Search Results:　 1-20 of 14722

1

Purification and Some Properties of Superoxide Dismutase from Pilei of Lentinus edodes Fruiting Bodies [in Japanese]

Masako FUWA , Keiichi IKEDA , Hiroaki KAWASAKI , Fumiyuki YAMAKURA , Hikari TAKA , Reiko MINEKI , Tsutomu FUJIMURA , Takashi MATSUMOTO

… Metal analysis of the native enzymes revealed 0.64g-atoms Mn per mole subunit in the preparations whose specific activity were 3500U/mg. …

學苑 854, 1-9, 2011-12-01

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2

α-Lipoic acid (LA) enantiomers protect SH-SY5Y cells against glutathione depletion

Yamada Takashi , Hashida Koji , Takarada-Iemata Mika , Matsugo Seiichi , Hori Osamu

… Although direct effects of LA on glutathione depletion or generation of the reactive oxygen species (ROS) were relatively small upon BSO treatment, LA enhanced expressions of anti-oxidative genes such as heme oxygenase-1 (HO-1) and phase II detoxification enzymes such as NAD(P)H:Quinone Oxidoreductase 1 (NQO1). … Our results suggest an important role of PI3K/Akt-mediated upregulation of genes including phase II enzymes such as NQO1 in LA-mediated neuroprotection. …

Neurochemistry International 59(7), 1003-1009, 2011-12

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3

Sulfation of glucuronic acid in the linkage tetrasaccharide by HNK-1 sulfotransferase is an inhibitory signal for the expression of a chondroitin sulfate chain on thrombomodulin.

Nakagawa Naoki , Izumikawa Tomomi , Kitagawa Hiroshi , Oka Shogo

… Moreover, using an in vitro enzyme assay system, the HNK-1-positive TM was found not to be utilized as a substrate for CS-polymerizing enzymes (chondroitin synthase (ChSy) and chondroitin polymerizing factor (ChPF)). …

Biochemical and biophysical research communications 415(1), 109-113, 2011-11-11

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4

Protective role of Nrf2 in age-related hearing loss and gentamicin ototoxicity

Hoshino Tomofumi , Tabuchi Keiji , Nishimura Bungo , Tanaka Shuho , Nakayama Masahiro , Ishii Tetsuro , Warabi Eiji , Yanagawa Toru , Shimizu Ritsuku , Yamamoto Masayuki , Hara Akira , 星野朝文 , 田渕経司 , 西村文吾 , 石井哲郎 , 蕨栄治 , 柳川徹 , 原晃

… Expression of antioxidant enzymes is regulated by transcription factor NF-E2-related factor (Nrf2) andinduced by oxidative stress. … The present findingsindicate that Nrf2 protects the inner ear against age-related hearing injuries and gentamicin ototoxicityby up-regulating antioxidant enzymes and detoxifying proteins. …

Biochemical and biophysical research communications 415(1), 94-98, 2011-11

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5

Cell surface expression and internalization of the murine erythroid AE1 anion exchanger tagged with an extracellular FLAG epitope

Wang Chen-Chi , Sato Kota , Otsuka Yayoi , Inaba Mutsumi

… These data demonstrate that the processing of N-glycan is not aprerequisite to cell surface expression of AE1 and suggest that the FLAG tag insertionaltered the accessibility of the N-glycan to enzymes in the Golgi which facilitate processingof oligosaccharides. …

Japanese Journal of Veterinary Research 59(4), 157-164, 2011-11

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6

Structures of Burkholderia thailandensis nucleoside kinase : implications for the catalytic mechanism and nucleoside selectivity

Yasutake Yoshiaki , Ota Hiroko , Hino Emisa , Sakasegawa Shin-ichi , Tamura Tomohiro

… The typical homodimeric architecture of Pfk-B enzymes was detected in three distinct conformational states: an asymmetric dimer with one subunit in an open conformation and the other in a closed conformation (the ligand-free form), a closed conformation (the binary complex with INO) and a fully closed conformation (the other ternary and quaternary complexes). … These findings provide insight into the conformational dynamics, catalytic mechanism and nucleoside selectivity of BthNK and related enzymes. …

Acta Crystallographica Section D, Biological Crystallography 67(11), 945-956, 2011-11

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7

Light-Induced Conformational Changes in Full-Length Arabidopsis thaliana Cryptochrome.

