Search Results:　 1-20 of 250

1

Effect of GH for Induced Seizures [in Japanese]

Miwa Kumiko/Nagaki Shigeru/Osawa Makiko

成長ホルモン分泌不全性低身長症(GHD)に対する成長ホルモン(GH)治療中にてんかん発作を認めた3症例を経験した。GHのけいれん惹起性を検討するために、自然発症GH欠損ラット(SDR)を用いてGH、インスリン様成長因子I(IGF-I)の急性、慢性投与によるSDRの脳内ソマトスタチン(SRIF)、ニューロペプチドY(NPY)、γ-アミノ酪酸(GABA)濃度、SRIFメッセンジャーRNA(SRIFmR …

Journal of Tokyo Women's Medical College 83(E1), E194-E204, 2013-01-31
2

Regulatory effect of vitamin B_6 on gene expression in breast cancer cell lines [in Japanese]

Kanouchi Hiroaki , Oka Tatsuzo

… We have evaluated the anti-tumor effect of vitamin B_6 (B_6) on action of breast cancer cell lines. … On the other hand, Insulin-like growth factor-binding protein-3 (IGFBP-3) is one of genes up-regulated by B_6. …

Vitamins 86(8), 425-431, 2012-08-25

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3

Normal Calves Produced After Transfer of Embryos Cultured in a Chemically Defined Medium Supplemented with Epidermal Growth Factor and Insulin-like Growth Factor I Following Ovum Pick Up and In Vitro Fertilization in Japanese Black Cows

SAKAGAMI Nobutada , UMEKI Hidenobu , NISHINO Osamu , UCHIYAMA Hiroko , ICHIKAWA Kyoko , TAKESHITA Kazuhisa , KANEKO Etsushi , AKIYAMA Kiyoshi , KOBAYASHI Shuji , TAMADA Hiromichi

… The objective of this study was to examine whether high concentrations of epidermal growth factor (EGF) and/or insulin-like growth factor I (IGF-I) would have a beneficial effect on bovine embryo development in vitro and to obtain normal calves by using an ovum pick up method and embryo culture in a chemically defined medium. …

Journal of Reproduction and Development 58(1), 140-146, 2012

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4

Effect of Dietary L-Arginine on Bone Protective Pathways via CAT Signaling in Effect of Dietary L-Arginine on Bone Protective Pathways via CAT Signaling in [in Japanese]

Tomomi MIYAUCHI , Hidemichi EBISAWA

… The OVX-Arg group showed 1)higher(but not significantly higher)values in bone mineral density(BMD)and the bone microstructure analysis, 2)significantly higher mRNA expression levels of BMP-2, RANKL, Insulin-like growth factor-1(IGF-1), and CAT-1, which is a transporter of L-Arg, in the rat femur, 3)relatively higher mRNA expression levels of estrogen receptor- (ER- )and endotherial nitric oxide synthase(eNOS), compared to the OVX-C group. …

學苑 854, 19-26, 2011-12-01

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5

Anti-tumor effect of the insulin-like growth factor-1 receptor (IGF-1R) on human pancreatic cancer cells in both in vitro and in vivo studies [in Japanese]

FUNAKOSHI Akihiro , KAWANAMI Takako , TAKIGUCHI Soichi

膵臓 = The Journal of Japan Pancreas Society 26(5), 575-582, 2011-10-25

Ichushi Web References (17)
6

Glucagon-like peptide-2 : its physiological effect on gut [in Japanese]

SATO Shingo , MIURA Soichiro

… Glucagon-like peptide-2（GLP-2）は33のアミノ酸で構成されるプログルカゴン由来ペプチドのひとつで，腸管内分泌細胞（L細胞）で生成される．G蛋白共役受容体に結合し，そのシグナル伝達は受容体発現細胞内のみならず，インスリン様成長因子（insulin-like growth factor；IGF-1）や迷走神経線維を介し全身に広く及ぶと想定される．小腸粘膜増殖・消化吸収の促進・粘膜バリアの維持など多 …

Nippon Shokakibyo Gakkai Zasshi 108(4), 564-574, 2011-04-05

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7

Effects of Inorganic Mercury on Osteoclasts and Osteoblasts of the Goldfish Scales In Vitro

