検索結果:　 36件中 1-20 を表示

1

ケージドグルタミン酸への局所的な光照射を用いたin vitro新規脳虚血モデルの開発

渡辺知晴 , 岩淵禎弘 , 河原剛一

脳虚血時においては、高濃度の細胞外グルタミン酸による神経細胞の過剰興奮が急性細胞死を生ずる原因となっている。また虚血から血流が回復しても、急性細胞死が生じている領域の周囲では遅発的な神経細胞死が認められる、いわゆる再灌流障害が報告されている。本研究では、ラット大脳皮質由来のニューロン・グリア共存培養系において、ケージドグルタミン酸への局所的な光照射を行うことによるin vitroにおける新規の脳虚 …

電子情報通信学会技術研究報告. MBE, MEとバイオサイバネティックス 110(111), 23-26, 2010-06-23

CiNii PDF - 未公開医中誌参考文献12件
2

Pioglitazone Reduces the Necrotic-Core Component in Coronary Plaque in Association With Enhanced Plasma Adiponectin in Patients With Type 2 Diabetes Mellitus(Ischemic Heart Disease)

Ogasawara Daisuke , Shite Junya , Shinke Toshiro , Watanabe Satoshi , Otake Hiromasa , Tanino Yusuke , Sawada Takahiro , Kawamori Hiroyuki , Kato Hiroki , Miyoshi Naoki , Hirata Ken-ichi

… VH-IVUS analysis revealed that, although the total plaque-to-vessel volume was not changed in either group, the necrotic-core area had significantly decreased in the pioglitazone group(-4.6±5.9% vs 1.1±9.3%, P=0.001). … There was a significant inverse correlation between the change in plasma adiponectin levels and the change in necrotic-core area (r=-0.46, P<0.0001). …

Circulation journal : official journal of the Japanese Circulation Society 73(2), 343-351, 2009-01-20

CiNii PDF - オープンアクセス J-STAGE 医中誌 CrossRef 参考文献31件被引用文献2件
3

Direct Experimental Occlusion of the Distal Middle Cerebral Artery Induces High Reproducibility of Brain Ischemia in Mice

KURAOKA Mutsuki , FURUTA Takahisa , MATSUWAKI Takashi , OMATSU Tsutomu , ISHII Yoshiyuki , KYUWA Shigeru , YOSHIKAWA Yasuhiro

… The focal ischemic model is a closer approximation to human stroke which includes a necrotic core, penumbra, and undamaged tissue. … Occlusion of a unilateral artery, especially the middle cerebral artery (MCA), is performed in this model, but collateral circulation often induces variation of ischemic lesions both qualitatively and quantitatively. … Direct MCA occlusion (MCAO) consistently induced ischemic lesions in cortical areas. …

Experimental Animals 58(1), 19-29, 2009

J-STAGE CrossRef
4

Assessment of Carotid Plaque Vulnerability Using Structural and Geometrical Determinants

Li Zhi-Yong , Tang Tjun , U-King-Im Jean , Graves Martin , Sutcliffe Michael , Gillard Jonathan H

… Background Because many acute cerebral ischemic events are caused by rupture of vulnerable carotid atheroma and subsequent thrombosis, the present study used both idealized and patient-specific carotid atheromatous plaque models to evaluate the effect of structural determinants on stress distributions within plaque. … The effects of varying fibrous cap thickness, lipid core size and lumen curvature on plaque stress distributions were examined. …

Circulation journal : official journal of the Japanese Circulation Society 72(7), 1092-1099, 2008-06-20

CiNii PDF - オープンアクセス J-STAGE 医中誌 CrossRef 参考文献35件被引用文献6件
5

Ginsenoside Rb_1 Reduces Neurodegeneration in the Peri-infarct Area of a Thromboembolic Stroke Model in Non-human Primates

YOSHIKAWA Tetsuya , AKIYOSHI Yuki , SUSUMU Teruo , TOKADO Hiroshi , FUKUZAKI Koichiro , NAGATA Ryoichi , SAMUKAWA Keiichi , IWAO Hiroshi , KITO Go

… Ginsenoside Rb1 (GRb1), a major component of the traditional herb ginseng, has been reported to show a neuroprotective effect in a rodent ischemic model. … At 7 days after embolization, neuron damage in the peri-infarct area and core region were assessed by NeuN, TUNEL, and GFAP staining. … In the GRb1 group, positive neurons expressed by NeuN staining were noted in the ischemic peri-infarct area, and TUNEL- and GFAP-positive cells significantly decreased, when compared with vehicle. …

