Search Results:　 1-20 of 26

1

Crystal Structure of Heterodiquinane Containing a Triazine,an Indoline, and a Pyrrolidine Skeletons Prepared by Photoreactionof 7-Methoxy-3-［1-（methoxyimino）ethyl］-N-phenyl-1, 2-dihydrocinnoline1, 2-Dicarboximide with Diethyl 1, 3-Acetonedicarboxylate

Seguchi Kazuyoshi

… The heterodiquinane derivative was prepared from the photochemical reaction of 7-methoxy-3-［1-（methoxyimino）ethyl］-N-phenyl-1, 2-dihydrocinnoline 1, 2-dicarboximide with diethyl 1, 3-acetonedicarboxylatein acetonitrile. …

武庫川女子大学紀要. 自然科学編 60, 11-15, 2013-03-31

IR
2

Crystal Structure of Heterodiquinane Containing a Triazine, an Indoline, and a Pyrrolidine Skeletons Prepared by Photoreaction of 7-Methoxy-3-[1-(methoxyimino)ethyl]-N-phenyl-1, 2-dihydrocinnoline 1, 2-Dicarboximide with Diethyl 1, 3-Acetonedicarboxylate

Seguchi Kazuyoshi

… The heterodiquinane derivative was prepared from the photochemical reaction of 7-methoxy-3-[1-(methoxyimino) ethyl]-N-phenyl-1, 2-dihydrocinnoline 1, 2-dicarboximide with diethyl 1, 3-acetonedicarboxylate in acetonitrile. …

The bulletin of Mukogawa Women's University. Natural science 60, 11-15, 2013-00-00

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3

Novel Acyl-CoA: Cholesterol Acyltransferase Inhibitor: Indoline-Based Sulfamide Derivatives with Low Lipophilicity and Protein Binding Ratio

Takahashi Kenji , Ohta Masaru , Shoji Yoshimichi , Kasai Masayasu , Kunishiro Kazuyoshi , Miike Tomohiro , Kanda Mamoru , Shirahase Hiroaki

To find a novel acyl-CoA: cholesterol acyltransferase inhibitor, a series of sulfamide derivatives were synthesized and evaluated. Compound 1d, in which carboxymethyl moiety at the 5-position of Pacti …

Chemical and Pharmaceutical Bulletin 58(8), 1057-1065, 2010

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4

Indoline Derivatives II : Synthesis and Factor Xa (FXa) Inhibitory Activities

NOGUCHI Tetsuji , TANAKA Naoki , NISHIMATA Toyoki , GOTO Riki , HAYAKAWA Miho , SUGIDACHI Atsuhiro , OGAWA Taketoshi , ASAI Fumitoshi , OZEKI Tomoko , FUJIMOTO Koichi

… In the course of our research, we have found that (R)-5-[1-(acetimidoyl) piperidin-4-yloxy]-2-(7-amidinonaphthalen-2-yl)-1-(ethanesulfonyl)indoline ((R)-1) showed potent FXa inhibitory activity in vitro. …

Chemical & pharmaceutical bulletin 55(3), 393-402, 2007-03-01

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5

30 Total Synthesis of (+)-Yatakemycin [in Japanese]

Okano Kentaro , Tokuyama Hidetoshi , Fukuyama Tohru

… The first amination reaction of 9 afforded indoline 10 with retention of the other bromo group. … After Mizoroki-Heck reaction with a dehydroalanine derivative 23 and removal of the nosyl group, bromo group was introduced regioselectively. …

天然有機化合物討論会講演要旨集 (48), 175-180, 2006-09-15

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6

Indoline Derivatives I : Synthesis and Factor Xa (FXa) Inhibitory Activities

NOGUCHI Tetsuji , TANAKA Naoki , NISHIMATA Toyoki , GOTO Riki , HAYAKAWA Miho , SUGIDACHI Atsuhiro , OGAWA Taketoshi , ASAI Fumitoshi , MATSUI Yumi , FUJIMOTO Koichi

… Among them, some indoline derivatives showed potent inhibitory activities in vitro. …

Chemical & pharmaceutical bulletin 54(2), 163-174, 2006-02-01

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7

13 Rearrangement from Indolines to Tetrahydroquinolines via Aziridine Intermediate Inspired by a Hypothetical Biogenesis : Total Syntheses of (+)-Benzastatin E and (-)-Virantmycin [in Japanese]

