Search Results:　 1-20 of 147

  • 1

    Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function

    Yoshioka Kazuaki , Yoshida Kotaro , Cui Hong , Wakayama Tomohiko , Takuwa Noriko , Okamoto Yasuo , Du Wa , Qi Xun , Asanuma Ken , Sugihara Kazushi , Aki Sho , Miyazawa Hidekazu , Biswas Kuntal , Nagakura Chisa , Ueno Masaya , Iseki Shoichi , Schwartz Robert J. , Okamoto Hiroshi , Sasaki Takehiko , Matsui Osamu , Asano Masahide , Adams Ralf H. , Takakura Nobuyuki , Takuwa Yoh

    … Global or endothelial-cell-specific deficiency of PI3K-C2α resulted in embryonic lethality caused by defects in sprouting angiogenesis and vascular maturation. … Endothelial PI3K-C2α deficiency in vivo suppressed postischemic and tumor angiogenesis and diminished vascular barrier function with a greatly augmented susceptibility to anaphylaxis and a higher incidence of dissecting aortic aneurysm formation in response to angiotensin II infusion. …

    Nature Medicine 18(10), 1560-1569, 2012-10-00

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  • 2

    Ectopic Cervical Thymoma:A Case Report with <sup>18</sup>F-fluorodeoxyglucose Positron Emission Tomography Findings

    Shien Kazuhiko , Shien Tadahiko , Soh Junichi , Ikeda Hirokuni , Nogami Tomohiro , Taira Naruto , Doihara Hiroyoshi , Miyoshi Shinichiro

    … Ectopic thymoma is considered to arise from ectopic thymus tissue deposited as a result of the abnormalmislocalization of thymus tissue during the embryonic stage. … A positron emission tomography (PET) study revealed heterogeneous accumulation of <sup>18</sup>F-fluorodeoxyglucose (FDG) in the tumor. …

    Acta Medica Okayama 66(4), 357-361, 2012-08-00

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  • 3

    Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development

    Hashizume Osamu , Shimizu Akinori , Yokota Mutsumi , Sugiyama Atsuko , Nakada Kazuto , Miyoshi Hiroyuki , Itami Makiko , Ohira Miki , Nagase Hiroki , Takenaga Keizo , Hayashi Jun-Ichi , 橋爪 脩 , 中田 和人 , 林 純一

    … It has been hypothesized that respiration defects caused by accumulation of pathogenic mitochondrial DNA (mtDNA) mutations and the resultant overproduction of reactive oxygen species (ROS) or lactates are responsible for aging and age-associated disorders, including diabetes and tumor development. … Our previous studies resolved this issue by using an mtDNA exchange technology and showed that a G13997A mtDNA mutation found in mouse tumor cells induces metastasis via ROS overproduction. …

    Proceedings of the National Academy of Sciences of the United States of America 109(26), 10528-10533, 2012-06-00

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  • 4

    A Model of Cancer Stem Cells Derived from Mouse Induced Pluripotent Stem Cells

    Chen Ling , Kasai Tomonari , Li Yueguang , Sugii Yuh , Jin Guoliang , Okada Masashi , Vaidyanath Arun , Mizutani Akifumi , Satoh Ayano , Kudoh Takayuki , Hendrix Mary J. C. , Salomon David S , Fu Li , Seno Masaharu

    … Cancer stem cells (CSCs) are capable of continuous proliferation and self-renewal and are proposed to play significant roles in oncogenesis, tumor growth, metastasis and cancer recurrence. … CSCs are considered derived from normal stem cells affected by the tumor microenvironment although the mechanism of development is not clear yet. …

    PLoS ONE 7(4), 2012-04-12

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  • 5

    A Report of Two Cases of Presacral Epidermoid Cyst in Adults  [in Japanese]