Suzuki Nobuo , Yachiguchi Koji , Hayakawa Kazuichi , Omori Katsunori , Takada Koji , Tabata Makoto , Kitamura Kei-Ichiro , Endo Masato , Wada Shigehito , Srivastav K. Ajai , Chowdhury S. Vishwajit , Oshima Yuji , Hattori Atsuhiko , 鈴木信雄 , 谷内口孝治 , 早川和一 , 大森克徳 , 高田耕司 , 田畑純 , 北村敬一郎 , 遠藤雅人 , 和田重人 , 大嶋雄治 , 服部淳彦

… Therefore, we developed original in vitro assay system using goldfish scales that contain osteoclasts and osteoblasts, and examined the direct effect of inorganic mercury (HgCl2) on osteoclasts and osteoblasts. … In our knowledge, this is the first report of a direct effect of inorganic mercury on osteoclasts. …

Journal of the Faculty of Agriculture, Kyushu University 56(1), 47-51, 2011-02-00

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8

Up-regulation of insulin-like growth factor-binding protein 3 by 5-fluorouracil (5-FU) leads to the potent anti-proliferative effect of androgen deprivation therapy combined with 5-FU in human prostate cancer cell lines

Kawabata Rumi , Oie Shinji , Takahashi Masayuki , Kanayama Hiroomi , Oka Toshinori , Itoh Kohji

INTERNATIONAL JOURNAL OF ONCOLOGY 38(6), 1489-1500, 2011-00-00

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9

Muscle Protein Metabolism during Compensatory Growth with Changing Dietary Lysine Levels from Deficient to Sufficient in Growing Rats

ISHIDA Aiko , KYOYA Takahito , NAKASHIMA Kazuki , KATSUMATA Masaya

… We elucidated the effect of lysine sufficiency on the dynamics of hormones, relevant to muscle protein synthesis and degradation, insulin-like growth factor-I (IGF-I) and corticosterone, and on the expression of proteolytic-related genes in skeletal muscle during compensatory growth. …

Journal of Nutritional Science and Vitaminology 57(6), 401-408, 2011

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10

Aglycon of Rhizochalin from the Rhizochalina incrustata Induces Apoptosis via Activation of AMP-Activated Protein Kinase in HT-29 Colon Cancer Cells

Khanal Prem , Kang Bong Seok , Yun Hyo Jeong , Cho Hae-Guk , Makarieva Tatyana Nikolaevna , Choi Hong Seok

… Rhizochalin is a two-headed sphingolipid-like compound isolated from the sponge Rhizochalina incrustata. … It has been reported that rhizocalin and its derivates have a chemopreventive and chemotherapeutic effect. … Notably, AglRhz inhibits insulin-like growth factor (IGF)-1-induced AP-1 activity and cell transformation in JB6 Cl41 cells. …

Biological and Pharmaceutical Bulletin 34(10), 1553-1558, 2011

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11

Challenge of Studies on the Development of New Zn Complexes to Treat Diabetes Mellitus [in Japanese]

YOSHIKAWA Yutaka , SAKURAI Hiromu , YASUI Hiroyuki

… However, insulin preparations and synthetic therapeutics, which are clinically used treatment of DM, have been associated with problems such as physical and mental pain due to daily injections and certain severe side effects, respectively. … Zn, which is an essential trace element in animals and humans and plays an important role in maintenance of their lives, has been indicated to exhibit insulin-like activity. …

YAKUGAKU ZASSHI 131(6), 925-930, 2011

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12

The effect that administering a serum-free medium containing epidermal growth (EGF), insulin-like growth factor-1 (IGF-1), and glucose has on the in vitro production of bovine embryos [in Japanese]

内山浩子 , 大田洋 , 西元俊文

Bulletin of the Miyazaki Livestock Experiment Station (23), 58-63, 2010-12-00
13

Anti-diabetic Activities of Chalcones Derived from Ashitaba [in Japanese]

ENOKI Tatsuji , OHNOGI Hiromu , KOBAYASHI Eiji , SAGAWA Hiroaki

アシタバ中に豊富に含まれるカルコンである4HDによる抗糖尿病作用をさらに解析するために，すでに糖尿病を発症し高血糖を呈したKK-Ayマウスに投与することで血糖値低下作用がみられるかどうか，また，そのグルコース取り込み促進活性のカギとなる構造について種々のカルコンを用いて検討した． 4HDは高血糖状態にあるKK-A …

