CiNii Search - multidrug-resistance

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Expressions of the multidrug resistance-related proteins in the rat olfactory epithelium : A possible role in the phase III xenobiotic metabolizing function

Kudo Hideaki , Doi Yoshiaki , Fujimoto Sunao

… Multidrug resistance-related proteins (MRPs) are the phase III xenobiotic metabolizing pumps that eliminate some conjugated ligands from cells. …

Neuroscience Letters 468(2), 98-101, 2010-01-04

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2

The disposition of pravastatin in a rat model of streptozotocin-induced diabetes and organic anion transporting polypeptide 2 and multidrug resistance-associated protein 2 expression in the liver

Hasegawa Yoshitaka , Kishimoto Shuichi , Shibatani Naoki [他]

Biological & pharmaceutical bulletin 33(1), 153〜156, 2010/1
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Molecular Analysis of Antimicrobial Resistance in Gram-Negative Bacteria Isolated from Fish Farms in Egypt

ISHIDA Yojiro , AHMED Ashraf M. , MAHFOUZ Nadia B. , KIMURA Tomomi , EL-KHODERY Sabry A. , MOAWAD Amgad A. , SHIMAMOTO Tadashi

… As little is known about antimicrobial resistance genes in fish farms, this study was conducted to monitor the incidence and prevalence of a wide range of antimicrobial resistance genes in Gram-negative bacteria isolated from water samples taken from fish farms in the northern part of Egypt. …

Journal of Veterinary Medical Science advpub(0), 1002020148, 2010

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Immunohistochemical Detection of Proteins Associated with Multidrug Resistance to Anti-Cancer Drugs in Canine and Feline Primary Pulmonary Carcinoma

HIFUMI Tatsuro , MIYOSHI Noriaki , KAWAGUCHI Hiroaki , NOMURA Kohji , YASUDA Nobuhiro

… Fifty-two canine and eighteen feline primary pulmonary carcinomas were evaluated immunohistochemically for the expression of proteins associated with multidrug resistance to anti-cancer drugs. …

Journal of Veterinary Medical Science advpub(0), 1001130121, 2010

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5

The Disposition of Pravastatin in a Rat Model of Streptozotocin-Induced Diabetes and Organic Anion Transporting Polypeptide 2 and Multidrug Resistance-Associated Protein 2 Expression in the Liver

Hasegawa Yoshitaka , Kishimoto Shuichi , Shibatani Naoki , Inotsume Nobuo , Takeuchi Yoshikazu , Fukushima Shoji

… Changes in the mRNA expressions of multidrug resistance-associated protein 2 (MRP2) and organic anion transporting polypeptide 2 (OATP2) in the liver were also estimated using reverse transcriptase-polymerase chain reaction (RT-PCR). …

Biological & Pharmaceutical Bulletin 33(1), 153-156, 2010

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6

Characterization of integrons and antimicrobial resistance genes in clinical isolates of Gram-negative bacteria from Palestinian hospitals

Hussein Amjad I. A. , Ahmed Ashraf M. , Sato Maiko [他]

Microbiology and immunology 53(11), 595〜602, 2009/11
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Liver X receptor regulates expression of MRP2 but not that of MDR1 and BCRP in the liver

Chisaki Ikumi , Kobayashi Masaki , Itagaki Shirou , Hirano Takeshi , Iseki Ken

… Multidrug resistance-associated protein 2 (MRP2), multidrug resistance 1 (MDR1) and breast cancer resistance protein (BCRP) play an important role in the efflux of a broad range of endogenous and xenobiotic compounds from hepatocytes. …

Biochimica et Biophysica Acta (BBA) : Biomembranes 1788(11), 2396-2403, 2009-11

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8

Roles of drug efflux pumps in bacterial multidrug resistance and virulence [in Japanese]

西野邦彦

表面 47(7), 235〜245, 2009/7
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Involvement of multidrug resistance-associated protein 1 in intestinal toxicity of methotrexate.

Kato Sayaka , Ito Katsuaki , Kato Yukio , Wakayama Tomohiko , Kubo Yoshiyuki , Iseki Shoichi , Tsuji Akira , 加藤清香 , 加藤将夫 , 若山友彦 , 井関尚一 , 辻彰

… 最終稿を登録可能.Purpose: Methotrexate (MTX) causes dose-limiting gastrointestinal toxicity due to exposure of intestinal tissues, and is a substrate of the multidrug resistance-associated protein (MRP) 1. …

Pharmaceutical Research 26(6), 1467-1476, 2009-06

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10

Involvement of multidrug resistance-associated protein 1 in intestinal toxicity of methotrexate

Kato Sayaka , Ito Katsuaki , Kato Yukio , Wakayama Tomohiko , Kubo Yoshiyuki , Iseki Shoichi , Tsuji Akira , 加藤将夫 , 若山友彦 , 井関尚一 , 辻彰

… Purpose: Methotrexate (MTX) causes dose-limiting gastrointestinal toxicity due to exposure of intestinal tissues, and is a substrate of the multidrug resistance-associated protein (MRP) 1. …

Pharmaceutical Research 26(6), 1467-1476, 2009-06

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11

Involvement of Multidrug Resistance-Associated Protein 1 in Intestinal Toxicity of Methotrexate

Kato Sayaka , Ito Katsuaki , Kato Yukio , Wakayama Tomohiko , Kubo Yoshiyuki , Iseki Shoichi , Tsuji Akira , 加藤将夫 , 若山友彦 , 井関尚一 , 辻彰

