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Downregulation of AP-2α Gene Expression in the Cadmium-Induced Ventral Body Wall Defect in the Chick Model
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Doi Takashi
,
Puri Prem
,
Bannigan John
,
Thompson Jennifer
,
Yamataka Atsuyuki
… However, the exact mechanism by which Cd acts in early embryogenesis still remains unclear. … We hypothesized that Cd-induced VBWD results from downregulation of AP-2α gene expression during the critical period of embryogenesis. … We speculate that the downregulation of AP-2α gene expression during this narrow window of embryogenesis may have caused VBWD. …
Journal of the Japanese Society of Pediatric Surgeons 48(5), 829-833, 2012-08-20
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