Search Results:　 1-20 of 3818

1

Infliximab Treatment for Intravenous Immunoglobulin Therapy-Resistant Kawasaki Disease [in Japanese]

Kishi Takayuki/Sakauchi Masako/Yoshii Keisuke/Karaki Katsuji/Nishikawa Aiko/Oda Eri/Hayashi Noriko/Inai Kei/Osawa Makiko

【緒言】免疫グロブリン大量療法(IVIG)不応川崎病は冠動脈瘤の発症頻度が高くなるため、適切で安全な治療法が必要とされる。我々はIVIG不応川崎病に対して、インフリキシマブ(IFX)治療を行い、血漿交換療法(PEX)例との比較からその適応と効果、安全性について報告する。,【方法】対象は発症年齢1歳6ヵ月以上かつ第10病日以内の川崎病症例で、IVIGを行い白血球数、CRPなどの改善のない例をIFX治 …

Journal of Tokyo Women's Medical College 83(E1), E160-E165, 2013-01-31
2

RT-PCR- and MALDI-TOF Mass Spectrometry-Based Identification and Discrimination of Isoforms Homologous to Pufferfish Saxitoxin- and Tetrodotoxin-Binding Protein in the Plasma of Non-Toxic Cultured Pufferfish (Takifugu rubripes)

TATSUNO Ryohei , YAMAGUCHI Kenichi , TAKATANI Tomohiro 他

Bioscience, Biotechnology, and Biochemistry 77(1), 208-212, 2013-01-00
3

Functional characterization of a novel plasma membrane intrinsic protein2 in barley

Shibasaka Mineo , Sasano Sizuka , Utsugi Sigeko , Katsuhara Maki

… Plasma membrane intrinsic proteins (PIPs) have been shown to be primary channels mediating water uptake in plant cells. … When HvPIP2;8 was transiently expressed in onion epidermal cells, it was localized to the plasma membrane. …

Plant Signaling & Behavior 7(12), 1842-1846, 2012-12-00

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4

In Vivo Imaging of Hierarchical Spatiotemporal Activation of Caspase-8 during Apoptosis.

Kominami Katsuya , Nagai Takeharu , Sawasaki Tatsuya , Tsujimura Yuki , Yashima Kenta , Sunaga Yasuhiro , Tsuchimochi Masateru , Nishimura Jun , Chiba Kumiko , Nakabayashi Jun , Koyamada Koji , Endo Yaeta , Yokota Hideo , Miyawaki Atsushi , Manabe Noboru , Sakamaki Kazuhiro

… Our dual FRET (dual-FRET) system, comprising a triple fusion fluorescent protein, enabled us to simultaneously monitor the activation of CASP8 and its downstream effector, caspase-3 (CASP3) in single live cells. … We reproduced these observations by in vitro reconstitution of the cascade, with a recombinant protein mixture that included procaspases. …

PloS one 7(11), 2012-11-21

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5

Membrane Protein Rim21 Plays a Central Role in Sensing Ambient pH in Saccharomyces cerevisiae

Obara Keisuke , Yamamoto Hayashi , Kihara Akio

… These proteins were found to form a complex and to localize to the plasma membrane in a patchy and mutually-dependent manner. … This finding strongly suggests that Rim21 is the pH-sensor protein and that Dfg16 and Rim9 play auxiliary functions through maintaining the Rim21 level and assisting its plasma membrane localization. …

Journal of Biological Chemistry 287(46), 38473-38481, 2012-11-09

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6

Insulin Resistance Induced by Estrogen and Progesterone [in Japanese]

WADA Tsutomu

… The E2 promoted accumulation of estrogen receptor α(ERα) at the plasma membrane, and stimulated phosphorylated of IRS1 at Ser^<307> … Subsequently, insulin-induced translocation of GLUT4 to the plasma membrane and glucose uptake were decreased. … Surprisingly, P4 suppressed glucose uptake elicited by adenovirus-mediated expression of constitutive-active mutant of PI3-kinase and Akt, indicating that P4 suppressed insulin signaling independent to the reduction of IRS1 protein. …

