検索結果:　 1182件中 1-20 を表示

Motojima Hideko , Villareal Myra O. , Han Junkyu , Isoda Hiroko , 韓 畯奎 , 礒田 博子

… Previously, we reported that FA extracted from solubilized excess sludge (SS-FA) had an inhibitory effect on β-hexosaminidase release in human leukemia basophilic (KU812) cells. … The inhibitory effect of SS-FA on degranulation in PMACI-stimulated KU812 cells was examined using histamine release assay. … SS-FA significantly decreased the histamine release in KU812 cells at concentrations of 0.1–10.0 μg mL−1. …

Cytotechnology 63(2), 181-190, 2011-03

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Nakao Satoshi , Komagoe Keiko , Inoue Tsuyoshi , Katsu Takashi

… The membrane-permeabilizing activities of mastoparans and related histamine-releasing agents were compared through measurements of K(+) efflux from bacteria, erythrocytes, and mast cells. … Changes in bacterial cell viability, hemolysis, and histamine release, as well as in the shape of erythrocytes were also investigated. …

Biochimica et Biophysica Acta (BBA) - Biomembranes 1808(1), 490-497, 2011-01

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CHO Ik-Hyun , LEE Min Jung , KIM Jong-Hyun , HAN Na Young , SHIN Kyu Won , SOHN Youngjoo , JUNG Hyuk-Sang

… It inhibited the compound 48/80-induced release of histamine from rat peritoneal mast cells in a concentration-dependent manner. …

Bioscience, Biotechnology, and Biochemistry 75(8), 1440-1445, 2011

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Yamada Parida , Iijima Rieko , Han Junkyu , Shigemori Hideyuki , Yokota Shinichi , Isoda Hiroko , 山田 パリーダ , 韓 畯奎 , 繁森 英幸 , 礒田 博子

… The effect of acteoside on β-hexosaminidase release and intracellular [Ca2+]i level from rat basophilic leukemia (RBL-2H3) cells was determined. … Also, ELISA was used to determine the level of histamine, tumor necrosis factor (TNF)-α, and interleukin (IL)-4 on human basophilic (KU812) cells. … These results indicated that 0.1-10.0 µg/mL acteoside inhibits the release of β-hexosaminidase and [Ca2+]i influx from IgE-mediated RBL-2H3 cells. …

Planta medica 76(14), 1512-1518, 2010-10

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HONG Myung Hee , KIM Jeong-Hyun , NA Sang Hyuk , BAE Hyunsu , SHIN Yong-Cheol , KIM Sung-Hoon , KO Seong-Gyu

… The ethanol extract of PSA (200 mg/kg) significantly inhibited the passive cutaneous anaphylaxis reaction in vivo, and suppressed the release of histamine from rat peritoneal mast cells induced by compound 48/80. …

Bioscience, biotechnology, and biochemistry 74(6), 1152-1156, 2010-06-23

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高杉 美佳子 , 加藤 雅子 , 前田 典子 , 島田 和子

14種の乾燥ハーブ熱水抽出物のヒスタミンおよびロイコトリエン（LT) B4放出抑制作用，DPPHラジカル消去活性，デオキシグアノシン酸化阻害活性を検討し，ポリフェノール量およびフラボノール類量を定量した．ペパーミント，ローレル，バジル（F），ローズマリーは，ラット腹腔細胞からのヒスタミンの放出を50％以上抑制し，ポリフェノール量の多い乾燥ハーブ熱水抽出物ほどヒスタミン放出量が低下する傾向が認められ …

日本食品科学工学会誌 : Nippon shokuhin kagaku kogaku kaishi = Journal of the Japanese Society for Food Science and Technology 57(3), 121-127, 2010-03-15

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Tokuda Akira　 , Ohkura Noriyuki , Fujimura Masaki , Furusho Shiho , Abo Miki , Katayama Nobuyuki

… Erythromycin dose-dependently inhibited the increases in the substance P, prostaglandin E2 and leukotriene B4 levels, but not the histamine levels, in the bronchoalveolar lavage fluid. … Conclusions: Both 14- and 15-membered, but not 16-membered, macrolides could reduce the antigen-induced cough reflex hypersensitivity by inhibiting the antigen-induced release of the afferent sensory nerve sensitizers. …

Pulmonary Pharmacology and Therapeutics 23(1), 55-61, 2010-02

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Singh Sanjay , Soni Rajeev , Rawat Manoj Kumar , Jain Achint , Deshpande Shripad Bheemrao , Singh Sanjeev Kumar , Muthu Madaswamy Sona

… The films were designed to release the drug for a prolonged period of time so as to reduce the frequency of administration of the available conventional dosage forms of SS. … The films were prepared by solvent casting method and evaluated for bioadhesion, in vitro drug release and anti asthmatic effect (bronchoprotection) in histamine induced bronchospasm of guinea pigs. …

CHEMICAL & PHARMACEUTICAL BULLETIN 58(3), 307-311, 2010

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Lee Ji Yun , Moon Hee , Kim Chang Jong

… Histamine and phospholipase A2 activity in BALF were significantly decreased by HTAs at 12.5 mg/kg, whereas eosinophil peroxide (EPO) activity in BALF and recruitment of eosinophils were significantly decreased by HTAs at 25 mg/kg, as well as improvement of pathological changes. … These results indicate HTAs had anti-asthmatic activity by decreasing of sRaw, and eosinophil recruitment and release of inflammatory mediators into the lungs. …

Biological & Pharmaceutical Bulletin 33(2), 230-237, 2010

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馬場 きみ江 , 谷口 雅彦 , 芝野 真喜雄 , 南 晴文

アシタバAngelica keiskei KOIDZUMIは八丈島を原産地とする日本固有のセリ科の大型多年草である．現地では古くから，野菜又は民間薬として利用されている．本植物は根，茎，葉に多量の黄色物質を含んでいるのが特徴である．著者等は植物学的形態と高速液体クロマトグラフィーによるクマリン成分のプロファイルに基づき，産地による比較分類を行った．またこの黄色成分の単離，構造解析を行い，10種の新 …

分析化学 = Japan analyst 58(12), 999-1009, 2009-12-05

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