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  • PET/CT scanning with 3D acquisition is feasible for quantifying myocardial blood flow when diagnosing coronary artery disease

    Manabe Osamu , Naya Masanao , Aikawa Tadao , Obara Masahiko , Magota Keiichi , Kroenke Markus , Oyama-Manabe Noriko , Hirata Kenji , Shinyama Daiki , Katoh Chietsugu , Tamaki Nagara

    … Background: The quantification of myocardial blood flow (MBF) and coronary flow reserve (CFR) are useful approaches for evaluating the functional severity of coronary artery disease (CAD). … We conducted this study to evaluate the diagnostic potential of MBF measurements using PET/CT for a comparison of a control group and patients suspected of having CAD. … Conclusions: 15O-water PET/CT with 3D data acquisition can be reliably used for the quantification of functional MBF and CFR in CAD patients. …

    EJNMMI research 7, 52, 2017-06-05

    機関リポジトリ DOI

  • Functional Vascular Anatomy of the Brain

    TANAKA Michihiro

    … <p>Functional vascular anatomy is the study of anatomy in its relation to the function that figures out the normal and pathological vascularization of the brain and spinal cord. … This perception may facilitate better understanding of the vascular pathologies and lead to the appropriate decision making not only in the diagnostic work, but also in the interventional procedures. …

    Neurologia medico-chirurgica, 2017

    J-STAGE

  • 歯科放射線科医に必要なPET/CTの知識

    中村 伸 , 倉林 亨

    … Positron emission tomography (PET) is a functional imaging technique based on the detection of a short-lived radioactive tracer isotope. … Although FDG-PET displays high diagnostic accuracy for nodal metastasis, inflammatory lymphadenopathy might sometimes produce false-positive results. … Concerning the evaluation of tumor recurrence, the diagnostic ability of FDG-PET might be superior to that of computed tomography (CT) and/or magnetic resonance imaging (MRI). …

    歯科放射線 57(1), 15-23, 2017

    J-STAGE

  • 中枢機能障害性疼痛患者における脳部位間の機能的結合と背景因子との関連:安静時fMRIによる検討

    寒 重之 , 大迫 正一 , 植松 弘進 , 渡邉 嘉之 , 田中 壽 , 柴田 政彦

    … </i>We aimed to investigate the relationship between alterations in spontaneous brain activity and demographic characteristics in patients with functional somatic syndrome (FSS) and associated pain.</p><p><i>Materials and Methods. … </i>Left amygdala–left insula functional connectivity had a significant positive correlation with average pain intensity.<b> …

    PAIN RESEARCH 32(1), 52-59, 2017

    J-STAGE 医中誌Web

  • iTRAQ-based Quantitative Proteomics Study in Patients with Refractory <i>Mycoplasma pneumoniae</i> Pneumonia

    Yu Jia-Lu , Song Qi-Fang , Xie Zhi-Wei , Jiang Wen-Hui , Chen Jia-Hui , Fan Hui-Feng , Xie Ya-Ping , Lu Gen

    … The identification and characterization of proteins related to RMPP could provide a proof of principle to facilitate appropriate diagnostic and therapeutic strategies for treating paients with MP. … Functional classification, sub-cellular localization, and protein interaction network analysis were carried out based on protein annotation through evolutionary relationship (PANTHER) and Cytoscape analysis. …

    Japanese Journal of Infectious Diseases 70(5), 571-578, 2017

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  • Mild thyroid peroxidase deficiency caused by <i>TPO</i> mutations with residual activity: Correlation between clinical phenotypes and enzymatic activity

    Narumi Satoshi , Fox Larry A , Fukudome Keisuke , Sakaguchi Zenichi , Sugisawa Chiho , Abe Kiyomi , Kameyama Kaori , Hasegawa Tomonobu

    functional analyses using HEK293 cells showed that the two amino acid-altering mutations (p.Asp224del and p.Trp527Cys) caused partial loss of the enzymatic activity. …

    Endocrine Journal, 2017

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  • Diagnostic Utility of Quantifying Myocardial Flow Reserve with <sup>99m</sup>Tc-Sestamibi Dynamic SPECT Using a Standard Dual-Head SPECT Camera

    Fukuyama Kae , Kitagawa Yoshitoshi , Hiraoka Yuji

    … This approach may apply for the quantitative evaluation of the MBF and functional severity of the CAD. …

