Search Results:　 1-20 of 338

1

4,8-Sphingadienine and 4-hydroxy-8-sphingenine activate ceramide production in the skin

Shirakura Yoshiyuki , Kikuchi Kanako , Matsumura Kenji , Mukai Katsuyuki , Mitsutake Susumu , Igarashi Yasuyuki

… Real-time quantitative RT-PCR was performed to assess the effect of d18:2 and t18:1 on gene expression in normal human epidermal keratinocytes, while their effect on the nuclear receptor, peroxisome proliferator-activated receptor (PPAR)γ, was measured using a receptor-cofactor assay system. …

Lipids in Health and Disease 11, 108, 2012-08-31

IR CrossRef
2

PPARγ protects hepatocytes against inflammatory injury and inhibits tumor growth of human HCC [in Japanese]

久保木知 , 野島広之 , 篠田公生他

消化器内科 54(6), 739-743, 2012-06-00

Ichushi Web
3

Danhong Inhibits Oxidized Low-Density Lipoprotein-Induced Immune Maturation of Dentritic Cells via a Peroxisome Proliferator Activated Receptor γ-Mediated Pathway

LIU Hongying , WANG Shijun , SUN Aijun , HUANG Dong , WANG Wei , ZHANG Chunyu , SHI Dazhuo , CHEN Keji , ZOU Yunzeng , GE Junbo

… Similar to ciglitazone, a peroxisome proliferator activated receptor (PPAR) γ … These effects of DHI could be partly reversed by silencing the PPARγ. … In conclusion, DHI could inhibit ox-LDL-induced maturation of DCs partly through activating a PPARγ-mediated signaling pathway. …

Journal of Pharmacological Sciences 119(1), 1-9, 2012-05-20

J-STAGE CrossRef References (32)
4

Activation of Peroxisome Proliferator-Activated Receptor-β/-δ (PPAR-β/-δ) Ameliorates Insulin Signaling and Reduces SOCS3 Levels by Inhibiting STAT3 in Interleukin-6-Stimulated Adipocytes [in Japanese]

Serrano-Marco Lucia , Rodriguez-Calvo Ricardo , El Kochairi Ilhem 他

Diabetes : a journal of the American Diabetes Association 5(2), 41-43, 2012-03-00
5

Potent PPARα Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice

Kim Young-il , Hirai Shizuka , Goto Tsuyoshi , Ohyane Chie , Takahashi Haruya , Tsugane Taneaki , Konishi Chiaki , Fujii Takashi , Inai Shuji , Iijima Yoko , Aoki Koh , Shibata Daisuke , Takahashi Nobuyuki , Kawada Teruo

… The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that regulates energy metabolism. … Previously, we reported that 9-oxo-10,12-octadecadienoic acid (9-oxo-ODA) is presented in fresh tomato fruits and acts as a PPARα agonist. …

PLoS ONE 7(2), e31317, 2012-02-09

IR CrossRef
6

American ginseng improves neurocognitive function in senescence-accelerated mice: Possible role of the upregulated insulin and choline acetyltransferase gene expression

Shi Shun , Shi Reika , Hashizume Kiyoshi

… Gene expressions of peroxisome proliferator-activated receptor delta (PPAR-d), insulin, choline acetyltransferase (ChAT) and amyloid precursor protein (APP) in the brain were measured by real-time quantitative reverse transcription polymerase chain reaction assays. … Gene upregulation of insulin and ChAT in the brain, but not of PPAR-d or APP, was evident in American ginseng-fed groups. …

GERIATRICS & GERONTOLOGY INTERNATIONAL 12(1), 123-130, 2012-01-00

IR Ichushi Web CrossRef
7

A Novel Mechanism for Hepatic Lipid Accumulation : A Physiological Role for Hepatic PPARγ-fsp27 Signal [in Japanese]

松末公彦

薬学雑誌 132(7), 823-829, 2012-00-00
8

Electrochemical SNP Detection Using Glucose Dehydrogenase

ABE Koichi , KIYOHARA Chiharu , SAITO Yoko , SODE Koji , IKEBUKURO Kazunori

… In this study, we constructed an electrochemical detection system of an SNP of peroxisome proliferator-activated receptor γ2 (PPARγ2) (C34G) using glucose dehydrogenase (GDH) based on a single base extension method. … In this system, PPARγ2 (C34G) was detected specifically with 10－8 mol dm－3 detection limit based on amperometric sensing system. …

