Search Results:　 1-20 of 13213

1

Growth inhibition of imatinib-resistant CML cells with the T315I mutation and hypoxia-adaptation by AV65 - a novel Wnt/β-catenin signaling inhibitor.

Nagao Rina , Ashihara Eishi , Kimura Shinya , Strovel Jeffrey W , Yao Hisayuki , Takeuchi Miki , Tanaka Ruriko , Hayashi Yoshihiro , Hirai Hideyo , Padia Janak , Strand Kathryn , Maekawa Taira

… AV65 inhibited the proliferation of various CML cell lines including T315I mutation-harboring cells. …

Cancer letters 312(1), 91-100, 2011-12-15

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2

Activation-Induced Cytidine Deaminase Expression in CD4(+)T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age.

Qin Hongyan , Suzuki Keiichiro , Nakata Mikiyo , Chikuma Shunsuke , Izumi Nakako , Thi Huong Le , Maruya Mikako , Fagarasan Sidonia , Busslinger Meinrad , Honjo Tasuku , Nagaoka Hitoshi

… In T cells, AID was expressed in a subset that produced IFN-γ and IL-10 but little IL-4 or IL-17, and showed no evidence of genetic mutation. …

PloS one 6(12), 2011-12

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3

Increased tolerance to salt stress in the phosphate-accumulating Arabidopsis mutants siz1 and pho2

Miura Kenji , Sato Aiko , Ohta Masaru , Furukawa Jun , 三浦謙治 , 古川純

… These mutations are also able to suppressthe Na+ hypersensitivity of the sos3-1 mutant, andgenetic analyses suggest that SIZ1 and SOS3 or PHO2 andSOS3 have an additive eVect on the response to salt stress.Furthermore, the siz1 mutation cannot suppress the Li+hypersensitivity of the sos3-1 mutant. …

Planta 234(6), 1191-1199, 2011-12

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4

Thermodynamic analysis of ionizable groups involved in the catalytic mechanism of human matrix metalloproteinase 7 (MMP-7).

Takeharu Hitoshi , Yasukawa Kiyoshi , Inouye Kuniyo

… The mutation of the active-site residue Glu198 into Ala completely abolished the activity, suggesting that Glu198 is the ionizable group for pK(e1). …

Biochimica et biophysica acta 1814(12), 1940-1946, 2011-12

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5

A novel type of familial hypercholesterolemia: Double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene

Tada Hayato , Kawashiri Masa-aki , Ohtani Rumiko , Noguchi Tohru , Nakanishi Chiaki , Konno Tetsuo , Hayashi Kenshi , Nohara Atsushi , Inazu Akihiro , Kobayashi Junji , Mabuchi Hiroshi , Yamagishi Masakazu

… Methods: A total of 146 heterozygous familial hypercholesterolemic (FH) patients with a mutation in LDLR gene were screened for genes encoding proprotein convertase subtilisin/kexin type 9 (PCSK9) and LDLRAP1. … Although the proband exhibited massive Achilles tendon xanthoma and coronary and aortic valvular disease, serum LDL-C level of subjects with double mutations was similar with that of subjects with single LDLR mutation (284.0 ± 43.5 versus 265.1 ± 57.4. …

Atherosclerosis 219(2), 663-666, 2011-12

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6

A novel type of familial hypercholesterolemia: Double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene

Tada Hayato , Kawashiri Masa-aki , Ohtani Rumiko , Noguchi Tohru , Nakanishi Chiaki , Konno Tetsuo , Hayashia Kenshi , Nohara Atsushi , Inazu Akihiro , Kobayashi Junji , Mabuchi Hiroshi , Yamagishi Masakazu

… Methods: A total of 146 heterozygous familial hypercholesterolemic (FH) patients with a mutation in LDLR gene were screened for genes encoding proprotein convertase subtilisin/kexin type 9 (PCSK9) and LDLRAP1. … Although the proband exhibited massive Achilles tendon xanthoma and coronary and aortic valvular disease, serum LDL-C level of subjects with double mutations was similar with that of subjects with single LDLR mutation (284.0 ± 43.5 versus 265.1 ± 57.4 mg/dl). …

Atherosclerosis 219(2), 663-666, 2011-12

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7

Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation.

