Search Results:　 1-20 of 912

1

Involvement of autophagy in the pharmacological effects of the mTOR inhibitor everolimus in acute kidney injury.

Nakagawa Shunsaku , Nishihara Kumiko , Inui Ken-Ichi , Masuda Satohiro

… We also found leakage of LC3 protein into rat urine after treatment with everolimus, and urinary LC3 protein was successfully measured between 0.1 and 500ng/mL by using an enzyme-linked immunosorbent assay. … Taken together, our results demonstrated that the induction of autophagy by everolimus aggravates tubular dysfunction during recovery from kidney injury. …

European journal of pharmacology 696(1-3), 143-154, 2012-12-05

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2

Protective action of nipradilol mediated through S-nitrosylation of Keap1 and HO-1 induction in retinal ganglion cells

Koriyama Yoshiki , Kamiya Marie , Takadera Tsuneo , Arai Kunizo , Sugitani Kayo , Ogai Kazuhiro , Kato Satoru

… We also demonstrated that Nip induced the expression of the NO-dependent antioxidant enzyme, heme oxygenase-1 (HO-1). …

Neurochemistry International 61(7), 1242-1253, 2012-12-00

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3

Induction of lymphangiogenesis through vascular endothelial growth factor-C/vascular endothelial growth factor receptor 3 axis and its correlation with lymph node metastasis in nasopharyngeal carcinoma

Wakisaka Naohiro , Hirota Kyoko , Kondo Satoru , Sawada-Kitamura Seiko , Endo Kazuhira , Murono Shigeyuki , Yoshizaki Tomokazu

… The VEGF-C induction by LMP1 was then tested with Western blotting and enzyme-linked immunosorbent assay in vitro. … Induction of VEGF-C protein by LMP1 was not detected in vitro. … These results suggest the involvement of the VEGF-C/VEGFR3 axis in the induction of lymphangiogenesis which results in lymphatic spread of NPC. …

Oral Oncology 48(8), 703-708, 2012-08-00

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4

Induction of lymphangiogenesis through vascular endothelial growth factor-C/vascular endothelial growth factor receptor 3 axis and its correlation with lymph node metastasis in nasopharyngeal carcinoma

Wakisaka Naohiro , Hirota Kyoko , Kondo Satoru , Sawada-Kitamura Seiko , Endo Kazuhira , Murono Shigeyuki , Yoshizaki Tomokazu

… The VEGF-C induction by LMP1 was then tested with Western blotting and enzyme-linked immunosorbent assay in vitro. … Induction of VEGF-C protein by LMP1 was not detected in vitro. … These results suggest the involvement of the VEGF-C/VEGFR3 axis in the induction of lymphangiogenesis which results in lymphatic spread of NPC. …

Oral Oncology 48(8), 703-708, 2012-08-00

IR CrossRef
5

Development of transgenic plants in jatropha with drought tolerance

TSUCHIMOTO Suguru , CARTAGENA Joyce , KHEMKLADNGOEN Naruemon , SINGKARAVANIT Suthitar , KOHINATA Tsutomu , WADA Naoki , SAKAI Hiroe , MORISHITA Yoshihiko , SUZUKI Hideyuki , SHIBATA Daisuke , FUKUI Kiichi

… Although we previously reported a transformation method, which involves wounding of tissue explants in order to increase the chance of Agrobacterium infection, for jatropha, it remains a challenge to enhance the shoot regeneration and root induction processes. … The first one overexpresses the PPAT gene, which encodes an enzyme that catalyzes the CoA biosynthetic pathway; …

Plant Biotechnology 29(2), 137-143, 2012-06-25

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6

Isolation of a novel alkaline-induced laccase from Flammulina velutipes and its application for hair coloring(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)

(Otsuka)Saito Kaori , Ikeda Ryuzo , Endo Katsunori , Tsujino Yoshio , Takagi Masahiro , Tamiya Eiichi

… In this study, we isolated a novel alkaline-induced laccase from the white-rot fungus Flammulina velutipes and studied the possibility to apply the enzyme for hair coloring. … velutipes might be a useful enzyme for hair color. …

Journal of bioscience and bioengineering 113(5), 575-579, 2012-05-00

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7

Urotensin II Stimulates Vascular Endothelial Growth Factor Secretion From Adventitial Fibroblasts in Synergy With Angiotensin II

SONG Nana , DING Wenhui , CHU Songyun , ZHAO Jing , DONG Xiao , DI Beibing , TANG Chaoshu

… The VEGF expression was evaluated using enzyme-linked immunosorbent assay (ELISA), while the proliferation and collagen I synthesis were detected using methyl thiazol tetrazolium (MTT) assay and ELISA. … Induction of VEGF expression may be a new mechanism involved in vascular remodeling for UII and Ang II. …

