoptosis of human lung adenocarcinoma A549 cells. … The results also showed that the effects of N-(3-trifluoromethyl-phenyl) retinamide on differentiation and apoptosis were the strongest among the newly synthesized ATRA retinamide derivatives. …

YAKUGAKU ZASSHI 131(10), 1465-1472, 2011

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3

Stereochemical Differentiation in the Simmons-Smith Reaction for Cyclopropanated Glucopyranose Derivatives as Molecular Probes for Glycosidases

AKIYAMA Nanako , NOGUCHI Shogo , HASHIMOTO Masaru

… The synthesis features differentiation of the α- and β-stereoselectivity in cyclopropanation of the corresponding cyclohexene derivative (5). …

Bioscience, Biotechnology, and Biochemistry 75(7), 1380-1382, 2011

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4

Pharmacology and in Vitro Profiling of a Novel Peroxisome Proliferator-Activated Receptor γ Ligand, Cerco-A

Wakabayashi Kenji , Hayashi Shinko , Matsui Yumi , Matsumoto Takuo , Furukawa Akihiro , Kuroha Masanori , Tanaka Naomi , Inaba Tomoko , Kanda Shoichi , Tanaka Jun , Okuyama Ryo , Wakimoto Satoko , Ogata Tsuneaki , Araki Kazushi , Ohsumi Jun

… Here we report the identification and characterization of a non-thiazolidinedione PPARγ partial agonist, Cerco-A, which is a derivative of the natural product, (−)-cercosporamide. … In PPARγ transcriptional activation assay and an adipocyte differentiation assay, Cerco-A was a potent partial agonist of PPARγ. …

Biological & Pharmaceutical Bulletin 34(7), 1094-1104, 2011

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5

SSH-BM-I, a Tryptamine Derivative, Stimulates Mineralization in Terminal Osteoblast Differentiation but Inhibits Osteogenesis of Pre-committed Progenitor Cells

Mikami Yoshikazu , Somei Masanori , Tsuda Hiromasa

… However, the effect of SSH-BM-I on osteoblast differentiation in mammalian cells has not yet been examined. … Therefore, this study examined the effect of SSH-BM-I on osteoblast differentiation in mesenchymal progenitor-like cells and mature osteoblast-like cells. … SSH-BM-I enhanced terminal osteoblast differentiation, as indicated by mineralization, which was accompanied by upregulation of the osteogenic marker genes bone sialoprotein (BSP) and osteocalcin (OC). …

Journal of Pharmacological Sciences 116(1), 63-72, 2011

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6

The Effect of Pantothenic Acid Deficiency on Keratinocyte Proliferation and the Synthesis of Keratinocyte Growth Factor and Collagen in Fibroblasts

Kobayashi Daisaku , Kusama Miho , Onda Masaaki , Nakahata Norimichi

… It has been reported that pantothenic acid (vitamin B5) and panthenol, an alcohol derivative of pantothenic acid, have beneficial moisturizing effects on the skin. … The depletion of pantothenic acid from the culture medium suppressed keratinocyte proliferation and promoted differentiation. … These results suggest that pantothenic acid is essential for maintaining keratinocyte proliferation and differentiation. …

Journal of Pharmacological Sciences 115(2), 230-234, 2011

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7

Boundary Element Shape Design Sensitivity Formulation of 3D Acoustic Problems Based on Direct Differentiation of Strongly-Singular and Hypersingular Boundary Integral Equations(Mechanical Systems) [in Japanese]

ZHENG Changjun , MATSUMOTO Toshiro , TAKAHASHI Toru , CHEN Haibo

… A set of new boundary integral equations relating the sensitivity coefficients of sound pressure and its normal derivative is presented for three-dimensional acoustic problems based on the direct differentiation method. …

Transactions of the Japan Society of Mechanical Engineers. C 76(771), 2899-2908, 2010-11-25

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8

Pharmaceutical Studies and Practical Syntheses of Active Vitamin D Derivatives [in Japanese]

KUBODERA Noboru

… The third has been characterized by the discovery of the differentiation-inducing properties of active vitamin D. …

Journal of Synthetic Organic Chemistry, Japan 68(9), 904-910, 2010-09-01

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9

Effect of peptide derived from Emdogain^[○!R] on human periodontal ligament fibroblasts

Kawanaka Ayako , Tominaga Kazuya , Tanaka Akio

… Although use of enamel matrix derivative (EMD) is one of the most effective, its mechanism is not well understood. … We explored how the proliferation, differentiation and gene expression of human periodontal ligament fibroblasts (HPdLF) are influenced by synthetic peptides derived from EMD. …

Journal of Osaka Dental University 43(1), 111-117, 2009-04

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10

1 Molecular biological study of periodontal ligament fibroblasts exposed to peptides derived from Emdogain^[○!R] [in Japanese]

Kawanaka Ayako , Tominaga Kazuya , Masuno Kazuya , Wato Masahiro , Nishikawa Tetsunari , Tanaka Akio

… Although enamel matrix derivative (EMD) is one of the most effective methods, its mechanism is not well understood. … We explored how the cell proliferation, differentiation and gene expression of periodontal ligament fibroblasts (HPdLF) are influenced by peptides derived from EMD. …

The Journal of the Osaka Odontological Society 72(1), 34, 2009-03-25

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11

Application of Monte Carlo Method to Solve the Neutron Kinetics Equation for a Subcritical Assembly

IWANAGA Kohei , SEKIMOTO Hiroshi , MORI Takamasa

… In the proposed method the time derivative of the neutron equation is set to zero, though the time derivative of the delayed neutron precursor equation is treated without any approximation in the time differentiation of delayed neutron precursor equation. …