Kobayashi Maki , Sabouri Zahra , Sabouri Somayeh , Kitawaki Yoko , Pommier Yves , Abe Takaya , Kiyonari Hiroshi , Honjo Tasuku

… Similarly, Top1 is involved in transcription-associated mutation at dinucleotide repeats in yeast and in triplet-repeat contraction in mammals. …

Proceedings of the National Academy of Sciences of the United States of America 108(48), 19305-19310, 2011-11-29

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8

QTL Analysis Identifies a Modifier Locus of Aganglionosis in the Rat Model of Hirschsprung Disease Carrying Ednrb^[sl] Mutations

Dang Ruihua , Torigoe Daisuke , Sasaki Nobuya , Agui Takashi

… As reported previously, when the same null mutation of the Ednrb gene, Ednrb^[sl], was introgressed into the F344 strain, almost 60% of F344-Ednrb^[sl/sl] pups did not show any symptoms of aganglionosis, appearing healthy and normally fertile. … Moreover, a known HSCR susceptibility gene, Gdnf, was found in QTL that suggested a novel non-coding sequence mutation in GDNF that modifies the penetrance and severity of the aganglionosis phenotype in EDNRB-deficient rats. …

PLoS One 6(11), e27902, 2011-11-22

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9

Interactions between canine RAD51 and full length or truncated BRCA2 BRC repeats

Ochiai K. , Yoshikawa Y. , Oonuma T. , Tomioka Y. , Hashizume K. , Morimatsu M.

… In serial deletion mutation experiments, the binding strengths were increased when the C-terminal BRC repeat was removed from BRC1-8, BRC1-5 and BRC1-3. …

The Veterinary Journal 190(2), 293-295, 2011-11

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10

Structures of Burkholderia thailandensis nucleoside kinase : implications for the catalytic mechanism and nucleoside selectivity

Yasutake Yoshiaki , Ota Hiroko , Hino Emisa , Sakasegawa Shin-ichi , Tamura Tomohiro

… Remarkably, the G170Q mutation increases the specificity of BthNK for ADO. …

Acta Crystallographica Section D, Biological Crystallography 67(11), 945-956, 2011-11

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11

Light-Induced Conformational Changes in Full-Length Arabidopsis thaliana Cryptochrome.

Kondoh Masato , Shiraishi Chiaki , Müller Pavel , Ahmad Margaret , Hitomi Kenichi , Getzoff Elizabeth D , Terazima Masahide

… AtCRY1 containing a single mutation (W324F) that abolishes an intra-protein electron transfer cascade did not exhibit this conformational change. …

Journal of molecular biology 413(1), 128-137, 2011-10-14

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12

Efficacy of increased-dose erlotinib for central nervous system metastases in non-small cell lung cancer patients with epidermal growth factor receptor mutation.

Togashi Yosuke , Masago Katsuhiro , Fukudo Masahide , Tsuchido Yasuhiro , Okuda Chiyuki , Kim Young Hak , Ikemi Yasuaki , Sakamori Yuichi , Mio Tadashi , Katsura Toshiya , Mishima Michiaki

Recent reports indicate that refractory central nervous system (CNS) metastases of non-small cell lung cancer (NSCLC) are improved by high-dose gefitinib or erlotinib administration. We describe a Jap …

Cancer chemotherapy and pharmacology 68(4), 1089-1092, 2011-10

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13

Tyrosine deprotonation and associated hydrogen bond rearrangements in a photosynthetic reaction center.

Ishikita Hiroshi

… While mutation of the tyrosine does not affect the kinetics of electron transfer from heme3 to P, recent time-resolved Laue diffraction studies reported displacement of Tyr-L162 in response to the formation of the photo-oxidized P(+•), implying a possible tyrosine deprotonation event. …

PloS one 6(10), 2011-10

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14

Reasons why the 677C>T mutation in human MTHFR gene indicates the substitution of Ala222 by Val: Is the number matched? [in Japanese]

YAMADA Kazuhiro

Vitamins 85(9), 499-500, 2011-09-25

CiNii Fulltext PDF - Limited Ichushi Web
15

Oral administration of bovine lactoferrin upregulates neutrophil functions in a dog with familial β2-integrin-related neutrophil dysfunction

Kobayashi Saori , Abe Yuya , Inanami Osamu , Oda Shinichi , Yamauchi Koji , Hankanga Careen , Yasuda Jun , Sato Reeko

… The disorder was caused by a decrease of β2-integrin expression encoding CD18 without mutation. …

Veterinary Immunology and Immunopathology 143(1-2), 155-161, 2011-09-15

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16

Distribution of a Knockdown Resistance Mutation (L1014S) in Anopheles gambiae s.s. and Anopheles arabiensis in Western and Southern Kenya.