Circulation Journal 76(5), 1267-1273, 2012-04-25

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8

BUTYRATE REDUCES FREE CHOLESTEROL ACCUMULATION IN NIEMANN-PICK DISEASE TYPE C1 CELLS (NOVA SCOTIA FORM) THROUGH THE INDUCTION OF ACID SPHINGOMYELINASE

Oyama Chikako , Hirayama Masashi , Noguchi Atsuko , Arai Hirokazu , Takahashi Tsutomu

… Acid sphingomyelinase (ASM) is a lysosomal enzyme in which an inherited deficiency leads to Niemann-Pick disease types A and B (NPDA/NPDB). …

Akita journal of medicine 38(3-4), 111-119, 2012-03-00

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9

Induction of phase ？ detoxification enzymes by oral administration of lenthionine, a flavor component from shiitake mushrooms [in Japanese]

片山倫陽 , 赤尾真 , 熊谷日登美

Aroma research = アロマリサーチ : journal of aroma science technology and safety 13(4), 374-378, 2012-00-00
10

Differentiation of Monkey Embryonic Stem Cells to Hepatocytes by Feeder-free Dispersion Culture and Expression Analyses of Cytochrome P450 Enzymes Responsible for Drug Metabolism

Maruyama Junya , Matsunaga Tamihide , Yamaori Satoshi , Sakamoto Sakae , Kamada Noboru , Nakamura Katsunori , Kikuchi Shinji , Ohmori Shigeru

… A previous study demonstrated the effectiveness of the Rho-associated kinase inhibitor Y-27632 for feeder-free dispersion culture and induction of differentiation of monkey ESCs into neural cells. … In the present study, the induction of differentiation of cynomolgus monkey ESCs (cmESCs) into hepatocytes was performed by the dispersion culture method, and the expression and drug inducibility of cytochrome P450 (CYP) enzymes in these hepatocytes were examined. …

Biological and Pharmaceutical Bulletin, 2012

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11

Hydroxyl Radical (·OH) Played a Pivotal Role in Oridonin-Induced Apoptosis and Autophagy in Human Epidermoid Carcinoma A431 Cells

Yu Yang , Fan Si Miao , Song Jun Ke , Tashiro Shin-ichi , Onodera Satoshi , Ikejima Takashi

… Reactive oxygen species (ROS) played a pivotal role in induction of cytotoxicity. … To further examine the mechanism of ROS, exogenous enzyme antioxidants (superoxide dismutase (SOD), catalase (CAT)) and non-enzyme antioxidants (glutathione (GSH)) were applied to detect the effect of oridonin on ROS generation. …

Biological and Pharmaceutical Bulletin 35(12), 2148-2159, 2012

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12

Antihypertensive Effects of Unripe Persimmon (Diospyros kaki L. cv. Hiratanenashi) Fruit and Its Component in Spontaneously Hypertensive Rats

LIU Chinfang , KURAKANE Shizue , TAKITA Jun , ITANO Ruriko , SOGA Tomoyoshi , OIKAWA Akira , IGARASHI Kiharu

… Increases in serum nitric oxide level and liver NOS3 gene expression in SHR fed PP suggests that the induction of nitric oxide formation by PP administration might be involved in decreasing SBP. … The decrease in ACE activity by PST administration suggests that, as a component of PP, PST mainly lowers SBP through its angiotensin I-converting enzyme (ACE) inhibitory effect. …

Food Science and Technology Research 18(3), 391-398, 2012

J-STAGE CrossRef
13

Apigenin Attenuates 2-Deoxy-D-ribose-Induced Oxidative Cell Damage in HIT-T15 Pancreatic .BETA.-Cells

Suh Kwang Sik , Oh Seungjoon , Woo Jeong-Taek , Kim Sung-Woon , Kim Jin-Woo , Kim Young Seol , Chon Suk

… Time- and dose-dependent cell viability was monitored using a cell counting kit (CCK-8), while the induction of apoptosis was analyzed using a cell death enzyme-linked immunosorbent assay (ELISA) kit. …

Biological and Pharmaceutical Bulletin 35(1), 121-126, 2012

J-STAGE Ichushi Web CrossRef
14

Establishment of a Stable Human Cell Line, HPL-A3, for Use in Reporter Gene Assays of Cytochrome P450 3A Inducers

Sekimoto Masashi , Sano Shinsuke , Hosaka Takuomi , Nemoto Kiyomitsu , Degawa Masakuni

