KAGEYAMA Masayuki
,
MIYAGI Takuho
,
YOSHIDA Mayumi
,
NAGASAWA Tomohiro
,
OHRUI Hiroshi
,
KUWAHARA Shigefumi
… EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine), a nucleoside reverse transcriptase inhibitor with extremely potent anti-HIV activity, was concisely synthesized from (R)-glyceraldehyde acetonide in an 18% overall yield by a 12-step sequence involving highly diastereoselective ethynylation of an α-alkoxy ketone intermediate. …
Bioscience, Biotechnology, and Biochemistry 76(6), 1219-1225, 2012-06-23
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References (34)