    SHIGETA Kohei , ISHII Yoshiyuki , HASEGAWA Hirotoshi , ENDO Takashi , OCHIAI Hiroki , HIRATA Akira , YONAGA Kazuhide , HOSHINO Hiroki , HOSHINO Yoshinori , MATSUNAGA Atsushi , SEO Yuki , HOSHINO Go , UCHIDA Hiroshi , MUKAI Makio , KITAGAWA Yuko

    症例は婦人科癌検診で骨盤腔内腫瘤を指摘され，当院受診した27歳と28歳の女性である．MRI検査では，それぞれ直腸左側に5cm大と6cm大の病変を認め，T2強調像で境界明瞭な高信号を呈する嚢胞性腫瘤を認めた．CT検査では，辺縁に被膜様濃染を認め，明らかな実質構造は認めなかった．2例とも前仙骨部嚢胞性腫瘍と診断し，尾骨合併切除による経仙骨的アプローチにより完全切除を施行した．病理組織学的検査で嚢胞壁内 …

    Nippon Daicho Komonbyo Gakkai Zasshi 65(2), 51-57, 2012-02-01

    J-STAGE Ichushi Web CrossRef References (17)

  • 6

    A Case of Extraosseous Chordoma of the Nasopharynx

    Yui Takefumi , Hayashi Takeshi , Honma Hiroomi , Suzuki Takahiro , Takemura Hideki , Suzaki Harumi

    … Chordoma is a relatively rare malignant tumor of the skull base and sacrum thought to originate from embryonic remnants of the notochord. … A 34-year-old woman was diagnosed as having a nasopharyngeal tumor on April, 2009. … Computed tomography and magnetic resonance imaging revealed a tumor in the nasopharynx not extending into the intracranial region. …

    Practica Oto-Rhino-Laryngologica 105(12), 1165-1170, 2012

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  • 7

    Regulation of Human β-1,4-Galactosyltransferase V Gene Expression in Cancer Cells  [in Japanese]

    Sato Takeshi , Furukawa Kiyoshi

    … Our recent study showed that β-1,4-GalT V-knockout mice are embryonic lethal, suggesting the importance of the glycans synthesized by β-1,4-GalT V for embryonic development. … Both transcription factors regulate the gene expression levels of not only glycosyltransferases, but also key molecules involved in tumor growth, invasion and metastasis. …

    YAKUGAKU ZASSHI 132(6), 691-697, 2012

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  • 8

    Upregulation of Interferon-stimulated Genes and Interleukin-10 in Peripheral Blood Immune Cells During Early Pregnancy in Dairy Cows

    SHIRASUNA Koumei , MATSUMOTO Haruka , KOBAYASHI Eiji , NITTA Akane , HANEDA Shingo , MATSUI Motozumi , KAWASHIMA Chiho , KIDA Katsuya , SHIMIZU Takashi , MIYAMOTO Akio

    … Twenty multiparous Holstein cows were subjected to AI on day 0 and categorized into the following groups: pregnancy (Preg, n = 9), embryonic death (ED, n = 5) and non-pregnancy (NP, n = 6). … Tumor necrosis factor α (TNFα, Th1 cytokine) mRNA expression was stable in all groups. …

    Journal of Reproduction and Development 58(1), 84-90, 2012

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  • 9

    Hepatocyte growth factor twenty years on: Much more than a growth factor

    Nakamura Takahiro , Sakai Katsuya , Nakamura Toshikazu , Matsumoto Kunio

    … In 1991, the scatter factor, tumor cytotoxic factor, and 3-D epithelial morphogen were identified as HGF, and Met tyrosine kinase was identified as the receptor for HGF. … The HGF-Met pathway plays important roles in the embryonic development of the liver and the placenta, in the migration of myogenic precursor cells, and in epithelial morphogenesis. …

    J. Gastroenterol. Hepatol. 26(1), 188-202, 2011-01-00

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  • 10

    Vascular Endothelial Growth Factor (VEGF), VEGF Receptors and Their Inhibitors for Antiangiogenic Tumor Therapy