    Annals of Nuclear Cardiology, 2017

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  • 人工ユビキチンリガーゼの分子設計法の開発─ユビキチン化活性に基づくがん診断に向けて─

    宮本 和英 , 砂川 真弓 , 齋藤 一樹

    生体内のユビキチン化反応は,不要なタンパク質の分解,DNA修復,シグナル伝達など多くの機能を担っている.そのユビキチン化反応を構成しているE2(ユビキチン結合酵素)は,白血病,乳がん,大腸がん等,様々ながん疾患と深く関与していることが知られている.将来的に,E2活性を高感度・定量的に捉えることができれば,E2をバイオマーカとして活用できるはずである.これまでに著者らは,簡便にE2活性を検出するため …

    分析化学 66(6), 393-402, 2017

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  • 遺伝性出血性毛細血管拡張症1型に合併した肺動脈性肺高血圧症への初期併用療法の効果

    原田 雅子 , 近藤 恭平 , 布井 博幸 , 山田 修

    <p><i>Endoglin</i> (<i>ENG</i>)は<i>ACVRL1</i>と共に遺伝性出血性毛細血管拡張症(hereditary hemorrhagic telangiectasia: HHT)の原因遺伝子であり,それぞれHHT 1型,2型に分類される.HHTでは,稀であるが肺動脈性肺高血圧症(PA …

    日本小児循環器学会雑誌 33(3), 221-227, 2017

    J-STAGE 医中誌Web

  • 分子イメージングを駆使したADCの開発

    安永 正浩 , 眞鍋 史乃 , 辻 厚至 , 古田 大 , 緒方 是嗣 , 古賀 宣勝 , 藤原 悠起 , 佐賀 恒夫 , 松村 保広

    … The selection of a tumor-specific antibody and development of a linker having an efficient controlled drug release (CDR) are critical steps in developing a fully functional and effective ADC. …

    薬学雑誌 137(5), 535-544, 2017

    J-STAGE 医中誌Web

  • インターネット依存傾向と相関する安静時脳機能的結合指標の抽出

    伊澤 俊 , 刀川 賢太 , 小野 弓絵 , 小林 浩 , 栗城 眞也 , 石山 敦士

    … Development of objective examination technique to assist the current diagnostic methods using medical interview and inquiry tests is desirable for detection of IAD at its early stage. … In this study, we extracted the values of functional connectivity (FC) that correlated with a tendency of IAD, using resting-state functional magnetic resonance imaging (rs-fMRI) data. …

    生体医工学 55(1), 39-44, 2017

    J-STAGE 医中誌Web

  • Asymptomatic Cocaine Abuse ― Myocardial Tissue Characterization Using Cardiac Biomarkers and Cardiovascular Magnetic Resonance Imaging ―

    Radunski Ulf K. , Fuger Ulrike , Bohnen Sebastian , Lund Gunnar K. , Stehning Christian , Zeller Tanja , Tahir Enver , Avanesov Maxim , Adam Gerhard , Blankenberg Stefan , Reimer Jens , Muellerleile Kai

    … We did not find significant differences between CA and controls either in functional CMR parameters such as LVEDVi, LVESVi, LVEF, LV mass index, or in global myocardial ECV. …

    Circulation Journal 81(5), 701-708, 2017

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  • てんかん外科手術から得られる病態生理

    鎌田 恭輔 , 小川 博司 , 田村 有希恵 , 広島 覚 , 安栄 良悟

    <p> てんかん外科手術の治療方法はてんかん焦点切除が基本であるが, 脳梁離断などの病的ネットワーク離断, 皮質および海馬多切術, さらに迷走神経刺激法併用などがある. 焦点診断のためには高サンプリングと高密度脳波, MRI, 脳磁図, 核医学検査など多方面からの精査が行われている. 画像所見と電気生理学的な異常, てんかん症候が一致した時は一期的な海馬, 焦点切除を行うことができる. …

    脳神経外科ジャーナル 26(4), 250-262, 2017

    J-STAGE 医中誌Web

  • Doppler Ultrasound Triggering for Cardiovascular MRI at 3T in a Healthy Volunteer Study

    Kording Fabian , Yamamura Jin , Lund Gunnar , Ueberle Friedrich , Jung Caroline , Adam Gerhard , Schoennagel Bjoern Philip