Journal of Nuclear Science and Technology 45(11), 1099-1107, 2008-11-01

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12

2P1-D04 An Evaluation Technique of Universal Design by a Sphygmography Using a Radio Module [in Japanese]

ASAKAWA Takashi , YOSHIDOME Tadashi , NISHIHARA Kazue

… Measured sphygmograph data were changed to pulse data by derivative2 differentiation. …

ロボティクス・メカトロニクス講演会講演概要集 2008, "2P1-D04(1)"-"2P1-D04(4)", 2008-06-06

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13

Identification of Novel Derivative of Helvolic Acid from Metarhizium anisopliae Grown in Medium with Insect Component(BIOCHEMICAL ENGINEERING)

Lee Si-Young , Kinoshita Hiroshi , Ihara Fumio , Igarashi Yasuhiro , Nihira Takuya

… Entomopathogenic fungi are unique owing to their versatile ability to produce many bioactive compounds and from the dependence of their morphological differentiation on the presence of insect-derived materials. … Two compounds were isolated: the major compound was determined to be helvolic acid and the minor one was a novel derivative of helvolic acid(1,2-dihydrohelvolic acid). …

Journal of bioscience and bioengineering 105(5), 476-480, 2008-05-25

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14

Enamel Matrix Derivative Promotes Human Periodontal Ligament Cell Differentiation and Osteoprotegerin Production in vitro

LOSSDORFER S. , SUN M. , GOTZ W. , DARD M. , JAGER A.

Journal of dental research 86(10), 980-985, 2007-10-01

References (24)
15

[Invited Paper] Some Considerations on the Instantaneous Frequency [in Japanese]

KIDO Ken'iti , SUZUKI Hideo

本文では瞬時周波数を波形の瞬時位相の時間微分として,その性質について考察する。瞬時位相を求めるためには,その波形と直交する(位相がπ/2遅れる)波形が必要であるが,それはスペクトルの正の周波数範囲に-jを,負の周波数範囲にjを乗じてフーリエ逆変換することでつくられる。これは波形から解析信号をつくることと同じである。数列で波形が表されているときには,時間による微分の代わりに差分を用いるので,サンプリ …

Technical report of IEICE. EA 107(186), 25-30, 2007-08-02

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16

Sampling theorems for periodic functions and interpolation formulae for sampled data [in Japanese]

OIE Samon

帯域制限された周期関数に対する時間域でのサンプリング定理が証明される。この定理は、帯域制限された周期関数は、1周期内の有限個のサンプルデータから一意的に定められるということを述べている。内挿関数は、1周期内のデータ数が偶数か奇数かに依存して異なった形を取る。是に対応した周波数域でのサンプリング定理も、また、与えられる。周波数域でのサンプリング定理は、時間域で局在している周期スペクトル関数は、周波数 …

Technical report of IEICE. EA 107(170), 7-12, 2007-07-20

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17

A New Design Sensitivity Analysis of Acoustic Problems Based on Bern Avoiding Fictitious Eigenfrequency Issue(Mechanical Systems) [in Japanese]

ARAI Youri , TANAKA Masataka , MATSUMOTO Toshiro

… The direct differentiation method is applied to the derivation of sensitivity formulas. … One equation is the combined boundary integral equation proposed by Burton-Miller and the other is the normal derivative boundary integral equation multiplied by the same coupling parameter as in the Burton-Miller expression. …

Transactions of the Japan Society of Mechanical Engineers. C 73(729), 1392-1399, 2007-05-25

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18

Development of Novel Nuclear Receptor Ligands Based on Receptor-Folding Inhibition Hypothesis [in Japanese]

TANATANI Aya

… Nuclear receptors are ligand-inducible transcriptional factors, and regulate various significant biological phenomena such as cell differentiation, proliferation, metabolism, and homeostasis. … Further, novel non-seco-steroidal vitamin D_3 analogs were designed and synthesized by using a 3, 3-diphenylpropane derivative, LG190178 as lead compound. …

Journal of the Pharmaceutical Society of Japan 127(2), 341-351, 2007-02-01

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19

2601 A Study of Railway Brake Systems Safety via Driver Model : Examination by simulations [in Japanese]

YAMAZAKI Hiro-o , IIZUKA Yasuyuki , KOJIMA Takashi , MARUMO Yoshitaka , TSUNASHIMA Hitoshi

… The driver model used the model proposed by Inguchi et al., and used the transfer function that consisted of the proportion, differentiation and the integration operation. … From the simulation results, derivative gain of transfer function of driver model is important in the brake and vehicle dynamics. …

Jointed railway technology symposium 2006(13), 453-456, 2006-12-13

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20

Inhibitory Activities of Plastoquinones and Chromene Derivative from a Brown Alga Sagassum micracanthum on Bone Resorption(Pharmacognosy)

KOMAI Eiko , MIYAHARA Tatsuro , MORI Jun , OBI Nobuko , OCHIAI Hiroshi , SAITO Haruo , HAYASHI Toshimitsu

… We evaluated inhibitory effects of plastoquinones (1, 2) and chromene derivative (3) from the methanol extract of Sargassum micracanthum on the differentiation of osteoclast progenitors into osteoclast-like cells (OCLs), bone-resorbing activity and the survival of OCLs. … These results suggest that the inhibitory effects of the three compounds on the differentiation, pit formation and the survival of OCLs might contribute to the suppression of bone resorption. …

Biological & pharmaceutical bulletin 29(9), 1980-1982, 2006-09-01

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