Search Results:　 1-20 of 283

1

The Influence of Intracellular Epidermal Growth Factor Receptor (EGFR) Signal Activation on the Outcome of EGFR Tyrosine Kinase Inhibitor Treatment for Pulmonary Adenocarcinoma

KAWANO DAIGO , YANO TOKUJIRO , SHOJI FUMIHIRO , ITO KENSAKU , MORODOMI YOSUKE , HARO AKIRA , MIURA NAOKO , TAKENAKA TOMOYOSHI , YOSHINO ICHIRO , MAEHARA YOSHIHIKO

Surgery today : the Japanese journal of surgery 41(6), 818-823, 2011-06-01

Ichushi Web References (25)
2

Inhibition of E-Cadherin Dependent Cell-Cell Contact Promotes MUC5AC Mucin Production through the Activation of Epidermal Growth Factor Receptors

IWASHITA Jun , OSE Kyohei , ITO Hiroki , MURATA Jun , ABE Tatsuya

… Mucin production by epithelial cells is modulated by many soluble factors, including epidermal growth factor (EGF). … E-Cadherin promotes EGF receptor (EGFR)-mediated MUC5AC mucin production in airway epithelial cells in dense cultures, suggesting the involvement of E-cadherin in activating EGFRs and mucin production. …

Bioscience, Biotechnology, and Biochemistry 75(4), 688-693, 2011-04-23

J-STAGE Ichushi Web CrossRef References (21)
3

Phase II Study of Gefitinib Readministration in Patients with Advanced Non-Small Cell Lung Cancer and Previous Response to Gefitinib

Asahina Hajime , Oizumi Satoshi , Inoue Akira , Kinoshita Ichiro , Ishida Takashi , Fujita Yuka , Sukoh Noriaki , Harada Masao , Maemondo Makoto , Saijo Yasuo , Dosaka-Akita Hirotoshi , Isobe Hiroshi , Nukiwa Toshihiro , Nishimura Masaharu

Objective: Salvage treatment for acquired resistance to gefitinib has yet to be developed. We conducted the first prospective phase II study of gefitinib readministration in previous gefitinib respond …

Oncology : International Journal for Cancer Research and Treatment 79(5-6), 423-429, 2011-04

IR CrossRef
4

Activation of epidermal growth factor receptor signaling by the prostaglandin E2 receptor EP4 pathway during gastric tumorigenesis

Oshima Hiroko , Popivanova Boryana K. , Oguma Keisuke , Kong Dan , Ishikawa Tomoo , Oshima Masanobu

… It has been shown by in vitro studies that PGE2 signaling transactivates epidermal growth factor receptor (EGFR) through an intracellular mechanism. … However, the mechanisms underlying PGE2-induced EGFR activation in in vivo tumors are still not fully understood. …

Cancer Science 102(4), 713-719, 2011-04

IR CrossRef
5

Reversion-inducing cysteine-rich protein with Kazal motifs interferes with epidermal growth factor receptor signaling

Kitajima Shunsuke , Miki T. , Takegami Yujiro , Kido Y. , Noda M. , Hara Eiji , Shamma Awad , Takahashi Chiaki

… In contrast, short hairpin RNA-mediated depletion of RECK induced irreversible growth arrest along with several features of the Arf, Trp53 and Cdkn1a-dependent cellular senescence. … In addition, we observed that epidermal growth factor receptor (EGFR) activity was transiently upregulated by RECK depletion in MEFs, and continuously downregulated by RECK overexpression in colon cancer cells. …

Oncogene 30(6), 737-750, 2011-02-10

IR CrossRef
6

Serum levels of surfactant protein D predict the anti-tumor activity of gefitinib in patients with advanced non-small cell lung cancer.

