Search Results:　 1-20 of 372

1

Novel monoclonal antibody recognizing triglyceride-rich oxidized LDLs associated with severe liver disease and small oxidized LDLs in normal subjects

Sakurai Toshihiro , Ichikawa Ayako , Furukawa Hiroyuki , Wada Norio , Nagasaka Atsushi , Takahashi Yuji , Fujikawa Masato , Ikuta Akiko , Furumaki Hiroaki , Shiga Maiko , Shimizu Chikara , Hui Shu-Ping , Jin Shigeki , Takeda Seiji , Fuda Hirotoshi , Nagasaka Hironori , Kobayashi Seiichi , Chiba Hitoshi

… The time course of copper-mediated LDL oxidation was monitored using this ELISA. … The results were compared to those of the two commercial ELISAs for oxidized LDL using DLH or ML25, thiobarbituric acid reactive substances (TBARS), and the optical absorbance for the conjugated dienes generated in lipid peroxides. … Results: G11-6 reacted with oxidized LDLs during only the early phase of copper-oxidation, being distinct from the other monoclonal antibodies and methods. …

Annals of Clinical Biochemistry 49(5), 456-462, 2012-09-00

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2

Re-evaluation of the oxidized LDL hypothesis : Prospects for oxidized LDL found in vivo [in Japanese]

板部洋之

昭和大学薬学雑誌 3(1), 15-25, 2012-07-00

Ichushi Web
3

Danhong Inhibits Oxidized Low-Density Lipoprotein-Induced Immune Maturation of Dentritic Cells via a Peroxisome Proliferator Activated Receptor γ-Mediated Pathway

LIU Hongying , WANG Shijun , SUN Aijun , HUANG Dong , WANG Wei , ZHANG Chunyu , SHI Dazhuo , CHEN Keji , ZOU Yunzeng , GE Junbo

… Here, we determined the effect and possible mechanism of DHI on oxidized low-density lipoprotein (ox-LDL)-induced maturation and immune function of DCs. … Human monocyte-derived DCs were incubated with DHI or ciglitazone and were subsequently stimulated with ox-LDL to induce maturation. … agonist, DHI, could significantly reduce ox-LDL-induced expressions of mature markers, enhance the endocytotic function, and inhibit secretions of cytokine on DCs. …

Journal of Pharmacological Sciences 119(1), 1-9, 2012-05-20

J-STAGE CrossRef References (32)
4

Dyslipidemia [in Japanese]

真下大和 , 前田朝美 , 寺本民生

日本臨床 70(5), 852-856, 2012-05-00

Ichushi Web
5

Protective Effect of Probucol Against Oxidative Cell Damage Induced by Oxidized Low-Density Lipoprotein and High Glucose ？n Human Mesangial Cells

番典子 , 齋木厚人 , 遠藤渓他

東邦医学会雑誌 = Journal of Medical Society of Toho University 59(3), 123-132, 2012-05-00

Ichushi Web
6

日本人の心血管リスク : 脂質異常症の意義 (代謝) -- (臨床分野での進歩) [in Japanese]

岡村智教 , 杉山大典

Annual review. 糖尿病・代謝・内分泌 2012(-), 126-131, 2012-00-00
7

Evaluation of oxidized LDL using LOX-1 ligand activity [in Japanese]

UCHIDA Kagehiro , SUEHIRO Akira , SAWAMURA Tatsuya , WAKABAYASHI Ichiro

Japanese Journal of Thrombosis and Hemostasis 23(3), 306-308, 2012

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8

Paeonol Inhibits Oxidized Low Density Lipoprotein-Induced Monocyte Adhesion to Vascular Endothelial Cells by Inhibiting the Mitogen Activated Protein Kinase Pathway