Kondoh Masato , Shiraishi Chiaki , Müller Pavel , Ahmad Margaret , Hitomi Kenichi , Getzoff Elizabeth D , Terazima Masahide

… Cryptochromes (CRYs) are widespread flavoproteins with homology to photolyases (PHRs), a class of blue-light-activated DNA repair enzymes. …

Journal of molecular biology 413(1), 128-137, 2011-10-14

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8

cDNA cloning of an alginate lyase from a marine gastropod Aplysia kurodai and assessment of catalytically important residues of this enzyme.

Rahman Mohammad Matiur , Inoue Akira , Tanaka Hiroyuki , Ojima Takao

… To date alginate lyases from Haliotidae species such as abalone have been well characterized and the primary structure analyses have classified abalone enzymes into polysaccharide-lyase-family 14 (PL-14). … However, other gastropod enzymes have not been so well investigated and only partial amino-acid sequences are currently available. …

Biochimie 93(10), 1720-1730, 2011-10

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9

Yeast Methylotrophy and Autophagy in a Methanol-Oscillating Environment on Growing Arabidopsis thaliana Leaves

Kawaguchi Kosuke , Yurimoto Hiroya , Oku Masahide , Sakai Yasuyoshi

… Among the C1-metabolicenzymes, enzymes in the methanol assimilation pathway, but not formaldehyde dissimilation or anti-oxidizing enzymes,were necessary for yeast proliferation at the phyllosphere. …

PLoS ONE 6(9), e25257, 2011-09-26

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10

Pachastrissamine (jaspine B) and its stereoisomers inhibit sphingosine kinases and atypical protein kinase C.

Yoshimitsu Yuji , Oishi Shinya , Miyagaki Jun , Inuki Shinsuke , Ohno Hiroaki , Fujii Nobutaka

… Sphingosine kinases (SphKs) are oncogenic enzymes that regulate the critical balance between ceramide and sphingosine-1-phosphate. … Much effort has been dedicated to develop inhibitors against these enzymes. …

Bioorganic & medicinal chemistry 19(18), 5402-5408, 2011-09-15

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11

Prediction of EC Numbers for Enzymatic Reactions Using Mutual Information and Support Vector Machine [in Japanese]

Yoshihiko Matsuta , Masahiro Ito , Yukako Tohsato

EC 番号は酵素反応を分類するための階層的なシステムであり,酵素活性の予測や反応の類似性の指標として用いられる.しかしながら,EC 番号は酵素活性から,手動で割り当てられるため,反応によっては不完全あるいは全く割り当てがなされていないものもある.そこで,本研究では MCS アルゴリズムと相互情報量を用いた EC 番号の推定方法を提案し,さらに機械学習ならびに相関係数で妥当な EC 番号を推定した. …

IPSJ SIG technical reports 2011-BIO-26(7), 1-6, 2011-09-06

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12

Traffic Jams Reduce Hydrolytic Efficiency of Cellulase on Cellulose Surface

Igarashi Kiyohiko , Uchihashi Takayuki , Koivula Anu , Wada Masahisa , Kimura Satoshi , Okamoto Tetsuaki , Penttilä Merja , Ando Toshio , Samejima Masahiro

… We report here the real-timevisualization of crystalline cellulose degradation by individual cellulase enzymes usingan advanced version of high-speed atomic force microscopy. … Cellulose was completely degraded by thesynergistic action between the two enzymes. …

Science 333(6047), 1279-1282, 2011-09-02

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13

Effect of Endoplasmic Reticulum Stress on Laccase Production and the 26S Proteasome Activity in the White Rot Fungus Trametes versicolor

Staszczak Magdalena , Sajewicz Joannna , Ohga Shoji , 大賀祥治

… It degrades many important proteins involved in signal transduction, cell cycle progression, and in general metabolism, including key metabolic enzymes and transcription factors. …

Journal of the Faculty of Agriculture, Kyushu University 56(2), 205-211, 2011-09

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14

Oxidative Stress and Mitochondrial Dysfunction in Neurovascular Injury after Stroke(<SPECIAL ISSUE>Neuroscience for the Development of Neurosurgery in the Near Futre)

Yoshioka Hideyuki , Sakata Hiroyuki , Okami Nobuya , Kinouchi Hiroyuki , Chan Pak H.