Acta Obstetrica et Gynaecologica Japonica 64(11), 2255-2264, 2012-11-01

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7

Social memory, amnesia, and autism : Brain oxytocin secretion is regulated by NAD (+) metabolites and single nucleotide polymorphisms of CD38

Higashida Haruhiro , Yokoyama Shigeru , Huang Jian-Jun , Liu Li , Ma Wen-Jie , Akther Shirin , Higashida Chiharu , Kikuchi Mitsuru , Minabe Yoshio , Munesue Toshio

… Previously, we demonstrated that CD38, a transmembrane protein with ADP-ribosyl cyclase activity, plays a critical role in mouse social behavior by regulating the release of oxytocin (OXT), which is essential for mutual recognition. … The plasma levels of OXT in ASD subjects with the R140W allele were lower than those in ASD subjects lacking this allele. …

Neurochem Int 61(6), 828-838, 2012-11-00

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8

Usefulness of plasma transferrin levels as dynamic assessment of protein nutrition in dog [in Japanese]

中嶋眞弓 , 大野耕一 , 竹内由則他

ペット栄養学会誌 15(2), 65-71, 2012-10-00

Ichushi Web
9

Vba5p, a Novel Plasma Membrane Protein Involved in Amino Acid Uptake and Drug Sensitivity in Saccharomyces cerevisiae

SHIMAZU Masamitsu , ITAYA Teruhiro , PONGCHAROEN Pongsanat 他

Bioscience, Biotechnology, and Biochemistry 76(10), 1993-1995, 2012-10-00
10

Plasma leukocyte cell-derived chemotaxin 2 is associated with the severity of systemic inflammation in patients with sepsis

Ando Kazuyoshi , Kato Hidehito , Kotani Toru 他

Microbiology and immunology 56(10), 708-718, 2012-10-00
11

Habitual aerobic exercise increases plasma pentraxin 3 levels in middle-aged and elderly women

Miyaki Asako , Maeda Seiji , Choi Youngju , Akazawa Nobuhiko , Tanabe Yoko , Ajisaka Ryuichi , 宮木亜沙子 , 前田清司 , 鰺坂隆一

… Additionally, excess inflammation can be reduced by the anti-inflammatory protein pentraxin 3 (PTX3). … However, it is unclear whether regular exercise leads to increased plasma PTX3 concentration. … In the present study, we investigated the effects of regular aerobic exercise on plasma PTX3 concentration in middle-aged and elderly women. …

Applied physiology, nutrition, and metabolism 37(5), 907-911, 2012-10-00

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12

Electron Cyclotron Resonance-Sputtered Nanocarbon Film Electrode Compared with Diamond-Like Carbon and Glassy Carbon Electrodes as Regards Electrochemical Properties and Biomolecule Adsorption

Xue Qiang , Kato Dai , Kamata Tomoyuki , Umemura Shigeru , Hirono Shigeru , Niwa Osamu

… The three carbon electrodes show significant current reductions with increased peak separations as a result of protein fouling before oxygen plasma treatment, but the current reductions of the ECR-sputtered nanocarbon and DLC film electrodes are smaller than that of the GC electrode due to their superior surface flatness. … The oxygen plasma pretreated ECR-sputtered nanocarbon film electrode exhibits a significant improvement in anti-fouling performance with an improved electron transfer. …

Jpn J Appl Phys 51(9), 090124-090124-6, 2012-09-25

The Japan Society of Applied Physics
13

Association of Plasma Concentration of Small Heat Shock Protein B7 With Acute Coronary Syndrome

CHIU Te-Fa , LI Chih-Huang , CHEN Chun-Chuan , CHEN Chien-Hsiun , CHENG Chien-Jui , YAN Yu-Ting , YANG Ruey-Bing

… Methods and Results: A mouse myocardial infarction (MI) model and samples from clinical human subjects were used to determine plasma HSPB7 concentration after acute MI. … The associations of plasma HSPB7 concentration with ACS and other risk factors of coronary artery disease were analyzed. … Plasma HSPB7 concentration was found to be rapidly elevated in mice after coronary artery ligation. …

Circulation Journal 76(9), 2226-2233, 2012-08-25

J-STAGE CrossRef References (44)
14

Intracranial Rosai-Dorfman Disease - a Case Report and a Review of the Literature

