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Mechanisms of NK cell activation stimulated by CD2 : granzyme B is released by CD2 crosslinking-stimulation on NK92 cells
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Inoue Hiroshi
,
Suwabe Takeshi
,
Fujimoto Tetsuya
,
Hirano Shun-ichiro
,
Aachi Tetsuya
,
Ohshima Takashi
,
Uchihashi Kenji
,
Fang Yi-ru
,
Meng Shu
,
Zhang Lin
,
Zhao Lei
,
Wu Ya-fei
,
Nishikawa Yasuo
… CD2 crosslinking-stimulation markedly induced phosphorylation of extracellular signal-regulated kinase (ERK)1/2 compared with nonstimulated NK92 cells. … Furthermore, we discovered that tyrosine phosphorylation of ERK1/2 was quickly induced within 1 min in an antibody concentration dependent manner. … These results suggest that CD2 crosslinking-stimulation enhances the release of granzyme B and phosphorylation of ERK1/2, which are critical events during NK cell-mediated cytotoxicity. …
Journal of Osaka Dental University 46(2), 229-235, 2012-10-00
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