Kogen Hiroshi , Ori Mayuko , Toda Narihiro , Takami Kazuko , Tago Keiko

… Benzastatins and (-)-virantmycin (2a) are a family of indoline and tetrahydroquinoline alkaloids isolated from Streptomyces nitrosporeus. … Based on this hypothesis, we designed the PPh_3-CCl_4 mediated rearrangement from α,α-disubstituted indoline-2-methanol 3 to 2,2,3-trisubstituted tetrahydroquinoline 4 via the aziridine intermediate followed by the ring opening attack of the chloride anion. …

天然有機化合物討論会講演要旨集 (45), 73-78, 2003-09-01

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8

Nucleophilic Substitution Reactions of 1-Methoxy-6-nitroindole-3-carbaldehyde

Yamada Koji , Yamada Fumio , Shiraishi Takei [他] , Tomioka Saori , Somei Masanori

… Preparation of a novel pyrimido[1,2-a]indole derivative is also reported. …

Heterocycles 58(-), 53-56, 2002-11-22

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9

85(P-18) Total Synthesis of (-)-Vallesamidine [in Japanese]

Tanino Hideo , Fukuishi Kazuhisa , Ushiyama Mina , Okada Kunisuke

… We report here first asymmetric total synthesis of (-)-Vallesamidine through indoline derivative 15a and its selenide (17a) by the aid of reductive radical ring closure reaction. … Starting from the known lactone (7), we synthesized carboxylic acid derivative (12), a chiral C_9-unit corresponding to non-tryptamine building block of Vallesamidine. …

天然有機化合物討論会講演要旨集 (44), 497-502, 2002-09-01

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10

11 Total Synthesis of (-)-Strychnine Using Palladium-Catalyzed Cyclization [in Japanese]

Mori Miwako , Nakanishi Masato , Kajishima Daisuke , Sato Yoshihiro

… The synthesis of a chiral indoline derivative having the ABC-rings of (-)-strychnine was achieved by palladium-catalyzed asymmetric allylic substitution of a cyclohexenol derivative having substituent at the 2-position followed by palladium-catalyzed cyclization. …

天然有機化合物討論会講演要旨集 (44), 61-66, 2002-09-01

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11

94(P-51) Synthetic studies toward cyclomarin A, an antiinflammatory cyclic peptide from a marine bacterium Streptomyces sp. [in Japanese]

Yokokawa Fumiaki , Sugiyama Hideyuki , Shioiri Takayuki

… The structure of cyclomarin A (1) was determined using 1D and 2D NMR methods, and the stereochemistry was determined from an X-ray crystal structure of its diacetate derivative. … The stereoselective synthesis of the β-methoxyphenylalanine derivative 12 was achieved by the Schollkopfs syn-selective aldol reaction between benzaldehyde (8) and the titanium derivative 7 of chiral bislactim ether 6, followed by O-methylation. …

天然有機化合物討論会講演要旨集 (43), 557-562, 2001-09-01

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12

A Novel Series of Thromboxane A_2 Synthetase Inhibitors with Free Radical Scavenging and Anti-peroxidative Activities

KAMIYA Shoji , SHIRAHASE Hiroaki , NAKAMURA Shohei , KANDA Mamoru , MATSUI Hiroshi , YOSHIMI Akihisa , KASAI Masayasu , TAKAHASHI Kenji , KURAHASHI Kazuyoshi

… A novel series of indoline derivatives with imidazole and carboxyl moieties were synthesized and evaluated for their thromboxane A_2(TXA_2)synthetase inhibiting, radical scavenging and anti-peroxidative activities. … The 5-hexyloxy derivative(13)showed about 35-fold higher inhibitory activity on TXA_2 synthesis than that of ozagrel and about 100-fold higher activity on lipid peroxidation than that of α-tocopherol. …

Chemical & pharmaceutical bulletin 49(5), 563-571, 2001-05-01

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13

Bioavailable Acyl-CoA : Cholesterol Acyltransferase Inhibitor with Anti-peroxidative Activity : Synthesis and Biological Activity of Novel Indolinyl Amide and Urea Derivatives

KAMIYA Shoji , SHIRAHASE Hiroaki , YOSHIMI Akihisa , NAKAMURA Shohei , KANDA Mamoru , MATSUI Hiroshi , KASAI Masayasu , TAKAHASHI Kenji , KURAHASHI Kazuyoshi

… We synthesized a series of indoline derivatives with an amide or urea moiety and examined their inhibitory effects on acyl-CoA : cholesterol acyltransferase (ACAT) activity, lipid-peroxidation and serum cholesterol levels in experimental animals. … The effect on ACAT activity was related to the length of the alkyl chain at the 1-position of indoline. … Indoline proved to be a useful pharmacophore for molecular design of new anti-peroxidative drugs. …