Yamauchi Taishi .et.al

… RDD is histologically characterized by emperipolesis,where large histiocytes become infiltrated with lymphocytes and plasma cells. … The histiocytes were immunoreactive for S-100 protein and CD68 and negativefor CD1a, leading to the diagnosis of intracranial RDD. …

Acta medica Nagasakiensia 57(2), 57-63, 2012-07-00

IR
15

A thiol-mediated active membrane transport of selenium by erythroid anion exchanger 1 protein

Hongoh Masafumi , Haratake Mamoru , Fuchigami Takeshi , Nakayama Morio

… In this paper, we describe a thiol-mediated and energy-dependent membrane transport of selenium by erythroid anion exchanger 1 (AE1, also known as band 3 protein). … The AE1 is the most abundant integral protein of red cell membranes and plays a critical role in the carbon dioxide transport system in which carbon dioxide is carried as bicarbonate in the plasma. …

Dalton Transactions 41(24), 7340-7349, 2012-06-28

IR
16

Protein N-Myristoylation Is Required for Cellular Morphological Changes Induced by Two Formin Family Proteins, FMNL2 and FMNL3

MORIYA Koko , YAMAMOTO Takuo , TAKAMITSU Emi , MATSUNAGA Yukari , KIMOTO Mayumi , FUKUSHIGE Daichi , KIMOTO Chihiro , SUZUKI Takashi , UTSUMI Toshihiko

… The subcellular localization of 13 recently identified N-myristoylated proteins and the effects of overexpression of these proteins on cellular morphology were examined with the aim of understanding the physiological roles of the protein N-myristoylation that occurs on these proteins. … Immunofluorescence staining of HEK293T cells transfected with cDNAs coding for the proteins revealed that most of them were associated with the plasma membrane or the membranes of intracellular compartments, and did not affect cellular morphology. …

Bioscience, Biotechnology, and Biochemistry 76(6), 1201-1209, 2012-06-23

J-STAGE CrossRef References (41)
17

Anethum graveloens Flower Extracts Inhibited a Lipopolysaccharide-Induced Inflammatory Response by Blocking iNOS Expression and NF-κB Activity in Macrophages

KIM Yong-Jae , SHIN Yusu , LEE Kwang Ho , KIM Tack-Joong

… Toll-like receptors (TLRs) in the plasma membranes of macrophages are activated when they recognize the molecular structure of a virus or bacterium. … It also inhibited iNOS protein levels in LPS-stimulated RAW 264.7 cells. … In addition, AGF decreased the LPS-induced phosphorylation of mitogen-activated protein kinases in LPS-stimulated RAW 264.7 cells. …

Bioscience, Biotechnology, and Biochemistry 76(6), 1122-1127, 2012-06-23

J-STAGE CrossRef References (41)
18

Evaluation of MGUS [in Japanese]

Watanabe Takehiro

生命保険の査定において,高齢者に多い骨髄腫は引受がきわめて難しい疾患の一つである。しかし骨髄腫の前癌病変とされるMGUSではどうだろうか。MGUSは無症状であり治療の対象にはならないが,MGUSの一部は1年に1%程度の割合で骨髄腫や関連疾患へ移行していくとされ,MGUSの診断後10年あるいは20年経過しても,骨髄腫等へ移行するリスクは減少しない。MGUSのうちどのようなタイプが骨髄腫等へ移行しやす …

The journal of the Association of Life Insurance Medicine of Japan 110(2), 138-145, 2012-06-17

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19

Plasma level of lipopolysaccharide-binding protein is indicative of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation

YE Haige , LV Meng , ZHAO Xiaosu , ZHAO Xiangyu , HUANG Xiaojun

International journal of hematology 95(6), 680-688, 2012-06-01

References (24)
20

Promoting effects of carminic acid-enriched cochineal extracts on capsular invasive thyroid carcinomas through targeting activation of angiogenesis in rats

KEMMOCHI Sayaka , SHIMAMOTO Keisuke , SHIRAKI Ayako , ONDA Nobuhiko , HASUMI Keiji , SUZUKI Kazuhiko , MITSUMORI Kunitoshi , SHIBUTANI Makoto

The Journal of toxicological sciences 37(3), 475-482, 2012-06-01

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