Wang Yue-Qin , Dai Min , Zhong Ji-Chang , Yin Deng-Ke

… The present study aims to investigate whether paeonol can inhibit monocyte adhesion to vascular endothelial cells induced by oxidized Low-Density Lipoprotein (ox-LDL) and its possible therapeutic molecular mechanism. … Exposure to ox-LDL (50, 100 µg/mL) induced damaged to VECs leading to decreased survival rates (p<0.01). …

Biological and Pharmaceutical Bulletin 35(5), 767-772, 2012

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9

Soluble Lectin-Like Oxidized LDL Receptor-1 and High-Sensitivity Troponin T as Diagnostic Biomarkers for Acute Coronary Syndrome : Improved Values With Combination Usage in Emergency Rooms

KOBAYASHI Nobuaki , HATA Noritake , KUME Noriaki , SHINADA Takuro , TOMITA Kazunori , SHIRAKABE Akihiro , KITAMURA Mitsunobu , NOZAKI Ayaka , INAMI Toru , SEINO Yoshihiko , MIZUNO Kyoichi

… We evaluated the diagnostic value of a new biomarker of plaque vulnerability (soluble lectin-like oxidized low-density lipoprotein receptor-1, sLOX-1) as compared with hs-TnT in the emergency room (ER). …

Circulation Journal 75(12), 2862-2871, 2011-11-25

J-STAGE Ichushi Web CrossRef References (41)
10

Oxidative modification of phosphatidylcholine in atherosclerotic vascular disease [in Japanese]

浅井明 , 及川眞一

Oleoscience 11(11), 419-424, 2011-11-00
11

Low-Density Lipoprotein Apheresis in Refractory Nephrotic Syndrome [in Japanese]

Muso Eri

… Low-density lipoprotein apheresis (LDL-A) using a dextran sulfate cellulose column in combination with conventional drug treatment is known to yield rapid relief of NS, and improve drug sensitivity especially in drug-resistant focal segmental glomerulosclerosis (FGS). …

Japanese journal of apheresis 30(2), 75-84, 2011-05-31

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12

Epidemiological evidence on the impact of postprandial hyperglycemia and dyslipidemia on the development of arterial sclerotic diseases [in Japanese]

Nakagami Tomoko , Iwamoto Yasuhiko

… そこでRLPの出現が促進、LDLは小型化し酸化LDLとなり、両者は容易に動脈壁マクロファージに取り込まれ動脈硬化プラークを形成する。 …

Journal of Tokyo Women's Medical College 81(E2), E100-E104, 2011-03-31

IR Ichushi Web
13

Dyslipidemia and atherosclerosis [in Japanese]

木庭新治 , 平野勉

Japanese journal of clinical medicine 69(1), 138-143, 2011-01-00

Ichushi Web
14

Cannabidiol-2',6'-dimethyl Ether as an Effective Protector of 15-Lipoxygenase-Mediated Low-Density Lipoprotein Oxidation in Vitro

Takeda Shuso , Hirayama Akari , Urata Shino , Mano Nobutaka , Fukagawa Keiko , Imamura Midori , Irii Ayumi , Kitajima Satomi , Masuyama Tomoko , Nomiyama Mai , Tatei Sachiko , Tomita Saari , Kudo Taichi , Noguchi Momoko , Yamaguchi Yasuhiro , Okamoto Yoshiko , Amamoto Toshiaki , Fukunishi Yoshifumi , Watanabe Kazuhito , Omiecinski Curtis John , Aramaki Hironori

… 15-Lipoxygenase (15-LOX) is one of the key enzymes responsible for the formation of oxidized low-density lipoprotein (ox-LDL), a major causal factor for atherosclerosis. … Both enzymatic (15-LOX) and non-enzymatic (Cu2+) mechanisms have been proposed for the production of ox-LDL. … In the LDL, linoleic acid is present as cholesteryl linoleate, the major fatty acid esterified to cholesterol, and is susceptible to oxidative modification by 15-LOX or Cu2+. …