Electrochemistry 80(5), 345-347, 2012

J-STAGE CrossRef
9

Ameliorative Effects of Telmisartan on the Inflammatory Response and Impaired Spatial Memory in a Rat Model of Alzheimer's Disease Incorporating Additional Cerebrovascular Disease Factors

Shindo Taro , Takasaki Kotaro , Uchida Kanako , Onimura Rika , Kubota Kaori , Uchida Naoki , Irie Keiichi , Katsurabayashi Shutaro , Mishima Kenichi , Nishimura Ryoji , Fujiwara Michihiro , Iwasaki Katsunori

… Telmisartan, an angiotensin type 1 receptor blocker, is used in the management of hypertension to control blood pressure. … In addition, telmisartan has a partial agonistic effect on peroxisome proliferator activated receptor γ (PPARγ). … These effects of telmisartan were antagonized by GW9662, an antagonist of PPARγ. …

Biological and Pharmaceutical Bulletin 35(12), 2141-2147, 2012

J-STAGE CrossRef
10

Effects of structural and electronic characteristics of chalcones on the activation of peroxisome proliferator-activated receptor gamma (PPARγ)

Schott Jason Taylor , Mordaunt Charles Edward , Vargas Anthony Joseph , Leon Martin Antonio , Chen Kevin Hsinwen , Singh Mandeep , Satoh Mikiko , Cardenas Emilio Leal , Maitra Santanu , Patel Nilay Vinod , de Lijser Hubrecht Johan Peter

… Chalcones share some structural similarities with GW-1929, a highly-selective and a potent agonist for peroxisome proliferator-activated receptor-gamma (PPARγ). … In this study, we tested 53 structurally diverse chalcones to identify characteristics essential for PPARγ activation in a GAL4-based transactivation assay. …

Chemical and Pharmaceutical Bulletin, 2012

J-STAGE CrossRef
11

Plantagiolides I and J, Two New Withanolide Glucosides from Tacca plantaginea with Nuclear Factor-kappaB Inhibitory and Peroxisome Proliferator-Activated Receptor Transactivational Activities

Quang Tran Hong , Ngan Nguyen Thi Thanh , Minh Chau Van , Kiem Phan Van , Yen Pham Hai , Tai Bui Huu , Nhiem Nguyen Xuan , Thao Nguyen Phuong , Anh Hoang Le Tuan , Luyen Bui Thi Thuy , Yang Seo Young , Kim Young Ho

… Compounds 1–8 enhanced the transcriptional activity of peroxisome proliferator-activated receptors (PPARs) in a dose-dependent manner, with EC50 values ranging from 1.6 to 49.7 µM. … In addition, the transactivational effects of compounds 1–8 on three individual PPAR subtypes, including PPARα, β(δ), and γ were evaluated. …

Chemical and Pharmaceutical Bulletin 60(12), 1494-1501, 2012

J-STAGE CrossRef
12

The Involvement of Mitogen-Activated Protein Kinases in the 1α,25-Dihydroxy-Cholecalciferol-Induced Inhibition of Adipocyte Differentiation In Vitro

SAKUMA Satoru , FUJISAWA Junji , SUMIDA Maki , TANIGAWA Mami , INODA Rie , SUJIHERA Takuya , KOHDA Tetsuya , FUJIMOTO Yohko

… 1α,25-(OH)2-VD3 potently reduced the mRNA and/or protein expressions of CCAAT-enhancer binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ), and the nuclear translocation of PPARγ. … Furthermore, it inhibited the mRNA expression and phosphorylation of extracellular signal-regulated kinase (ERK), one of mitogen-activated protein kinases. …

Journal of Nutritional Science and Vitaminology 58(1), 1-8, 2012

J-STAGE Ichushi Web CrossRef
13

A Novel Mechanism for Hepatic Lipid Accumulation: A Physiological Role for Hepatic PPARγ-fsp27 Signal [in Japanese]

Matsusue Kimihiko

… The expression of fsp27 was markedly decreased in livers lacking the nuclear receptor peroxisome proliferator-activated receptor γ(PPARγ). … A functional PPAR response element site was identified in the fsp27 promoter region. …

YAKUGAKU ZASSHI 132(7), 823-829, 2012

J-STAGE CrossRef
14

A Naturally Occurring Rexinoid, Honokiol, Can Serve as a Regulator of Various Retinoid X Receptor Heterodimers