Yamaguchi Hiroyuki , Soda Hiroshi , Nakamura Yoichi , Takasu Mineyo , Tomonaga Nanae , Nakano Hirofumi , Doi Seiji , Nakatomi Katsumi , Nagashima Seiji , Takatani Hiroshi , Fukuda Minoru , Hayashi Tomayoshi , Tsukamoto Kazuhiro , Kohno Shigeru

… PURPOSE: Gefitinib is an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that has dramatic effects in selective patients with non-small cell lung cancer (NSCLC). … In addition, EGFR mutations were analyzed in 24 patients. … EGFR mutation analysis of 24 patients showed that 16 patients had exon 19 deletion and/or exon 21 point mutations. …

Cancer chemotherapy and pharmacology 67(2), 331-338, 2011-02

IR
7

A Case of Pulmonary Adenocarcinoma with Mutated EGFR Detected by EBUS-TBNA in an Elderly Patient with Poor Performance Status [in Japanese]

Minami Daisuke , Kiura Katsuyuki , Takigawa Nagio , Hotta Katsuyuki , Murakami Toshi , Takata Saburo , Taniguchi Akihiko , Ozaki Saeko , Tanaka Hisaaki , Ichihara Eiki , Tabata Masahiro , Tanimoto Mitsune

… 断を得た.同時に採取された検体にてEGFR遺伝子変異検索を行いexon21の点突然変異(L858R)を認めた.骨転移巣に対する放射線照射後にゲフィチニブの投与を開始したところ,治療開始後より腰痛は改善し,最良総合効果はSDで6カ月後の時点で明らかな病勢増悪を認めていない.結論.EBUS-TBNAは肺門部原発病変へのアプローチにも有用であり,かつ得られた組織検体を用いてEGFR遺伝子変異検索を行うことで,適切な …

The journal of the Japan Society for Bronchology 33(1), 53-56, 2011-01-25

CiNii Fulltext PDF - Open Access Ichushi Web References (9)
8

Immunohistochemical expression of epidermal growth factor receptor in breast cancer

NOZOE Tadahiro , MORI Emiko , IGUCHI Tomohiro , EGASHIRA Akinori , ADACHI Eisuke , MATSUKUMA Akito , EZAKI Takahiro

Breast cancer : the journal of the Japanese Breast Cancer Society 18(1), 37-41, 2011-01-01

Ichushi Web References (22)
9

Molecular markers and targeted therapy in non-small cell lung cancer: the role of epidermal growth factor receptor mutation and EML4-ALK fusion-type oncogene [in Japanese]

山口葉子 , 後藤功一

最新医学 66(9), 1929-1937, 2011-09

Ichushi Web
10

A role of airway mucus-secreting cells in onset and severity of asthma [in Japanese]

武山廉 , 玉置淳

Clinical immunology & allergology 56(2), 183-188, 2011-08

Ichushi Web
11

EGFR-TKI as first-line therapy for advanced non-small-cell lung cancer with EGFR mutations [in Japanese]

軒原浩

Clinical oncology 7(6), 505-513, 2011-06

Ichushi Web
12

Treatment strategy for non-small cell lung cancer on gene profile [in Japanese]

平井文彦 , 瀬戸貴司

Respiratory medicine 19(4), 300-305, 2011-04

Ichushi Web
13

Detection of Epidermal Growth Factor Receptor Mutations in Circulating Tumor Cells in Blood Specimens in Non-Small Cell Lung Cancer

Isobe Kazutoshi , Hata Yoshinobu , Sato Keita , Sano Go , Sugino Keishi , Sakamoto Susumu , Takai Yujiro , Homma Sakae

… systemを用いた末梢血液中の循環腫瘍細胞（circulating tumor cells：CTCs）から上皮成長因子受容体（epidermal growth factor receptor：EGFR ）遺伝子変異が検出可能か否かを明らかにする．方法．原発巣においてEGFR 遺伝子変異陽性が確認されている進行期肺腺癌10例の末梢血液検体から，CellSearch® …

Haigan 51(6), 689-693, 2011

J-STAGE CrossRef
14

Two Lung Adenocarcinomas in the Same Lobe: Multiple Primaries or Intrapulmonary Metastasis?