… Purpose: Methotrexate (MTX) causes dose-limiting gastrointestinal toxicity due to exposure of intestinal tissues, and is a substrate of the multidrug resistance-associated protein (MRP) 1. …

Pharmaceutical Research 26(6), 1467-1476, 2009-06

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12

Transport characteristics of multidrug resistance-associated protein 5 in human erythrocyte membranes

Yumoto Ryoko , Yamakawa Keiko , Nagai Junya [他]

Membrane 34(3), (201) 152〜158, 2009/5

Ichushi
13

L1EPO, a Novel Podophyllotoxin Derivative Overcomes P-Glycoprotein-Mediated Multidrug Resistance in K562/A02 Cell Line(Pharmacology)

CHEN Hong , WANG Jing , ZHANG Jingze , WANG Yizheng , CAO Bo , BAI Shufang , YU Peng-Fei , BI Wenchao , XIE Wenli

… The resistance of tumor cells to various cytotoxic drugs is defined as multidrug resistance (MDR). …

Biological & pharmaceutical bulletin 32(4), 609-613, 20090401

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14

Aged Garlic Extract Stimulates P-Glycoprotein and Multidrug Resistance Associated Protein 2 Mediated Effluxes(Biopharmacy)

BERGINC Katja , ZAKELJ Simon , URSIC Darko , KRISTL Albin

… Aged garlic extract induced increase of the absolute value of the transepithelial potential difference and of the shortcircuit current in both permeability models tested (rat jejunum, Caco-2 cell monolayers) without affecting transepithelial electrical resistance. … It also caused a significant increase of the P-glycoprotein and multidrug resistance associated protein 2 mediated effluxes through rat jejunum of marker substrates Rhodamine 123 and 2,4-dinitrophenyl-S-glutathione, respectively. …

Biological & pharmaceutical bulletin 32(4), 694-699, 20090401

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15

Aged Garlic Extract Stimulates P-Glycoprotein and Multidrug Resistance Associated Protein 2 Mediated Effluxes

BERGINC Katja , ZAKELJ Simon , URSIC Darko , KRISTL Albin

Biological & pharmaceutical bulletin 32(4), 694-699, 20090401

References (24)
16

L1EPO, a Novel Podophyllotoxin Derivative Overcomes P-Glycoprotein-Mediated Multidrug Resistance in K562/A02 Cell Line

CHEN Hong , WANG Jing , ZHANG Jingze , WANG Yizheng , CAO Bo , BAI Shufang , YU Peng-Fei , BI Wenchao , XIE Wenli

Biological & pharmaceutical bulletin 32(4), 609-613, 20090401

References (16)
17

Effect of Methotrexate Treatment on Expression Levels of Organic Anion Transporter Polypeptide 2, P-Glycoprotein and Bile Salt Export Pump in Rats(Pharmacology)

SHIBAYAMA Yoshihiko , TAKEDA Yasuo , YAMADA Katsushi

… MTX is a substrate for drug transporters, which are multidrug resistance protein 2 (Mrp2), organic anion transporter polypeptide 2 (Oatp2) and other transporters. …

Biological & pharmaceutical bulletin 32(3), 493-496, 20090301

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18

A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes.

Nakagawa Shinsuke , Deli Mária A , Kawaguchi Hiroko , Shimizudani Takeshi , Shimono Takanori , Kittel Agnes , Tanaka Kunihiko , Niwa Masami

… The transendothelial electrical resistance (TEER) of brain endothelial monolayers in triple co-culture, indicating the tightness of TJs reached 400Omegacm(2) on average, while the endothelial permeability coefficients (P(e)) for fluorescein was in the range of 3x10(-6)cm/s. … Brain endothelial cells in the new model expressed glucose transporter-1, efflux transporters P-glycoprotein and multidrug resistance protein-1, and showed a polarized transport of rhodamine 123, a ligand for P-glycoprotein. …

Neurochemistry international 54(3-4), 253-263, 2009-03

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19

Involvement of P-glycoprotein and Multidrug Resistance Associated Protein 1 on the Transepithelial Transport of a Mercaptoacetamide-Based Histone-Deacetylase Inhibitor in Caco-2 Cells(Pharmacology)

KONSOULA Zacharoula , JUNG Mira

… Such asymmetry was associated with multidrug resistance associated protein 1 (MRP1) and P-glycoprotein (P-gp), as evidenced by specific inhibition of these proteins. …

Biological & pharmaceutical bulletin 32(1), 74-78, 20090101

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20

Salmonella Typhimurium Isolated from Healthy Pigs and Their Ability of Horizontal Transfer of Multidrug Resistance and Virulence Genes

Thuy Nguyen Thi Bich , Takeshi Koichi , Kusumoto Akiko , Makino Sou-ichi , Kawamoto Keiko

… Rapid dissemination of multidrug-resistant strains, in particular from animal origins, is a growing concern to human and animal health, and it is mostly attributed to conjugative DNA exchange in the intestinal tract of food animals. … To understand the potential role of pigs as a reservoir for antimicrobial-resistant Salmonella, we isolated Salmonella from slaughtered pigs and examined their drug resistance and gene transfer ability. … In conjugation experiments, one multidrug-resistant S. …

Bioscience and Microflora 28(4), 135-143, 2009

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