CiNii Articles - nucleoside antibiotic

1

Production improvement of antifungal, antitrypanosomal nucleoside sinefungin by rpoB mutation and optimization of resting cell system of Streptomyces incarnatus NRRL8089(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)

Fukuda Koji , Tamura Takashi , Ito Hideyuki , Yamamoto Sayaka , Ochi Kozo , Inagaki Kenji

… Sinefungin, a nucleoside antibiotic with potent antifungal, antiviral, and anti-trypanosome activities, has been a target for production enhancement in the past decades through medium optimization and strain improvement. …

Journal of bioscience and bioengineering 109(5), 459-465, 2010-05-00

CiNii Fulltext PDF - Paid References (47) Cited by (2)
2

Identification of Ornithine-lactam Converted from Arginine in Streptomyces incarnatus NRRL8089 [in Japanese]

福田康二 , 田村隆 , 稲垣賢二

… incarnatus がアルギニンからオルニチンラクタムへの変換酵素を有する事を示唆する．このような酵素の報告例はこれまでになく，ニ次代謝酵素であることが示唆され，シネフンギン生合成との関連性に興味が持たれる．Sinefungin is a nucleoside antibiotic, in which a molecule of L-ornithine is linked to the 5' end of adenosine through a C-C bond. … The antibiotic was isolated from the culture broth of Streptomyces incarnatus. …

岡山大学農学部学術報告 99(1), 1-5, 2010-02-01

IR
3

Enhanced Production of the Fluorinated Nucleoside Antibiotic Nucleocidin by a rif^R-Resistant Mutant of Streptomyces calvus IFO13200

FUKUDA Koji , TAMURA Takashi , SEGAWA Yuko , MUTAGUCHI Yuta , INAGAKI Kenji

Actinomycetologica 23(2), 51-55, 2009-12-25

References (42)
4

Structural Investigations of Mode of Action of Drugs : Structure and Conformation of a Novel Peptidyl Nucleoside Antibiotic Chryscandin Hydrochloride Pentahydrate

LIU M. , ARORA S. K.

Journal of antibiotics = An International Journal Devoted to Research on Bioactive Microbial Products 61(5), 322-325, 2008-05-25

References (9)
5

Synthetic studies of liposidomycin degradation product: model studies of uracil group introductlon

Fukunishi Shouhei , Ubukata Makoto , Nakajima Noriyuki

Heterocycles 73(-), 627-640, 2007-12-01
6

P-425 Synthetic Study of the Nucleoside Antibiotic Polyoxin J

Miyauchi Satoko , Ichikawa Yoshiyasu , Nakano Keiji

International Symposium on the Chemistry of Natural Products 2006, "P-425", 2006-07-23

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7

Synthesis of Nitrogen-containing Natural Products Using Allyl Cyanate-to-isocyanate Rearrangement [in Japanese]

ICHIKAWA Yoshiyasu

… Applications of this rearrangement in the context of the natural product synthesis have realized a new approach to the synthesis of amino-sugars, a new protocol for stereocontrolled allyl amine synthesis, and the first total synthesis of the peptidyl nucleoside antibiotic, blasticidin S. …

Journal of Synthetic Organic Chemistry, Japan 64(2), 96-108, 2006-02-01

J-STAGE CrossRef References (65)
8

7 Total Synthesis of Blasticidin S [in Japanese]

Ohbayashi Masayoshi , Hirata Keiko , Ichikawa Yoshiyasu , Isobe Minoru

… Blasticidin S (1) is a representative peptidyl-nucleoside antibiotic first isolated from Streptomyces griseochromogenes in 1958 by Yonehara and co-workers. … This antibiotic was once commercialized as a fungicide against the virulent fungus, Piricularia oryzae, a serious cause of rice blast disease in Asia. …

天然有機化合物討論会講演要旨集 (45), 37-42, 2003-09-01

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9

Toward the Assignment of Liposidomycin Stereochemistry: Synthesis of 1,4-Diazepan-3-one Analogues by Reductive Amination Approach

Nakajima Noriyuki , Isobe Takahiro , Irisa Shiro 他

Heterocycles 59(1), 107-113, 2003-01-01

Cited by (4)
10

Studies on the formation and incorporation of streptolidine in the biosynthesis of the peptidyl nucleoside antibiotic streptothricin F

JACKSON M. D.

