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Influence of Murine Hepatitis Induced by D-(+)-Galactosamine Hydrochloride and Lipopolysaccharide on Gene Expression of Polyethylenimine/plasmid DNA Polyplex(Biopharmacy)
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MIYANAGA Kei
,
YOSHIOKA Takashi
,
NAKAGAWA Hiroo
,
KITAHARA Takashi
,
TO Hideto
,
ICHIKAWA Nobuhiro
,
NAKASHIMA Mikiro
,
NISHIDA Koyo
,
NAKAMURA Junzo
,
SASAKI Hitoshi
… We investigated the influence of murine hepatitis induced by D-(+)-galactosamine and lipopolysaccharide (DGalN/LPS) on polyethylenimine (PEI)-mediated plasmid DNA (pDNA) delivery. … In conclusion, we found that murine hepatitis induced by D-GalN/LPS injection can influence PEI-mediated pDNA delivery and its influence was different from that induced by CCl4 injection which was reported previously. …
Biological & pharmaceutical bulletin 31(8), 1585-1589, 2008-08-01
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