Kawada Hitoshi , Futami Kyoko , Komagata Osamu , Kasai Shinji , Tomita Takashi , Sonye George , Mwatele Cassian , Njenga Sammy M , Mwandawiro Charles , Minakawa Noboru , Takagi Masahiro

… In order to determine the distribution of the point mutation L1014S in An. … arabiensis in southern and western Kenya, we collected larvae and screened for the mutation by DNA sequencing. … We found high allelic and homozygous frequencies of the L1014S mutation in An. … The L1014S mutation was also widely distributed in An. …

PLoS One 6(9), e24323, 2011-09-09

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17

On the Relation between OneMax Problem and Asymmetric Mutation [in Japanese]

Kiminobu Koga , Qinglian Ma , Makoto Sakamoto , Hiroshi Furutani

遺伝的アルゴリズム (GA) における OneMax 問題について,その確率論的解析で得られた結果のいくつかを報告する.まず,OneMax 問題は非対称な突然変異率をもつ GA と同等となることを示す.さらに 1 次スキーマ分布を Markov 連鎖として取り扱い,その遷移確率行列の固有値の明示的な形を与える.

IPSJ SIG Notes 2011-MPS-85(24), 1-2, 2011-09-08

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18

Analysis of the database in hemophilia B by Support Vector Machine -Influence of Amino-acid substitution on factor IX- [in Japanese]

Kenji Aoki , Kenji Sueyoshi , Taro Ishibashi , Makoto Sakamoto , Hiroshi Furutani

血友病 B は血液凝固因子の一つである第 IX 因子の異常によって引き起こされる遺伝性疾患である.血友病 B については,患者の遺伝子異常がデータベース化され,血友病 B を分子レベルで組織的に研究することが可能である.本論文は,第 IX 因子のアミノ酸ミスセンス変異において,アミノ酸置換に伴う物理化学的パラメータ (分子体積,疎水性,極性,等電点,残基間接触エネルギー) の変化量を用いてサポート …

IPSJ SIG Notes 2011-MPS-85(7), 1-8, 2011-09-08

CiNii Link1
19

Genetic Background Strongly Modifies the Severity of Symptoms of Hirschsprung Disease, but not Hearing Loss in Rats Carrying Ednrb^[sl] Mutations

Dang Ruihua , Torigoe Daisuke , Suzuki Sari , Kikkawa Yoshiaki , Moritoh Kanako , Sasaki Nobuya , Agui Takashi

… In this study, we found that the null mutation of the Ednrb gene, thought indispensable for enteric neuron development, is insufficient to result in HSCR disease when bred onto a different genetic background in rats carrying Ednrb^[sl] mutations. … Moreover, we found that this mutation results in serious congenital sensorineural deafness, and these strains may be used as ideal models of Waardenburg Syndrome Type 4 (WS4). …

PLoS One 6(9), e24086, 2011-09-07

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20

NBS1 Recruits RAD18 via a RAD6-like Domain and Regulates Pol η-Dependent Translesion DNA Synthesis.

Yanagihara Hiromi , Kobayashi Junya , Tateishi Satoshi , Kato Akihiro , Matsuura Shinya , Tauchi Hiroshi , Yamada Kouichi , Takezawa Jun , Sugasawa Kaoru , Masutani Chikahide , Hanaoka Fumio , Weemaes Corry M , Mori Toshio , Zou Lee , Komatsu Kenshi

… Disruption of NBS1 abolished RAD18-dependent PCNA ubiquitination and Polη focus formation, leading to elevated UV sensitivity and mutation. …

Molecular cell 43(5), 788-797, 2011-09-02

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Search Results:　 1-20 of 13213

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Search Results:　 1-20 of 13213