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IZUMO Takayuki , IZUMI Fumi , NAKAGAWA Ichiro , KITAGAWA Yoshinori , SHIBATA Hiroshi , KISO Yoshinobu

… In the present study, we investigated the influence of S-PT84 ingestion on the mucosal immunity of healthy and Salmonella Typhimurium (S. …

Bioscience and microflora 30(2), 27-35, 2011-04-01

J-STAGE 参考文献34件

山西 弘一

日本臨床 69(9), 1535-1540, 2011-09

医中誌

Kajikawa Akinobu , Igimi Shizunobu

… Our research group has been investigating the development of oral mucosal vaccines against Salmonella enterica serovar Enteritidis (SE) using Lactobacillus casei IGM393 as an antigen delivery vehicle. … Antigen specific immune responses and protective immunity were elicited after the immunization. …

Bioscience and Microflora 30(4), 93-98, 2011

J-STAGE

MORIMOTO Motoko , TAKAGI Yasuhiro , HIGASHI Natsumi , SUZUKI Tateo

… To determine whether dietary rutin could modulate mucosal immunity, we examined the gene expression of Th1/Th2 cytokines and the receptors in the gut and lung. …

Journal of Veterinary Medical Science advpub(0), 1105180521, 2011

J-STAGE CrossRef

Li KeXin , Zhao XiuLi , Xu ShiYi , Pang DaHai , Yang ChunRong , Chen DaWei

… The conjugation of Ulex europaeus agglutinin I (UEAI) onto surface of liposomes has been demonstrated to effectively improve the intestinal absorption of antigen, subsequently induced strong mucosal and systemic immune responses. … The immune-stimulating activity in vivo was studied by measuring immunoglobulin G (IgG) levels in serum and immunoglobulin A (IgA) levels in intestinal mucosal secretions following oral administration of BSA solution, LIP and UEAI-LIP in mice. …

CHEMICAL & PHARMACEUTICAL BULLETIN 59(5), 618-623, 2011

J-STAGE CrossRef

岩田 誠

体の中で最大の表面積をもつ腸管では，外界からの異物の侵入に対して免疫細胞の配備が必須である．抗原と出会ったことのないナイーブ・リンパ球は，リンパ節などの二次リンパ系器官にしか移入できない．しかし，小腸を担当する二次リンパ系器官の樹状細胞は，リンパ球に抗原提示する際にレチノイン酸を産生し与えることによって，小腸組織特異的に移入(ホーミング)する能力を刷り込む．一方，腸においては食物抗原に対する免疫反 …

化学と生物 48(6), 389-394, 2010-06-01

J-STAGE 医中誌 CrossRef 参考文献30件

Yamanaka Hitoki , Hoyt Teri , Yang Xinghong , Bowen Richard , Golden Sarah , Crist Kathryn , Becker Todd , Maddaloni Massimo , Pascual David W

… The LTN-encoding F1-V or V-Ag vaccines were given by the intranasal (i.n.) or intramuscular (i.m.) routes, and although serum IgG and mucosal IgA antibodies (Abs) were induced, F1-Ag boosts were required for robust anti-F1-Ag Abs. … These results show that LTN can be used as a molecular adjuvant to enhance protective immunity against plague. …

Vaccine 28(18), 3219-3230, 2010-04-19

機関リポジトリ

Ishii Hiroyuki , Isomoto Hajime , Shikuwa Saburo , Hayashi Tomayoshi , Inoue Naoki , Yamaguchi Naoyuki , Ohnita Ken , Nanashima Atsushi , Ito Masahiro , Nakao Kazuhiko , Kohno Shigeru

… Peyer's patches (PPs), a major component of the gut-associated lymphoid tissue, serve as important antigen entry sites in mucosal immunity. … These abnormal findings within the PPs were associated with minimal mucosal lesions but not with backwash ileitis; …

Journal of clinical biochemistry and nutrition 46(2), 111-118, 2010-03

機関リポジトリ

萱室 裕之 , 角田 慎一 , 堤 康央

粘膜ワクチンは，全身面と粘膜面の二重の防御免疫を誘導可能な唯一の方法であることから，新興・再興感染症に対する予防法として期待されている．しかし，生ワクチンを除いて，いまだ実用的な粘膜ワクチンは皆無であり，その実現に向けては，有効かつ安全なアジュバント開発が必要とされている．筆者らが開発を進めている機能性サイトカインは，防御免疫を効率よく誘導しうることから，粘膜アジュバントとしての可能性が大きく期待 …

Drug delivery system 25(1), 22-28, 2010-01-29

J-STAGE 医中誌 CrossRef 参考文献12件

川名 敬

臨床免疫・アレルギー科 54(6), 710-716, 2010-12

医中誌