Journal of pharmacological sciences 107(1), 32-40, 2008-05-20

J-STAGE 医中誌 CrossRef 参考文献26件
6

Anesthetic management in coronary artery bypass grafting

Sugiura Junko , Futagawa Koichi , Suwa Ichiro , Okamoto Shinji , Okuda Takahiko , Kamamoto Hiromichi , Kajikawa Ryuji , Uchida Tomohisa , Koga Yoshihisa

… Patients with risk factors such as multivessel disease, cerebrovascular disease, chronic renal failure on hemodialysis, atheromatous and calcified ascending aorta, old age, hypertension, and ischemic heart disease were frequently encountered. … Monitoring includes multilead ECG, pulse oximetry, urine output, core temperature, and arterial and central venous catheters. …

Acta medica Kinki University 32(1), 19-25, 2007-06

CiNii PDF - オープンアクセス医中誌
7

Effect of Edaravone, a Free Radical Scavenger, on Ischemia Cerebral Edema Assessed by Magnetic Resonance Imaging

SUDA Satoshi , IGARASHI Hironaka , ARAI Yasushi , ANDOU Jyun , CHISHIKI Tetsuro , KATAYAMA Yasuo

… The anti-edema effect of edaravone, a free radical scavenger, was evaluated by magnetic resonance imaging in six patients with extensive hemispheric ischemic stroke. … T_2 relaxation time in the infarct core, the boundary zone of the infarct, and the noninfarcted hemisphere were calculated, and T_2 mapping was performed before and after edaravone administration. …

Neurologia medico-chirurgica 47(5), 197-202, 2007-05-15

CiNii PDF - オープンアクセス J-STAGE 医中誌 CrossRef 参考文献26件
8

Gasperini Syndrome, A Report of Two Cases

Hayashi-Hayata Miwa , Nakayasu Hiroyuki , Doi Mitsuru , Fukada Yasuyo , Murakami Takenobu , Nakashima Kenji

… We report 2 cases of Gasperini syndrome and consider them with the 11 previously reported cases to describe the clinical characteristics of this rare syndrome: Core neurological signs are peripheral facial nerve palsy and abducens nerve palsy of the affected side: Among all cases, imaging demonstrated a small lesion in the mediolateral tegmental pons (10/13 cases of microinfarction; …

Internal Medicine 46(3), 129-133, 2007

J-STAGE 医中誌 CrossRef
9

Cell Death Mode Switch from Necrosis to Apoptosis in Brain

UEDA Hiroshi , FUJITA Ryousuke

… In brain ischemia, cell destructive necrosis occurs in the core, which in turn links to cell death expansion in the vicinity. … Apoptosis, on the other hand, occurs in the surroundings of the core, called the penumbra, several days later. … As cells showing apoptosis disappear by microglial phagocytosis in the brain, cell death induced by ischemic stress should eventually be terminated. …

Biological & pharmaceutical bulletin 27(7), 950-955, 2004-07-01

CiNii PDF - オープンアクセス機関リポジトリ J-STAGE 医中誌 CrossRef 参考文献61件被引用文献2件
10

Differences in Diffusion-Weighted and T_2-Weighted Magnetic Resonance Imaging Findings in the Acute and Chronic Stages of Ischemic Cerebrovascular Disease : Two Case Reports

YAMAMOTO Junkoh , NISHIZAWA Shigeru , YAMAGUCHI Mitsuo , AKAMINE Soichi , TOKUYAMA Tsutomu , SUGIYAMA Kenji , NAMBA Hiroki

… These results indicate that findings of hyperintense areas by diffusion-weighted MR imaging in the acute stage of ischemic cerebrovascular disease indicate not only the ischemic core but also parts of the reversible incomplete ischemic lesion and suggest that intensive treatment in the acute stage might reverse ischemic brain damage in some patients. …

Neurologia medico-chirurgica 44(5), 245-248, 2004-05-15

CiNii PDF - オープンアクセス J-STAGE 医中誌 CrossRef 参考文献16件被引用文献1件
11

脳保護剤(フリーラジカル消去剤)エダラボンの研究開発

渡辺俊明 , 田中正彦 , 渡邉和俊 , 高松康雄 , 戸部昭広

… Increasing data suggest that oxygen free radical species play detrimental roles in ischemic diseases. … A free radical scavenger capable of inhibiting oxidative injury is expected to become a new drug for the treatment of ischemic diseases such as cerebral ischemia. … In clinical studies, edaravone improved the core neurologic deficits, activities of daily living, and functional outcome of stroke patients. …