    … DUS and POX triggering were compared to the reference standard of ECG in terms of trigger quality (trigger detection and temporal variability), image quality [endocardial blurring (EB)], and functional measurements [left ventricular (LV) volumetry and aortic blood flow velocimetry].<br>Results: Trigger signal detection and temporal variability did not differ significantly between ECG/DUS (I = 0.6) and ECG/POX (<i>P</i> …

    Magnetic Resonance in Medical Sciences 16(2), 98-108, 2017

    J-STAGE

  • カラードプラとパワードプラの使用法のコツ

    関口 隆三 , 長基 雅司 , 藤崎 純

    カラードプラ法は,目的とする血管の血行動態や腫瘍内血流の多寡を把握でき,通常のBモードによる形態情報に加え,血行動態という機能情報も得ることができることから,診断精度の向上に大いに貢献できる非常に有用な機能である.その利用にあたっては,流速スケール,カラードプラゲイン,カラー表示範囲,フィルター,ドプラ周波数などの各種パラメータを適切に設定することが大切である.

    超音波医学, 2017

    J-STAGE

  • Progress of research on microRNAs with diagnostic value in asbestos exposure: A call for method standardization

    Micolucci Luigina , Rippo Maria Rita , Olivieri Fabiola , Procopio Antonio Domenico

    … MicroRNAs (miRNAs) are endogenous, non-coding, small RNAs with a well-established diagnostic role in cancer and pollution exposure. … In a recent systematic review and qualitative meta-analysis followed by a functional investigation, we examined all the available data on the miRNA biomarkers involved in asbestos exposure and MM pathways. …

    BioScience Trends 11(1), 105-109, 2017

    J-STAGE

  • 耳下腺手術後の口唇運動麻痺の多様性と顔面神経下顎辺縁枝傷害の関係について

    横島 一彦 , 中溝 宗永 , 稲井 俊太 , 酒主 敦子 , 加藤 大星 , 大久保 公裕

    頭頸部手術において,顔面神経下顎辺縁枝の機能温存は,術後QOLを保つために大切である。また,その結果のフィードバックは手技向上のためにも重要である。本研究では,術後の口唇運動麻痺の多様性とその評価について検討した。<br>2013年以降に手術を行った耳下腺良性疾患100例を対象に,口角下制時,口唇突き出し時の口唇運動の左右差を評価した。<br> 口唇下制の左右差は36例で確 …

    頭頸部外科 26(3), 363-366, 2017

    J-STAGE 医中誌Web

  • Small nonfunctional parathyroid cysts: single institution experience

    Fustar Preradovic Ljubica , Danic Davorin , Dzodic Radan

    … PCs are important because they can pose a differential diagnostic challenge against other cystic formations of the neck. … PCs can be functional (elevated serum parathyroid hormone level) and nonfunctional. … Cystic neck masses can pose a major differential diagnostic problem considering different approach, treatment method, and preoperative and postoperative follow up. …

    Endocrine Journal 64(2), 151-156, 2017

    J-STAGE

  • Hepatoid Adenocarcinoma of the Extrahepatic Bile Duct in a Patient with Polysplenia Syndrome

    Yorita Kenji , Sasaki Shiori , Kawada Ai , Okazaki Michiyo , Yamai Hiromichi , Uchita Kunihisa , Iwamura Shinichi , Nakatani Kimiko , Ito Satoshi , Kuroda Naoto

    … <p>Hepatoid adenocarcinoma (HAC) is a rare subtype of extrahepatic adenocarcinoma that is characterized by its morphological and functional similarities to hepatocellular carcinoma. …

    Internal Medicine 56(4), 401-407, 2017

    J-STAGE

  • Asymptomatic Cocaine Abuse ― Myocardial Tissue Characterization Using Cardiac Biomarkers and Cardiovascular Magnetic Resonance Imaging ―

    Radunski Ulf K. , Fuger Ulrike , Bohnen Sebastian , Lund Gunnar K. , Stehning Christian , Zeller Tanja , Tahir Enver , Avanesov Maxim , Adam Gerhard , Blankenberg Stefan , Reimer Jens , Muellerleile Kai

    … We did not find significant differences between CA and controls either in functional CMR parameters such as LVEDVi, LVESVi, LVEF, LV mass index, or in global myocardial ECV. …

    Circulation Journal, 2017

    J-STAGE

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