Biological and Pharmaceutical Bulletin 34(8), 1252-1256, 2011

J-STAGE CrossRef
15

Effects of Serum Amyloid A and Lysophosphatidylcholine on Intracellular Calcium Concentration in Human Coronary Artery Smooth Muscle Cells

Tanaka Tomofumi , Ikeda Kenichi , Yamamoto Yumiko , Iida Haruko , Kikuchi Hironobu , Morita Toshihiro , Yamasoba Tatsuya , Nagai Ryozo , Nakajima Toshiaki

… Serum amyloid A (SAA), an acute-phase protein, and lysophosphatidylcholine (LPC), an oxidized LDL component, contribute to the physiological processes of atherosclerosis and cardiovascular disease. …

International Heart Journal 52(3), 185-193, 2011

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16

Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox

NISHIZUKA Taichi , FUJITA Yoshiko , SATO Yuko , NAKANO Atushi , KAKINO Akemi , OHSHIMA Shunji , KANDA Tomomasa , YOSHIMOTO Ryo , SAWAMURA Tatsuya

… Lectin-like oxidized LDL receptor-1 (LOX-1) is an endothelial receptor for oxidized LDL (oxLDL) and plays multiple roles in the development of cardiovascular diseases. …

Proceedings of the Japan Academy, Series B 87(3), 104-113, 2011

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17

Effect of hormone replacement therapy on total serum anti-oxidant potential and oxidized LDL/β2-glycoprotein I complexes in postmenopausal women

DARABI Maryam , ANI Mohsen , MOVAHEDIAN Ahmad , ZAREAN Elahe , PANJEHPOUR Mojtaba , RABBANI Mohammed

Endocrine journal 57(12), 1029-1034, 2010-12-01

References (30)
18

Inhibitory Effects of Balsamic Vinegar on LDL Oxidation and Lipid Accumulation in THP-1 Macrophages

IIZUKA Maki , TANI Mariko , KISHIMOTO Yoshimi , SAITA Emi , TOYOZAKI Miku , KONDO Kazuo

… Oxidized low-density lipoprotein (LDL) is believed to contribute to atherosclerosis in part by being taken up into macrophages via scavenger receptors, thus accounting for foam cells. … In this study, we investigated the preventive effects of balsamic vinegar on LDL oxidation and foam cell formation. … Balsamic vinegar dramatically inhibited LDL oxidation by azoradicals and endothelial cell-mediated oxidation in vitro. …

Journal of Nutritional Science and Vitaminology 56(6), 421-427, 2010-12-01

J-STAGE Ichushi Web CrossRef References (25)
19

Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice

Wang Fei , Okamoto Yasuo , Inoki Isao , Yoshioka Kazuaki , Du Wa , Qi Xun , Takuwa Noriko , Gonda Koichi , Yamamoto Yasuhiko , Ohkawa Ryunosuke , Nishiuchi Takumi , Sugimoto Naotoshi , Yatomi Yutaka , Mitsumori Kunitoshi , Asano Masahide , Kinoshita Makoto , Takuwa Yoh

… Consequently, they also displayed reduced cytokine expression, reduced oxidized LDL uptake, and stimulated cholesterol efflux associated with decreased scavenger receptor expression and increased cholesterol efflux transporter expression. … mice diminished the atherosclerotic plaque area in aortas and modified LDL accumulation in macrophages. …

J Clin Invest. 120(11), 3979-3995, 2010-11-01

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20

Visualization of Lipid Components in Human Coronary Plaques Using Color Fluorescence Angioscopy

UCHIDA Yasumi , UCHIDA Yasuto , KAMEDA Noriaki

… <b><i>Background:</i></b> If oxidized low-density lipoprotein (oxLDL), LDL, lysophosphatidylcholine (LPC) and apolipoprotein B (apoB) can be visualized simultaneously, their roles in the initiation, progression and destabilization of atherosclerotic plaques can be objectively evaluated. …

Circulation Journal 74(10), 2181-2186, 2010-09-25

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