Kotani Hitoshi , Tanabe Hiroki , Mizukami Hajime , Amagaya Sakae , Inoue Makoto

… We investigated the properties of honokiol, a natural rexinoid, as a regulator of retinoid X receptor (RXR) heterodimers with various partner nuclear receptors (NRs), in comparison with those of the synthetic rexinoid bexarotene. …

Biological and Pharmaceutical Bulletin 35(1), 1-9, 2012

J-STAGE Ichushi Web CrossRef
15

Recent Advances in the Study on Resveratrol

Nakata Rieko , Takahashi Satoru , Inoue Hiroyasu

… Historically, resveratrol has been identified as a phytoalexin, antioxidant, cyclooxygenase (COX) inhibitor, peroxisome proliferator-activated receptor (PPAR) activator, endothelial nitric oxide synthase (eNOS) inducer, silent mating type information regulation 2 homolog 1 (SIRT1) activator, and more. …

Biological and Pharmaceutical Bulletin 35(3), 273-279, 2012

J-STAGE Ichushi Web CrossRef
16

Molecular Mechanisms of Environmental Organotin Toxicity in Mammals

Kotake Yaichiro

… TBT and TPT are dual agonists of retinoid X receptor (RXR) and peroxisome proliferator-activated receptor γ (PPARγ); … they also induce the differentiation of adipocytes in vitro and in vivo, probably through PPARγ activation, suggesting that they may work as obesogens. …

Biological and Pharmaceutical Bulletin 35(11), 1876-1880, 2012

J-STAGE CrossRef
17

The Role of Acetoacetyl-CoA Synthetase, a Ketone Body-Utilizing Enzyme, in 3T3-L1 Adipocyte Differentiation

Hasegawa Shinya , Ikeda Yotaro , Yamasaki Masahiro , Fukui Tetsuya

… Moreover, knockdown of AACS inhibits differentiation of 3T3-L1 cells and suppresses expression of the adipocyte markers, peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα). …

Biological and Pharmaceutical Bulletin 35(11), 1980-1985, 2012

J-STAGE CrossRef
18

Polymethoxyflavonoids from Kaempferia parviflora Induce Adipogenesis on 3T3-L1 Preadipocytes by Regulating Transcription Factors at an Early Stage of Differentiation

Horikawa Takumi , Shimada Tsutomu , Okabe Yui , Kinoshita Kaoru , Koyama Kiyotaka , Miyamoto Ken-ichi , Ichinose Koji , Takahashi Kunio , Aburada Masaki

… In addition, these PMFs enhanced the expression of peroxisome proliferator-activated receptor γ (PPARγ), but did not show PPARγ ligand activity. … We then investigated the expression of the differentiation-regulator located upstream of PPARγ. …

Biological and Pharmaceutical Bulletin 35(5), 686-692, 2012

J-STAGE Ichushi Web CrossRef
19

1β-Hydroxy-2-oxopomolic Acid Isolated from Agrimonia pilosa Extract Inhibits Adipogenesis in 3T3-L1 Cells

Ahn Eun-Kyung , Lee Jung A , Seo Dong-Wan , Hong Seong Su , Oh Joa Sub

… anti-adipogenic effect, this study investigated 1β-hydroxy-2-oxopomolic acid (HOA) isolated from Agrimonia pilosa inhibits adipocyte differentiation and expression of adipogenic marker genes, such as peroxisome proliferator activated receptor γ (PPARγ), CCAAT-enhancer-binding protein α (C/EBPα), glucose transporter 4 (GLUT4), adiponectin, adipocyte fatty acid-binding protein 2 (aP2), adipocyte determination and differentiation factor 1/sterol …

Biological and Pharmaceutical Bulletin 35(5), 643-649, 2012

J-STAGE Ichushi Web CrossRef
20

Feasibility of Structural Modification of Retinoid X Receptor Agonists to Separate Blood Glucose-Lowering Action from Adverse Effects: Studies in KKAy Type 2 Diabetes Model Mice

Kakuta Hiroki , Ohsawa Fuminori , Yamada Shoya , Makishima Makoto , Tai Akihiro , Yasui Hiroyuki , Yoshikawa Yutaka

… Retinoid X receptor (RXR) agonists are reported to exhibit blood glucose-lowering action owing to peroxisome proliferator-activated receptor (PPAR)/RXR or liver X receptor (LXR)/RXR activation, but may also cause adverse effects such as blood triglyceride elevation. …

Biological and Pharmaceutical Bulletin 35(4), 629-633, 2012

J-STAGE Ichushi Web CrossRef

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