Chemical & pharmaceutical bulletin 48(6), 817-827, 2000-06-01

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14

Novel 5-Hydroxytryptamine (5-HT_3) Receptor Antagonists. II. Synthesis and Structure-Activity Relationships of 4,5,6,7-Tetrahydro-1H-benzimidazole Derivatives

OHTA Mitsuaki , SUZUKI Takeshi , OHMORI Junya , KOIDE Tokuo , MATSUHISA Akira , FURUYA Toshio , MIYATA Keiji , YANAGISAWA Isao , , , , , , ,

… values of below 0.1 μg/kg, and the indoline derivative 6c, indole derivatives 7a, d, g, benzofurane derivative 7j and indolizine derivative 7k were observed to be very potent on the colonic contraction with IC_<50> …

Chemical & pharmaceutical bulletin 44(5), 1000-1008, 1996-05-15

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15

Novel 6-5 Fused Ring Heterocycle Antifolates with Potent Antitumor Activity : Bridge Modifications and Heterocyclic Benzoyl Isosters of 2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine Antifolate

KOTAKE Yoshihiko , OKAUCHI Tatsuo , IIJIMA Atsumi , YOSHIMATSU Kentaro , NOMURA Hiroaki

… indoline, 2h; … Among them, 2a (the 10-methyl derivative of 1) and 2i were most potent, being 2- to 3-fold more potent than 10-EDAM. …

Chemical & pharmaceutical bulletin 43(5), 829-841, 1995-05-15

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16

7 SYNTHESIS OF THE HUMANTENINE- AND GELSEDINE-CLASS OF GELSEMIUM ALKALOIDS BASED ON A BIOGENETIC SPECULATION [in Japanese]

Takayama H. , Kitajima M. , Phisalaphong C. , Seki N. , Tominaga Y. , Aimi N. , Sakai S.

… I: 3,3-Disubstituted oxindole (16) could be converted to the Na-methoxy-oxindole (20) via tungstate-catalyzed oxidation of the indoline derivative (17). …

天然有機化合物討論会講演要旨集 (35), 49-56, 1993-09-10

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17

91 SYNTHETIC STUDIES OF DUOCARMYCINS [in Japanese]

Fukuda Yasumichi , Nakatani Kazuhiko , Ito Yoshio , Terashima Shiro

… Thus, the N-boc-indoline derivative (13) prepared from 2-chloro-5-methoxy-nitrobenzene was converted to the 5-amino derivative (15) by nitration and reduction sequence. … Introduction of the C1 unit into the C-4 position was achieved through the isatin derivative (17) by oxidative ring opening followed by methanolysis, affording the anthranilic acid methyl ester (21). …

天然有機化合物討論会講演要旨集 (32), 686-693, 1990-09-25

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18

Reduction of Alkylindoles with Sodium Borohydride-Aluminium Chloride in Pyridine

KIKUGAWA YASUO

… N-Benzoyltryptamine (1f) was selectively reduced to the indoline derivative without reduction of the amide group. …

Chemical & pharmaceutical bulletin 26(1), 108-110, 1978-01-25

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19

Spiro Heterocyclic Compounds. I. Synthesis of Spiro-[imidazolidine-4,3'-INDOLINE]-2,2', 5-triones

OTOMASU HIROTAKA , NATORI KYUJI , TAKAHASHI HIROSHI

… 1'-Substituted spiro [imidazolidine-4,3'-indoline]-2,2', 5-triones (5-8) were prepared by the reaction of 1-substituted indoline-2,3-diones with KCN and (NH_4)_2 CO_3. … The reaction of indoline-2,3-diones with KCN and amines afforded 3-amino-3-cyanoindolin-2-ones (9-11), which on reacting with KOCN, only 9 gave 3-methyl derivative of the spiro compound (16). …

Chemical & pharmaceutical bulletin 23(7), 1431-1435, 1975-07-25

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20

23 Transformation of Indole Alkaloids : The Chemical Transformation of Corynantheine Type Alkaloids to C-Mavacurine Type Alkaloids [in Japanese]

Sakai Shin-ichiro , Shinma Nobuo

… The final ring closing reaction of 14 (either from the C_3 epimeric mixture 14a,b or C_3-(R) 14a itself) was achieved by heating with aq.HOAc/ NH_4OAc to give 16, 20-α-ethyl-19,20-dihydroepi-pleiocarpamine mp 169-171°, (C_<20>H_<24>O_2N_2) and an indoline derivative 17. …

天然有機化合物討論会講演要旨集 (18), 171-178, 1974-10-01

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