J. Org. Chem. 67, 2934-2941, 2002

Cited by (2)
11

15 Total Synthesis of Spicamycin [in Japanese]

Suzuki Tamotsu , Tanaka Sayaka , Yamada Iwao , Koashi Yoshiaki , Yamada Kazue , Chida Noritaka

… Spicamycin (1), a novel nucleoside antibiotic isolated from Streptomyces shows potent antitumor activities. … The structure of 1 is quite unique among the nucleoside antibiotics: while conventional adenine-nucleoside antibiotics bear a furanose at the N(9) position, 1 is glycosylated at the C(6)-amino group of adenine. … Deacetylation of 24, followed by deprotection with BBr_3 provided spicamycin amino nucleoside (SAN, 2). …

天然有機化合物討論会講演要旨集 (42), 85-90, 2000-10-01

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12

First Total Syntheses of (+)-Polyoxin B and (+)-Polyoxin D

Uchida Kimio , Kato Keisuke , Yamaguchi Kentaro 他

Heterocycles 53(10), 2253-2259, 2000-10-00
13

Synthesis of Oxetanocin and Related Compounds and Oxetanose Chemistry. [in Japanese]

NISHIYAMA Shigeru , YAMAMURA Shosuke

… Related to antiviral agents, nucleoside antibiotic oxetanocin-A isolated from culture broth of <I>Bacillus megaterium</I> … Of interest is the novel oxetanoside moiety (four-membered ring sugar) of this antibiotic which would promise developments of new antiviral agents. … Recent progress of nucleoside analogues relevant to oxetanocin-A is also included. …

Journal of Synthetic Organic Chemistry, Japan 49(7), 670-681, 1991

J-STAGE CrossRef
14

67 SYNTHESIS OF OXETANOCIN, A NOVEL NUCLEOSIDE AND CHEMISTRY OF OXETANOSE [in Japanese]

Nishiyama S. , Ohgiya T , Yamamura S. , Kato K. , Nagai M. , Takita T.

… Oxetanocin, a novel nucleoside antibiotic carrying a oxetanose as a sugar moiety, has exhibited remarkable antiviral activities. … This intriguing antibiotic prompted us to start synthetic studies including related compounds as well as a new oxetanose chemistry, which are ultimately focused on developments of efficient antiviral agents deeming 1 a lead compound. …

天然有機化合物討論会講演要旨集 (32), 503-509, 1990-09-25

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15

CYTOTOXIC EFFECT OF ACYCLOVIR ON CULTURED MAMMALIAN CELLS TO WHICH HERPESVIRUS THYMIDINE KINASE GENE WAS INTRODUCED

TANABE Kiyoshi , HIRAOKA Wakako , KUWABARA Mikinori , SATO Fumiaki , NARITA Takahiro , NIIKURA Masahiro

… The cytotoxic effects of acyclovir, which is a purine nucleoside analogue and is known as an antibiotic substance, were examined on three lines of rat skin fibroblast FR cells ; … This also means that FRtk^-HSVtk^+ cells are useful for the investigation of the biological activity of nucleoside analogues. …

Japanese journal of veterinary research 37(3/4), 181-185, 1989-11-10

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16

Liposidomycin C Inhibits Phospho-N-acetylmuramyl-pentapeptide Transferase in Peptidoglycan Synthesis of Escherichia coli Y-10(Biological Chemistry)

KIMURA Ken-ichi , MIYATA Nobuo , KAWANISHI Gosei , KAMIO Yoshiyuki , IZAKI Kazuo , ISONO Kiyoshi

… 1009) is a novel nucleoside antibiotic containing uracil, a sulfated aminosugar, and a fatty acid. …

Agricultural and biological chemistry 53(7), 1811-1815, 1989-07-23

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17

The structure of a new nucleoside antibiotic, cepuramycin

SETO H.

Tetrahedron Lett. 29, 2343-2346, 1988

Cited by (5)
18

The structure of a new nucleoside antibiotic, capuramycin

SETO H.

Tetrahedron Lett. 29, 2343-2346, 1988

CrossRef Cited by (2)
19

36 Structures of Liposidomycins, inhibitors of Bacterial Peptidoglycan Synthesis [in Japanese]

Ubukata Makoto , Noguchi Machiko , Isono Kiyoshi , Kimura Kenichi , Nelson Chad C. , McCloskey James A.

… We propose the structure of a nucleoside antibiotic liposidomycinB(1), which is a main component produced by Streptomyces griseosporeus, as shown in Fig. 1 on the basis of chemical and spectroscopic evidences. …

天然有機化合物討論会講演要旨集 (29), 271-278, 1987-07-25

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20

Synthesis of Bredinin from 1-β-D-Ribofuranosyl-5-aminoimidazole-4-carboxamide by a Photo-Reaction

FUKUKAWA KIYOFUMI , SHUTO SATOSHI , HIRANO TAKAO , UEDA TOHRU

… Photolysis of 1-β-D-ribofuranosyl-5-aminoimidazole-4-carboxamide (AICA-riboside) gave 2-amino-N-(β-D-ribofuranosyl)malondiamide, which was cyclized by treatment with ethyl orthoformate to furnish 1-β-D-ribofuranosyl-5-hydroxyimidazole-4-carboxamide (bredinin), a potent immunosuppressive nucleoside antibiotic. …

Chemical & pharmaceutical bulletin 34(9), 3653-3657, 1986-09-25

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