藥學雜誌 124(3), 99-111, 2004-03-01

CiNii PDF - オープンアクセス J-STAGE 医中誌 CrossRef 参考文献50件被引用文献1件
12

Any measurable coronary artery disease identified in women presenting with ischemic chest pain is associated with an adverse outcome : findings from the National Institutes of Health-National Heart, Lung, and Blood Institute sponsored Women's Ischemia Syndrome Evaluation (WISE) study angiographic core laboratory (abstr)

SHARAF BL

J Am Coll Cardiol 43(Suppl A), 292, 2004

CrossRef 被引用文献1件
13

Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain

MANABAT C

Stroke 34, 207-213, 2003

CrossRef 被引用文献1件
14

Hydroxyl radical formation is greater in striatal core than in penumbra in a rat model of ischemic stroke

LIU S.

J. Neurosci. Res. 71, 882-888, 2003

CrossRef 被引用文献1件
15

Increased Expression of Intercellular Adhesion Molecule-1 (ICAM-1) in Mouse Brain Following Transient Cerebral Ischemia

Ohtaki Hirokazu , Endo Sakura , Nakamachi Tomoya , Yin Li , Dohi Kenji , Kudo Yoshifumi , Iwai Yumiko , Matsunaga Masaji , Goto Noboru , Shioda Seiji

… ICAM-1-ir after tMCAO was noted in the ischemic region of the ipsilateral hemisphere within 3 to 6 hr, and increased significantly from 24 to 96 hr. …

Acta histochemica et cytochemica 36(4), 385-391, 2003

CiNii PDF - 定額アクセス可能 J-STAGE 医中誌 CrossRef 参考文献28件被引用文献1件
16

急性期脳梗塞におけるischemic coreとpenumbraの同定

中川原譲二

… は15〜30ml/100g/min,3〜6時間では20〜30ml/100g/minの領域がischemic penumbraの領域と推定された.拡散強調画像(DWI)上の皮質高信号域(HIA)における残存脳血流量(Y)と発症からの時間(X)との間にはY=3.12X+3.61(r=0.73,p<0.05)の関係式が得られ,皮質HIAはischemic coreに相当することが示唆された.血栓溶解療法により救済されるischemic penumbraは発症から6時間以内のDWl上に皮質HIAのみられ …

脳神経外科ジャーナル 11(9), 567-573, 2002-09-20

CiNii PDF - オープンアクセス医中誌参考文献19件
17

脳保護薬(フリーラジカルスカベンジャー)エダラボン(ラジカット注30mg)の非臨床および臨床プロフィール

田中正彦

フリーラジカルが脳虚血後の主な傷害因子の1つであることは数多く報告されている．エダラボン（3-methyl-1-phenyl-2-pyrazolin-5-one（分子量174.20），MCI-186，ラジカット注30 mg）は有害なラジカルを消去無害化することで，脳虚血後の神経細胞や血管内皮細胞の酸化傷害を防ぐ脳保護薬である．エダラボンはラット脳虚血モデルにおいて，脳局所虚血後あるいは虚血再開通後 …

日本薬理学雑誌 119(5), 301-308, 2002-05-01

J-STAGE 医中誌 CrossRef 参考文献21件被引用文献1件
18

4.心筋梗塞好発WHHLウサギ, 病理所見と心電図所見

塩見雅志 , 伊藤隆 , 山田悟士 , 田村敏昌

… Ischemic heart disease is important in developed countries. … Some others showed thin fibromuscular cap with large lipid core. … In this case, macrophages were detected at the border between the attenuated fibromuscular cap and the lipid core. …

日本疾患モデル学会記録 18(0), 18-21, 2002

Journal@rchive CrossRef
19

Management of Patients with Ischemic Stroke

Nakagawara Jyoji

… In a case with embolic occlusion of cerebral artery, residual cerebral blood flow (CBF) in symptomatic ischemic region is distributed heterogeneously and cerebral infarction is developed gradually from ischemic core to penumbra. …

2001-12-20

機関リポジトリ
20

温阻血臓器摘出における人工心肺下コアークーリング法の有用性の検討

尾崎公彦 , 小山勇

日本外科系連合学会誌 26(4), 1140-1145, 2001-08-30

医中誌参考文献24件

検索結果:　 36件中 1-20 を表示

関連著者

関連刊行物

検索結果: 36件中 1-20 を表示

関連著者

関連刊行物

検索結果:　 36件中 1-20 を表示