Nippon Shokuhin Kagaku Kogaku Kaishi 57(11), 456-463, 2010-11-15

Japanese Agricultural Sciences Index J-STAGE CrossRef References (18)
14

Development of a bioassay to screen for chemicals mimicking the anti-aging effects of calorie restriction

Chiba Takuya , Tsuchiya Tomoshi , Komatsu Toshimitsu , Mori Ryoichi , Hayashi Hiroko , Shimano Hitoshi , Spindler Stephen R. , Shimokawa Isao

… Suppression of the growth hormone/insulin-like growth factor-I pathway in Ames dwarf (DF) mice, and caloric restriction (CR) in normal mice extends lifespan and delays the onset of age-related disorders. … In combination, these interventions have an additive effect on lifespan in Ames DF mice. …

Biochemical and Biophysical Research Communications 401(2), 213-218, 2010-10-15

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15

Development of a bioassay to screen for chemicals mimicking the anti-aging effects of calorie restriction

Chiba Takuya , Tsuchiya Tomoshi , Komatsu Toshimitsu , Mori Ryoichi , Hayashi Hiroko , Shimano Hitoshi , Spindler Stephen R. , Shimokawa Isao , 島野仁

… Suppression of the growth hormone/insulin-like growth factor-I pathway in Ames dwarf (DF) mice, and caloric restriction (CR) in normal mice extends lifespan and delays the onset of age-related disorders. … In combination, these interventions have an additive effect on lifespan in Ames DF mice. …

Biochemical and biophysical research communications 401(2), 213-218, 2010-10-00

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16

The 2008 Okayama Medical Association Awards: Dual tyrosine kinase inhibitor for focal adhesion kinase and insulin-like growth factor-1 receptor exhibits an anticancer effect in esophageal adenocarcinoma in vitro and in vivo [in Japanese]

渡辺信之 , 高岡宗徳 , 櫻間一史他

Journal of Okayama Medical Association 122(1), 17-25, 2010-04-00

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17

Involvement of Insulin-like Growth Factor 2 in Angiogenic Factor Transcription in Bi-maternal Mouse Conceptuses

KAWAHARA Manabu , WU Qiong , KONO Tomohiro

… Imprinted genes in which only one of the two parental chromosome copies is expressed have a substantial effect on mammalian ontogenesis. … On mouse distal chromosome 7, the paternally expressed gene insulin-like growth factor 2 (Igf2) is separated by approximate 100 kb from the maternally expressed non-coding gene H19. …

Journal of Reproduction and Development 56(1), 79-85, 2010-02-01

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18

Effect of paraquat-induced oxidative stress on insulin regulation of insulin-like growth factor-binding protein-1 gene expression

KIMURA K.

J. Clin. Biochem. Nutr. 46, 157-167, 2010

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19

The Relation between Concentric and Eccentric Exercise and the Carbohydrate Metabolism in Healthy Individuals

ZEBROWSKA Aleksandra

… The purpose of the present study was to determine the response of glucose (G), insulin (In) and insulin-like growth factor (IGF)-I to eccentric (ECC) vs. concentric (CON) resistance exercise in healthy trained and untrained subjects. … Different types of muscle contractions (ECC vs. CON) and resistance training had a significant effect on serum IGF-I concentration at maximal exercise intensity. …

Biophilia Rehabilitation Journal 6(1), 27-34, 2010

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20

Sugar Supplementation Stimulates Growth Performance in Calves with Growth Retardation

SATO Tomohiro , HIDAKA Yuichi , KAMIMURA Shunichi

… The growth effect of sugar supplementation was determined in 49 retarded growth calves. … The blood concentrations of both insulin-like growth factor-1 (IGF-1) and glucose showed significant increases in L-H-H and L-L-H, but decreases in non-esterified fatty acid were observed in L-H-H and L-L-L on day Post compared with day Pre, respectively (p<0.05). …

Journal of Veterinary Medical Science 72(1), 29-33, 2010

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