    Takahashi Satoru

    … VEGFR-1 (fms-like tyrosine kinase-1, Flt-1) negatively regulates embryonic vasculogenesis and is involved in tumor angiogenesis via activation of monocytes and macrophages. … VEGFR-2 (KDR in humans or Flk-1 in mice) is predominantly responsible for both embryonic vasculogenesis and tumor angiogenesis. … They neutralize VEGF-A, resulting in prevention of tumor angiogenesis. …

    Biological and Pharmaceutical Bulletin 34(12), 1785-1788, 2011

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  • 11

    An embryo-specific expressing TGF-β family protein, growth-differentiation factor 3 (GDF3), augments progression of B16 melanoma

    Ehira Nobuyuki , Oshiumi Hiroyuki , Matsumoto Misako , Kondo Takeshi , Asaka Masahiro , Seya Tsukasa

    … Malignant tumor cells often express embryonic antigens which share the expression with embryonic stem (ES) cells. … The embryonic antigens are usually encoded by ES cell-specific genes, a number of which are associated with tumorigenesis and/or tumor progression. …

    Journal of Experimental & Clinical Cancer Research 29, 135, 2010-10-15

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  • 12

    The innate immune system in host mice targets cells with allogenic mitochondrial DNA

    Ishikawa Kaori , Toyama-Sorimachi Noriko , Nakada Kazuto , Morimoto Mami , Imanishi Hirotake , Yoshizaki Mariko , Sasawatari Shigemi , Niikura Mamoru , Takenaga Keizo , Yonekawa Hiromichi , Hayashi Jun-Ichi , 中田 和人 , 林 純一

    … We examined this issue by generating trans-mitochondrial tumor cells and embryonic stem cells that shared the syngenic C57BL/6 (B6) strain–derived nuclear DNA background but possessed mtDNA derived from allogenic mouse strains. … These results introduce novel roles of mtDNA and innate immunity in tumor immunology and transplantation medicine. …

    Journal of experimental medicine 207(11), 2297-2305, 2010-10-00

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  • 13

    Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice.

    Chandana Ediriweera P S , Maeda Yasuhiro , Ueda Akihiko , Kiyonari Hiroshi , Oshima Naoko , Yamamoto Mako , Kondo Shunya , Oh Junseo , Takahashi Rei , Yoshida Yoko , Kawashima Satoshi , Alexander David B , Kitayama Hitoshi , Takahashi Chiaki , Tabata Yasuhiko , Matsuzaki Tomoko , Noda Makoto

    … Mice lacking the membrane-anchored metalloproteinase regulator Reck die in utero around embryonic day 10.5 with halted vascular development; …

    BMC developmental biology 10, 2010-08-06

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  • 14

    Involvement of Lgl and Mahjong/VprBP in Cell Competition

    Tamori Yoichiro , Bialucha Carl Uli , Tian Ai-Guo , Kajita Mihoko , Huang Yi-Chun , Norman Mark , Harrison Nicholas , Poulton John , Ivanovitch Kenzo , Disch Lena , Liu Tao , Deng Wu-Min , Fujita Yasuyuki

    … Lgl (lethal giant larvae) is a tumor suppressor protein and plays a crucial role in oncogenesis in flies and mammals. … In Drosophila, Mahjong is an essential gene, but zygotic mahjong mutants (mahj^[-/-]) do not have obvious patterning defects during embryonic or larval development. …

    PLoS Biol. 8(7), e1000422, 2010-07-13

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  • 15

    Bio-Resource of Human and Animal-Derived Cell Materials

    NAKAMURA Yukio

    … Most human cell lines are derived from tumor cells. … In addition, stem cell lines such as embryonic stem (ES) cells and induced pluripotent stem (iPS) cells are of great value in current biology and medical science. …

    Experimental Animals 59(1), 1-7, 2010-01-01

    J-STAGE Ichushi Web CrossRef References (19)

