Takeda Shuso
,
Hirayama Akari
,
Urata Shino
,
Mano Nobutaka
,
Fukagawa Keiko
,
Imamura Midori
,
Irii Ayumi
,
Kitajima Satomi
,
Masuyama Tomoko
,
Nomiyama Mai
,
Tatei Sachiko
,
Tomita Saari
,
Kudo Taichi
,
Noguchi Momoko
,
Yamaguchi Yasuhiro
,
Okamoto Yoshiko
,
Amamoto Toshiaki
,
Fukunishi Yoshifumi
,
Watanabe Kazuhito
,
Omiecinski Curtis John
,
Aramaki Hironori
… In the LDL, linoleic acid is present as cholesteryl linoleate, the major fatty acid esterified to cholesterol, and is susceptible to oxidative modification by 15-LOX or Cu2+. … In this investigation, we examined the efficacy of CBDD on i) 15-LOX-catalyzed oxygenation of cholesteryl linoleate, and ii) ox-LDL formation catalyzed by 15-LOX versus Cu2+-mediated non-enzymatic generation of this important mediator. …
Biological and Pharmaceutical Bulletin 34(8), 1252-1256, 2011
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