… The induction of CALUX in HPL-A3 by hPXR activators, including rifampicin, occurred in time- and concentration-dependent fashions, whereas no such induction was observed using rat/mouse PXR activators, such as pregnenolone-16α-carbonitrile and dexamethasone. … The hPXR activator-mediated induction of CYP3As, especially CYP3A4, was observed at levels of both mRNA and enzyme activity. …

Biological and Pharmaceutical Bulletin 35(5), 677-685, 2012

J-STAGE Ichushi Web CrossRef
15

GP-1447, an Inhibitor of Aldose Reductase, Prevents the Progression of Diabetic Cataract in Rats

Kawakubo Ken , Mori Asami , Sakamoto Kenji , Nakahara Tsutomu , Ishii Kunio

… GP-1447 is an inhibitor of aldose reductase, which is the first enzyme in the polyol pathway. … Cataracts in the central region of the lens were observed in 7 of 14 eyes (50%) by the fifth week after induction of diabetes, and development of mature cataracts was observed in most lenses by the ninth week. … In diabetic rats that received GP-1447 treatment beginning in the fifth week after induction of diabetes, progression of cataracts was observed for 1 week after initiation of treatment. …

Biological and Pharmaceutical Bulletin 35(6), 866-872, 2012

J-STAGE Ichushi Web CrossRef
16

Propolis Suppresses CdCl2-Induced Cytotoxicity of COS7 Cells through the Prevention of Intracellular Reactive Oxygen Species Accumulation

Kamiya Tetsuro , Izumi Misato , Hara Hirokazu , Adachi Tetsuo

… Propolis extracts not only showed superoxide dismutase and antioxidative activities, but also increased the expression of heme oxygenase-1 (HO-1), an antioxidative enzyme. … Moreover, we determined the involvement of hypoxia inducible factor-1α in propolis extract-derived HO-1 induction. …

Biological and Pharmaceutical Bulletin 35(7), 1126-1131, 2012

J-STAGE CrossRef
17

The Possible Use of Zinc Ions for Anti-pigmentation and Anti-wrinkling Skin Care

Masaki Hitoshi

… Zn2+ is well-known as an inducer of MT (metallothionein) and γGCS (γ-glutamyl cysteinyl synthetase: a rate-limiting enzyme of glutathione synthesis) via the up-regulation of their mRNAs through a metal transcription factor. … Among the complexes tested, we found a superior induction by a Zn2+ glycine complex, Zn(Gly)2. …

YAKUGAKU ZASSHI 132(3), 261-269, 2012

J-STAGE Ichushi Web CrossRef
18

The Release of EGF Domain from EGF-like Factors by a Specific Cleavage Enzyme Activates the EGFR-MAPK3/1 Pathway in Both Granulosa Cells and Cumulus Cells During the Ovulation Process

YAMASHITA Yasuhisa , SHIMADA Masayuki

… EGF-like factors are composed of a signal sequence, transmembrane domain and EGF domain, suggesting that release of the EGF domain by a specific enzyme is essential for interaction with the EGFR to induce the ovulation process. … In our studies, TACE/ADAM17, which is known to be a proteolytic enzyme of EGF-like factors in many types of tissue, was found to be expressed in FSH/LH-stimulated granulosa cells and cumulus cells together with activation of the EGFR-MAPK3/1 pathway. …

Journal of Reproduction and Development 58(5), 510-514, 2012

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19

Secretory expression of human proteins in Pichia pastoris : Production of midkine, pleiotrophin, and bile salt-stimulated lipase in controlled fermentor [in Japanese]

Murasugi Akira

メタノール資化性酵母,ピキア酵母(Pichia pastoris)の異種タンパク質発現系は,現在ではいろいろなタンパク質の発現に広く使用されている.目的タンパク質を分泌することができる組換えピキア酵母細胞の高密度培養により,大量の目的タンパク質の,培地中への効率的な発現を達成できる可能性がある.筆者らは,このシステムを用いて,組換えピキア酵母の高密度培養により,3種のヒトタンパク質,サイトカイン( …

Seibutsu-kogaku Kaishi 89(10), 570-583, 2011-10-25

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20

Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-1

ASHINO Takashi , SUGIUCHI Jinko , UEHARA Junna , NAITO YAMAMOTO Yumiko , KENMOTSU Sachiyo , IWAKURA Yoichiro , SHIODA Seiji , NUMAZAWA Satoshi , YOSHIDA Takemi

… Concurrently, overexpression of heme oxygenase-1 (HO-1), a rate-limiting enzyme for heme degradation and an oxidative stress marker, was identified at the edges of cocaine-mediated necrotic area. …

The Journal of Toxicological Sciences 36(5), 635-643, 2011-10-01

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