  • 16

    Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells

    Nakamura Kazumasa , Sasajima Junpei , Mizukami Yusuke , Sugiyama Yoshiaki , Yamazaki Madoka , Fujii Rie , Kawamoto Toru , Koizumi Kazuya , Sato Kazuya , Fujiya Mikihiro , Sasaki Katsunori , Tanno Satoshi , Okumura Toshikatsu , Shimizu Norihiko , Kawabe Junichi , Karasaki Hidenori , Kono Toru , Ii Masaaki , Bardeesy Nabeel , Chung Daniel C. , Kohgo Yutaka

    … Recent studies have suggested that the oncogenic function of Hh in PDAC involves signaling in the stromal cells rather than cell autonomous effects on the tumor cells. … Since Hh signaling plays a crucial role during embryonic and postnatal vasculogenesis, we speculated that Hh ligand may act on tumor vasculature specifically focusing on bone marrow (BM)-derived cells. …

    PLoS One 5(1), e8824-1-e8824-11, 2010-01-00

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  • 17

    Effect of Multimerization of a Linear Arg-Gly-Asp Peptide on Integrin Binding Affinity and Specificity

    Jin Zhao-Hui , Furukawa Takako , Waki Atsuo , Akaji Kenichi , Coll Jean-Luc , Saga Tsuneo , Fujibayashi Yasuhisa

    … Using human embryonic kidney HEK293 (naturally αV-positive and β3-negative), HEK293(β1) (β1-transfected and αVβ3-negative), HEK293(β3) (β3-transfected and strongly αVβ3-positive), and human glioblastoma U87MG (naturally αVβ3-positive) cell lines we evaluated their binding affinity and specificity. …

    Biological and Pharmaceutical Bulletin 33(3), 370-378, 2010

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  • 18

    Regenerative medicine of maxillofacial bone using somatic stem cells  [in Japanese]

    YAMADA Yoichi

    … Recently it pays attention to regenerative medicine by the discovery of embryonic stem cells(ES cells)and induced pluripotent stem(iPS)cells. …

    Japanese Journal of Oral and Maxillofacial Surgery 55(11), 532-544, 2009-11-20

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  • 19

    Adenovirus-mediated eukaryotic initiation factor 4E binding protein-1 in combination with rapamycin inhibits tumor growth of pancreatic ductal adenocarcinoma in vivo

    Mishra Roshan , Miyamoto Masaki , Yoshioka Tatsuya , Ishikawa Keidai , Matsumura Yoshiyuki , Shoji Yasuhito , Ichinokawa Kazuomi , Itoh Tommo , Shichinohe Toshiaki , Hirano Satoshi , Kondo Satoshi

    … In the present study, we investigated the frequency of eIF4E, 4E-BP1 and phosphorylated 4E-BP1 expression in PDAC cell lines, gastric carcinoma (GC) cell lines and human embryonic pancreatic cells, as well as gene therapy using translation repressor gene 4E-BP1 in combination with the mTOR inhibitor rapamycin. … Our study revealed that all PDAC cell lines, GC cell lines and human embryonic pancreas-derived cells expressed the 25-kDa eIF4E protein (MIAPaca-2 cells also expressed the 13-kDa protein 4E-BP1). …

    International Journal of Oncology 34(5), 1231-1240, 2009-05-00

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  • 20

    A Case Report of a Cerebellar Neuroblastoma in a p53 Null Mutation Mouse(Pathology)

    AGO Kyohei , SHIBUTANI Makoto , SAEGUSA Yukie , SHIMA Tomomi , TANIAI Eriko , MITSUMORI Kunitoshi

    … Histologically, the tumor consisted of solid growth of round to oval pleomorphic cells with frequent mitotic figures. … While there were no typical cellular arrangements of embryonic neurogenic tumors, such as Homer-Wright rosette, perivascular pseudorosette, or streaming of neoplastic neurocytes, small populations of the neoplastic cells were immunohistochemically positive for synaptophysin, microtubule-associated protein 2, S-100 and nestin. …

    The journal of veterinary medical science 71(3), 345-347, 2009-03-25

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