… Our neurovascular protective strategies targeting these two enzymes may expand the therapeutic window of the currently approved therapies. …

Japanese journal of neurosurgery 20(8), 559-565, 2011-08-20

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15

Nuclear translocation of glutathione S-transferase π is mediated by a non-classical localization signal.

Kawakatsu Miho , Goto Shinji , Yoshida Takako , Urata Yoshishige , Li Tao-Sheng

… Glutathione S-transferase π (GSTπ), a member of the GST family of multifunctional enzymes, is highly expressed in human placenta and involved in the protection of cellular components against electrophilic compounds or oxidative stress. …

Biochemical and Biophysical Research Communications 411(4), 745-750, 2011-08-12

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16

3-13-4 Reuse of residual enzymes in the solid residue after enzymatic hydrolysis [in Japanese]

HASEGAWA Fumio , INOUE Hiroyuki , YANO Shinichi , YOKOYAMA Shinya , IMOU Kenji

… In this work we evaluated the effect of reuse of residual enzymes in the solid residue after enzymatic hydrolysis. … The amount of enzyme consumption per gram glucose decreased to about half by the reuse of residual enzymes in the solid residue. …

日本エネルギー学会大会講演要旨集 (20), 160-161, 2011-08-09

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17

3-13-3 Simulation for the Optimal Condition of Enzymatic Saccharification in Bioethanol Production [in Japanese]

KUROSAWA Miyuki , KOKUBO Miki , SEKINO Hideo , IGARASHI Kiyohiko , SAMEJIMA Masahiro

… To achieve the reduction of enzyme cost for ethanol production from cellulosic biomass, improvement of three technologies, i) Low-cost production of enzymes, ii) Optimization of enzyme cocktail for saccharification, and iii) Recycle and/or reuse of enzymes, are quite important. …

日本エネルギー学会大会講演要旨集 (20), 158-159, 2011-08-09

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18

Sex steroid-metabolizing enzymes in the rodent olfactory mucosa [in Japanese]

Horie Sawa , 高見茂

嗅覚系が性ステロイドの影響を受けていることは以前から知られているが、その細胞生物学的基盤については不明な点が多い。そこで我々は、嗅覚系における性ステロイドの生理作用を解明することを最終目的として、齧歯類のラットを研究対象として、ステロイド代謝酵素のうち、ステロイド側鎖切断酵素(P450scc)、17β-水酸基脱水素酵素タイプ1(17β-HSD-1)、タイプ2(17β-HSD-2)、芳香化酵素(ar …

The Japanese journal of taste and smell research 18(2), 133-138, 2011-08

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19

Studies of enzymes in the senescence of the Lentinula edodes fruiting body after harvesting [in Japanese]

SAKAMOTO Yuichi

シイタケ子実体は,収穫直後から急激に子実体の褐変化や軟化といった老化現象が起こる.子実体の老化は,シイタケの品質の著しい低下を引き起こす.本論文ではこれまで著者の所属する研究センターで行ってきた収穫後の老化に関わる酵素の研究を中心に,収穫後の子実体の老化のメカニズムを紹介する.きのこの子実体の着色には,ラッカーゼやチロシナーゼといった,フェノールオキシダーゼ類が関与していると考えられている.シイタ …

Mushroom science and biotechology 19(2), 73-78, 2011-07-31

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20

A case of Mediastinal Mature Teratoma Complicated by Empyema Due to Rupture into the Pleural Cavity [in Japanese]

Yoshihiko Ikeno/ Ikuo Akutsu/ Kazuhiko Hagane/ Kazuki Mashio/ Hiroyuki Sakio/Fumito Omi/ Takeshi Hirabayashi/ Akihiro Fujino/ Kumiya Sugiyama/ Yasutugu Fukusima/ Yoshiki Ishii/ Takeshi Fukuda

症例は16 歳女性,咳嗽,発熱,左前胸部痛を主訴に来院.胸部CT にて内部不均一な径7 cm の前縦隔腫瘍及び左舌区・下葉の完全無気肺を確認,また,MRI にて前縦隔腫瘍内に脂肪組織と同一の吸収域を認め,成熟型奇形腫穿破による膿胸と診断.膿胸に対し胸腔内繊維素溶解療法,ドレナージ及び抗生剤にて加療,膿胸改善を確認した上で,前縦隔腫瘍摘出術施行,病理にて嚢胞性成熟型奇形腫と診断した.病理組織にて膵類 …

Dokkyo journal of medical sciences 38(2), 171-177, 2011-07-25

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