Yoshimoto Kentaro , Yoshida Junji , Ishii Genichiro , Nishimura Mitsuyo , Hishida Tomoyuki , Nagai Kanji

… Epidermal growth factor receptor gene mutations were examined, and the 2 lesions shared an L858R mutation. … Although we expected EGFR gene mutation analysis would help us distinguish the 2 lesions from each other, it was of little help. …

Annals of Thoracic and Cardiovascular Surgery advpub(0), 1107220052, 2011

J-STAGE CrossRef
15

Continuous treatment with EGFR-TKI in the terminal stage for non-small cell lung cancer patients who initially responded to EGFR-TKI

Miyamoto Shingo , Okuma Yusuke , Takagi Yusuke , Shimokawa Tsuneo , Shimokawa Yukio , Iguchi Mari , Okamura Tatsuru , Shibuya Masahiko

… 【目的】非小細胞肺がんに対する終末期epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI)継続投与の意義を検討した. …

Palliative Care Research 6(1), 119-125, 2011

J-STAGE CrossRef
16

An Autopsied Case of Lung Cancer Which Simultaneously Expressed L858R and T790M Mutations Before Gefitinib Therapy

Tokuhashi Fumiko , Sakaguchi Shinji , Isobe Kazutoshi , Sugino Keishi , Hatori Tsutomu , Homma Sakae

… 背景．ゲフィチニブ投与前にEGFR耐性遺伝子変異を認めることは極めて稀である．症例．64歳，男性．血痰・背部痛を主訴に近医受診．胸部CTで右下葉の腫瘤影を指摘され当院紹介受診となった．精査の結果，右下葉原発非小細胞癌cT2aN2M1b（OSS，BRA），stage IVと診断した．気管支洗浄液のEGFR遺伝子変異の検索でエクソン21のL858Rおよびエクソン20のT790Mを認めた．PS低下のため初回治療でゲフィチニブを投 …

Haigan 51(2), 84-88, 2011

J-STAGE Ichushi Web CrossRef
17

A Case of Advanced Lung Adenocarcinoma with Paranasal Sinus Metastases, in Which Gefitinib Was Effective as First-line Therapy and Cyberknife® Was Efficacious for Local Control

Honda Takeshi , Saito Haruhiro , Murakami Shuji , Hasegawa Chikako , Isobe Takeshi , Yamada Kouzo

… した．また，上皮成長因子受容体（EGFR）遺伝子変異（exon 21 point mutation）が陽性であったため，初回化学療法としてゲフィチニブ内服治療を行い，病巣は12ヶ月間にわたり制御されていた．その後，骨転移が進行したためエルロチニブに変更し，治療開始20ヶ月後の現在も，担癌生存中である．結論．肺癌の副鼻腔転移は，一般的に予後が不良である．しかし，EGFR遺伝子変異が陽性の症例の場合，初 …

Haigan 51(1), 5-10, 2011

J-STAGE Ichushi Web CrossRef
18

Malignant Pleural Effusion from Lung Adenocarcinoma Treated by Gefitinib

Kubo Akihito , Koh Yasuhiro , Kawaguchi Tomoya , Isa Shun-Ichi , Okamoto Isamu , Fukuoka Junya , Kusunoki Yoko , Kitaichi Masanori , Takada Minoru , Nakagawa Kazuhiko

… Small molecule inhibitors targeting epidermal growth factor receptor (EGFR) are known to be active against non-small cell lung cancer (NSCLC) although the pharmacodynamics of these agents on malignant pleural effusion (MPE) remains unclear. …

Internal Medicine 50(7), 745-748, 2011

J-STAGE CrossRef
19

The 2009 Okayama Medical Association Awards: Effects of vandetanib on lung adenocarcinoma cells harboring epidermal growth factor receptor T790M mutation in vivo [in Japanese]

市原英基 , 大橋圭明 , 瀧川奈義夫 [他]

Journal of Okayama Medical Association 123(1), 13-18, 2011-04

IR Ichushi Web CrossRef
20

Overexpression of Transglutaminase in the Drosophila Wing Imaginal Disc Induced an Extra Wing Crossvein Phenotype

ICHIKAWA Akira , YAMADA Ayako , SAKAMOTO Harunobu , UMEHARA Masaru , YOSHIOKA Yasuhide , YAMAGUCHI Masamitsu , IKURA Koji

… This phenotype was suppressed by crossing with epidermal growth factor receptor (Egfr) signaling pathway mutant flies. … These results indicate that this phenotype, induced by dTG-A, is related to enhancement of the Egfr signaling pathway. …

Bioscience, Biotechnology, and Biochemistry 74(12), 2494-2496, 2010-12-23

J-STAGE CrossRef References (15) Cited by (1)

Search Results:　 1-20 of 283

Related Authors

Related Journals

Search Results: 1-20 of 283

Related Authors

Related Journals

Search Results:　 1-20 of 283